Metabolism and susceptibility to aflatoxins toxicity;Le métabolisme: Un facteur de susceptibilité à la toxicité des aflatoxines

Revue de Medecine Veterinaire

Volumn 147, Issue 12, 1996, Pages 879-892

  Guerre, P ^a   Galtier, P ^b   Burgat, V ^a  

^a UNIVERSITÉ DE TOULOUSE   (France)

^b CEMAGREF   (France)

Author keywords

Aflatoxins; Blotransforma tion; Cytochrome p450; Drug metabolizing enzymes; Glutathione S transferase; Mycotoxins; Review

Indexed keywords

EID: 0030367621     PISSN: 00351555     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (178)

1. ALLAMEH (A.), SAXENA (M.) et RAJ (H.G.) : Differential effects of buthylhydroxyanisole on metabolism of aflatoxin B1 in vitro by liver and lung microsomes. Cancer Lett., 1988, 40, 49-57.
2. AOYAMA (T.), YAMANO (S.), GUZELIAN (P.S.), GELBOIN (H.V.) et GONZALEZ (F.J.) : Five of 12 forms of vaccinia virus-expressed human hepatic cytochrome P450 metabolically activate aflatoxin B1. Proc. Natl. Acad. Sci. USA, 1990, 87, 4790-93.
3. APPLETON (B.S.), GOETCHIUS (M.P.) et CAMPBELL (T.C.) : Linear dose-response curve for the hepatic macromolecular binding of aflatoxin B1 in rats at very low exposures. Cancer Res., 1982, 42, 36593662.
4. AUTRUP (H.), ESSIGMAN (J.M.), CROY (R.G.), TRUMP (B.F.), WOGAN (G.N.) et HARRIS (C.C.) : Metabolism of aflatoxin B1 and identification of the major aflatoxin B1-DNA adducts formed in cultured human bronchus and colon. Cancer Res., 1979, 39, 694-698.
5. AUTRUP (H.), SCHWARTZ (R.D.), ESSIGMAN (I.M.), SMITH (L.), TRUMP (B.F.) et HARRIS (C.C.) : Metabolism of aflatoxin BI, benzo[a]pyrene, and 1,2-dimethylhydrazine by cultured rat and human colon. Terat Carc. Mutagen., 1980, 1, 3-13.
6. BAERTSCHI (S.W.), RANEY (K.D.), SHIMADA (T.S.), HARRIS (T.M.) et GUENGERICH (F.P.) : Comparison of rates of enzymatic oxidation of aflatoxin Bl, aflatoxin Gl, and sterigmatocystin and activities of the epoxidcs in forming guanyl-N7-adducts and inducing different genetic responses. Chem. Res. Toxicol., 1989, 2, 114-120.
7. BAILEY (G.S.), WILLIAMS (D.E.), WILCOX (J.S.), LOVELAND (P.M.), COULOMBE (R.A.) et HENDRICKS (J.D.) : Aflatoxin Bl carcinogenesis and its relation to DNA adduct formation and adduct persistence in sensitive and resistant salmonid fish. Carcinogenesis, 1988, 9, 1919- 1926.
8. BALDWIN (S.) et PARKER (R.S.) : Influence of dietary fat and selenium in initiation and promotion of aflatoxin Bl-induced preneoplastic foci in rat liver. Carcinogenesis, 1987, 8, 101-107.
9. BALL (R.W.), WILSON (D.W.) et COULOMBE (R.A.) : Comparative formation and removal of aflatoxin Bl-DNA adducts in cultured mammalian tracheal epithelium. Cancer Res., 1990, 50, 4918-4922.
10. BALL (R.W.) et COULOMBE (R.A.) : Comparative biotransformation of aflntoxin Bl in mammalian airway epithelium. Carcinogenesis, 1991, 12, 305-310.
11. BATTISTA (J.R.) et MARNETT (L.J.) : Prostaglandin H synthetase-dependant epoxidation of aflatoxin Bl. Carcinogenesis, 1985, 6, 1227-29.
12. BERI (R.) et CHANDRA (R.) : Chemistry and biology of heme: effect of metal salts, organometals. and metalloporphyrins on heme synthesis and catabolism, with special reference to clinical implications and interactions with cytochrome P450. Drug Metabolism Rev., 1993, 25, 49-152.
13. BHATTACHARYA (R.K.), FIROZI (P.F.) et ABOOBAKER (V.S.) : Factors modulating the formation of DNA adduct by aflatoxin Bl in vitro, Carcinogenesis, 1984, 5, 1359-62.
14. BORROZ (K.I.), RAMSDELL (H.S.) et EATON (D.L.) : Mouse strain differences in glutathione S-transferase activity and aflatoxin Bl biotransformation, Toxic. Letters, 1991, 58, 97-105.
15. BOYD (J.N.) et STOEWSAND (G.S.) : Blood alpha-foetoprotein changes in rats fed aflatoxin Bl and various levels cabbage. J. Food Sci., 1981, 46, 1923-26.
16. BOYD (J.N.), BABISH (J.G.) et STOEWSAND (G.S.) : Modificaiion by beet and cabbage diets of aflatoxin Bl - induced rat plasma alpha-foetoprotein elevation, hepatic tumorigenesis, and mutngenicity of urine. Fnotl Chem, Toxicol., 1982, 20, 47-52,
17. CAMPBELL (T.C.) et HAYES (J.R.) : The role of aflatoxin metabolism in ils toxic lesion. Toxicol. Appl. Pharmacol,. 1976, 35, 199-222.
18. GH'IH (J.J.), LIN (T.) et DEVLIN (T.M.) : Activation and deactivation of aflatoxin Bl in isolated rat hepatocytes. Biochem. Biophys. Res. Commun., 1983, 110, 668-674.
19. CH'IH (J.J.), LIN (T.) et DEVLIN (T.M.) : Effect of inhibitors of microsomal enzymes on aflatoxin Bl-induced cytotoxicity and inhibition of RNA synthesis in isolated rat hepatocytes. Biochem. Biophys. Res. Commun., 1983, 115, 15-21.
20. GH'IH (J.J.), BIEDRZYCKA (D.W.) et DEVLIN (T.M.) : Isolated hepatocytes are capable of excreting aflatoxin metabolites. Biochem. Biophys. Res. Commun., 1991, 178, 1002-1007.
