Inhibition of NADH oxidation by 1-methyl-4-phenylpyridinium analogs as the basis for the prediction of the inhibitory potency of novel compounds

Journal of Biochemical Toxicology

Volumn 11, Issue 1, 1996, Pages 33-43

  Sablin, Sergey O ^a,b   Krueger, Matthew J ^a,b   Yankovskaya, Victoria L ^a,b   Tkachenko, Sergey E ^d   Razdolsky, Alexander N ^d   Bachurin, Sergey O ^d   Ramsay, Rona R ^a,b,e   Singer, Thomas P ^a,b,c  

^a SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d INSTITUTE OF PHYSIOLOGICALLY ACTIVE COMPOUNDS   (Russian Federation)

^e UNIVERSITY OF ST ANDREWS   (United Kingdom)

Author keywords

Complex I Inhibitor; Rotenone Sites; Structure Activity Relations; Styrylpyridinium Inhibitors

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; DOPAMINE RECEPTOR STIMULATING AGENT; DRUG DERIVATIVE; HERBICIDE; PYRIDINIUM DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE;

ANIMAL; ARTICLE; CELL MEMBRANE; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; LD 50; LIVER MITOCHONDRION; METABOLISM; OXIDATION REDUCTION REACTION; OXYGEN CONSUMPTION; RAT; STRUCTURE ACTIVITY RELATION;

1-METHYL-4-PHENYLPYRIDINIUM; ANIMALS; CELL MEMBRANE; DOPAMINE AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HERBICIDES; LETHAL DOSE 50; MITOCHONDRIA, LIVER; NADH DEHYDROGENASE; OXIDATION-REDUCTION; OXYGEN CONSUMPTION; PYRIDINIUM COMPOUNDS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030348207     PISSN: 08872082     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1522-7146(1996)11:1<33::AID-JBT5>3.0.CO;2-W     Document Type: Article

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