Neomycin selectively inhibits 5-hydroxytryptamine-induced contraction in the guinea pig trachea

Journal of Pharmacology and Experimental Therapeutics

Volumn 277, Issue 2, 1996, Pages 954-959

  Cox, David A ^a   Watts, Stephanie W ^a,b   Cohen, Marlene L ^a  

^a ELI LILLY AND COMPANY   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; BRADYKININ; CARBACHOL; HISTAMINE; NEOMYCIN; NITRENDIPINE; PHOSPHATIDYLINOSITOL; PHOSPHOLIPASE D; SEROTONIN;

ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; ENZYME ACTIVITY; GUINEA PIG; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE CONTRACTION; TRACHEA MUSCLE;

ANIMALS; ANTI-BACTERIAL AGENTS; CALCIUM; CALCIUM CHANNELS; CALCIUM CHANNELS, L-TYPE; CARBACHOL; GUINEA PIGS; HISTAMINE; MALE; MUSCLE CONTRACTION; NEOMYCIN; PHOSPHATIDYLINOSITOLS; PHOSPHOLIPASE D; SEROTONIN; TRACHEA;

EID: 0030424370     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. ATCHINSON, W. D., ADGATE, L. AND BEAMAN, C. M.: Effects of antibiotics on uptake of calcium into isolated nerve terminals. J. Pharmacol. Exp. Ther. 245: 394-401, 1988.
2. BAUMGARTNER, R. A., WILLS-KARP, M., KAUFMAN, M. J., MUNAKATA, M. AND HIRSHMAN, C.: Serotonin induces constriction and relaxation of the guinea pig airway. J. Pharmacol. Exp. Ther. 255: 165-173, 1990.
3. BROWN, E., KENDALL, D. A. AND NAHORSKI, S. R.: Inositol phospholipid hydrolysis in rat cerebral cortical slices: 1. Receptor characterization. J. Neurochem. 42: 1379-1378, 1984.
4. BURCH, R. M.: Kinin signal transduction: Role of phosphomositides and eieosanoids. J. Cardiovasc. Pharmacol. 15: (Suppl. 6), S44-S45, 1990.
5. COHEN, M. L. AND WITTENAUER, L. A.: Serotonin receptor activation of phosphoinositide turnover in uterine, fundal, vascular, and tracheal smooth muscle. J. Cardiovasc. Pharmacol. 10: 176-181, 1987.
6. 2+ influx and intracellular calcium release in agonist-induced contractions in guinea pig trachea. Am. J. Physiol. 266: L620-L627, 1994.
7. 2 receptors is the bradykinin-induced relaxation of guinea-pig isolated trachea. Br. J. Pharmacol. 114: 103-108, 1995.
8. 2 receptor sites. J. Biol. Chem. 260: 7603-7608, 1986.
9. DOWNES, C. P. AND MICHELL, R. H.: The polyphosphoinositide phosphodiesterase of erythrocyte membranes. Biochem. J. 198: 133-140, 1981.
10. EXTON, J. H.: Signaling through phosphatidylcholine breakdown. J. Biol. Chem. 265: 1-4, 1990.
11. FOREMAN, M. A., FULLER, R. W., KURTZ, K. D. NELSON, D. L., CALLIGARO, D. O., KURZ, K D., MISNER, J. W., GARBRECHT, W. L. AND PARLI, C. J.: Preclinical studies of LY237733, a potent and selective serotonergic antagonist. J. Pharmacol. Exp. Ther. 260: 51-57, 1992.
12. FRANK, C., LONGO, R. AND SAGRATELLA, S.: Pertussis toxin prevents neomycin-induced calcium-dependent electrophysiological effects in rat hippocampal slices. Gen. Pharmacol. 25: 957-961, 1994.
13. GUSTIN, M. AND HENNESSEY, T. M.: Neomycin inhibits the calcium current of Paramecium. Biochem. Biophys. Acta 940: 99-104, 1988.
14. 1-receptors in guinea-pig left atria. Naunyn Schmiedeberg Arch. Pharmacol. 340: 196-203, 1989.
15. 2+ channels by serotonin 2 receptor stimulation in vascular smooth muscle cells. Am. J. Physiol. 268: H544-H549, 1995.
16. 2+ influx stimulated by vasopressin is mediated by phosphoinositide hydrolysis in rat smooth muscle cells. Biochem. Biophys. Res. Commun. 161: 677-682, 1989.
17. KOREH, K. AND MONCADA, M E.: The relationship of hormone-sensitive and hormone-insensitive phosphatidylinositol to phosphatidylinositol 4,5-bisphosphate in the WRK-1 cell. J. Biol. Chem. 261: 88-91, 1986.
18. KURSCHEID-REICH, D., THROCKMORTON, D. C. AND RASMUSSEN, H.: Serotonin activates phospholipase D in rat mesangial cells. Am. J. Physiol. 268: F997-F1003, 1995.
19. LISCOVITCH, M., CHALIFA, V., DANIN, M. AND YONA, E.: Inhibition of neural phospholipase D activity by aminoglycoside antibiotics. Biochem. J. 279: 319-321, 1991.
