Mechanism of cyclooxygenase-2 inhibition by indanone derivatives

Advances in Experimental Medicine and Biology

Volumn 407, Issue , 1996, Pages 503-507

  Klein, Thomas ^a   Nüsing, Rolf M ^a  

^a UNIVERSITY HOSPITAL MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; FLOSULIDE; INDANONE DERIVATIVE;

CONFERENCE PAPER; CONTROLLED STUDY; CROSS LINKING; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; PRIORITY JOURNAL;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; INDANS; ISOENZYMES; MOLECULAR STRUCTURE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; SHEEP; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030419129     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (12)

1. J.R. Vane, Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs, Nature (New Biology) 231:232 (1971).
2. D. Schlondorff, Renal complications of non-steroidal anti-inflammatory drugs, Kidney Int 44:643 (1993).
3. T. Klein, R.M. Nüsing, J. Pfeilschifter, and V. Ullrich, Selective inhibition of cyclooxygenase 2, Biochem Pharmacol 48:1605 (1994).
4. N. Futaki, M. Takahashi, S. Higuchi, and S. Otomo, NS-398, a new anti-inflammatory agent selectively inhibits prostaglandinG/ H synthase/ cyclooxygenase (COX 2) activity in vitro. Prostaglandins 47: 55 (1994).
5. I. Wiesenberg-Boettcher, A. Schweizer, J.R. Green, F. Maerki, and J. Pfeilschifter, The pharmacological profile of CGP 28238, a novel highly potent anti-inflammatory compound, Drugs Exptl Clin Rex XV:501 (1989).
6. E. Schrëder, M. Lehmann, C. Rufer, and I. Boettcher, Nichtsteroidale Entzündungshemmer, 7. Eur J Med-Chim Ther 17:165 (1982).
7. R.A. Copeland, J.M. Wiliams, J. Giannaras, D. Pinto, S. Pick, and M. Trzaskos, Mechanism of selective inhibition of the inducible isoform of prostaglandin G/H synthase, Proc Natl Acad Sci USA 91:11202 (1995).
8. W.E.M. Lands, Mechanism of action of antiinflammatory drugs, Adv Drug Res 14:147 (1985).
9. 4, Biochem Biophy Res Commun 74:1297 (1977).
10. 2 synthase-1, Nature 367:243 (1994).
11. J.E. Dinchuk, B.D. Car , R.J. Focht, J.J. Johnston, B.D. Jaffee, M.D. Covington, N.R. Contel, V.M. Eng, R.J. Collins, P.M. Czerniak, S.A. Gorry, and M. Trzaskos, Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase 2, Nature 378:406 (1995).
12. D.L. DeWitt, E.A. Meade, and W.L. Smith, PGH synthase isoenzyme selectivity: the potential for safer nonsteroidal antiinflammatory drugs, Am J Med 95:2A (1993).