Endogenous tumor necrosis factor enhances topoisomerase II inhibitors activity in human ovarian cancer cell lines

Journal of Pharmacology and Experimental Therapeutics

Volumn 279, Issue 1, 1996, Pages 84-90

  Debernardis, Domizia ^a   Stanzione, Sabrina ^a   Ottoboni, Cristina ^a   Clerico, Luana ^a   Mancuso, Tommaso ^a   Parodi, Silvio ^a   Russo, Patrizia ^a  

^a UNIVERSITY OF GENOA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN; CISPLATIN; DOXORUBICIN; ETOPOSIDE; GYRASE INHIBITOR; MITOXANTRONE; TUMOR NECROSIS FACTOR; VINBLASTINE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL STRAIN L 929; CONTROLLED STUDY; DRUG INHIBITION; DRUG POTENTIATION; HUMAN; HUMAN CELL; OVARY CANCER; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; CISPLATIN; DNA DAMAGE; DNA TOPOISOMERASES, TYPE II; ENZYME INHIBITORS; FEMALE; HUMANS; MITOXANTRONE; OVARIAN NEOPLASMS; TETRADECANOYLPHORBOL ACETATE; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0030425316     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. ACKERMAN, P., GLOVER, C. V. C. AND OSHEROFF, N.: Phosphorylation of DNA topoisomerase II by casein kinase II: Modulation of eukaryotic topoisomerase II activity in vitro. Proc. Natl. Acad. Sci. U.S.A. 82: 3164-3168, 1985.
2. ADERKA, D., ENGELMAN, H., HORNIH, V., LEVO, Y., WALLACK, D. AND KUSHTAI, G.: Increased serum levels of soluble receptors for tumor necrosis factor in cancer. Cancer Res. 51: 5602-5607, 1991.
3. AGGARWAL, B. B. AND VILCEK, J., EDITORS: Tumor Necrosis Factor: Structure, Function and Mechanisms of Action, pp. 1-600, Marcel Dekker, New York, 1991.
4. ALUIGI M. A., DEBERNARDIS, D., CIMOLI, G., OTTOBONI, C., PARODI, S. AND RUSSO, P.: Tumor necrosis factor and DNA topoisomerase II inhibitors in human ovarian cancer: Potential role in chemotherapy. Int. J. Oncol. 7: 461-467, 1995.
5. BALKWILL, F. R.: Tumor necrosis factor. Br. Med. Bull. 45: 389-400, 1989.
6. CIMOLI, G., RUSSO, P., BILLI, G., MARIANI, G. L., ROVINI, E. AND VENTURINI, M.: Human granulocyte-macrophage colony-stimulating factor is a growth factor active in human ovarian cancer cell lines. Jpn. J. Cancer Res. 82: 1196-1198, 1991.
7. CIMOLI, G., VALENTI, M., VENTURINI, M., CONTE, P. F. AND RUSSO, P.: Augmentation of antineoplastic effects by the combination of recombinant human tumor necrosis factor and Mitoxantrone on primary culture of human ovarian cancer cells. Anticancer Res. 12: 1411-1414, 1992.
8. CIMOLI, G., VALENTI, M., PARODI, S., MAZZONI, A., DE SESSA, F., CONTE, P. F. AND RUSSO, P.: Reversal of "atypical"-multidrug resistance by recombinant human tumor necrosis factor in the human ovarian cancer cell line A2780-DX3. Oncol. Res. 5: 311-323, 1993.
9. D'ARPA, P. AND LIU, L. F.: Topoisomerase-targeting antitumor drugs. Biochim. Biophys. Acta 989: 163-177, 1989.
10. DEL MASTRO, L., VENTURINI, M., GIANNESSI, P. G., VIGANI, A., GARRONE, O., CARNINO, F., RUSSO, P., GALLETTI, P. G., ROSSO, R. AND CONTE, P. F.: Intraperitoneal infusion of recombinant human tumor necrosis factor and Mitoxantrone in neoplastic ascites: A feasibility study. Anticancer Res. 15: 2207-2212, 1995.
