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Volumn 20, Issue 6-7, 1996, Pages 549-559

Mechanisms of action of ursodeoxycholic acid in cholestatic liver diseases;Mecanisme d'action de l'acide ursodesoxycholique dans les maladies du foie cholestatiques

Author keywords

bile acids; cholestasis; liver; treatment; ursodeoxycholic acid

Indexed keywords

BILE ACID; CHENODEOXYCHOLIC ACID; HLA ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; URSODEOXYCHOLIC ACID; CHOLAGOGUE;

EID: 0030338678     PISSN: 03998320     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (5)

References (130)
  • 1
    • 0027482390 scopus 로고
    • Ursodeoxycholic acid in the ursidae: Biliary bile acids of bears, pandas and related carnivores
    • Hagey LR, Crombie DL, Espinoza E, Carey MC, Igimi H, Hofmann AF. Ursodeoxycholic acid in the ursidae: biliary bile acids of bears, pandas and related carnivores. J Lipid Res 1993;34:1911-7.
    • (1993) J Lipid Res , vol.34 , pp. 1911-1917
    • Hagey, L.R.1    Crombie, D.L.2    Espinoza, E.3    Carey, M.C.4    Igimi, H.5    Hofmann, A.F.6
  • 2
    • 84963097394 scopus 로고
    • Über die Ursodesoxycholäure aus Barengalle und irhe physiologische Wirking
    • Shoda M. Über die Ursodesoxycholäure aus Barengalle und irhe physiologische Wirking. J Biochem 1927;7:505-17.
    • (1927) J Biochem , vol.7 , pp. 505-517
    • Shoda, M.1
  • 3
    • 0020318866 scopus 로고
    • Ursodeoxycholic acid in the treatment of cholesterol lithiasis
    • Bachrach WH, Hofmann AF. Ursodeoxycholic acid in the treatment of cholesterol lithiasis. Dig Dis Sci 1982;24:737-61.
    • (1982) Dig Dis Sci , vol.24 , pp. 737-761
    • Bachrach, W.H.1    Hofmann, A.F.2
  • 4
    • 0027460322 scopus 로고
    • Efficacy of bile acid therapy for gallstone dissolution: A meta-analysis of randomized trials
    • May GR, Sutherland LR, Shaffer EA. Efficacy of bile acid therapy for gallstone dissolution: a meta-analysis of randomized trials. Aliment Pharmacol Ther 1993;7:139-48.
    • (1993) Aliment Pharmacol Ther , vol.7 , pp. 139-148
    • May, G.R.1    Sutherland, L.R.2    Shaffer, E.A.3
  • 5
    • 0004779202 scopus 로고
    • Clinical experience with ursodeoxycholic acid (S-Urso) for chronic hepatitis
    • Ichida F. Clinical experience with ursodeoxycholic acid (S-Urso) for chronic hepatitis. Diagn Treat 1961;36:388.
    • (1961) Diagn Treat , vol.36 , pp. 388
    • Ichida, F.1
  • 6
    • 8944251233 scopus 로고
    • Effect of Ursosan tablets on chronic hepatic disorders
    • Nakahara T, Yoshida H, Bando T. Effect of Ursosan tablets on chronic hepatic disorders. Diagn Treat 1975;50:1070-3.
    • (1975) Diagn Treat , vol.50 , pp. 1070-1073
    • Nakahara, T.1    Yoshida, H.2    Bando, T.3
  • 7
    • 8944251233 scopus 로고
    • Effectiveness of S-Urso tablets against chronic liver diseases
    • Wakahara T. Effectiveness of S-Urso tablets against chronic liver diseases. Diagn Treat 1975;63:1070.
    • (1975) Diagn Treat , vol.63 , pp. 1070
    • Wakahara, T.1
  • 8
    • 0342802036 scopus 로고
    • Effect of ursodeoxycholic acid on liver function of chronic liver disease
    • Miyaji K. Effect of ursodeoxycholic acid on liver function of chronic liver disease. Jpn J Clin Exp Med 1976;53:1395.
