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Volumn 36, Issue 2, 1996, Pages 199-206

Antibody-catalyzed uni-and multi-substrate reactions compared using transition-state binding (KTS)

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EID: 0030351424     PISSN: 00212148     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijch.199600027     Document Type: Article
Times cited : (5)

References (42)
  • 14
    • 0003518480 scopus 로고
    • John Wiley & Sons, New York
    • M for the catalyst-first substrate complex in the presence or absence of complexed other substrate. α =1 means no dependence. See Segel, I.H.; Enzyme Kinetics; John Wiley & Sons, New York, 1975, pp 273-283.
    • (1975) Enzyme Kinetics , pp. 273-283
    • Segel, I.H.1
  • 22
    • 85163196517 scopus 로고
    • For aldol condensations catalyzed by primary and secondary amires in water, see: (a) Fischer, F.G.; Marschall, A. Chem. Ber. 1931, 64, 2825.
    • (1931) Chem. Ber. , vol.64 , pp. 2825
    • Fischer, F.G.1    Marschall, A.2
  • 31
    • 0000246845 scopus 로고
    • refs cited therein
    • For amino acid catalysis of an aldol process in non-aqueous medium. (j) Agami, C. Bull. Soc. Chim. Fr. 1988, 3, 499 and refs cited therein.
    • (1988) Bull. Soc. Chim. Fr. , vol.3 , pp. 499
    • Agami, C.1
  • 35
    • 0040681052 scopus 로고    scopus 로고
    • note
    • 2O, detection by UV at 250 nm).
  • 36
    • 0039495743 scopus 로고    scopus 로고
    • note
    • R(11) = 15.2 min and 19.2 min. The enantioselectivity is corrected for the racemic background reaction.
  • 40
    • 0024298964 scopus 로고
    • Here we cite a paragraph on the issue of substrate binding in enzymatic catalysis: "Why is there a Michaelis-Menten complex? The existence of an ES complex is postulated to account for the phenomenon of substrate saturation in steady-state kinetics." And later: "Probably the ES complex represents binding of a Boltzmann distribution of substrate molecules in states preceding the transition-state bottleneck. That these bound states are well populated may be due simply to the inevitable fact that the transition-state of the usual substrate molecule does not look very different from its ground state."
    • Kraut, J. Science 1988, 242, 533. Here we cite a paragraph on the issue of substrate binding in enzymatic catalysis: "Why is there a Michaelis-Menten complex? The existence of an ES complex is postulated to account for the phenomenon of substrate saturation in steady-state kinetics." And later: "Probably the ES complex represents binding of a Boltzmann distribution of substrate molecules in states preceding the transition-state bottleneck. That these bound states are well populated may be due simply to the inevitable fact that the transition-state of the usual substrate molecule does not look very different from its ground state."
    • (1988) Science , vol.242 , pp. 533
    • Kraut, J.1
  • 42
    • 0029018511 scopus 로고
    • uncat. This leads to a classification of all catalyzed reactions as either uni-or bimolecular, so that higher-order processes like those discussed here cannot be analyzed
    • uncat. This leads to a classification of all catalyzed reactions as either uni-or bimolecular, so that higher-order processes like those discussed here cannot be analyzed.
    • (1995) Nature , vol.375 , pp. 388
    • Stewart, J.D.1    Benkovic, S.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.