Discriminative stimulus effects of butorphanol: Influence of training dose on the substitution patterns produced by mu, kappa and delta opioid agonists

Journal of Pharmacology and Experimental Therapeutics

Volumn 279, Issue 3, 1996, Pages 1130-1141

  Picker, Mitchell J ^a   Benyas, Steven ^a   Horwitz, Jonas A ^a   Thompson, Kevin ^a   Mathewson, Christopher ^a   Smith, Mark A ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUPRENORPHINE; BUTORPHANOL; DELTA OPIATE RECEPTOR AGONIST; FENTANYL; KAPPA OPIATE RECEPTOR AGONIST; METAZOCINE; METHADONE; MORPHINE; MU OPIATE RECEPTOR AGONIST; NALBUPHINE; NALORPHINE; NALOXONE; NALTRINDOLE; PENTAZOCINE;

ANALGESIA; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG RECEPTOR BINDING; FEMALE; NONHUMAN; PIGEONS AND DOVES; PRIORITY JOURNAL;

ANALGESICS, OPIOID; ANIMALS; BENZAMIDES; BUTORPHANOL; COLUMBIDAE; DISCRIMINATION (PSYCHOLOGY); FEMALE; FENTANYL; PIPERAZINES; RECEPTORS, OPIOID;

EID: 0030425570     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. ARUNLAKSHANNA, O. AND SCHILD, H. O.: Some quantitative uses of drug antagonists. Br. J. Pharmacol. 14: 48-58, 1959.
2. BROADBEAR, J. H., NEGUS, S. S., BUTELMAN, E. R., DE COSTA, B. R. AND WOODS, J. H.: Differential effects of systemically administered nor-binaltorphimine (nor-BNI) on κ-opioid agonists in the mouse writhing assay. Psychopharmacology 115: 311-319, 1994.
3. BUTELMAN, E. R., WINGER, G., ZERNIG, G. AND WOODS, J. H.: Butorphanol: Characterization of agonist and antagonist effects in rhesus monkeys. J. Pharmacol. Exp. Ther. 272: 845-853, 1995.
4. CHANG, K.-J., RIGDON, G. C., HOWARD, J. L. AND MCNUTT, R. W.: A novel, potent and selective nonpeptidic delta opioid receptor agonist BW373U86. J. Pharmacol. Exp. Ther. 267: 852-857, 1993.
5. COMER, S. D., MCNUTT, R. W., CHANG, K.-J., DE COSTA, B. R., MOSBERG, H. I. AND WOODS, J. H.: Discriminative stimulus effects of BW373U86: A nonpeptide ligand with selectivity for delta opioid receptors. J. Pharmacol. Exp. Ther. 267: 866-874, 1993.
6. DYKSTRA, L. A.: Butorphanol, levallorphan, nalbuphine and nalorphine as antagonists in the squirrel monkey. J. Pharmacol. Exp. Ther. 254: 245-252, 1990.
7. FRANCE, C. P., MEDZIHRADSKY, F. AND WOODS, J. H.: Comparison of kappa opioids in rhesus monkeys: Behavioral effects and receptor binding affinities. J. Pharmacol. Exp. Ther. 268: 47-58, 1994.
8. FRANCE, C. P. AND WOODS, J. H.: Discriminative stimulus effects of opioid agonists in morphine-dependent pigeons. J. Pharmacol. Exp. Ther. 254: 626-632, 1990.
9. GAUVIN, D. V. AND YOUNG, A. M.: Effects of prior saline-morphine discrimination by pigeons on three-way discrimination including two morphine doses. Psychopharmacology 98: 222-230, 1989.
10. HOLTZMAN, S. G. AND STEINFELS, G. F.: Antagonism of the discriminative stimulus effects of the kappa-opioid agonist spiradoline. Psychopharmacology 116: 243-248, 1994.
11. HORAN, P. AND HO, I. K.: Butorphanol precipitates abstinence in morphine dependent rats. Eur. J. Pharmacol. 170: 263-268, 1989a.
12. HORAN, P. AND HO, I. K.: Comparative pharmacological and biochemical studies between butorphanol and morphine. Pharmacol. Biochem. Behav. 34: 847-854, 1989b.
13. HORAN, P. AND HO, I. K.: The physical dependence liability of butorphanol: a comparative study with morphine. Eur. J. Pharmacol. 203: 387-391, 1991.
