Preclinical pharmacology of CB30900, a novel dipeptide inhibitor of thymidylate synthase, in mice 1

Journal of Pharmacology and Experimental Therapeutics

Volumn 277, Issue 2, 1996, Pages 909-916

  Walton, M I ^a,c   Gibson, W ^a   Aherne, G W ^a   Lawrence, N ^a   Stephens, T C ^b   Smith, M N ^b   Jackman, A L ^a  

^a CRC Centre for Cancer Therapeutics   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

^c INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; N [N [4 [N [(3,4 DIHYDRO 2,7 DIMETHYL 4 OXO 6 QUINAZOLINYL)METHYL] N (2 PROPYNYL)AMINO] 2 FLUOROBENZOYL] GAMMA GLUTAMYL] DEXTRO GLUTAMIC ACID; N [N [4 [N [(3,4 DIHYDRO 2,7 DIMETHYL 4 OXO 6 QUINAZOLINYL)METHYL] N PROP 2 YNYLAMINO] 2 FLUOROBENZOYL] GAMMA GLUTAMYL] GLUTAMIC ACID; THYMIDYLATE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG BLOOD LEVEL; DRUG EXCRETION; DRUG METABOLISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME INHIBITION; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LYMPHOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; TISSUE DISTRIBUTION;

ANIMALS; DIPEPTIDES; ENZYME INHIBITORS; INTESTINES; LYMPHOMA; METABOLIC CLEARANCE RATE; MICE; MICE, INBRED DBA; PROTEIN BINDING; QUINAZOLINES; THYMIDYLATE SYNTHASE; TISSUE DISTRIBUTION;

EID: 0030423709     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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