Antiphencyclidine monoclonal fab fragments reverse phencyclidine-induced behavioral effects and ataxia in rats

Journal of Pharmacology and Experimental Therapeutics

Volumn 278, Issue 2, 1996, Pages 709-716

  Valentine, John L ^a,d   Mayersohn, Michael ^b   Wessinger, William D ^a   Arnold, Larry W ^c   Owens, S Michael ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d CIIT CENTERS FOR HEALTH RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIZOCILPINE; IMMUNOGLOBULIN F(AB) FRAGMENT; MONOCLONAL ANTIBODY; PHENCYCLIDINE;

ANIMAL EXPERIMENT; ANTIBODY SPECIFICITY; ARTICLE; ATAXIA; BEHAVIOR DISORDER; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; DRUG OVERDOSE; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ATAXIA; BEHAVIOR, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; LOCOMOTION; MALE; PHENCYCLIDINE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0030425697     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. ALLEN, H. L. AND IVERSEN, L. L.: Phencyclidine, dizocilpine, and cerebrocortical neurons. Science (Wash. DC) 247: 221, 1990.
2. ANILINE, O. AND PITTS, F. N., JR.: Phencyclidine (PCP): A review and perspectives. CRC Crit. Rev. Toxicol. 10: 145-177, 1982.
3. BENTON, B. J., RIVERA, V. R., HEWETSON, J. F. AND CHANG, F.-C. T.: Reversal of saxitoxin-induced cardiorespiratory failure by a burro-raised α-STX antibody and oxygen therapy. Toxicol. Appl. Pharmacol. 124: 39-51, 1994.
4. BURNS, R. S. AND LERNER, S. E.: Perspectives: Acute phencyclidine intoxication. Clin. Toxicol. 9: 477-501, 1976.
5. BRUNN, G. J., KEYLER, D. E., POND, S. M. AND PENTEL, P. R.: Reversal of desipramine toxicity in rats using drug-specific antibody Fab' fragment: Effects on hypotension and interaction with sodium bicarbonate. J. Pharmacol. Exp. Ther. 269: 1392-1399, 1992.
6. CHAUDIEU, I., VIGNON, J., CHICHEPORTICHE, M., KAMENKA, J.-M., TROUILLER, G. AND CHICHEPORTICHE, R.: Role of the aromatic group in the inhibition of phencyclidine binding and dopamine uptake by PCP analogs. Pharmacol. Biochem. Behav. 32: 699-705, 1989.
7. CHO, A. K., HIRAMATSU, M., SCHMITZ, D. A., NABESHIMA, T. AND KAMEYAMA, T.: Pharmacokinetic and pharmacodynamic properties of some phencyclidine analogs in rats. Pharmacol. Biochem. Behav. 39: 947-953, 1991.
8. COLBURN, W. A.: Specific antibodies and Fab fragments to alter the pharmacokinetics and reverse the pharmacologic/toxicologic effects of drugs. Drug Metab. Rev. 11: 223-262, 1980.
9. CONTRERAS, P. C., CONTRERAS, M. C., O'DONOHUE, T. C. AND LAIR, C. C.: Biochemical and behavioral effects of sigma and PCP ligands. Synapse 2: 240-243, 1988.
10. COOK, C. E., BRINE, D. R., JEFFCOAT, A. R., HILL, J. M., WALL, M. E., PEREZ-REYES, M. AND DI GUISEPPI, S. R.: Phencyclidine disposition after intravenous and oral doses. Clin. Pharmacol. Ther. 31: 625-634, 1982.
11. DOMINO, E. F.: Neurobiology of phencyclidine (Sernyl), a drug with an unusual spectrum of pharmacological activity. Int. Rev. Neurobiol. 6: 303-347, 1969.
12. DOMINO, E. F.: History and pharmacology of PCP and PCP-related analogs. J. Psychedelic Drugs 12: 223-227, 1980.
13. FAUMAN, M. A. AND FAUMAN, B. J.: Violence associated with phencyclidine abuse. Am. J. Psychiatry 136: 1584-1586, 1979.
14. GREIFENSTEIN, F. E., DEVAULT, M., YOSHITAKE, J. AND GAJEWSKI, J. E.: A study of a 1-arylcyclohexylamine for anesthesia. Anesth. Anal. 37: 283-294, 1958.
15. ITIL, T., KESKINER, A., KIREMITCI, N. AND HOLDEN, J. M. C.: Effects of phencyclidine in chronic schizophrenics. Can. Psychiatr. Assoc. J. 12: 209-212, 1967.
16. JOHNSTONE, M., EVANS, V. AND BAIGEL, S.: Sernyl (Cl-395) in clinical anaesthesia. Br. J. Anaesth. 31: 433-439, 1959.
17. LODGE, D., ANIS, N. A., BERRY, S. C. AND BURTON, N. R.: Arylcyclohexylamines selectively reduce excitation of mammalian neurons by aspartate-like amino acids. In Phencyclidine and Related Arylcyclohexylamines: Present and Future Applications, ed. by J.-M. Kamenka, E. F. Domino and P. Geneste, pp. 595-616, NPP Books, Ann Arbor, 1983.