14. JAW, S. P., MAKIMURA, M., HOSKINS, B. AND HO, I. K.: Effects of norbinaltorphimine on butorphanol dependence. Eur. J. Pharmacol. 239: 133-140, 1993.
15. KENAKIN, T. P.: Pharmacologic Analysis of Drug-Receptor Interaction, Raven Press, New York, 1993.
16. KOEK, W. AND WOODS, J. H.: Partial generalization in pigeons trained to discriminate morphine from saline: Applications of receptor theory. Drug Dev. Res. 16: 169-181, 1989.
17. LAHTI, R. A., VONVOIGTLANDER, P. F. AND BARSUHN, C.: Properties of a selective kappa agonist, U-50,488H. Life Sci. 31: 2257-2260, 1982.
18. LEANDER, J. D.: Evidence that nalorphine, butorphanol and oxilorphan are partial agonists at a κ-opioid receptor. Eur. J. Pharmacol. 86: 467-470, 1983.
19. NEGUS, S. S., BUTELMAN, E. R., CHANG, K.-J., DECOSTA, B. R., WINGER, G. AND WOODS, J. H.: Behavioral effects of the systemically active delta opioid agonist BW373U86 in rhesus monkeys. J. Pharmacol. Exp. Ther. 270: 1025-1034, 1994.
20. NEGUS, S. S., MORGAN, D., COOK, C. AND PICKER, M. J.: Effects of the delta opioid agonist BW373U86 in pigeons trained to discriminate fentanyl, bremazocine and water in a three-choice drug discrimination procedure. Psychopharmacology, 126:1 199-205, 1996.
21. NEGUS, S. S., PICKER, M. J. AND DYKSTRA, L. A.: Interactions between mu and kappa opioid agonists in the rat drug discrimination procedure. Psychopharmacology 102: 465-473, 1990.
22. OH, K. W., MAKIMURA, M., JAW, S. P., HOSKINS, B. AND HO, I. K.: Effects of β-funaltrexamine on butorphanol dependence. Pharmacol. Biochem. Behav. 42: 29-34, 1992.
23. OHNO, M., YAMAMOTO, T. AND UEKI, S.: Analgesic and discriminative stimulus properties of U-62,066E, the selective kappa-opioid receptor agonist, in the rat. Psychopharmacology 106: 31-38, 1992.
24. PICKER, M. J.: Discriminative stimulus and response rate-decreasing effects of kappa opioids: Antagonism by naloxone. Life Sci. 54: 1767-1775, 1994.
25. PICKER, M. J., CRAFT, R. M., NEGUS, S. S., POWELL, K. R., MATTOX, S. R., JONES, S. R., HARGROVE, B. K. AND DYKSTRA, L. A.: Intermediate efficacy mu opioids: Examination of their morphine-like stimulus effects and response rate-decreasing effects in morphine-tolerant rats. J. Pharmacol. Exp. Ther. 263: 668-681, 1992.
26. PICKER, M. J., DOTY, P., NEGUS, S. S., MATTOX, S. R. AND DYKSTRA, L. A.: Discriminative stimulus properties of U50,488 and morphine: Effects of training dose on stimulus substitution patterns produced by mu and kappa opioid agonists. J. Pharmacol. Exp. Ther. 254: 13-22, 1990a.
27. PICKER, M. J., MORGAN, D. AND NEGUS, S. S.: Interaction between the discriminative stimulus effects of mu opioids and the delta opioid, BW373U86. Natl. Inst. Drug Abuse Res. Monogr. Ser. 162: 106, 1995.
28. PICKER, M. J., NEGUS, S. S. AND CRAFT, R. M.: Butorphanol's efficacy at mu and kappa opioid receptors: Inferences based on the schedule-controlled behavior of nontolerant and morphine-tolerant rats and on the responding of rats in a drug discrimination procedure. Pharmacol. Biochem. Behav. 36: 563-568, 1990b.
29. PICKER, M. J., YARBROUGH, J., HUGHES, C. E., SMITH, M. A., MORGAN, D. AND DYKSTRA, L. A.: Agonist and antagonist effects of mixed action opioids in the pigeon drug discrimination procedure: Role of training dose, intrinsic efficacy and inter-animal differences. J. Pharmacol. Exp. Ther. 266: 756-767, 1993.
