Structure-function relationships of the complement regulatory protein, CD59

Blood Cells, Molecules and Diseases

Volumn 22, Issue 3, 1996, Pages 281-296

  Petranka, John ^a   Zhao, Ji ^a   Norris, John ^a   Tweedy, Neil B ^a   Ware, Russell E ^a   Sims, Peter J ^a   Rosse, Wendell F ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

CD59; Function; Mutation; Structure

Indexed keywords

CD59 ANTIGEN; SNAKE VENOM;

ARTICLE; CONFORMATIONAL TRANSITION; GENE INSERTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CONFORMATION; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

ELAPIDAE; MAMMALIA; SERPENTES;

EID: 0030391598     PISSN: 10799796     EISSN: None     Source Type: Journal    
DOI: 10.1006/bcmd.1996.0111     Document Type: Article

References (47)

1. 1. Davies A, Lachmann PJ. Membrane defense against complement lysis: the structure and biological properties of CD59. Immunol Res. 12:258-275, 1993.
2. 2. Rollins SA, Zhao J, Ninomiya H, Sims PJ. Inhibition of homologous complement by CD59 is mediated by a species-selective recognition conferred through binding to C8 within C5b-8 or C9 within C5b-9. J Immunol 146:2345-2351, 1991.
3. 3. Meri S, Morgan BP, Davies A, et al. Human protectin (CD59), an 18,000-20,000 MW complement lysis restricting factor, inhibits C5b-8 catalysed insertion of C9 into lipid bilayers. Immunology. 71:1-9, 1990.
4. 4. Korty PE, Brando C, Shevach EM. CD59 functions as a signal-transducing molecule for human T cell activation. J Immunol 146:4092-4098, 1991.
5. 5. Deckert M, Kubar J, Zoccola D, et al. CD59 molecule: a second ligand for CD2 in T cell adhesion. Eur J Immunol 22:2943-2947, 1992.
6. 6. Hahn WC, Menu E, Bothwell AL, Sims PJ, Bierer BE. Overlapping but nonidentical binding sites on CD2 for CD58 and a second ligand CD59. Science 256:1805-1807, 1992.
7. 7. Ninomiya H, Sims PJ. The human complement regulatory protein CD59 binds to the α chain of C8 and to the "b" domain of C9. J Biol Chem 267:13675-13680, 1992.
8. 8. Zhao J, Rollins SA, Maher SE, Bothwell AL, Sims PJ. Amplified gene expression in CD59-transfected Chinese hamster ovary cells confers protection against the membrane attack complex of human complement. J. Biol Chem. 266:13418-13422, 1991.
9. 9. Davies A, Simmons DL, Hale G, et al. CD59, an Ly-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells. J Exp Med 170:637-654, 1989.
10. 10. Sawada R, Ohashi K, Anaguchi H, et al. Isolation and expression of the full-length cDNA encoding CD59 antigen of human lymphocytes. DNA Cell Biol 9:213-220, 1990.
11. 11. Sugita Y, Nakano Y, Oda E, et al. Determination of carboxyl-terminal residue and disulfide bonds of MACIF (CD59), a glycosyl-phosphatidylinositol-anchored membrane protein. J Biochem (Tokyo) 14:473-477, 1993.
12. 12. Ezzell JL, Wilcox LA, Bernshaw NJ, Parker CJ. Induction of the paroxysmal nocturnal hemoglobinuria phenotype in normal human erythrocytes: effects of 2-aminoethylisothiouronium bromide on membrane proteins that regulate complement. Blood 77:2764-2773, 1991.
13. 13. Sirchia G, Ferrone S, Mercuriali F. The action of two sulfhydryl compounds on normal human red cells: relationship to red cells of paroxysmal nocturnal hemoglobinuria. Blood 25:502-508, 1965.
14. 14. Stead NW, Rosse WF. Quantitative studies on the sensitivity to complement lysis of red cells treated with thiol-reactive reagents. Blood 37:454-462, 1971.