21. CLARK (J.D.), HATCH (R.C.), JAIN (A.V.) et WEISS (R.) : Effect of enzyme inducers and inhibitors and glutathione precursor and depleter on induced acute aflatoxicosis in rabbits. Am. J. Vet. Res., 1982, 43, 1027-1033.
22. COLES (B.), MEYER (D.J.), KETTERER (B.), STANTON (C.A.) et GARNER (R.C.) : Studies on the detoxication of microsomally-activatcd aflatoxin Bl by glutathione and glutathione transferases in vitro. Carcinogenesis, 1985, 6, 693-697.
23. CRESPI (C.L.), STEIMEL (D.T.), AOYAMA (T.), GELBOIN (H.V.) et GONZALEZ (F.J.) : Stable expression of human cytochrome P450 IA2 cDNA in a human lymphoblastoid cell line: role of the enzyme in the metabolic activation of aflatoxin Bl. Molecular Carcino., 1990, 3, 5- 8.
24. CRESPI (C.L.), PENMAN (B.W.), STEIMEL (D.T.), GELBOIN (H.V.) et GONZALEZ (F.J.) : The development of a human cell line stably expressing human CYP3A4: role in the metabolic activation of aflatoxin Bl and comparison to CYPIA2 and CYP2A3. Carcinogenesis, 1991, 12, 355-359.
25. CROY (R.G.) et WOGAN (G.N.) : Identification of an aflatoxin Pl-DNA adduct formed in vivo in rat liver. Proc. Am. Assoc. Cancer Res., 1979, 20, 182.
26. CROY (R.G.) et WOGAN (G.N.) : Quantitative comparison of cnvalent aflatoxin-DNA adducts formed in rat and mouse livers and kidneys. J. Natl. Cancer Inst., 1981, 66, 761-768.
27. CULL.EN (J.M.), REUBNER (B.H.), HSIEH (L.S.), HYDE (D.M.) et HSIEH (D.P.H.) : Carcinogenicity of dietary aflatoxin Ml in male Fischer rats compared to aflatoxinBI, Cancer Res., 1987, 47, 1913-1917.
28. DALEZIOS (J.l.)et WOGAN (G.N.) : Metabolism of aflatoxin BI in rhesus monkeys. Cancer Res., 1972, 32, 2297-2303.
29. DALVI (R.R.) et McGOWAN (C.) ; Experimental induction of chronic aflatoxicosis in chickens by purified aflatoxin Bl and its reversal by activated charcoal, phenobarbital, and reduced glutathione. Poultry Sci., 1984, 63, 485-491.
30. DALVI (R.R,) et ADEMOYERO (A.A.) : Toxic effects of aflatoxin Bl in chickens given feed contaminated with Aspergillus flavus and reduction of the toxicity by activated charcoal and some chemical agents. Avitin Diseases, 1984, 28, 61-69.
31. DANIELS (J.M.) et MASSEY (T.E.) : Modulation of aflatoxin Bl biotransformation in rabbit pulmonary and hepatic microsomes. Toxicology, 1992, 74, 19-32.
32. DANN (R.E.), MISCHER (L.A.) et COURI (D.) : The in vivo metabolism of 14C-labclcd aflatoxins Bl, B2, G l in rats. Res. Commun. Chem. Pathol. Pharmacol., 1972, 3, 667-675.
33. DECAD (G.M.), DOUGHERTY (K.K.), HSIEH (D.P.H.) et BYARD (J.L.) : Metabolism of aflatoxin Bl in cultured mouse hepatocytes: comparison with rat and effects of cyclohexene oxide and diethyl maleate. Toxicol Appl. Pharmacol., 1979, 50, 429-436.
34. DOEHMER (J.), DOGRA (S.), FRIEDBERG (T.), MONIER (S.), ADESNIK (M.), GLATT (H.) et OESCH (F.) : Stable expression of rat cytochrome P450 2B1 cDNA in chinese hamster cells (V79) and metahol c activation of aflatoxin Bl. Proc. Acad. Sci. USA, 1988, 85, 5769-73.
35. DUNAIF (G.E.) et CAMPBELL (T.C.) : Relative contribution of dietary protein level and aflatoxin Bl dose in generation of presumptive preneoplastic foci in rat liver. J.N.C.I., 1987, 78, 365-369.
36. EATON (D.L.), MONROE (D.H.), BELLAMY (G.) et KALMAN (D.A.) : Identification of a novel metabolite of aflatoxin Bl produced in vitro and in vivo in rats and mice. Chem. Res. Toxicol., 1988, 1, 108-114.
37. EATON (D.L.), RAMSDELL (H.S.) et NEAL (G.E.) : Biotransformation of aflatoxins. In: The toxicology of aflatoxins: human health, veterinary and agricultural significance. D.L. EATON and J.D. GROOPMAN (ed.), Academic press INC., London, 1994, p. 45-72.
38. EDDS (G.T.) : Acute aflatoxicosis: a review. Am. J. Vet. Med. Assoc., 1973, 162, 304-309,
39. ELLIS (E.M.), JUDAH (D.J.), NEAL (G.E.) et HAYES (J.D.) : An ethoxyquin-inductible aldehyde reductase from rat liver that metabolizes aflatoxin Bl defines a subfamily of aldo-keto reductiises. Proc. Natl. Acad. Sci. USA, 1993, 90, 10350-54,
40. ESSIGMAN (J.M.), CROY (R.G.), NADZAN (A.M.), BUSBY (W.F.), REINHOLD (V.N.), BUCHI (G.) et WOGAN (G.N.) : Structural identification of the major DNA adducts formed by aflatoxin B, in vitro. Proc. Natl. Acad. Sci. U.S.A., 1977, 74, 1870-1874.
41. FIROZI (P.F.), ABOOBAKER (V.S.) et BHATTACHARYA (R.K.) : Modulation by certain factors of metabolic activation of aflatoxin BI as detected in vitro in a simple fluorimetric assay. Chain. Biol. Interactions, 1986, 58, 173-184.
42. FIROZI (P.F.), ABOOBAKER (V.S.) et BHATTACHARYA (R.K.) : Action of vitamin A on DNA adduct formation by aflatoxin Bl in a microsome catalyzed reaction. Cancer Lett., 1987, 34, 213-220.