    • (1976) Jpn J Clin Exp Med , vol.53 , pp. 1395
    • Miyaji, K.1
  • 9
    • 0001347709 scopus 로고
    • Study of curative effect of ursodeoxycholic acid for chronic hepatitis by double-blind trial
    • Yamanaka M. Study of curative effect of ursodeoxycholic acid for chronic hepatitis by double-blind trial. Diagn Treat 1976;64:2150.
    • (1976) Diagn Treat , vol.64 , pp. 2150
    • Yamanaka, M.1
  • 11
    • 0028148195 scopus 로고
    • Hepatoprotection by hydrophilic bile salts
    • Queneau PE, Montet JC. Hepatoprotection by hydrophilic bile salts. J Hepatol 1994;21:260-8.
    • (1994) J Hepatol , vol.21 , pp. 260-268
    • Queneau, P.E.1    Montet, J.C.2
  • 12
    • 0027998655 scopus 로고
    • Pharmacology of ursodeoxycholic acid, an enterohepatic drug
    • Hofmann AF. Pharmacology of ursodeoxycholic acid, an enterohepatic drug. Scand J Gastroenterol 1994;29(suppl. 204): 1-15.
    • (1994) Scand J Gastroenterol , vol.29 , Issue.204 SUPPL. , pp. 1-15
    • Hofmann, A.F.1
  • 13
    • 0021178162 scopus 로고
    • Influence of hydroxylation and conjugation of bile salts on their membrane-damaging properties. Studies on isolated hepatocytes and lipid membrane vesicules
    • Schölmerich J, Becher MS, Schmidt K, Schubert R, Becher MS, Feldhaus S, et al. Influence of hydroxylation and conjugation of bile salts on their membrane-damaging properties. Studies on isolated hepatocytes and lipid membrane vesicules. Hepatology 1984;4:661-6.
    • (1984) Hepatology , vol.4 , pp. 661-666
    • Schölmerich, J.1    Becher, M.S.2    Schmidt, K.3    Schubert, R.4    Becher, M.S.5    Feldhaus, S.6
  • 16
    • 0025047432 scopus 로고
    • Ursodeoxycholic acid-induced changes of plasma and urinary bile acids in patients with primary biliary cirrhosis
    • Stiehl A, Rudolph G, Raedsch R, Möller B, Hopff U, Lotterer E, et al. Ursodeoxycholic acid-induced changes of plasma and urinary bile acids in patients with primary biliary cirrhosis. Hepatology 1990;12:492-7.
    • (1990) Hepatology , vol.12 , pp. 492-497
    • Stiehl, A.1    Rudolph, G.2    Raedsch, R.3    Möller, B.4    Hopff, U.5    Lotterer, E.6
  • 17
    • 0024847339 scopus 로고
    • Structure-activity relationship studies on natural and synthetic bile acids analogs
    • Roda A, Grigolo B, Pelliciari R, Natalini B. Structure-activity relationship studies on natural and synthetic bile acids analogs. Dig Dis Sci 1989;34 (suppl 12):24S-35S.
    • (1989) Dig Dis Sci , vol.34 , Issue.12 SUPPL.
    • Roda, A.1    Grigolo, B.2    Pelliciari, R.3    Natalini, B.4
  • 18
    • 0015415107 scopus 로고
    • Bile acids, liver injury and liver disease
    • Palmer RH. Bile acids, liver injury and liver disease. Arch Intern Med 1972;130:606-17.
    • (1972) Arch Intern Med , vol.130 , pp. 606-617
    • Palmer, R.H.1
  • 19
    • 0025155478 scopus 로고
    • Ursodeoxycholate reduces hepatotoxicity of bile salts in primary human hepatocytes
    • Galle PR, Theilmann L, Raedsch R, Otto G, Stiehl A. Ursodeoxycholate reduces hepatotoxicity of bile salts in primary human hepatocytes. Hepatology 1990;12:486-91.
