Bilateral orchidectomy and flutamide versus orchidectomy alone in newly diagnosed patients with metastatic carcinoma of the prostate - An Australian multicentre trial

British Journal of Urology

Volumn 77, Issue 6, 1996, Pages 865-869

  Zalcberg, J R ^a   Raghaven, D ^d   Marshalli, V ^c   Thompson, P J ^b  

^a AUSTIN HEALTH   (Australia)

^b ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^c Hinders Medical Centre   (Australia)

^d Sir Charles Gairdinar Hospital   (Australia)

Author keywords

Anti androgen; Maximal androgen blockade; Prostate cancer

Indexed keywords

FLUTAMIDE; PLACEBO;

ADULT; AGED; ARTICLE; AUSTRALIA; CANCER GRADING; CANCER SURVIVAL; CLINICAL TRIAL; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; HORMONAL THERAPY; HOT FLUSH; HUMAN; IMPOTENCE; MAJOR CLINICAL STUDY; MALE; METASTASIS; MULTICENTER STUDY; NAUSEA; ORCHIECTOMY; PRIORITY JOURNAL; PROSTATE CARCINOMA; RANDOMIZED CONTROLLED TRIAL; TESTOSTERONE BLOOD LEVEL; TREATMENT OUTCOME; VOMITING;

AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS, HORMONAL; COMBINED MODALITY THERAPY; DISEASE PROGRESSION; DOUBLE-BLIND METHOD; FLUTAMIDE; HUMANS; MALE; MIDDLE AGED; NEOPLASM METASTASIS; ORCHIECTOMY; PROSTATIC NEOPLASMS; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 0030423155     PISSN: 00071331     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1464-410x.1996.01517.x     Document Type: Article

References (12)

1. Huggin C, Stevens RE. Hodges CV. Studies on prostatic Cancer II. The effects of castration on advanced carcinoma of the prostate gland. Arch Surg 1941: 43: 209-23
2. Kozlowski JM. Ellis WJ. Grayhack fT. Advanced prostalic carcinoma: early versus late endocrine therapy. Urol Clin North Am 1991: 18: 15-24
3. Labrie F. A new approach in the hormonal treatment of prostatic cancer: complete instead of partial blockade of androgens. Andrology 1984: 7: 1-4
4. Young HH II, Kent JR. Plasma testosterone levels in patients with prostatic carcinoma before and after treatment. J Urol 1968: 99: 788-92
5. Sogani PC. Whitmore WF Experience with flulamide in previously untreated patients with advanced prostatic cancer. J Urol 1978: 122: 640-3
6. Neri R. Florence K, Koziol P et al. A biological profile of a nonsteroidal antiandrogen SCH 13521 (4-nitro-8'-trilluoromethyl-isobutyranilide). Endocrinology 1972: 91: 427-37
7. Marshall V. Thompson P. Raghaven D. Zalcberg JR. First report of an Australian multicentre randomized prostate cancer trial: flutamide does not add to the effect of orchidectomy for metastatic prostate cancer. Proc Am âSSOC Cancer Res 1992: 33: 220 (abstr)
8. Oken MM, Creech RH. Tormey DC et al. Toxidty and response criteria of the Eastern Cooperative Oncology Group. Am }Clin Oncol 1982: 5: 649-55
9. Janknegt RA. Abbou. CC. Bartoletti R et al, Orchiectomy and nilutamide or placebo as treatment of metastatic prostate cancer in a multinational double-blind randomized trial. J Urol 1993; 149: 77-83
10. The Canadian Anandron Study Group. Total androgen ablation in the treatment of metastatic prostate cancer. Sem Urol 1990: 8: 159-65
11. Crawlbrd DE, Fisenberger MA. McLeod DG et al A controlled trial of leuprolide with and without flutamide in prostatic carcinoma. .\V\v Emjl }Med 1989: 32: 419-24
12. Prostate Cancer Trialists Collaborative Group. Maximum androgen blockade in advanced cancer: an overview of 22 randomised trials with 3283 deaths in 5710 patients. iMiicet 1995: 346: 265-9