15. 15. Ninomiya H, Stewart BH, Rollins SA, Zhao J, Bothwell AL, Sims PJ. Contribution of the N-linked carbohydrate of erythrocyte antigen CD59 to its complement-inhibitory activity. J Biol Chem 267:8404-8410, 1992.
16. 16. Holguin MH, Wilcox LA, Bernshaw NJ, Rosse WF, Parker CJ. Erythrocyte membrane inhibitor of reactive lysis: effects of phosphatidylinositol-specificphospholipase C on the isolated and cell-associated protein. Blood 75:284-289, 1990.
17. 17. Philbrick WM, Palfree RG, Maher SE, Bridgett MM, Sirlin S, Bothwell AL. The CD59 antigen is a structural homologue of murine Ly-6 antigens but lacks interferon inducibility. Eur J Immunol 20:87-92, 1990.
18. 18. Petranka JG, Fleenor DE, Sykes K, Kaufman RE, Rosse WF. Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein. Proc Natl Acad Sci USA 89:7876-7879, 1992.
19. 19. Roldan AL, Cubellis MV, Masucci MT, et al. Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis. EMBO J 9:467-474, 1990.
20. 20. Dufton MJ, Hider RC. The structure and pharmacology of elapid cytotoxins. In: Harvey AL, ed, Snake Toxins, New York, Pergamon Press, p. 259, 1993.
21. 21. Williams AF, Tse AG-D, Gagnon J. Squid glycoproteins with structural similarities to Thy-1 and Ly-6 antigens. Immunogenetics 27:265-272, 1988.
22. 22. Albrecht JC, Nicholas J, Cameron KR, Newman C, Fleckenstein B, Honess RW. Herpesvirus saimiri has a gene specifying a homologue of the cellular membrane glycoprotein CD59. Virology 190:527-530, 1992.
23. 23. Fuse N, Tsuchiya T, Nonomura Y, Menez A, Tamiya T. Structure of the snake short-chain neurotoxin, erabutoxin c, precursor gene. Eur J Biochem 193:629-633, 1990.
24. 24. Casey J, Petranka J, Kottera J, Fleenor DE, Rosse WF. The structure of the gene for the urokinase plasminogen activator receptor (UPAR). Blood 84:1151-1156, 1994.
25. 25. Fletcher CM, Harrison RA, Lachmann PJ, Neuhaus D. Structure of a soluble, glycosylated form of the human complement regulatory protein CD59. Structure 2:185-199, 1994.
26. 26. Kieffer B, Driscoll PC, Campbell ID, Willis AC, van der Merwe PA, Davis SJ. Three-dimensional solution structure of the extracellular region of the complement regulatory protein CD59, a new cell-surface protein domain related to snake venom neurotoxins. Biochemistry 33:4471-4482, 1994.
27. 27. Corfield PW, Lee TJ, Low BW The crystal structure of erabutoxin a at 2.0-A resolution. J Biol Chem 264:9239-9242, 1989.
28. 28. Yu C, Bhaskaran R, Chuang LC, Yang CC. Solution conformation of cobrotoxin: a nuclear magnetic resonance and hybrid distance geometry-dynamical simulated annealing study. Biochemistry 32:2131-2136, 1993.
29. 29. Zinn JS, Roumestand C, Gilquin B, Bontems F, Menez A, Toma F. Three-dimensional solution structure of a curaremimetic toxin from Naja nigricollis venom: a proton NMR and molecular modeling study. Biochemistry 31:11335-11347, 1992.
30. 30. Sutcliffe MJ, Dobson CM, Oswald RE. Solution structure of neuronal bungarotoxin determined by two-dimensional NMR spectroscopy: calculation of tertiary structure using systematic homologous model building, dynamical simulated annealing, and restrained molecular dynamics. Biochemistry 31:2962-2970, 1992.
31. 31. Horton RM, Pease LR. Recombination and mutagenesis of DNA sequences using PCR. In: McPherson MJ ed, Directed Mutagenesis. A Practical Approach, New York, IRL Press at Oxford Press, 1991.