18. LUISADA, P. V.: The phencyclidine psychosis: Phenomenology and treatment. In Phencyclidine (PCP) Abuse: An Appraisal, ed. by R. C. Petersen and R. C. Stillman, pp. 241-253, National Institute on Drug Abuse Research Monograph Series 21, Washington, 1978.
19. MCCLURKAN, M. B., VALENTINE, J. L. AND OWENS, S. M.: Disposition of a monoclonal anti-phencyclidine Fab fragment of immunoglobulin G in rats. J. Pharmacol. Exp. Ther. 266: 1439-1445, 1993.
20. MITRUKA, B. M. AND RAWNSLEY, H. M.: Clinical Biochemical and Hematological Reference Values in Normal Experimental Animals and Normal Humans, 2nd ed., Masson Publishing U.S.A., Inc., New York, 1981.
21. NABESHIMA, T., YAMAGUCHI, K., YAMADA, K., HIRAMATSU, M., KUWABARA, Y., FURUKAWA, H. AND KAMEYAMA, T.: Sex-dependent differences in the pharmacological actions and pharmacokinetics of phencyclidine in rats. Eur. J. Pharmacol. 97: 217-227, 1984.
22. NAGAO, M., TAKATORI, T., WU, B., TERAZAWA, K., GOTOUDA, H. AND AKABANE, H.: Immunotherapy for the treatment of acute paraquat poisoning. Human Toxicol. 8: 121-123, 1989.
23. OLNEY, J. W., LABRUYERE, J. AND PRICE, M. T.: Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs. Science (Wash. DC) 244: 1360-1362, 1989.
24. OWENS, S. M. AND MAYERSOHN, M.: Phencyclidine-specific Fab fragments alter phencyclidine disposition in dogs. Drug Metab. Dispos. 14: 52-58, 1986.
25. OWENS, S. M., ZORBAS, M., LATTIN, D. L., GUNNELL, M. AND POLK, M.: Antibodies against arylcyclohexylamines and their similarities in binding specificity with the phencyclidine receptor. J. Pharmacol. Exp. Ther. 246: 472-477, 1988.
26. PENTEL, P. R., KEYLER, D. E., GILBERTSON, D. G., RUTH, G. AND POND, S. M.: Pharmacokinetics and toxicity of high doses of antibody Fab fragments in rats. Drug Metab. Dispos. 16: 141-145, 1988.
27. SABOURAUD, A., URTIZBEREA, M., GRANDGEORGE, M., GATTEL, P., MAKULA, M. E. AND SCHERRMANN, J.-M.: Dose-dependent reversal of acute murine colchicine poisoning by goat colchicine-specific Fab fragments. Toxicology 68: 121-132, 1991.
28. SCHERRMANN, J.-M., TERRIEN, N., URTIZBEREA, M., PIERSON, P., DENIS, H. AND BOURRE, J. M.: Immunotoxicotherapy: Present status and future trends. J. Toxicol. Clin. Toxicol. 27: 1-35, 1989.
29. SMITH, D. E., WESSON, D. R., BUXTION, M. E., SEYMOUR, R. AND KRAMER, H. M.: The diagnosis and treatment of the PCP abuse syndrome. In Phencyclidine (PCP) Abuse: An Appraisal, ed. by R. C. Petersen and R. C. Stillman, pp. 229-240, National Institute on Drug Abuse Research Monograph Series 21, Washington, 1978.
30. SMITH, T. W., HABER, E., YEATMAN, L. AND BUTLER, V. P., JR.: Reversal of advanced digoxin intoxication with Fab fragments of digoxin-specific antibodies. N. Engl. J. Med. 294: 797-800, 1976.
31. STURGEON, R. D., FESSLER, R. G. AND MELTZER, H. Y.: Behavioral rating scales for assessing phencyclidine-induced locomotor activity, stereotyped behavior and ataxia in rats. Eur. J. Pharmacol. 58: 169-179, 1979.
32. TERRIEN, N., URTIZBEREA, M. AND SCHERRMANN, J.-M.: Reversal of advanced colchicine toxicity in mice with goat colchicine-specific antibodies. Toxicol. Appl. Sci. 104: 504-510, 1990.
33. VALENTINE, J. L., ARNOLD, L. W. AND OWENS, S. M.: Anti-phencyclidine monoclonal Fab fragments markedly alter PCP pharmacokinetics in rats. J. Pharmacol. Exp. Ther. 269: 1079-1085, 1994.
34. VALENTINE, J. L. AND OWENS, S. M.: Antiphencyclidine monoclonal antibody therapy significantly changes phencyclidine concentrations in brain and other tissues in rats. J. Pharmacol. Exp. Ther. 278: 717-724, 1996.
35. VIGNON, J., VINCENT, J. P., BIDARD, J. N., KAMENKA, J.-M., GENESTE, P., MONIER, S. AND LAZDUNSKI, M.: Biochemical properties of the brain phencyclidine receptor. Eur. J. Pharmacol. 81: 531-542, 1982.
36. VINCENT, J. P., DARTALOVSKI, B., GENESTE, P., KAMENKA, J.-M. AND LAZDUNSKI, M.: Interaction of phencyclidine ("angel dust") with a specific receptor in rat brain membranes. Proc. Natl. Acad. Sci. U.S.A. 76: 4678-4682, 1979.
37. 3H]-phencyclidine binding in rat central nervous system. Proc. Natl. Acad. Sci. U.S.A. 76: 5372-5376, 1979.