Clinical characteristics and biotransformation of sevoflurane in paediatric patients during antiepileptic drug therapy

Paediatric Anaesthesia

Volumn 6, Issue 5, 1996, Pages 379-382

  Komatsu, Hisao ^a,b   Ueki, Masaaki ^b   Morita, Junko ^a   Chujo, Kousuke ^a   Ogli, Kenji ^b  

^a National Hospital Organization   (Japan)

^b KAGAWA UNIVERSITY   (Japan)

Author keywords

Anaesthetics: sevoflurane; Antiepileptic drug therapy; Complication: hepatorenal function; Inorganic fluoride; Metabolism

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ANTICONVULSIVE AGENT; ASPARTATE AMINOTRANSFERASE; ETHER DERIVATIVE; FLUORIDE; INHALATION ANESTHETIC AGENT; SEVOFLURANE;

ADOLESCENT; ARTICLE; BIOTRANSFORMATION; BLOOD; CHILD; DRUG EFFECT; HUMAN; LIVER; LIVER FUNCTION TEST; PATHOPHYSIOLOGY; PRESCHOOL CHILD;

ADOLESCENT; ALANINE TRANSAMINASE; ALKALINE PHOSPHATASE; ANESTHETICS, INHALATION; ANTICONVULSANTS; ASPARTATE AMINOTRANSFERASES; BIOTRANSFORMATION; CHILD; CHILD, PRESCHOOL; ETHERS; FLUORIDES; HUMANS; LIVER; LIVER FUNCTION TESTS; METHYL ETHERS;

EID: 0030345445     PISSN: 11555645     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9592.1996.d01-7.x     Document Type: Article

References (17)

1. Julien, RM. Antiepileptic agents. In: Smith NTY, Corbascio AN, eds. Drug Interaction in Anesthesia. Philadelphia, USA: Lea & Febiger, 1986; 2nd edn, pp. 245-260.
2. Cousins MJ, Mazze RI, Kosek JC et al. The etiology of methoxyflurane nephrotoxicity. J Pharmacol Exp Ther 1974; 190: 530-541.
3. Kobayashi Y, Ochiai R, Takeda J et al. Serum and urinary inorganic fluoride concentrations after prolonged inhalation of sevoflurane in humans. Anesth Analg 1992; 74: 753-757.
4. Higuchi H, Satoh T, Arimua S et al. Serum inorganic fluoride levels in mildly obese patients during and after sevoflurane anesthesia. Anesth Analg 1993; 77: 1018-1021.
5. Brodeur J, Paquin P, Authier L et al. Influence of phenobarbital pretreatment on methoxyflurane and sodium fluoride nephropathy in Fisher 344 rats. Toxicol Appl Pharmacol 1976; 37: 349-361.
6. Churchill D, Yacoub JM, Siu KP et al. Toxic nephropathy after low-dose methoxyflurane anesthesia: Drug interaction with secobarbital. Calif Med J 1976; 114: 326-366.
7. Cook TJ, Beppu WJ, Hitt BA et al. A comparison of renal effects and metabolism of sevoflurane and methoxyflurane in enzyme-induced rats. Anesth Analg 1975; 54: 829-835.
8. Frink EJ, Chantous H, Malan TP et al. Plasma inorganic fluoride with sevoflurane anesthesia: Correlation with indices of hepatic and renal function. Anesth Analg 1992; 74: 231-235.
9. Ohira N, Inada T, Hamai R. Influence of sevoflurane and isoflurane anesthesia on renal function in elderly patients. Jpn J Anesth (Masui) (in Japanese, abstract in English) 1994; 43: 1842-1845.
10. Kataria B, Montana JRN. Inorganic fluoride levels after inhalation of sevoflurane anesthetic in healthy children. Anesthesiology 1994; 81: A1317.
11. Frink EJ, Malan TP, Isner RJ et al. Renal concentrating function with prolonged sevoflurane or enflurane anesthesia in volunteers. Anesthesiology 1994; 80: 1019-1025.
12. Stoelting RK & Peterson C. Methoxyflurane anesthesia in pediatric patients: Evaluation of anesthetic metabolism and renal function. Anesthesiology 1975; 42: 26-29.
13. Dooley JR, Mazze RI, Rice SA et al. Is enflurane defluorination inducible in humans? Anesthesiology 1979; 50: 213-217.
14. Kharasch ED, Thummel KE. Identification of cytochrome P450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane, and methoxyflurane. Anesthesiology 1993; 79: 795-807.
15. Kharasch ED, Hankins DC, Thummel KE. Human kidney methoxyflurane and sevoflurane metabolism. Anesthesiology 1995; 82: 689-699.
16. Stoelting RK. Antiepileptic Drugs: Pharmacology and Physiology in Anesthetic Practice. Philadelphia: J.B. Lippincott, 2nd edn, 1991, pp. 521-529.
17. Nijhawan R, Wierzbicki AS, Tozer R, et al. Antiepileptic drugs, hepatic enzyme induction and raised serum alkaline phosphatase isoenzymes. Int J Clin Pharmacol Res 1990; 10: 319-323.