Phencyclidine metabolite irreversible binding in the rat: Gonadal steroid regulation and CYP2C11

Journal of Pharmacology and Experimental Therapeutics

Volumn 277, Issue 1, 1996, Pages 292-298

  Shelnutt, S R ^a   Badger, T M ^b   Owens, S M ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b ARKANSAS CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; DRUG METABOLITE; ESTROGEN; PHENCYCLIDINE; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG METABOLISM; DRUG PROTEIN BINDING; FEMALE; GENDER; HORMONAL REGULATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BLOTTING, WESTERN; CASTRATION; CYTOCHROME P-450 ENZYME SYSTEM; ESTRADIOL; FEMALE; MALE; MICROSOMES, LIVER; PHENCYCLIDINE; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; STEROID 16-ALPHA-HYDROXYLASE; STEROID HYDROXYLASES; TESTOSTERONE;

EID: 0030423697     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. BANDIERA, S., RYAN, D. E., LEVIN, W. AND THOMAS, P. E.: Age- and sex-related expression of cytochromes P450f and P450g in the rat liver. Arch. Biochem. Biophys. 248: 658-676, 1986.
2. BANDIERA, S. AND DWORSCHAK, C.: Effects of testosterone and estrogen on hepatic levels of cytochromes P450 2C7 and P450 2C11 in the rat. Arch. Biochem. Biophys. 296: 286-295, 1992.
3. BRADY, J. F., DOKKO, J., DI STEFANO, E W. AND CHO, A. K: Mechanism-based inhibition of cytochrome P-450 by heterocyclic analogs of phencyclidine. Drug Metab Dispos. 15: 648-652, 1987.
4. BUTLER, A. M. AND MURRAY, M.: Inhibition and inactivation of constitutive cytochromes P450 in rat liver by parathion. Mol. Pharmacol. 43: 902-908, 1993.
5. GONZALEZ, F. J., SONG, B.-J. AND HARDWICK, J. P.: Pregnenolone 16α-carbonitrile-inducible P-450 gene family: Gene conversion and differential regulation. Mol. Cell. Biol. 6: 2969-2976, 1986.
6. HALPERT, J., BALFOUR, C., MILLER, N. E., MORGAN, E. T., DUNBAR, D. AND KAMINSKY, L. S.: Isozyme selectivity of the inhibition of rat liver cytochromes P-450 by chloramphenicol in vivo. Mol. Pharmacol. 28: 290-296, 1985.
7. HIRATSUKA, A., CHU, T. Y. Y., DISTEFANO, E. W., LIN, L. Y., SCHMITZ, D. A. AND CHO, A. K.: Inactivation of constitutive hepatic cytochromes P450 by phencycldine in the rat. Drug Metab. Dispos. 23: 201-206, 1995.
8. HOAG, M. K. P., TREYOR, A. J., ASSCHER, Y., WEISSMAN, J. AND CASTAGNOLI, JR., N.: Metabolism-dependent inactivation of liver microsomal enzymes by phencyclidine. Drug Metab. Dispos. 12: 371-375, 1984.
9. HOAG, M. K. P., TREVOR, A. J., KALIR, A. AND CASTAGNOLI, N., JR.: Phencyclidine iminium ion: NADPH-dependent metabolism, covalent binding to macromolecules, and inactivation of cytochrome(s) P450. Drug Metab. Dispos. 15: 485-490, 1987.
10. JOHANNESEN, K. A. AND DEPIERCE, J. W.: Measurement of cytochrome P450 content in the presence of large amounts of contaminating hemoglobin and methemoglobin. Anal. Biochem. 86: 725-732, 1978.
11. KAMATAKI, T., MAEDA, K., YAMAZOE, Y., NAGAI, T. AND KATO, R.: Sex differences of cytochrome P-450 in the rat: Purification, characterization, and quantitation of constitutive forms of cytochrome P-450 from liver microsomes of male and female rats. Arch. Biochem. Biophys. 223: 758-770, 1983.
12. KATO, R. AND YAMAZOE, Y.: Sex-dependent regulation of cytochrome P-450 expression In Frontiers in Biotransformation, Vol. 2, ed. by K. Ruckpaul and H Rein, pp. 83-113, Taylor and Francis Inc., Philadelphia, PA, 1990.
13. KRANER, J. C., MORGAN, E. T. AND HALPERT, J. R.: Selective suppression of rat hepatic cytochrome P450 2C11 by chloramphenicol. J. Pharmacol. Exp. Ther. 270: 1367-1372, 1995.
14. LAW, F C. P.: Metabolic disposition and irreversible binding of phencyclidine in rats. Toxicol. Appl. Pharmacol. 57: 263-272, 1981.
