Mechanisms of amiodarone-induced inhibition of Ca2+ current in isolated neonatal rabbit ventricular myocytes

Journal of Investigative Medicine

Volumn 44, Issue 9, 1996, Pages 583-589

  Chen, Fuhua ^a   Wetzel, Glenn T ^a   Cho, Paula ^a   Friedman, William F ^a   Klitzner, Thomas S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Amiodarone; Antiarrhythmic therapy; Ca2+ current; Heart cell; Voltage clamp

Indexed keywords

AMIODARONE; ANTIARRHYTHMIC AGENT; CALCIUM CHANNEL;

AGE; ANIMAL; ARTICLE; DRUG EFFECT; DRUG SCREENING; HEART MUSCLE; HEART VENTRICLE; METABOLISM; NEWBORN; PATCH CLAMP; RABBIT;

AGE FACTORS; AMIODARONE; ANIMALS; ANIMALS, NEWBORN; ANTI-ARRHYTHMIA AGENTS; CALCIUM CHANNELS; DRUG EVALUATION, PRECLINICAL; HEART VENTRICLES; MYOCARDIUM; PATCH-CLAMP TECHNIQUES; RABBITS;

EID: 0030338777     PISSN: 17088267     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Singh BN. Amiodarone: historical development and pharmacologie profile. Am Heart J 1983;106:788-97.
2. Klitzner TS, Friedman WF. Cardiac arrhythmias: the role of pharmacologic intervention. Cardiol Clin 1989;7:299-318.
3. Heger JJ, Prystowsky EN, Miles WM, Zipes DP. Clinical use and pharmacology of amiodarone. Med Clin North Am 1984;68:1339-66.
4. Hohnloser SH, Meinertz T, Dammbacher T, Steiert K, Jahnchen E, Zehender M, Fraedrich G, Just H. Electrocardiographic and antiarrhythmic effects of intravenous amiodarone: results of a prospective, placebo-controlled study. Am Heart J 1991;121:89-95.
5. Singh BN, Vaughan Williams EM. The new antianginal drug, on cardiac muscle. Br J Pharmacol 1970;39:657-67.
6. Naccarelli GV, Jalal S. Intravenous amiodarone. Another option in the acute management of sustained ventricular tachyarrhythmias. Circulation 1995;92:3154-5.
7. Scheinman MM, Levin JH, Cannom DS, Friehling T, Kopelman HA, Chilson DA, Platia EV, Wilber DJ, Kowey PR for the Intravenous Amiodarone Multicenter Investigators Group. Dose-ranging study of intravenous amiodarone in patients with life-threatening ventricular tachyarrhythmias. Circulation 1995;92:3264-72.
8. Kowey PR, Levin JH, Herre JM, Pacifico A, Lindsay BD, Plumb VJ, Janosik DL, Kopelman HA, Chilson DA, Platia EV, Wilber DJ, Scheinman MM for the Intravenous Amiodarone Multicenter Investigators Group. Randomized, double-blind comparison of intravenous amiodarone and bretylium in the treatment of patients with recurrent, hemodynamically destabilizing ventricular tachycardia or fibrillation. Circulation 1995;92:3255-63.
9. Gomes JAC, Kanf PS, Hariman RJ, El-Sherif N, Lyons J. Electrophysiologic effects and mechanisms of termination of supraventricular tachycardia by intravenous amiodarone. Am Heart J 1984;107:214-21.
10. Mason JW, Hondeghem LM. Katzung BG. Block of inactivated sodium channels and of depolarization-induced automaticity in guinea-pig papillary muscle by amiodarone. Circ Res 1984;55:277-85.
11. Morady F, Di Carlo LA Jr, Krol BB, deBuitleir M. Acute and chronic effects of amiodarone on ventricular refractoriness, intraventricular conduction, and ventricular tachycardia induction. J Am Coll Cardiol 1986;71:148-57.
