Effects of recombinant human erythropoietin on porphyrin metabolism in uremic patients on hemodialysis

Journal of the American Society of Nephrology

Volumn 7, Issue 5, 1996, Pages 774-779

  Fontanellas, Antonio ^a   Herrero, Jose A ^b   Coronel, Francisco ^b   Santos, Jose L ^a   Morán, María J ^a   Barrientos, Alberto ^b   Enríquez De Salamanca, Rafael ^a,c  

^a HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^b HOSPITAL CLÍNICO SAN CARLOS   (Spain)

^c NONE   (Spain)

Author keywords

Aminolevulinate dehydratase; End stage renal failure; Heme biosynthesis pathway; Porphobilinogen deaminase; Uremic anemia (therapy)

Indexed keywords

PORPHOBILINOGEN DEAMINASE; PORPHOBILINOGEN SYNTHASE; PORPHYRIN; PROTOPORPHYRIN; RECOMBINANT ERYTHROPOIETIN;

ADULT; AGED; ANEMIA; ARTICLE; CHRONIC KIDNEY FAILURE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HEMATOCRIT; HEME SYNTHESIS; HEMODIALYSIS; HUMAN; MALE; PORPHYRIN METABOLISM; PRIORITY JOURNAL; RETICULOCYTE COUNT; UREMIA;

EID: 0030377444     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Erslev AJ: Erythropoietin. N Engl J Med 1991;324: 1339-1344.
2. Nissenson AR (moderator): Recombinant human erythropoietin and renal anemia: Molecular biology, clinical efficacy, and nervous system effects. Ann Intern Med 1991;114:402-416.
3. Eschbach JW, Adamson JW. Anemia in renal disease. In: Schrier RW, Gottschalk CW, Eds. Diseases of the Kidney. Boston: Little Brown; 1988;3019-3034.
4. Zappacosta AR, Perras ST, Bell A: Weekly subcutaneous recombinant human erythropoietin corrects anemia of progressive renal failure. Am J Med 1991;91:229-232.
5. Yalouris AG, Lyberatos C, Chalevelakis G, Theodosiadou E, Billis A, Raptis S: Some parameters of haem synthesis in dialysed and non-dialysed uraemic patients. Scand J Haematol 1986;37:404-410.
6. Gebril M, Weinkove C, Ead R, McDonald K, Morton R: Plasma porphyrins in chronic renal failure. Nephron 1990;55:159-163.
7. Siersema PD, De Rooij FWM, Edixhoven-Bosdijk A, Weimar W, Wilson JHP: Heme synthesis in chronic renal failure: The effects of hemodialysis, peritoneal dialysis and erythropoietin treatment. Nephron 1995;71:297-302.
8. Fontanellas A, Coronel F, Santos JL, et al.: Heme biosynthesis in uremic patients on CAPD or hemodialysis. Kidney Int 1994;45:220-223.
9. Bottomley SS, Muller-Eberhard U: Pathophysiology of heme synthesis. Semin Hematol 1988;25:282-302.
10. Berlin A, Schaller KH: European standardized method for the determination of aminolevulinic acid dehydratase activity in blood. Z Klin Chem Klin Biochem 1974;12: 389-390.
11. Anderson PM, Desnick RJ: Porphobilinogen deaminase: Methods and principles of the enzymatic assay. Enzyme (Basel) 1982;28:146-157.
12. Piomelli S: Free erythrocyte porphyrins in the detection of undue absortion of Pb and of Fe deficiency. Clin Chem 1977;23:264-289.
13. Hart D, Piomelli S: Simultaneous quantitation of zinc protoporphyrin and free protoporphyrin in erythrocytes by acetone extraction. Clin Chem 1981;27:220-222.
14. Fujita H, Orii Y, Sano S: Evidence of increased synthesis of 5-aminolevulinic acid dehydratase in experimental lead poisoned rats. Blochim Biophys Acta 1981;678:39-50.
15. Arroyo M, Molina MA, Martin-Serrano J, Perez-Cuadrado S: Determinación analítica conjunta de Plomo y Cadmio en viales de resistoceles. Med Segur Trab (Madr) 1989;36:49-64.
16. Nimer SD, Wolcott DL: Recombinant human erythropoietin and renal anemia: Molecular biology, clinical efficacy and nervous system effects. Ann Intern Med 1991; 114:402-416.
17. Hosokawa S, Yoshida O: Effects of erythropoietin on trace elements in patients with chronic renal failure undergoing hemodialysis. Nephron 1993;65:414-417.
18. Beguin Y, Loo M, R' Zik S, Sautois B, Lejeune F, Rorive G, Fillet G: Quantitative assessment of erythropoiesis in haemodialysis patients demonstrates gradual expansion of erythroblasts during constant treatment with recombinant human erythropoietin. Br J Haematol 1995;89: 17-23.
19. Eschbach JW, Haley NR, Egrie JC, Adamson JW: A comparison of the responses to recombinant human erythropoietin in normal and uremic subjects. Kidney Int 1992;42:407-416.
20. Bottomley SS. Sideroblastic anaemia. In: Jacobs A, Worwood M, Eds. Iron in Biochemistry and Medicine. London: Academic Press; 1980:362-392.
21. Leber HW, Sinning P, Schutterle G: Porphobilinogen and porphyrin synthesis in reticulocytes from uraemic patients. Proc Eur Dial Transplant Assoc 1975;11:383-390.
22. Kraupp M, Linkesch W, Watzinger U, Legenstein E, Graf H: Enzymes of heme biosynthesis in erythrocytes of patients treated with recombinant erythropoietin. Blut 1989;59:340.
23. Djordjevic VB, Pavlovic D, Pejovic M, et al.: Effect of human recombinant erythropoietin treatment on erythrocyte 5-aminolevulinic acid dehydratase in patients on maintenance hemodialysis. Nephron 1993;65:497-498.
24. Beru N, Goldwasser E: The regulation of herne biosynthesis during erythropoietin-induced erythroid differentiation. J Biol Chem 1985;260:9251-9257.
25. Abraham NG, Nelson JC, Ahmed T, Konwalinka G, Levere RD: Erythropoietin controls heme metabolic enzymes in normal human bone marrow culture. Exp Hematol (NY) 1989;17:908-913.
26. Rosenlöf K, Fyhrquist F, Tenhunen R: Erythropoietin, aluminium, and anaemia in patients on haemodialysis. Lancet 1990;335:247-249.
27. Piazza V, Villa G, Galli F, et al.: Recombinant human erythropoietin reduces free erythrocyte protoporphyrin levels in patients on chronic dialysis. Nephron 1992;61: 54-57.
28. Fontanellas A, Herrero JA, Moran MJ, et al: Efficiency of three different hemodialysis membranes for plasma porphyrin removal. Am J Kidney Dis 1995;25:30-33.
29. Matarredonda J, Martin R, Enriquez de Salamanca R: Bullous dermatosis of hemodialysis. J Dermatol 1985; 12:410-415.