20. LISCOVITCH, M., CHALIFA, V., PERTILE, P., CHEN, C.-S. AND CANTLEY, L. C.: Novel function of phosphatidylinositol 4,5-bisphosphate as a cofactor for brain membrane phospholipase D. J. Biol. Chem. 269: 21403-21406, 1994.
21. MACK, M. M., ZIMANYI, I. AND PESSAH, I. N.: Discrimination of multiple binding sites for antagonists of the calcium release channel complex of skeletal and cardiac sarcoplasmic reticulum J. Pharmacol. Exp. Ther. 262: 1028-1037, 1992.
22. MARCHE, P., KOUTOUZOV, S. AND GIRARD, A : Impairment of membrane phosphoinositide metabolism by aminoglycoside antibiotics: streptomycin, amikacin, kanamycin, dibekacin, gentamicin and neomycin. J. Pharmacol. Exp. Ther. 227: 415-420, 1983.
23. MULLER, E., HEGEWALD, H , JAROSZEWICZ, K., CUMME, G. A., HOPPE, H. AND FRUNDER, H.: Turnover of phosphomonoester groups and compartmentation of polyphosphoinositides in human erythrocytes. Biochem. J. 235: 775-783, 1986.
24. PAI, J.-I., SIEGEL, M. I., EGAN E. W. AND BILLAH, M. M.: Phospholipase D catalyzes phospholipid metabolism in chemotactic peptide-stimulated HL-60 granulocytes. J. Biol. Chem. 263: 12472-12477, 1988.
25. 2+ release by organic polyamines. J. Biol. Chem. 262: 6149-6154, 1987.
26. PERRIER, M. L., SCATTON B. AND BENAVIDES, J.: Dihydropyridine- and ω-conotoxin-resistant, neomycin-sensitive calcium channels mediate the depolarization-induced increase in internal calcium levels in corticol slices from immature rat brain. J. Pharmacol. Exp. Ther. 261: 324-330, 1992.
27. PYNE, S. AND PYNE, N. J.: Bradykinin stimulates phospholipase D in primary cultures of guinea pig tracheal smooth muscle. Biochem. Pharmacol. 45: 593-603, 1993.
28. ROTH, B. L., NAKAKI, T., CHUANG D.-M. AND COSTA, E.: Aortic recognition sites for serotonin (5-HT) are coupled to phospholipase C and modulate phosphatidylinositol turnover. Neuropharmacology 23: 1223-1225, 1984.
29. SCHACHT, J.: Purification of polyphosphoinositides by chromatography on immobilized neomycin. J. Lipid Res. 19: 1063-1067, 1978.
30. SIESS, W. AND LAPETINA, E. G.: Neomycin inhibits inositol formation in human platelets stimulated by thrombin but not other agonists. FEBS Lett. 207: 53-57, 1986.
31. 125]omega-conotoxin GVIA binding to neuronal membranes by neomycin may be mediated by a GTP-binding protein. Eur. J. Pharmacol 206: 155-158, 1991.
32. 3H/10T1/2 fibroblasts. Biochim. Biophys. Acta 1054: 207-212, 1990.
33. WATTS, S. W. AND COHEN, M. L.: Characterization of the contractile serotonergic receptor in guinea pig trachea with agonists and antagonists. J. Pharmacol. Exp. Ther. 260: 1101-1106, 1992.
34. 2 receptor: Use of 5-methyltryptamine and dipropyl-5-carboxamidotryptamine. J. Pharmacol Exp. Ther. 264: 271-275, 1993a.
35. WATTS, S. W. AND COHEN, M. L.: Time-dependent improvement in guinea pig tracheal contractility: Modification by cyclooxygenase inhibitors. J. Pharmacol. Exp. Ther. 266: 950-957, 1993b.
36. WATTS, S. W., COX, D. A., B. G. JOHNSON, B. G., SCHOEPP, D. D. AND COHEN, M. L.: Contractile serotonin-2A receptor signal transduction in guinea pig trachea: Importance of protein kinase C and extracellular calcium but not phosphoinositide hydrolysis. J. Pharmacol. Exp. Ther. 271: 832-844, 1994a.
37. WATTS, S. W., COHEN, M. L., MOONEY, P. Q., JOHNSON, B. J., SCHOEPP, D. J. AND BAEZ, M.: Disruption of potential α-helix in the G loop of the guinea pig 5-hydroxytryptamine2 receptor does not prevent receptor coupling to phosphoinositide hydrolysis. J. Neurochem. 62: 934-943, 1994b.
38. XIONG, Z. AND SPERELAKIS, N.: Regulation of L-type calcium channels of vascular smooth muscle. J. Mol. Cell. Cardiol. 27: 75-91, 1995.
39. YAMADA, K., NAKAYAMA, S., SHIOTANI, T , HASEGAWA T. AND NABESHIMA, T.. Possible involvement of the activation of voltage-sensitive calcium channels in the ameliorating effects of nefiracetam on scopolamine-induced impairment of performance in a passive avoidance task. J. Pharmacol. Exp. Ther. 270: 881-892, 1994.