30. PIRCIO, A. W., GYLYS, J. A., CAVANAGH, R. L., BUYNISKI, J. P AND BIERWAGEN, M. E.: The pharmacology of butorphanol, a 3,14-dihydroxymorphinan narcotic antagonist analgesic. Arch. Int. Pharmacodyn. 220: 231-257, 1976.
31. PRESTON, K. L. AND BIGELOW, G. E.: Drug discrimination assessment of agonist-antagonist opioids in humans: A three-choice saline-hydromorphone-butorphanol procedure. J. Pharmacol. Exp. Ther. 271: 48-60, 1994.
32. PRESTON, K. L., BIGELOW, G. E. AND LIEBSON, I. A.: Butorphanol-precipitated withdrawal in opioid-dependent humans. J. Pharmacol. Exp. Ther. 248: 929-937, 1988.
33. PRESTON, K. L., BIGELOW, G. E. AND LIEBSON, I. A.: Discrimination of butorphanol and nalbuphine in opioid-dependent humans. Pharmacol. Biochem. Behav. 37: 511-522, 1990.
34. PRESTON, K. L., BIGELOW, G. E., BICKEL, W. K. AND LIEBSON, I. A.: Drug discrimination in human postaddicts: Agonist-antagonist opioids. J. Pharmacol. Exp. Ther. 250: 184-196, 1989.
35. PRESTON, K. L., LIEBSON, I. A. AND BIGELOW, G. E.: Discrimination of agonist-antagonist opioids in humans trained on a two-choice saline-hydromorphone discrimination. J. Pharmacol. Exp. Ther. 261: 62-71, 1992.
36. SHANNON, H. E. AND HOLTZMAN, S. G.: Further evaluation of the discriminative effects of morphine in the rat. J. Pharmacol. Exp. Ther. 201: 55-66, 1977.
37. SHANNON, H. E. AND HOLTZMAN, S. G.: Morphine training dose: A determinant of stimulus generalization to narcotic antagonists. Psychopharmacology 61: 239-244, 1979.
38. SMITH, M. A. AND PICKER, M. J.: Examination of the kappa-like discriminative stimulus effects of kappa opioids and mixed action opioids in rats: Influence of training dose and intrinsic efficacy. Behav. Pharm. 6: 703-717, 1995.
39. TALLARIDA, R. J. AND MURRAY, R. B.: Manual of Pharmacologic Calculations with Computer Programs, Springer-Verlag, New York, 1987.
40. WALKER, E. A. AND YOUNG, A. M.: Discriminative-stimulus effects of the low efficacy mu agonist nalbuphine J. Pharmacol. Exp. Ther. 267: 322-330, 1993.
41. WESSINGER, W. D. AND MCMILLAN, D. E.: Quantitative analysis of naloxone antagonism of the discriminative stimulus properties of morphine in the pigeon. Pharmacol. Biochem. Behav. 25: 209-214, 1986.
42. WILD, K. D., MCCORMICK, J., BILSKY, E. J., VANDERAH, T., MCNUTT, R. W., CHANG, K.-J. AND PORRECA, F.: Antinociceptive actions of BW373U86 in mouse. J. Pharmacol. Exp. Ther. 267: 858-865, 1993.
43. WOODS, J. H. AND GMEREK, D. E.: Substitution and primary dependence studies in animals. Drug Alcohol. Depend. 14: 233-247, 1985.
44. WOODS, J. H., WINGER, G. AND FRANCE, C. P.: Use of in vivo apparent pA2 analysis in assessment of opioid abuse liability. Trends Pharmacol. Sci. 13: 282-296, 1992.
45. YOUNG A. M., MASAKI, M. A. AND GEULA, C.: Discriminative stimulus effects of morphine: Effects of training dose on agonist and antagonist effects of mu opioids. J. Pharmacol. Exp. Ther. 261: 246-257, 1992.
46. YOUNG, A. M., STEPHENS, K. R., HEIN, D. W. AND WOODS, J. H.: Reinforcing and discriminative stimulus properties of agonist-antagonist opioids. J. Pharmacol. Exp. Ther. 229: 118-126, 1984.
47. YOUNG, A. M., WALTON, M. A. AND PERKINS, A. N.: Characteristics of a discrimination among two doses of morphine and saline in pigeons. Drug Dev. Res. 16: 163-168, 1989.