15. MATSUNAGA, T., NAGATA, K., HOLSZTYNSKA, E. J., LAPENSON, D. P., SMITH, A., KATO, R., GELBOIN, H. V., WAXMAN, D. J. AND GONZALEZ, F. J.: Gene conversion and differential regulation in the rat P-450 IIA gene subfamily. J. Biol. Chem. 263: 17995-18002, 1988.
16. MCCLELLAN-GREEN, P. D., LINKO, P., YEOWELL, H. N. AND GOLDSTEIN, J. A.: Hormonal regulation of male-specific rat hepatic cytochrome P450g (P-450IIC13) by androgens and the pituitary. J. Biol. Chem. 264:18960-18965, 1989.
17. NELSON, D. R., KAMATAKI, T., WAXMAN, D. J., GUENGERICH, F. P., ESTABROOK, R. W., FEYEREISEN, R., GONZALEZ, F. J., COON, M. J., GUNSALUS, I. C., GOTOH, O., OKUDA, K. AND NEBERT, D. W.: The P450 superfamily: Update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell Biol. 12: 1-51, 1993.
18. OMUHA, T. AND SATO, R.: The carbon monoxide-binding pigment of liver microsomes. J. Biol Chem 239: 2370-2378, 1964.
19. OSAWA, Y. AND COON, M. J.: Selective mechanism-based inactivation of the major phenobarbital-inducible P-450 cytochrome from rabbit liver by phencyclidine and its oxidation product, the iminium compound. Drug Metab. Dispos. 17: 7-13, 1989.
20. OWENS, S. M, GUNNELL, M., LAURENZANA, E. M. AND VALENTINE, J. L.: Dose- and time-dependent changes in phencyclidine metabolite covalent binding in rats and the possible role of CYP2D1. J. Pharmacol. Exp. Ther. 265:1261-1266, 1993a.
21. OWENS, S. M., GUNNELL, M. AND SORRELS, S. L.: Sex is a major determinant of phencyclidine (PCP) metabolism and metabolite covalent binding in rats. In Problems of Drug Dependence, 1993: Proceedings of the 55th Annual Scientific Meeting, National Institute on Drug Abuse Research Monograph Series U.S. Government Printing Office, Washington, DC, 141: 246, 1993b.
22. PARK, S. S., WAXMAN, D. J., LAPENSON, D. P., SCHENKMAN, J. B. AND GELBOIN, H. V.: Monoclonal antibodies to rat liver cytochrome P-450 2c/RLM5 that regiospecifically inhibit steroid metabolism. Biochem. Pharmacol. 38: 3067-3074, 1989.
23. WAXMAN, D. J.: Rat hepatic P450IIA and P450IIC subfamily expression using catalytic, immunochemical, and molecular probes. Methods Enzymol. 206: 249-267, 1991a.
24. WAXMAN, D. J.: P450-catalyzed steroid hydroxylation: Assay and product identification by thin-layer chromatography. Methods Enzymol. 206: 462-476, 1991b.
25. WAXMAN, D. J., DANNAN, G. A. AND GUENGERICH, F. P.: Regulation of rat hepatic cytochrome P-450: Age-dependent expression, hormonal imprinting, and xenobiotic inducibility of sex-specific isozymes. Biochemistry 24: 4409-4417, 1985.
26. WAXMAN, D. J., LEBLANC, G. A., MORRISSEY, J. J., STAUNTON, J. AND LAPENSON, D. P.: Adult male-specific and neonatally programmed rat hepatic P-450 forms RLM2 and 2a are not dependent on pulsatile plasma growth hormone for expression. J. Biol. Chem. 263: 11396-11406, 1988.
27. WAXMAN, D. J., MORRISSEY, J. J. AND LEBLANC, G. A.: Female-predominant rat hepatic P-450 forms j (IIE1) and 3 (IIA1) are under hormonal regulatory controls distinct from those of the sex-specific P-450 forms. Endocrinology 124: 2954-2966, 1989.
28. WESSINGER, W. D. AND OWENS, S. M.: Chronic administration of phencyclidine: Pharmacokinetic comparison of intravenous and subcutaneous infusions in Sprague-Dawley rats. Drug Metab. Dispos. 19: 719-721, 1991a.
29. WESSINGER, W. D. AND OWENS, S. M.: Phencyclidine dependence: The relationship of dose and serum concentrations to operant behavioral effects J. Pharmacol. Exp. Ther. 258: 207-215, 1991b.
30. WITKAMP, R. F. NIJMEIJER, S. M., YUN, H., NOORDHOEK, J. AND VAN MIERT, A. S. J. P. A. M.: Sufamethazine as a model compound to assess sex hormone-dependent cytochrome P450 activity in rats. Drug Metab. Dispos. 21: 441-445, 1993.
31. ZAPHIROPOULOS, P. G., MODE, A., NORSTEDT, G. AND GUSTAFSSON, J.: Regulation of sexual differentiation in drug and steroid metabolism. Trends Pharmaceut. Sci. 10: 149-153, 1989.