32. 32. Rushmere NK, Harrison RA, van den Berg CW, Morgan BP. Molecular cloning of the rat analogue of human CD59: structural comparison with human CD59 and identification of a putative active site. Biochem J 304:595-601, 1994.
33. 33. Love RA, Stroud RM. The crystal structure of alpha-bungarotoxin at 2.5 A resolution: relation to solution structure and binding to acetylcholine receptor. Protein Eng 1:37-46, 1986.
34. 34. Walkinshaw MD, Saenger W, Maelicke A. Three-dimensional structure of the long neurotoxin from cobra venom. Proc Natl Acad Sci USA 77:2400-2404, 1980.
35. 35. Rees B, Bilwes A, Samama JP, Moras D. Cardiotoxin V4/II from Naja mossambica mossambica: The refined crystal structure. J Mol Biol 214:281-297, 1990.
36. 36. Ploug M, Kjalke M, Ronne E, Weidle U, Hoyer Hansen G, Dano K. Localization of the disulfide bonds in the NH2-terminal domain of the cellular receptor for human urokinase-type plasminogen activator. A domain structure belonging to a novel superfamily of glycolipid-anchored membrane proteins. J Biol Chem 268:17539-17546, 1993.
37. 37. Lockert DH, Kaufman KM, Chang C-P, Husler T, Sodetz JM, Sims PJ. Identity of the segment of human complement C8 recognized by complement regulatory protein CD59. J Biol Chem 270:3483-3486, 1995.
38. 38. Husler T, Lockert DH, Kaufman KM, Sodetz JM, Sims PJ. Chimeras of human complement C9 reveal the site recognized by complement regulatory protein CD59. J Biol Chem 270:3483-3486, 1995.
39. 39. Chang C-P, Husler T, Zhao J, Wiedmer T, Sims PJ. Identity of a peptide domain of human C9 that is bound by the cell-surface inhibitor, CD59. J Biol Chem. 269:26424-26430, 1994.
40. 40. Radding W, Corfield PW, Levinson LS, Hashim GA, Low BW. Alpha-toxin binding to acetylcholine receptor alpha 179-191 peptides: intrinsic fluorescence studies. FEBS Lett 231:212-216, 1988.
41. 41. Ruan R-H, Spurling J, Quiocho FA, Atassi MZ. Acetylcholine receptor-bungarotoxin interactions: Determination of the region-to-region contacts by peptide-peptide interactions and molecular modeling of the receptor cavity. Proc Natl Acad Sci USA 87:6156-6160, 1990.
42. 42. Le Du MH, Marchot P, Bougis PE, Fontecilla Camps JC. 1.9-A resolution structure of fasciculin 1, an anti-acetylcholinesterase toxin from green mamba snake venom. J Biol Chem. 267:22122-22130, 1992.
43. 43. McDowell RS, Dennis MS, Louie A, Shuster M, Mulkerrin MG, Lazarus RA. Mambin, a potent glycoprotein IIb-IIIa antagonist and platelet aggregation inhibitor structurally related to the short neurotoxins. Biochemistry. 31:4766-4772, 1992.
44. 44. Pillet L, Tremeau O, Ducancel F, et al. Genetic engineering of snake toxins. Role of invariant residues in the structural and functional properties of a curaremimetic toxin, as probed by site-directed mutagenesis. J Biol Chem 268:909-916, 1993.
45. 45. Rother RP, Zhao J, Zhou Q, Sims PJ. Elimination of potential sites of glycosylation fails to abrogate complement regulatory function of cell surface CD59. J Biol Chem 271:23842-23845, 1996.
46. 46. Akami T, Arakawa K, Okamoto M, et al. Enhancement of the complement regulatory function of CD59 by site-directed mutagenesis at the N-glycosylation site. Transplant Proc 26:1256-1258, 1994.
47. 47. Bhkaskaran R, Huang C-C, Tsia Y-C, Jayaraman G, Chang D-K, Yu C. Cardiotoxin II from Taiwan cobra venom, Naja naja atra. Structure in solution and comparison among homologous cardiotoxins. J Biol Chem 269:23500-23508, 1994.