43. FORRESTER (L.M.), NEAL (G.E.), JUDAH (D.J.), GLANCEY (M.J.) et WOLF (C.R.) : Evidence for involvement of multiple forms of cytochrome P450 in aflatoxin Bl metabolism in human liver. Proc. Natl. Acad. Sci. USA, 1990, 87, 8306-10.
44. FRANCIS (A.R.), SHETTY (T.K.) et BHATTACHARIA (R.K.) : Modifying role of dietary factors on the mutagenicity of aflatoxin Bl: in vitro effect of trace elements. Mutation Res., 1988, 199, 85-93.
45. FRANCIS (A.R.), SHETTY (T.K.) et BHATTACHARIA (R.K.) : Modifying role of dietary factors on the mutagenicity of aflatoxin Bl: in vitro effect of plant flavonoids. Mutation Res., 1989, 222, 393-401.
46. FUKAYAMA (M.Y.) et HSIEH (D.P.H,) : The effects of butylated hydroxytoluene on the in vitro metabolism, DNA-binding and mutagenicity of aflatoxin Bl in the rat. Fd Chem. Toxic., 1984, 22, 355- 360.
47. GALLAGHER (E.P.), WIENKERS (L.C.), KUNZE (K.L.) et EATON (D.L.) : Role of human microsomal and human complementary DNA-expressed cytochromes P450 IA2 and 3A4 in the bioactivation of afltoxin Bl. Cancer Res., 1994, 54, 101-108.
48. GALLAGHER (E.P.) et EATON (D.L.) : In vitro biotransformation of aflatoxin Bl in channel catfish liver. Toxicol. Appl Pharmacol., 1995, 132, 82-90.
49. GARNER (R.C.), MILLER (E.G.) et MILLER (J.A.) : Liver microsomal metabolism of aflatoxin Bl to a reactive derivate toxic to Salmonella typhimurium TA 1530. Cancer Res., 1972, 32, 2058.
50. GODLEWSKI (C.F.), BOYD (J.N.), SHERMAN (W.K.), ANDERSON (J.L.) et STOEWSAND (G.S.) : Hepatic glutathione S-transferase activity and aflatoxin Bl-induced enzyme altered foci in rats fed fractions of brussels sprouts. Cancer Lett., 1985, 28, 151-157.
51. GOEGER (D.E.), SHELTON (D.W.), HENDRICKS (J.D.) et BAILEY(G.S.): Mechanism of anti-carcinogenesis by indole-3-carbinol: effect on the distribution and metabolism of aflatoxin Bl in rainbow trout. Carcinogenesis. 1986, 7, 2025-31.
52. GONZALEZ (F.J.) : Molecular genetics of the P450 superfamily. Pharmac. Ther., 1990, 45, 1-38.
53. GOSWAMI (U.C.), SALOI (T.N.), FIROZI (P.F.) et BHATTACHARYA (R.K.) : Modulation by some natural carotenoids of DNA adduct formation by aflatoxin Bl in vitro. Cancer Lett., 1989, 47, 127-132.
54. GREGORY (J.F.), GOLDSTEIN (S.L.) et EDDS (G.T.) : Metabolite distribution and rate of residue clearance in turkeys fed a diet containing aflatoxin Bl. Fd Chem. Toxic., 1983, 21, 463-467.
55. GREGORY (J.F.) et EDDS (G.T.) : Effect of dietary selenium on the metabolism of aflatoxin Bl in turkeys. Fd Chem. Toxic., 1984, 22, 637-642.
56. GROOPMAN (J.D.), FOWLER (K.W.), BUSBY (W.F.) et WOGAN (G.N.) : Interaction of aflatoxin B2 with rat liver DNA and histones in vivo. Carcinogenesis, 1981, 2, 1371-73.
57. GUENGERICH (F.P.) et KIM (D.H.) : In vitro inhibition of dihydropyridinc oxidation and aflatoxin Bl activation in human liver microsomes by naringenin and other flavonoids. Carcinogenesis, 1990, 11, 2275-79.
58. GUERRE (P.), GALTIER (P.) et BURGAT (V.) : Les aflatoxicoses chez l'animal: des manifestations cliniques aux mécanismes d'action, Rec. Méd. Vét., 1996. in press.
59. GURTOO (H.L.), DAHMS (R.P.) et PAIGEN (B.) : Metabolic activation of aflatoxins related to their mutagenicity. Biochem. Biophys. Res. Commun., 1978, 81, 965-972.
60. HABER-MlGNARD (D.), SUSCHETE (M.), BERGES (R.), ASTORG (P.) et SIESS (M.H.) : Inhibition of aflatoxin Bl-and N-nitrosodiethylamineinduced liver preneoplastic foci in rats fed naturally occuring allyl Sulfides. Nutr. Cancer, 1996, 25, 61-70.
61. HALVORSON (M.R.), SAFE (S.H.), PARKINSON (A.) et PHILLIPS (T.D.) : Aflatoxin Bl hydroxylation by the pregnenolone-loalpha-carbonitrile-inductihle form of rat liver microsomal cytochrome P450. Carcinogensis, 1988, 9, 2103-08.
62. HASTINGS (C.E.) et LLEWELLYN (G.C.) : Reduced aflatoxicosis in livers of hamsters fed a manganese sulfate supplement. Nutr. Cancer, 1987, 10, 67-77.
63. HATCH (R.C.), CLARK (J.D.), JAIN (A.V.) et MAHAFFEY (E.A.) : Experimentally induced acute aflatoxicosis in goats treated with ethyl maleate, glutathione precursors, or thiosulfate. Am. J. Vet Res., 1979. 40, 505-511.
64. HATCH (R.C), CLARK (J.D.), JAIN (A.V.), MAHAFFEY (E.A.) et WEISS (R.) : Effect of some inducers, fluids, and methionine-thiosulfate on induced acute aflatoxicosis in goats. Am. J. Vet. Res., 1982, 43, 246- 251.
65. HAYES (M.A.), MURRAY (C.A.) et RUSHMORE (T.H.) : Influence of glutathione status on different cytocidal responses of monolayer rat hepatocytes exposed to aflatoxin Bl or acetaminophen. Tox. Appl. Pharmacol., 1986, 85, 1-10.
