Antidiarrheal activity of Kigelia africana in experimental animals

Journal of Herbs, Spices and Medicinal Plants

Volumn 4, Issue 2, 1996, Pages 31-38

  Akah, Peter A ^a  

^a UNIVERSITY OF NIGERIA   (Nigeria)

Author keywords

Antidiarrheal activity; Motility inhibition; Traditional medicine

Indexed keywords

ACETYLCHOLINE; ANTIDIARRHEAL AGENT; CASTOR OIL; GUM ARABIC; HISTAMINE; KIGELIA AFRICANA EXTRACT; LOPERAMIDE; NICOTINE; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIARRHEA; DRUG EFFECT; FEMALE; GASTROINTESTINAL INFECTION; GUINEA PIG; ILEUM; INTESTINE MOTILITY; INTRAPERITONEAL DRUG ADMINISTRATION; LD 50; MALE; MEDICINAL PLANT; NONHUMAN; PLANT LEAF;

ACACIA SENEGAL; ANIMALIA; CAVIA PORCELLUS; KIGELIA AFRICANA; SUS SCROFA;

EID: 0030357666     PISSN: 10496475     EISSN: None     Source Type: Journal    
DOI: 10.1300/J044v04n02_06     Document Type: Article

References (21)

1. Dalziel, J.M. 1937. The Useful Plants of West Tropical Africa. Crown Agents for the Colonies, London.
2. Burkill, H.M. 1985. The Useful Plants of West Tropical Africa. Royal Botanic Garden Kew, London.
3. Irvine, F.R. 1961. Woody Plants of Ghana. Oxford University Press, London. 736 p.
4. Ainslie, J.R. 1937. A list of plants used in native medicine in Nigeria. Imp. Forest Inst., Oxford Inst. Paper 7.
5. Iwu, M.M. 1986. African Ethnomedicine. 2nd ed. SNAAP Press, Enugu, Nigeria. 173 p.
6. Kela, S.L., R.A. Ogunsusi, V.C. Ogbogu, and N. Nwude. 1989. Screening of some Nigerian plants for molluscicidal activity. Rev. Elevege. Med. Vet. Tropicaux 42:189-192.
7. Kela, S.L., R.A. Ogunsusi, V.C. Ogbogu, and N. Nwude. 1989. Susceptibility of two-week old Lymnaea natalensis to some plants extracts. Rev. Elevage, Med. Vet. Tropicaux 42:195-202.
8. Akunyili, D.N., P.J. Houghton, and A. Raman. 1991. Antimicrobial activities of the stembark of Kigelia pinnata. J. Ethnopharmacol. 35:193-197.
9. Houghton, P.J., A. Photiou, S. Uddin, P. Shah, M. Browning, S.J. Jackson, and S. Retsas. 1994. Activity of extracts of Kigelia pinnata against melanoma and renal carcinoma cell lines. Planta. Med. 60:430-433.
10. Ratia, M., A. Jabri, T.A. Khan, and S.I. Husain. 1991. Effect of bark extracts of some angiosperme on the larval hatching of Melaidogyne incognita. Cur. Nematology 2:175-176.
11. Akunyili, D.N. and P.J. Houghton. 1993. Monoterpenoids and naphthaquinones from Kigelia pinnata. Phytochemistry 30:1015-1023.
12. Trease, C.E. and W.C. Evans. 1983. Textbook of Pharmacognosy. 12th Ed. Bailiere, Tindall, London, pp. 383-385.
13. Lorke, D. 1983, A new approach to practical acute toxtcity testing. Arch. Toxicology 54:275-282.
14. Pillai, N.R. 1992. Antidiarrheal activity of Punica granatum in experimental animals. Int. J. Pharmacog. 30:201-204.
15. Akah, P.A. 1989. Purgative potentials of Euphorbia heteropylla. Fitoterapia 60:45-48.
16. Akah, P.A. and V.N. Offah. 1992. Gastrointestinal effects of Allamanda cathartica leaf extracts. Int. J. Pharmacog. 30:213-217.
17. Lefkowitz, R.J., B.B. Hoffman, and P. Taylor. 1990. Neurohumoral transmission: The autonomie and somatic motor nervous systems: In A. Goodman and G. Gilman, eds., The Pharmacological Basis of Therapeutics. 8th Ed. Pergamon Press, New York. pp. 84-101.
18. Macander, P.J. 1986. Flavonoids affect acetylcholine, prostaglandin E and antigen-mediated smooth muscle contraction. Prog. Clin. Biol. Res. 213:489-492.
19. 4-induced contractions on the guinea-pig isolated ileum. Pharmacol. Res. Commun. 20 (suppl. 1):201-202.
20. Carlo, G.D., N. Mascolo, A.A Izzo, F. Capasso, and G. Autore. 1994. Effects of quercetin on the gastrointestinal tract of rats and mice. Phytother. Res. 8:42-45.
21. Viswanathan, S., S.P. Thirugnana, and J.S. Bapha. 1984. Flavonoid-induced delay in the small intestinal transit: possible mechanism of action. Arch. Int. Pharmacodyn. 270:151-157.