Modulation of extracellular kynurenic acid content by excitatory amino acids in primary cultures of rat astrocytes

Advances in Experimental Medicine and Biology

Volumn 398, Issue , 1996, Pages 273-276

  Curatolo, L ^a   Caccia, C ^a   Speciale, C ^a   Raimondi, L ^a   Cini, M ^a   Marconi, M ^a   Molinari, A ^a   Schwarcz, R ^b  

^a Nerviano Medical Sciences   (Italy)

^b MARYLAND PSYCHIATRIC RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINOADIPIC ACID; AMINO ACID RECEPTOR STIMULATING AGENT; DRUG DERIVATIVE; GLUTAMIC ACID; HOMOCYSTEIC ACID; HOMOCYSTEINE; KYNURENIC ACID;

ANIMAL; ARTICLE; ASTROCYTE; BRAIN CORTEX; CELL CULTURE; DRUG EFFECT; KINETICS; METABOLISM; NEWBORN; RAT; SPRAGUE DAWLEY RAT;

2-AMINOADIPIC ACID; ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; CELLS, CULTURED; CEREBRAL CORTEX; EXCITATORY AMINO ACID AGONISTS; GLUTAMIC ACID; HOMOCYSTEINE; KINETICS; KYNURENIC ACID; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0030346443     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4613-0381-7_43     Document Type: Article

References (8)

1. Du F., Schmidt W., Okuno E., Kido R., K"hler C and Schwarcz R., 1992, Localization of kynurenine aminotransferase immunoreactivity in the rat hippocampus, J. Comp. Neurol. 321:477.
2. Gramsbergen J.B.P., Turski W.A. and Schwarcz R., 1989, Sodium-dependent inhibition of kynurenate synthesis by quisqualate in rat brain. Soc. Neurosci. Abstr. 15:328
3. Schwarcz R., Du F., Schmidt W., Turski W.A., Gramsbergen J.B.P., Okuno E. and Roberts R.C., 1992, Kynurenic acid: a potential pathogen in brain disorders, in: "Neurotoxins and Neurodegenerative Disease", J.W. Langston and A. Young eds., Ann. N.Y. Acad. Sci., New York 648:140
4. Stone T.W., 1993, Neuropharmacology of quinolinic and kynurenic acids, Pharmacol. Rev. 45: 310
5. Swartz K.J., Matson W.R., MacCarvey U., Ryan E.A. and Beal M.F., 1990, Measurement of kynurenic acid in mammalian brain extracts and cerebrospinal fluid by high-performance liquid chromatography with fluorimetric and coulometric electrode array detection, Anal. Biochem. 185:363.
6. Turski W.A., Gramsbergen J.B.P., Traitler H. and Schwarcz R., 1989, Rat brain slices produce and liberate kynurenic acid upon exposure to L-kynurenine, J. Neurochem. 52:1629
7. Wu H.-Q., Baran H., Ungerstedt U. and Schwarcz R., 1992, Kynurenic acid in the quinolinate- lesioned rat hippocampus: studies in vitro and in vivo, Eur. J. Neurosci. 4:1264
8. Wu H.-Q., Ungerstedt U. and Schwarcz R., 1955, L-α-Aminoadipic acid as a regulator of kynurenic acid production in the hippocampus: a microdialysis study in freely moving rats, Eur. J. Pharmacol. 281: 55.