11. DVORAK, H. F.: Tumors wounds that do not heal. N. Engl. J. Med. 315: 1650-1659, 1986.
12. FREI III, E. AND SPRIGGS, D.: Tumor necrosis factor: Still a promising agent. J. Clin. Oncol. 7: 291-294, 1989.
13. HIGUCHI, M. AND AGGARWAL, B. B.: Modulation of two forms of tumor necrosis factor receptors and their cellular response by soluble receptors and their monoclonal antibodies. J. Biol. Chem. 267: 20892-20897, 1992.
14. HOHMANN, H. P., REMY, R., BROCKHAUS, M. AND VAN LOON, A. P. G. M.: Two different cell types have different major receptors for human tumor necrosis factor (TNF-α). J. Biol. Chem. 265: 14497-14501, 1989.
15. HWANG, J., SHYY, S., CHEN, A. Y., JAUN, C. C. AND WHANG-PENG, J.: Studies of topoisomerase-specific antitumor drugs in human lymphocytes using rabbit antisera against human topoisomerase II polypeptide. Cancer Res. 49: 958-962, 1989.
16. HWANG, C., GATANAGA, M., GRANGER, G. A. AND GATANAGA, T.: Mechanism of release of soluble forms of Tumor necrosis factor/lymphotoxin receptors by phorbol myristate acetate-stimulated human THP-1 cells in vitro. J. Immunol. 151: 5631-5638, 1993.
17. JOHNS, L. D., SARR, T. AND RANGES, G. E.: Inhibition of ceramide pathway does not affect ability of TNF-α to activate nuclear factor-κB. J. Immunol. 152: 5877-5882, 1994.
18. MALIK, S. AND BALKWILL F.: Epithelial ovarian cancer: A cytokine propelled disease? Br. J. Cancer 64: 617-620, 1991.
19. NAYLOR, M. S., MALIK, S. T. A., STAMP, G. W., JOBLING, T. AND BALKWILL, F. R.: In situ detection of tumor necrosis factor in human ovarian cancer specimens. Eur. J. Cancer. 26: 1027-1030, 1990.
20. NAYLOR M. S., STAMP, G. W. H., FOULKES, W. D., ECCLES, D. AND BALKWILL, F. R.: Tumor necrosis factor and its receptors in human ovarian cancer. Potential role in disease progression. J. Clin. Invest. 91: 2194-2206, 1993.
21. NOVIELLO, E., CIMOLI, G., COSIMI, A., ALLIEVI, E., GALLETTI, P. G., PARODI, S. AND RUSSO, P.: Tumor necrosis factor enhances the therapeutic effect of Mitoxantrone in human ovarian cancer xenograft. Cytokine 8: 330-333, 1996.
22. OLD, L. J.: Tumor necrosis factor (TNF). Science (Wash. D.C.) 230: 630, 1986.
23. ORENGO, G., NOVIELLO, E., CIMOLI, G., PAGNAN, G., PARODI, S., VENTURINI, M., CONTE, P. F., SCHENONE, F., CONZI, G. F. AND RUSSO, P.: Potentiation of topoisomerase I and II inhibitors cell killing by Tumor Necrosis Factor: Relationship to DNA strand breakage formation. Jpn. J. Cancer Res. 83: 1132-1136, 1992.
24. OZOLS, R. F.: New approaches to management of ovarian cancer. Adv. Oncol. 6: 9-17, 1990.
25. RAMAKRISHNAN, S., HU, F. L., BRANDT, S. J., NIEDEL, J. E., BAST, R. C. AND BROWN, E. L.: Constitutive production of macrophage-colony stimulating factor by human brest and ovarian cancer cell lines. J. Clin. Invest. 83: 921-927, 1989.