12. Valenzuela C, Bennett PB. Voltage- and use-dependent modulation of calcium channel current in guinea pig ventricular cells by amiodarone and des-oxo-amiodarone. J Cardiovasc Pharmacol 1991;6:894-902.
13. Chen F, Wetzel GT, Klitzner TS. Acute effects of amiodarone on sodium currents in isolated neonatal ventricular myocytes: comparison with procainamide. Dev Pharmacol Ther 1992;19:118-30.
14. + currents in fetal, neonatal, and adult heart cells. Circ Res 1992;70:508-15.
15. Wetzel GT, Chen F, Friedman WF, Klitzner TS. Calcium current measurements in acutely isolated neonatal cardiac myocytes. Pediatr Res 1991;30:83-9.
16. Chen F, Wetzel GT, Friedman WF, Klitzner TS. Single-channel recording of inwardly rectifying potassium currents in developing myocardium. J Mol Cell Cardiol 1991;23:259-67.
17. Wetzel GT, Chen F, Klitzner TS. Calcium channel kinetics in acutely isolated fetal, neonatal, and adult rabbit cardiac myocytes. Circ Res 1993;72:1065-74.
18. Follmer CH, Aomine M, Yeh JZ, Singer DH. Amiodarone-induced block of sodium current in isolated cardiac cells. J Pharmacol Exp Ther 1987;243:187-94.
19. Perry JC, Knilans TK, Marlow D, Denfield SW, Fenrich AL, Friedman RA. Intravenous amiodarone for life-threatening tachyarrhythmias in children and young adults. J Am Coll Cardiol 1993;22:95-8.
20. Riggio DW, Peters RW, Feliciano Z, Gottlieb SS, Shorofsky SR, Gold MR. Acute electrophysiologic effects of amiodarone in patients with congestive heart failure. Am J Cardiol 1995;75:1158-61.
21. Yabek SM, Kato R, Singh BN. Effects of amiodarone and its metabolite, desethylamiodarone, on the electrophysiologic properties of isolated cardiac muscles. J Cardiovasc Pharmacol 1986;8:197-207.
22. Polster P, Broekhuysen J. The adrenergic antagonism of amiodarone. Biochem Pharmacol 1976;25:131-4.
23. Yabek SM, Kato R, Singh BN. Acute effects of amiodarone on the electrophysiologic properties of isolated neonatal and adult cardiac fibers. J Am Coll Cardiol 1985;5:1109-15.
24. Nattel S, Talajic M, Quantz M, De Roode M. Frequency-dependent effects of amiodarone on atrioventricular nodal function and slow-channel action potentials: evidence for calcium channel blocking activity. Circulation 1987;76:442-9.
25. Nishimura M, Follmer CH, Singer DH. Amiodarone blocks calcium current in single guinea pig ventricular myocytes. J Pharmacol Exp Ther 1989;251:650-9.
26. Lubic SP, Nguyen KP, Dave B, Giacomini JC. Antiarrhythmic agent amiodarone possesses calcium channel blocker properties. J Cardiovasc Pharmacol 1994;24:707-14.
27. Sperelakis N, Shigenobu K. Changes in membrane properties of chick embryonic hearts during development. J Gen Physiol 1972;60:430-53.
28. Nygaard TW, Sellers TD, Cook TS, Di Marco JP. Adverse reactions to antiarrhythmic drugs during therapy for ventricular arrhythmias. JAMA 1986;256:55-7.
29. Mostow ND, Rakita L, Urobel TR, Noon DL, Blumer J. Amiodarone: correlation of serum concentration with suppression of complex ventricular ectopic activity. Am J Cardiol 1984;54:569-74.
30. Mason JW. Drug therapy: amiodarone. N Engl J Med 1987;316:455-66.
31. Coumel PL, Fidelle J. Amiodarone in the treatment of cardiac arrhythmias in children: one hundred thirty-five cases. Am Heart J 1980;100:1063-9.