    • (1990) Hepatology , vol.12 , pp. 486-491
    • Galle, P.R.1    Theilmann, L.2    Raedsch, R.3    Otto, G.4    Stiehl, A.5
  • 20
    • 2042480449 scopus 로고
    • Effects of bile salts on membranes
    • Calandra S, Carulli N, Salvioli G, eds. New York: Elsevier
    • Salvioli G, Lugli R, Pradelli JM. Effects of bile salts on membranes. In: Calandra S, Carulli N, Salvioli G, eds. Liver and lipid metabolism. New York: Elsevier, 1984:163-79.
    • (1984) Liver and Lipid Metabolism , pp. 163-179
    • Salvioli, G.1    Lugli, R.2    Pradelli, J.M.3
  • 21
    • 0027227827 scopus 로고
    • Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes. Role for ATP depletion and cytosolic free calcium
    • Spivey JR, Bronk SF, Gores GJ. Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes. Role for ATP depletion and cytosolic free calcium. J Clin Invest 1993;92:17-24.
    • (1993) J Clin Invest , vol.92 , pp. 17-24
    • Spivey, J.R.1    Bronk, S.F.2    Gores, G.J.3
  • 22
    • 0026748765 scopus 로고
    • Stereological and functional analysis of liver mitochondria from rats with secondary biliary cirrhosis: Impaired mitochondrial metabolism and increased mitochondrial content per hepatocyte
    • Krähenbuhl S, Krähenbuhl-Glauser S, Stucki J, Geht P, Reichen J. Stereological and functional analysis of liver mitochondria from rats with secondary biliary cirrhosis: impaired mitochondrial metabolism and increased mitochondrial content per hepatocyte. Hepatology 1992;15:1167-72.
    • (1992) Hepatology , vol.15 , pp. 1167-1172
    • Krähenbuhl, S.1    Krähenbuhl-Glauser, S.2    Stucki, J.3    Geht, P.4    Reichen, J.5
  • 23
    • 0028091169 scopus 로고
    • Toxicity of bile acids on the electron transport chain of isolated rat mitochondria
    • Krähenbuhl S, Talos C, Fischer S, Reichen J. Toxicity of bile acids on the electron transport chain of isolated rat mitochondria. Hepatology 1994;19:471-9.
    • (1994) Hepatology , vol.19 , pp. 471-479
    • Krähenbuhl, S.1    Talos, C.2    Fischer, S.3    Reichen, J.4
  • 24
    • 0026654982 scopus 로고
    • Reduced activity of electron transport chain in liver mitochondria isolated from rats with secondary biliary cirrhosis
    • Krähenbuhl S, Stucki J, Reichen J. Reduced activity of electron transport chain in liver mitochondria isolated from rats with secondary biliary cirrhosis. Hepatology 1992;15: 1160-6.
    • (1992) Hepatology , vol.15 , pp. 1160-1166
    • Krähenbuhl, S.1    Stucki, J.2    Reichen, J.3
  • 25
    • 0027207769 scopus 로고
    • Evidence for involvement of oxygen free radicals in bile acid toxicity to isolated rat hepatocytes
    • Sokol RJ, Devereaux M, Khandwala R, O'Brien K. Evidence for involvement of oxygen free radicals in bile acid toxicity to isolated rat hepatocytes. Hepatology 1993;17:869-81.
    • (1993) Hepatology , vol.17 , pp. 869-881
    • Sokol, R.J.1    Devereaux, M.2    Khandwala, R.3    O'Brien, K.4
  • 26
    • 0028795316 scopus 로고
    • Liver cell necrosis: Cellular mechanisms and clinical implications
    • Rosser BG, Gores GJ. Liver cell necrosis: cellular mechanisms and clinical implications. Gastroenterology 1995;108: 252-75.