66. HAYES (J.D.), JUDAH (D.J.), MCLEI.LAN (L.I.) et NEAL (G.E.) : Contribution of the glutathione S-transferases to the mechanisms of resistance to aflatoxin Bl. Pharmacol. Ther., 1991, 50, 443-472
67. HAYES (J.D.) et PULFORD (D.J.) : The glutathione S-tranferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Critical Rev. Biochem. Mol Biol., 1995, 30, 445-600.
68. HENDRICKS (J.D.) : Carcinogenicity of aflatoxins in nonmammalian organisms. In: The toxicology of aflatoxins: human health, veterinary and agricultural significance. D.L. EATON and J.D. GROOPMAN (ed.), Academic press INC., London, 1994, p. 103-136.
69. HOLESKI (C.J.), EATON (D.L.), MONROE (D.H.) et BELLAMY (G.M.) : Effects of phenobarbital on the biliary excretion of aflatoxin Pl-glucuronide and aflatoxin Bl-S-glutathione in the rat. Xenobiotica, 1987, 17, 139-153.
70. HSIEH (D.P.H.), SALHAB (A.S.), WONG (J.J.) et YANG (S.L.) : Toxicity of aflatoxin Ql as evaluated with the chicken embryo and bacterial auxotrophs. Toxicol. Appl. Pharmacol., 1974, 30, 237-42.
71. IMAOKA (S.), IKEMOTO (S.), SHIMADA (T.) et FUNAE (Y.) : Mutagenic activation of aflatoxin Bl by pulmonary, renal, and hepatic cytochrome P450s from rats. Mutation Res., 1992, 269, 231-236.
72. ISHII (K.), MAEDA (K.), KAMATAKI (T.) et KATO (R.) : Mutagenic activation of aflatoxin Bl by several forms of purified cytochrome P450. Mutation Res., 1986, 174, 85-88.
73. JACOBSEN (J.S.), REFOLO (L.M.), SAMBAMBURTI (K.) et HUMAYAN (M.Z.) : DNA replication blocking properties of adducts formed by aflatoxin Bl-2,3-dichloride and aflatoxin Bl-2,3-oxide. Mutation Res., 1987, 179, 89-101.
74. JENNINGS (G.S.), OESCH (F.) et STEINBERG (P.) : In vivo formation of aflatoxin Bl-DNA adducts in parenchymal and non-parenchymal cells of rat liver. Carcinogenesis, 1992, 13, 831-835.
75. JUDAH (D.J.), HAYES (J.D.), YANG (J.C.), LIAN (L.Y.), ROBERTS (C.K.), FARMER (P.B.), LAMB (J.H.) et NEAL (G.E.) : A novel aldehyde reductase with activity towards a metabolite of aflatoxin Bl is expressed in rat liver during carcinogenesis and following the administration of an anti-oxidint. Biochem. J., 1993, 292, 13-18.
76. KAMDEM (L.), SIEST (G.) et MAGDALOU (J.) : Differential toxicity of aflatoxin Bl in male and female rats: relationship with hepatic drugmetabolizing enzymes. Biochem. Pharmacol., 1982, 31, 3057-62.
77. KAMDEM (L.), MAGDALOU (J.), SIEST (G.), BAN (M.) et Zissu (D.) : Induced hepatotoxicity in female rats by aflatoxin Bl and ethynylestradiol interaction. Toxicol. Appl. Pharmacol., 1983, 67, 26-40.
78. KENSLER (T.W.), EGNER (P.A.), DAVIDSON (N.E.), ROEBUCK (B.D.), PIKUL (A.) et GROOPMAN (J.D.) : Modulation of aflatoxin metabolism, aflatoxin-N7-guanine fermation, and hepatic tumorigenesis in rats fed ethoxyquin: role of induction of glutathione S-transferase. Cancer Rex., 1986, 46, 3924-31.
79. KENSLER (T.W.), EGNER (P.A.), DOLAN (P.M.), GROOPMAN (J.D.) et ROEBUCK (B.D.) : Mechanism of protection against aflatoxin tumorigenicity in rats fed 5-(2-pyrazinyl)-4-methyl- 1, 2-dithiol-3-thione (oltipraz) and related 1,2-dithiol-3-thiones and 1,2-dithiol-3-ones. Cancer Res., 1987, 47, 4271-77.
80. KENSLER (T.W.), DAVIS (E.F.) et BOLTON (M.G.) : Strategies for chemoprotection against aflatoxin-induced liver cancer. In: The toxicology of aflatoxins: human health, veterinary and agricultural significance, D.L, EATON and J.D. GROOPMAN (ed.), Academic press INC., London, 1994, p. 281-306.
81. KETTERER (B.) : Detoxication reactions of glutathione and glutathione transferases. Xenobiotica, 1986, 16, 957-973.
82. KITADA (M.), TANEDA (M.), OHI (H.), KOMORI (M.), ITAHASHI (K.), NAOAO (M.) et KAMATAKI (T.) : Mutagenic activation of aflatoxin Bl by P450 HFLa in human fetal livers. Mutation Res., 1989, 227, 53- 58.
83. KOMADA (M.), INDUE (F.) et AKAO (M.) : Enzymatic and non-enzymatic formation of free radicals from aflatoxin Bl. Free Rad. Res. Comms., 1990, 10, 137-142.
84. KRISHNAMURTUY (P.B.) et NEELARAM (G.S.) : Effect of dietary fat on aflatoxin B l-induced chromosomal aberrations in mice. Toxicol. Lett., 1986, 31, 229-234.
85. KuMAGAI (S.), NAKANO (N.) et AIBARA (K.) : Interactions of aflatoxin Bl and blood components of various species in vitro: interconversion of aflatoxin Bl and aflatoxicol in the blood. Tox. Appl. Pharmacol., 1983, 67, 292-301.
86. LAI (T.S.) et CHIANG ( J.Y.L.) : Aflatoxin Bl metabolism by 3-methylcholanthrene-induced hamster hepatic cytochrome P450s. J. Biochem. Toxicol., 1990, 5, 147-153.
87. LARSSON (P.), PETTERSSON (H.) et TJALVE (H.) : Metabolism of aflatoxin Bl in the bovine olfactory mucosa. Carcinogenesis, 1989, 10, 1113-18.
