Production of type IV collagen and 72-kDa gelatinase by human endothelial cells cultured in high glucose. Effects of a protein kinase C inhibitor, GF 109203X

Biochemistry and Cell Biology

Volumn 74, Issue 5, 1996, Pages 659-667

  Grigorova Borsos, Anne Marie ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

High glucose; Human umbilical vein endothelial cells; Protein kinase C inhibitor; Type IV collagen; Type IV collagenase

Indexed keywords

BISINDOLYLMALEIMIDE I; COLLAGEN; GELATINASE; GLUCOSE; INDOLE DERIVATIVE; MALEIMIDE DERIVATIVE; MANNITOL; PROTEIN KINASE C;

ARTICLE; BIOSYNTHESIS; BLOOD; CELL CULTURE; CELL FREE SYSTEM; CULTURE MEDIUM; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; HUMAN; METABOLISM; MOLECULAR WEIGHT; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

CELL-FREE SYSTEM; CELLS, CULTURED; COLLAGEN; CULTURE MEDIA; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; GELATINASES; GLUCOSE; HUMANS; INDOLES; MALEIMIDES; MANNITOL; MOLECULAR WEIGHT; PROTEIN KINASE C; UMBILICAL VEINS;

EID: 0030347606     PISSN: 08298211     EISSN: None     Source Type: Journal    
DOI: 10.1139/o96-071     Document Type: Article

References (3)

1. Cagliero, E., Maiello, M., Boeri, D., Roy, S., and Lorenzi, M. 1988. Increased expression of basement membrane components in human endothelial cells cultured in high glucose. J. Clin. Invest. 82: 735-738.
2. Cagliero, E., Roth, T., Roy, S., Maiello, M., and Lorenzi, M. 1991. Expression of genes related to the extracellular matrix in human endothelial cells. Differential modulation by elevated glucose concentrations, phorbol esters, and cAMP. J. Biol. Chem. 266: 14 244-14250.
3. Chakrabarti, S., and Sima, A.A.F. 1989. Effect of aldose reductase inhibition and insulin treatment on retinal capillary basement membrane thickening in BB rats. Diabetes, 38: 1181-1186.