    • (1995) Gastroenterology , vol.108 , pp. 252-275
    • Rosser, B.G.1    Gores, G.J.2
  • 27
    • 0028135420 scopus 로고
    • Increases of intracellular magnesium promote glycodeoxycholate-induced apoptosis in rat hepatocytes
    • Patel T, Bronk SF, Gores GJ. Increases of intracellular magnesium promote glycodeoxycholate-induced apoptosis in rat hepatocytes. J Clin Invest 1994;94:2183-92.
    • (1994) J Clin Invest , vol.94 , pp. 2183-2192
    • Patel, T.1    Bronk, S.F.2    Gores, G.J.3
  • 28
    • 0006173722 scopus 로고
    • Pattern of bile acids in cholestasis
    • Gentilini P, Arias IM, McIntyre N, Rodès J, eds. Amsterdam: Elsevier
    • Stiehl A. Pattern of bile acids in cholestasis. In: Gentilini P, Arias IM, McIntyre N, Rodès J, eds. Cholestasis. Amsterdam: Elsevier, 1994:231-7.
    • (1994) Cholestasis , pp. 231-237
    • Stiehl, A.1
  • 29
    • 0028305738 scopus 로고
    • In vitro studies of bile salts
    • Ostrow JD. In vitro studies of bile salts. Hepatology 1994; 19:1538-9.
    • (1994) Hepatology , vol.19 , pp. 1538-1539
    • Ostrow, J.D.1
  • 30
    • 0021722362 scopus 로고
    • Epimerization of the four 3,7-dihydroxy bile acid epimers by human fecal microorganisms in anaerobic mixed cultures and in feces
    • Setoguchi T, Higashi S, Tateno S, Yahiro K, Katsuki T. Epimerization of the four 3,7-dihydroxy bile acid epimers by human fecal microorganisms in anaerobic mixed cultures and in feces. J Lipid Res 1984;25:1246-56.
    • (1984) J Lipid Res , vol.25 , pp. 1246-1256
    • Setoguchi, T.1    Higashi, S.2    Tateno, S.3    Yahiro, K.4    Katsuki, T.5
  • 31
    • 0019831281 scopus 로고
    • In vitro transformation of chenodeoxycholic acid and ursodeoxycholic acid by human intestinal flora, with particular reference to the natural conversion between the two bile acids
    • Hirano S, Masuda N, Oda H. In vitro transformation of chenodeoxycholic acid and ursodeoxycholic acid by human intestinal flora, with particular reference to the natural conversion between the two bile acids. J Lipid Res 1981;22:735-43.
    • (1981) J Lipid Res , vol.22 , pp. 735-743
    • Hirano, S.1    Masuda, N.2    Oda, H.3
  • 32
    • 0023919344 scopus 로고
    • Ileal excretion of bile acids: Comparison with biliary bile composition and effect of ursodeoxycholic acid treatment
    • Stiehl A, Raedsch R, Rudolph G. Ileal excretion of bile acids: comparison with biliary bile composition and effect of ursodeoxycholic acid treatment. Gastroenterology 1988;94:1201-6.
    • (1988) Gastroenterology , vol.94 , pp. 1201-1206
    • Stiehl, A.1    Raedsch, R.2    Rudolph, G.3
  • 33
    • 0028039878 scopus 로고
    • Expression cloning and characterization of the hamster ileal sodium-dependent bile acid transporter
    • Wong MH, Oelkers P, Craddock AL, Dawson PA. Expression cloning and characterization of the hamster ileal sodium-dependent bile acid transporter. J Biol Chem 1994;269:1340-7.