88. LARSSON (P.) et TJALVE (H.) : Distribution and metabolism of aflatoxin Bl in the marmoset monkey (Callithrix jacchus). Carcinogenesis, 1993, 14, 1-6,
89. LARSSON (P.) : Biotransformation and retention of aflatoxin Bl in extrahepatic tissues of various animal species. Swedish university of agricultural sciences, Unpsala, 1994.
90. LEI (D.N.), WANG (L.Q.), RUEBNER (B.H.), HSIEH (D.P.H.), Wu (B,F), ZHU (C.R.) et DU (M.J.) : Effect of selenium on aflatoxin hepatocarcinogenesis in the rat. Biomed. Environ. Sci., 1990, 3, 65-80.
91. Liu (Y.L.), ROEBUCK (B.D.), YAGER (J.D.), GROOPMAN (J.D.) et KENSLER (T.W.) : Protection by 5-(2-pyrazinyl)-4-methyl-l,2 dithiol-3-thione (oltipnz) against the hepatotoxicity of aflatoxin Bl in rat. Toxicol. Appl. Pharmacal., 1988, 93, 442-51.
92. Liu (L.), DANIELS (J.M ), STEWART (R.K.) et MASSEY (T.E.) : In vitro prostaglandin H synthase and monooxygenase-mediated binding of aflatoxin Bl to DNA in guinea pig tissue microsomes, Carcinogenesis, 1990, 11, 1915-1919.
93. Liu (L.) et MASSEY (T.E.) : Bioactivation of aflatoxin Bl by lipooxygenases, prostaglandin H synthase and cytochrome P450 monooxygenase in guinea-pig tissues. Carcinogenesis, 1992, 13, 533-39.
94. LOTLIKAR (P.D.), JHEE (E.C), INSETTA (S.M.) et CLEARFIELD (M.S.) : Modulation of microsome-mediated aflatoxin Bl binding to exogenous and endogenous DNA by cytosolic glutathione S-transferases in rat and hamster livers. Carcinogenesis, 1984, 5, 269-276.
95. LOTLIKAR (P.D.), RAJ (H.G.), BOHM (L.S.), JHEE (E.C), TSUJI (K.) et GOPALAN (P.) : A mechanism of inhibition of aflatoxin Bl-DNA binding in the liver by phenobarbital presentment of rats. Cancer Res, 1989, 49, 951-957.
96. LOURY (D.J.), HSIEH (D.P.H.) et BYARD (J.L.) : The effect of phenobarbital pre-treatment on the metabolism, covalent binding, and cytotoxicity of aflatoxin Bl in primary cultures of rat hepatocytes. J. Toxic. Env. Health, 1984, 13, 145-159.
97. LOURY (D.J.) et HSIEH (D.P.H.) : Effects of chronic exposure to aflatoxin Bl and aflatoxin Ml on the in vivo covalent binding of aflatoxin Bl to hepatic macromolecules. J. Toxic. Env. Health, 1984, 13, 575-587.
98. LOVELAND (P.M.), WILCOX (J.S.) et BAILEY (G.S.) : Metabolism and DNA binding of aflatoxicol and aflatoxin Bl in vivo and in isolated hepatocytes from rainbow trout (Salmo gairdneri). Carcinogenesis, 1987, 8, 1065-70.
99. LOVELAND (P.M.), WILCOX (J.S.), HENDRICKS (J.D.) et BAILEY (G.S.) : Comparative metabolism and DNA binding of aflatoxin BI, aflatoxin Ml, aflatoxicol and aflatoxicol-Ml in hepatocytes from rainbow trout (Salmo gairdneri). Carciogenesis, 1988, 9, 441-446.
100. MADAHAVAN (T.V.) et GOPALAN (C.) : The effect of dietary protein on carcinogenesis of aflatoxin. Arch. Pathol., 1968, 85, 133-137.
101. MAINIGI (K.D.) et CAMPBELL (T.C.) : Subcellular distribution and covalent binding of aflatoxins as functions of dietary manipulation. J. Toxic. Env. Health, 1980, 6, 659-671.
102. MANNERVICK (B.) et al. : Nomenclature for human glutathione transferases. Biochim. J., 1992, 285, 305-306.
103. MANNING (R.O.), WYATT (R.D.) et MARKS (H.L.) : Effects of phenobarbital and ß-naphtoflavone on the in vivo toxicity and in vitro metabolism of aflatoxin in an aflatoxin-resistant and control line of chickens. J. Toxicol. Env. Health, 1990, 31, 291-311.
104. MARIEN (K.), MOYER (R.), LOVELAND (P.), VAN HOLDE (K.) et BAILEY (G.) : Comparative binding and sequence interaction specificities of aflatoxin Bl, aflatoxicol, aflatoxin Ml, and aflatoxicol MI with purified DNA.J. Biol. Chein., 1987, 262, 7455-7462.
105. MARZUKY (A.) et NORRED (W.P.) : Effects of saturated and unsaturated dietary fat on aflatoxin Bl metabolism. Fd Chew. Toxic., 1984, 22, 383-389.
106. MBIAPO (F.), MOUNUIPA (Ph.D.) et MOUNDIPA (P.F.) : Hepatic microsomnl drug-metabolizing enzyme in aflatoxin Bl-treated rats after feeding vegetable diet Amaranthus hybridus. Nutr. Res., 1993, 13, 941-951.
107. MGBODILE (M.U.K.), HOLSCHER (M.) et NEAL (R.A.) : A possible protective role for reduced glutathione in aflatoxine BI toxicity: effect of pretreatment of rats with phenobarbital and 3-methylcholanthrene on aflatoxin toxicity. Toxicol. Appl. Pharmacol., 1975, 34, 128-142.
108. MILKS (M.M.), WILT (S.R.), ALI (I.I.) et COURI (D.) : The effects of selenium on the emergence of aflatoxin Bl-induced enzyme-altered foci in rat liver. Fund. Appl. Toxicol., 1985, 5, 320-326.
109. MIRMOMENI (M.H.), SUZANGAR (M.), WISE (A.), MESSRIPOUR (M.) et EMAMI (H.) : Biochemical studies during aflatoxin Bl-induced liver damage in rats fed different levels of dietary protein. Int. J. Cancer, 1979, 24, 471-476.