26. RATH, U., KAUFMANN, M., SCHMD, H., HOFMAN, J., WIEDENMANN, B., KIST, A., KEMPENI, J., SCHLICK, E., BASTERT, G., KOMMERELL, B. AND MANNEL, D.: Effect of intraperitoneal recombinant human tumor necrosis factor alpha on malignant ascites. Eur. J. Cancer 27: 121-125, 1991.
27. RUSSO, P., PARODI, S., BILLI, G., OLIVA, C., VENTURINI, M., NOVIELLO, E. AND CONTE, P. F.: Potentiation by tumor necrosis factor of mitoxantrone cytotoxicity to human ovarian cancer cell lines. Jpn. J. Cancer Res. 83: 684-687, 1992.
28. RUSSO P., CIMOLI, G., VALENTI, M., DE SESSA, F., PARODI, S. AND POMMIER, Y.: Induction of DNA double-strand breaks by 8-methoxycaffeine: cell cycle, dependence and comparison with topoisomerase II inhibitors. Carcinogenesis 15: 2491-2496, 1994.
29. SPRIGGS, D. R., IMAMURA, K., RODRIGUEZ, C., SARIBAN, E. AND KUFE, D. W.: Tumor necrosis factor expression in human epithelial tumor cell lines. J. Clin. Invest. 81: 455-460, 1988.
30. UTSUGI T., MATTERN, M. R., MIRABELLI, C. K. AND HANNA, N.: Potentiation of topoisomerase inhibitor-induced DNA strand breakage and cytotoxicity by tumor necrosis factor: Enhancement of topoisomerase activity as a mechanism of potentiaton. Cancer Res. 50: 2636-2640, 1990.
31. VALENTI, M., CIMOLI, G., PARODI, S., MARIANI, M. L., VENTURINI, M. CONTE, P. F. AND RUSSO, P.: Potentiation of tumor necrosis factor-mediated cell killing by VP16 on human ovarian cancer cell lines. ["in vitro" results and clinical implications]. Eur. J. Cancer. 29A: 1157-1161, 1993a.
32. VALENTI M., CIMOLI, G., MARIANI, M. L., CONTE, P. F., PARODI, S. AND RUSSO, P.: Potentiation of TNF-mediated cell killing by Mitoxantrone: Relationship to DNA single-strand breaks formation. Biochem. Pharmacol. 46: 1199-1206, 1993b.
33. VIGANI, A., CHIARA, S., MIGLIETTA, L., REPETTO, L., CONTE, P. F., CIMOLI, G., MORELLI, L., BILLI, G., PARODI, S. AND RUSSO, P.: Effect of recombinant human tumor necrosis factor on A2774 human ovarian cancer cell line: Potentiation of mitoxantrone cytotoxicity. Gynecol. Oncol. 41: 52-55, 1991.
34. WATSON, J. M., SENSITAFFAR, J. L., BEREK, J. S. AND MARTINEZ-MAZA, O.: Constitutive production of interleukin-6 by ovarian cancer cell lines and by primary ovarian tumor cultures. Cancer Res. 60: 6959-6965, 1990.
35. WU, S., RODABAUGH, K., MARTINEZ-MAZA, O., WATSON, J. M., SILBERSTEIN, D. S., BOYER, C. M., PETERS, W. P., WEINBERG, J. B., BEREK, J. S. AND BAST, R. C.: Stimulation of ovarian tumor cell proliferation with monocyte products including interleukin-1-alpha, interleukin-6 and tumor necrosis factor-alpha. Am. J. Obstet. Gynecol. 166: 997-1007, 1992.
36. WU, S., BOYER, C. M., WHITAKER, R. S., BERCHUCK, A., WIENER, J. B., WEINBERG, J. B. AND BAST JR., R. C.: Tumor necrosis factor α as an autocrine and paracrine growth factor for ovarian cancer: Monokine induction of tumor cell proliferation and tumor necrosis factor α expression. Cancer Res. 53: 1939-1944, 1993.