    • (1994) J Biol Chem , vol.269 , pp. 1340-1347
    • Wong, M.H.1    Oelkers, P.2    Craddock, A.L.3    Dawson, P.A.4
  • 34
    • 8944252428 scopus 로고
    • Carrier mediated transport of conjugated bile acids in the guinea pig jejunum: A new mechanism for conjugated bile acid absorption
    • Amselberg A, Boyapalli RR, Schteingart CD, Hofmann AF. Carrier mediated transport of conjugated bile acids in the guinea pig jejunum: a new mechanism for conjugated bile acid absorption (abstract). Gastroenterology 1994;106:A219.
    • (1994) Gastroenterology , vol.106
    • Amselberg, A.1    Boyapalli, R.R.2    Schteingart, C.D.3    Hofmann, A.F.4
  • 36
    • 0021972274 scopus 로고
    • Serum concentration of ursodeoxycholic acid in portal veinous and systemic venous blood of fasting humans as determined by isotope dilution-mass spectrometry
    • Ewerth S, Angelin B, Einarsson K, Nilsell K, Björkhem I. Serum concentration of ursodeoxycholic acid in portal veinous and systemic venous blood of fasting humans as determined by isotope dilution-mass spectrometry. Gastroenterology 1985;88:126-33.
    • (1985) Gastroenterology , vol.88 , pp. 126-133
    • Ewerth, S.1    Angelin, B.2    Einarsson, K.3    Nilsell, K.4    Björkhem, I.5
  • 37
    • 0022632634 scopus 로고
    • Serum bile acids. Physiological determinants and results in liver disease
    • Paumgartner G. Serum bile acids. Physiological determinants and results in liver disease. J Hepatol 1986;2:291-8.
    • (1986) J Hepatol , vol.2 , pp. 291-298
    • Paumgartner, G.1
  • 38
    • 8944233454 scopus 로고
    • Physico-chemical properties of bile salts determine their hepatoprotective or toxic effects
    • Carrubi F, Guicciardi ME, Concari M, Bozzoli M, Carulli N. Physico-chemical properties of bile salts determine their hepatoprotective or toxic effects (abstract). J Hepatol 1993; 18(suppl. 1):S103.
    • (1993) J Hepatol , vol.18 , Issue.1 SUPPL.
    • Carrubi, F.1    Guicciardi, M.E.2    Concari, M.3    Bozzoli, M.4    Carulli, N.5
  • 39
    • 0026086134 scopus 로고
    • Conjugates of ursodeoxycholate protect against cholestasis and hepatocellular necrosis caused by more hydrophobic bile salts: In vitro studies in rat hepatocytes and human erythrocytes
    • Heuman D, Scott Mills A, McCall J, Hylemon P, Pandak W, Vlahcevic Z. Conjugates of ursodeoxycholate protect against cholestasis and hepatocellular necrosis caused by more hydrophobic bile salts: in vitro studies in rat hepatocytes and human erythrocytes. Gastroenterology 1991;100:203-11.
    • (1991) Gastroenterology , vol.100 , pp. 203-211
    • Heuman, D.1    Scott Mills, A.2    McCall, J.3    Hylemon, P.4    Pandak, W.5    Vlahcevic, Z.6
  • 40
  • 41
    • 0027717484 scopus 로고
    • Ursodeoxycholic acid improves ethinyl estradiol-induced cholestasis in the rat
    • Jacquemin E, Dumont M, Mallet A, Erlinger S. Ursodeoxycholic acid improves ethinyl estradiol-induced cholestasis in the rat. Eur J Clin Invest 1993;23:794-802.
    • (1993) Eur J Clin Invest , vol.23 , pp. 794-802
    • Jacquemin, E.1    Dumont, M.2    Mallet, A.3    Erlinger, S.4
  • 42
    • 0025091194 scopus 로고
    • Effects of bile salt supplementation on biliary secretion in estrogen-treated rats
    • Zhao XM, Montet JC. Effects of bile salt supplementation on biliary secretion in estrogen-treated rats. J Nutr Biochem 1990;1:420-5.