110. MIZOKAMI (K.), NOHMI (T.), FUKUHARA (M.), TAKANAKA (A.) et OMORI (Y.) : Purification and characterization of a form of cytochrome P450 with high specificity for aflatoxin Bl from 3-methylcholanthrene-treated hamster liver. Bioehem. Biopliys. Res. Commun., 1986, 139, 466-472.
111. MONROE (D.H.) et EATON (D.L.) : Effects of modulation of hepatic glutathione on biotransformation and covalent binding of aflatoxin BI to DNA in the mouse. Toxicol. Appl. Pharmacol., 1988, 94, 118- 127.
112. Moss (E.J.), MANSON (M.M.) et NEAL (G.E.) : Effect of manipulation of gamma-glutamyl transpeptidase levels on biliary excretion of aflatoxin Bl conjugates. Carcinogenesis, 1984, 5, 869-874,
113. MOUNDIPA (PF.) et MBIAPO DOMNOANO (F.) : Effect of the leafy vegetable Solanum nigrum on the activities of some liver drug-metabolizing enzymes after aflatoxin Bl treatment in female rats. British J. Nutri., 1991, 65, 81-91
114. MURRAY (M.) et REIDY (G.F.) : Selectivity in the inhibition of mammalian cytochromes P450 by chemical agents. Pharmacological Rev., 1990, 42, 85-101.
115. NEAL (O.E.), JUDAH (D.J.), STIRPE (F.) et PATTERSON (D.S.P.) : The formation of 2,3-dihydroxy-2,3-dihydro-aflatoxm Bl by the metabolism of aflatoxin Bl by liver microsomes isolated from certain avian and mammalian species and the possible role of this metabolite in the acute toxicity of aflatoxin Bl. Toxicol. Appl. Pharmacol., 1981, 58, 431-437.
116. NELSON (R.D.) et NEBERT (D.W.) : P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmactigenetic, 1996, 6, 1-42.
117. NEWBERNE (P.M.) et ROGERS (A.M.) : Rat colon carcinomas associated with aflatoxin and marginal vitamin A. J. Natl. Cancer lnst., 1973, 50, 439-448.
118. NEWBERNE (P.M.) et SUPHAKARN (V.) : Preventive role of vitamin A in colon carcinogcnesis in rats, Cancer, 1977, 40, 2553-2556.
119. NEWBERNE (P.M.), WEIGERT (J.) et KULA (N.) : Effects of dietary fat on hepatic mixed-function oxidases and hepatocellular carcinoma induced by aflatoxin in rats. Cancer Res., 1979, 39, 3986-91.
120. NEWBERNE (P.M.) et ROGERS (A.M.) : Labile methyl groups and the promotion of cancer. Ann. Rev. Nutr., 1986, 6, 407-432.
121. Nnvi (A.M.) : Regression or aflatoxin B l-induced hepatocellular carcinomas by reduced glutathionc. Science, 1981, 212, 541-542.
122. NYANDIEKA (H.S.) : Effects of dietary fat and aflatoxin Bl on microsomal monooxygenases activity. Arch. Toxicol., 1987, 60, 59-60.
123. NYANDIEKA (H.S.), WAKHIS (J.) et KILONZO (M.M.) : Association of reduction of AFBI-induced liver tumours by antioxidants with increased activity on microsomal enzymes. Indian J. Med. Res., 1990, 92, 332-336
124. O'BRIEN(K.), Moss (E.), JUDAH (D.)et NEAL (G.) : Metabolic basis of the species difference to aflatoxin Bl induced hepatotoxicity, Biochem. Biophys. Res. Commun., 1983, 114, 813-821.
125. PATTERSON (D.S.P.) : Metabolism as a factor in determining the toxic action of the aflatoxins in different animal species, Food Cosmei. Toxicol., 1973, 11, 287-294.
126. PELISSIER (M.A.), FRAYSSINETIC.), BOISSET(M.) et ALBRECHT(R.); Effect of phenoclor DP6 on enzyme-altered foci and lipid peroxidation in livers of aflatoxin Bl-initiated rats. Fd Chem. Toxic., 1992, 30, 133-137.
127. PLUMMER(S.), BOOBIS (A.R.) et DAVIES (D.S.) : Strain differences in the metabolic activation of aflatoxin Bl in the rat. Xenobiotica, 1987, 17, 199-208.
128. PRASANNA (H.R.), Lu (M.H.), BELAND (F.A.) et HART (R.W.) : Inhibition of aflatoxin Bl binding to hepatic DNA by dehydroepiandrosterone in vivo. Carcinogenesis, 1989, 10, 2197-2200.
129. PRASANNA (H.R,), HEFLIOH (R.H.), Lu (M.H.), MINOR (T.Y.) et HART (R.W.) : Altered hepatic microsome-mediated activation of aflatoxin Bl by dehydroepiandrosterone. Biochem. Arch., 1990, 6, 61-68.
130. PUTT (D.A.), DING (X.), COON (M.J.) et HOLLENBRG (P.F.) : Metabolism of aflatoxin BI hy rabbit and rat nasal mucosa microsomes and purified cytochrome P450, including isoforms 2A10 and 2A11. Carcinogenesis, 1995, 16, 1411-17,
131. QUINN (B.A.), CRANE (T.L.), KOCAL (T.E.), BEST (S.J.), CAMERON (R.G.), RUSHMORE (T.H.), FARBER (E.) et HAYES (M.A.) : Protective activity of different hepatic cytosolic glutathione S-trnnsferasus against DNA-binding metabolites of aflatoxin Bl. Toxicol. Appl. Pharmarol., 1990, 105, 351-363.
132. RAINA (V.), WILLIAMS (H.L.) et GURTOO (H.L.) : Genetic expression of aflatoxin metabolism. Effects of 3-methylcholanthrene and ß- naphtoflavone on hepatic microsomal metabolism and mutngenic activation of aflatoxins. Biochem. Phamacol., 1983, 32, 3755-63.
133. RAINA (V.), KOSER (P.) et GURTOO (H.L.) : Differential sensitivity of Ah-responsive mice to ß-naphtoflavone-induced metabolism and mutagenesis of benzo[a]pyrene and aflatoxin Bl. J. Toxicol. Env. Health, 1985, 16, 255-261.
134. RAJ (H.G.), CLEARFIELD (M.S.) et LOTLIKAR (P.D.) : Comparative kinetic studies on aflatoxin Bl-DNA binding and aflatoxin B l-glutathione conjugation with rat and hamster livers in vitro. Carcinogenesis, 1984, 5, 879-884.
135. RAJ (H.G.) et LOTLIKAR (P.D.) : Urinary excretion of thiol conjugates of aflatoxin Bl in rats and hamsters. Cancer Lett., 1984, 22, 125-133.
136. RAJ (H.G.), PRASANNA (H.R.), MAGEE (P.N.) et LOTLIKAR (P.D.) : Effect of purified rat and hamster hepatic glutathione S-transferases on the microsomc mediated binding of aflatoxin Bl to DNA. Cancer Let., 1986, 33, 1-9.
137. RAJPUROHIT (R.) et KRISHNASWAMY (K.) : Differences in response of glucuronide and glutathione conjugating enzymes to aflatoxin Bl and N-acetylaminofluorene in underfed rats. J. Toxicol. Env. Health, 1988, 24, 103-109.
138. RAMSDELL (H.S.) et EATON (D.L.) : Modification of aflatoxin Bl biotransformation in vitro and DNA binding in vivo by dietary broccoli in rats. J. Toxicol. Env. Health, 1988, 25, 269-284.
139. RAMSDELL (H.S.) et EATON (D.L.) : Species susceptibility to aflatoxin Bl carcinogenesis: comparative kinetics of microsomal biotransformation. Cancer Res., 1990, 50, 615-620.
140. RAMSDELL (H.S.), PARKINSON (A.), EDDY (A.C.) et EATON (D.L.) : Bioactivation of aflatoxin Bl by human liver microsomes: role of cytochrome P450 3A enzymes. Toxicol. Appl. Pharmacol., 1991, 108, 436-447.
141. RANEY (K.D.), SHIMADA (T.), KIM (D.H.), GROOPMAN (J.D.), HARRIS (T.M.) et GUENGERICH (F.P.) : Oxidation of aflatoxins and sterigmatocystin by human liver microsomes: significance of aflatoxin Ql as a detoxication product of aflatoxin Bl. Chem, Res. Toxicol., 1992, 5, 202-210.
142. REFOLD (L.M.), BENNETT (C.B.) et HUMAYUN (M.Z.) : Mechanisms of frameshift mutagenesis by aflatoxin Bl-2,3-dichloride. J. Mol. Biol., 1987, 193, 609-636.
143. ROGERS (A.E. ) et NEWBERNE (P.M.) : Aflatoxin B l carcinogenesis in lipotrope deficient rat. Cancer Res., 1969, 29, 1965-72.
144. ROGERS (A.E.) : Nutritional modulation of aflatoxin carcinogenesis. In: The toxicology of aflatoxins: human health, veterinary and agricultural significance. D.L. EATON and J.D. GROOPMAN (ed.), Academic press INC., London, 1994, p. 207-230,
145. SABBIONI (G.), AMBS (S.), WOGAN (G.N.) et GROOPMAN (J.D.) : The aflatoxin-lysinc adduct quantified by high-performance liquid chromatography from human albumin samples, Carcinogenesis, 1990, 11, 2063-2066,
146. SALHAB (A.S.) et EDWARDS (G.S.) : Comparative in vitro metabolism of aflatoxicol by liver preparations from animals and humans. Cancer Res., 1977, 37, 1016-21.
147. SANTHANAM (K.) et LOTLIKAR (P.D.): Effect of ß-naphtoflavone on the metabolism of aflatoxin B l in hamsters. Cancer Lett., 1989, 45, 129-134.
148. SCHOENHARD (G.L.), HENDRICKS (J.D.), NIXON (J.E.), LEE (J.D.), WALES (J.H.), SINNHUBER (R.O.) et PAWLOWSKI (N.E.) : Aflatoxicolinduced hepatocellulnr carcinoma in rainbow trout (Salmo gairdneri) and the synergistic effects of cyclopropenoid fatty acids. Cancer Res., 1981, 41, 1011-14.
149. SHELTON (D.W.), GOEGER (D.E.), HENDRICKS (J.D,) et BAILEY (G.S.) : Mechanisms of anti-carcinogcnesis: the distribution and metabolism of aflatoxin Bl in rainbow trout fed aroclor 1254. Carcinogenesis, 1986, 7, 1065-71.
150. SHETTY (T.K.), FRANCIS (A.R.) et BHATTACHARYA (R.K.) : Modifying role of dietary factors on the mutagenicity of aflatoxin Bl: HI vitro effect of sulphur-containing amino acids. Mutation Res., 1989, 222, 403-407.
151. SHIMADA (T.) et GUENGERICH (F.P.) : Evidence for cytochrome P450NF. the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver. Proc. Natl. Acad. Sci. USA, 1989, 86, 462-465.
152. SLONE (D.H.), GALLAGHER (E.P.), RAMSDELL (H.S.), RETTIE(A.E.), STAPLETON (P.L.), BERLAD (L.G.) et EATON (D.L.) : Human variability in hepatic glutathione S-transferase-mediated conjugation of aflatoxin Bl-epoxide and other susbstrates. Pharmacogenetics, 1995, 5, 224-233.
153. STEIKBERG (P.), SCHLEMPER (B.), MOLITOR (E.), PLATT (K.L.), SEIDnL(A.) et OESH(F.) : Rat liver endothelial and Kupffer cell-mediated mutagenicity of polycyclic aromatic hydrocarbons and aflatoxin Bl. Environ. Health Perspec., 1990, 88, 71-76.
154. STOLOFF (L.), VERRET (M.J.), DANTZMAN (J.) et REYNALDO (E.F.) : Toxicological study of aflatoxin PI using the fertile chicken egg. Taxicol. Appl. Pharmacol., 1972, 23, 528-31.
155. SUNOUCHI (M.), ISHIMI (Y.), MIZOKAMI (K.), FUKUHARA (M.), TAKA- NAKA (A.), HANAOKA (F.) et YAMADA (M.) : Preparation and characterization of monoclonal antibodies against a form of hamster liver cytochrome P450 highly specific to aflatoxin Bl. Biochem. Binphys. Res. Commun., 1988, 153, 441-447.
156. SWENSON (D.H.), MILLER (J. A.) et MILLER (E.C.) : The reactivity and carcinogenicity of aflatoxin Bl -2,3-dichloride, a model for the putative 2.3-oxide metabolite of aflatoxin Bl, Cancer Res., 1975, 35, 3811-3823.
157. SWENSON (D.H.), LIN (J.K.), MILLER (E.C.) et MILLER (J.A.) : Aflatoxin Bl-2,3-oxide as a probable intermediate in the covalent binding of aflatoxins Bl and B2 to rat liver DNA and ribosomal RNA in vivo. Cancer Res., 1977, 37, 172-181.
158. TADI (P.P.), TEEL (R.W.) et LAU (B.H.S.) : Organosulfur compounds of garlic modulate mutagenesis, metabolism, and DNA binding of aflatoxin Bl. Nutr. Cancer, 1991, 15, 87-95.
159. TAKAHASHI (N.), STRESSER (D.M.), WILLIAMS (D.E.) et BAILEY (G.S.) : Induction of hepatic CYP1A by indole-3-carbinol in protection against aflatoxin Bl hepatocarcinogenesis in rainbow trout. Fd Chem. Toxicol., 1995, 33, 841-50.
160. TEEL (R.W.) : Effect of capsaicin on rat liver S9-mediated metabolism and DNA binding of aflatoxin. Nutr. Cancer, 1991, 15, 27-32.
161. TESTA (B.) et JENNER (P.) : Inhibitors of cytochrome P450s and their mechanism of action. Drug Metabolism Rev., 1981, 12, 1-117.
162. TJALVE (H.), LARSSON (P.), ANDERSSON (C.) et BUSK (L.) : Bioactivation of aflatoxin Bl in the bovine olfactory mucosa: DNA binding, mutagenicity and induction of sister chromatid exchanges. Carcinogenesis, 1992, 13, 1345-1350.
163. TOSKULKAO (C.), YOSHIDA (T.), GLINSUKON (T.) et KUROIWA (Y.) : Potentiation of aflatoxin Bl induced hepatotoxicity in male Wistar rats with ethanol pretreatment. J. Toxicol. Sci., 1986, 11, 41-51.
164. TOSKULKAO (C.) et GLINSUKON (T.) : Effect of ethanol on the in vivo covalent binding and in vitro metabolism of aflatoxin Bl in rats. ToxicoL Lett., 1986, 30, 151-157.
165. TOSKULKAO (C.) et GLINSUKON (T.) : Hepatic mitochondrial function and lysosomal enzyme activity in ethanol-potentiated aflatoxin Bl hepatotoxicity. Toxicol Lett., 1990, 52, 179-190.
166. UENG (Y.F.), SHIMADA (T.), YAMAZAKI (H.) et GUENGERICH (F.P.) : Oxidation of aflatoxin Bl by bacterial recombinant human cytochrome P450 enzymes. Chem. Res. Toxicol., 1995, 8, 218-225.
167. UENO (Y.), FRIEDMAN (L.) et STONE (C.L.) : Species differences in the binding of AFB1 to hepatic macromolecules. Toxicol. Appl. Pharmacol., 1980, 52, 177-180.
168. WALTERS (J.M.) et COMBES (R.D.) : Activation of benzo[a]pyrene and aflatoxin Bl to mutagenic chemical species by microsomal preparations from rat liver and small intestine in relation to microsomal epoxide hydrolase. Muragenesis, 1986, 1, 45-48.
169. WEI (C.I.), MARSHALL (M.R.) et HSIEH (D.P.H.) : Characterization of water-soluble glucuronide and sulphate conjugates of aflatoxin Bl. 1. Urinary excretion in monkey, rat, and mouse. Fd Chem. Toxic, 1985, 23, 809-819.
170. WEI (C.I.) et HSIEH (D.P.H.) : Characterization of water-soluble glucuronide and sulfate conjugates of aflatoxin Bl. 2. Studies in primary cultures of rat hepatocytes, Fd Chem. Toxic., 1985, 23, 821825.
171. WHITTY (J.P.) et BJELDANES (L.F.) : The effects of dietary cabbage on xenobiotic metabolizing enzymes and the binding of aflatoxin Bl to hepatic DNA in rats. Fd Chem. Toxic., 1987, 25, 581-87
172. WILLIAMS (G.M.), TANAKA (T.) et MACURA (Y.) : Dose-related inhibition of aflatoxin B l-induced hepatocarcinogenesis by the antioxidant butylated hydroxyanisole and butylated hydroxytoluene. Carcinogenesis, 1986, 7, 1043-50.
173. WONG (Z.A.) et HSIEH (D.P.H.) : The comparative metabolism and toxicokinetics of aflatoxin Bl in the monkey, rat, and mouse. Toxicol. Appl. Pharmacol., 1980, 55, 115-125.
174. WOOD (L.M.), SMITH (J.R.L.) et GARNER (R.C.) : Structural characterization of the major adducts obtained after reaction of an ultimate carcinogen aflatoxin Bl-dichloride with calf thymus DNA in vitro. Cancer Res., 1988, 48, 5391-96.
175. YOSHIZAWA (H.), UCHIMARU (R.), KAMATAKI (T.), KATO (R.) et UENO (Y.) : Metabolism and activation of aflatoxin Bl by reconstituted cytochrome P450 system of rat liver. Cancer Res., 1982, 42, 1120- 24.
176. YOURTEE (D.M.) et ROHRIG (T.M.) : The in vitro metabolism of aflatoxin Ql by mouse and rabbit liver preparations. Res. Com. Client. Pathol. Pharmacol., 1985, 50, 103-123.
177. YOURTEE (D.M.) et KIRK-YOURTEE(C.L.) : The mutagenicity of aflatoxin Ql to Salmonella typhimurium TA 100 with or without rat or human liver microsomal preparations. Res. Commun. Chem. Pathol. Pharmacol., 1986, 54, 101-113.
178. YOURTEE (D.M.) et KIRK-YOURTEE (C.L.) : The direct mutagenicity of aflatoxin Bl and metabolites to Salmonella typhimurium : structure mutagenicity relationships and mechanisms of action. Res. Commun. Chem. Pathol. Pharmacol., 1987, 57, 55-76.