    • (1990) J Nutr Biochem , vol.1 , pp. 420-425
    • Zhao, X.M.1    Montet, J.C.2
  • 43
    • 0026503561 scopus 로고
    • Ursodeoxycholic acid limits liver histologic alterations and portal hypertension induced by bile duct ligation in the rat
    • Poo JL, Feldmann G, Erlinger S, Braillon A, Gaudin C, Dumont M, et al. Ursodeoxycholic acid limits liver histologic alterations and portal hypertension induced by bile duct ligation in the rat. Gastroenterology 1992;102:1752-9.
    • (1992) Gastroenterology , vol.102 , pp. 1752-1759
    • Poo, J.L.1    Feldmann, G.2    Erlinger, S.3    Braillon, A.4    Gaudin, C.5    Dumont, M.6
  • 44
    • 0027386764 scopus 로고
    • Biotransformation of orally administered ursodeoxycholic acid in man as observed in gallbladder bile, serum and urine
    • Fisher S, Neubrand M, Paumgartner G. Biotransformation of orally administered ursodeoxycholic acid in man as observed in gallbladder bile, serum and urine. Eur J Clin Invest 1993; 23:28-36.
    • (1993) Eur J Clin Invest , vol.23 , pp. 28-36
    • Fisher, S.1    Neubrand, M.2    Paumgartner, G.3
  • 45
    • 0026596936 scopus 로고
    • Effect of ursodeoxycholic acid on the kinetics of the major hydrophobic bile acids in health and chronic cholestatic liver disease
    • Beuers U, Spengler U, Zwiebel FM, Pauletski J, Fisher S, Paumgartner G. Effect of ursodeoxycholic acid on the kinetics of the major hydrophobic bile acids in health and chronic cholestatic liver disease. Hepatology 1992:15:603-8.
    • (1992) Hepatology , vol.15 , pp. 603-608
    • Beuers, U.1    Spengler, U.2    Zwiebel, F.M.3    Pauletski, J.4    Fisher, S.5    Paumgartner, G.6
  • 46
    • 0025823660 scopus 로고
    • Effect of ursodeoxycholic acid treatment on ileal absorption of bile acids in man as determined by the SeHCAT test
    • Eusufzai S, Ericsson S, Cederlund T, Einarsson K, Angelin B. Effect of ursodeoxycholic acid treatment on ileal absorption of bile acids in man as determined by the SeHCAT test. Gut 1991;32:1044-8.
    • (1991) Gut , vol.32 , pp. 1044-1048
    • Eusufzai, S.1    Ericsson, S.2    Cederlund, T.3    Einarsson, K.4    Angelin, B.5
  • 48
    • 0024819478 scopus 로고
    • Characterization of serum and urinary bile acids in patients with primary biliary cirrhosis by gas-liquid chromatographymass spectrometry: Effect of ursodeoxycholic acid treatment
    • Batta AK, Arora R, Salen G, Tint GS, Eskreis D, Katz S. Characterization of serum and urinary bile acids in patients with primary biliary cirrhosis by gas-liquid chromatographymass spectrometry: effect of ursodeoxycholic acid treatment. J Lipid Res 1989;30:1953-62.
    • (1989) J Lipid Res , vol.30 , pp. 1953-1962
    • Batta, A.K.1    Arora, R.2    Salen, G.3    Tint, G.S.4    Eskreis, D.5    Katz, S.6
  • 50
    • 0027056746 scopus 로고
    • Ursodeoxycholate has no beneficial effect on liver function or histology in biliary cirrhosis in the rat
    • Zimmermann H, Reichen J. Ursodeoxycholate has no beneficial effect on liver function or histology in biliary cirrhosis in the rat. J Hepatol 1992;16:355-9.
    • (1992) J Hepatol , vol.16 , pp. 355-359
    • Zimmermann, H.1    Reichen, J.2
  • 51
    • 8944252427 scopus 로고
    • Ursodeoxycholic acid does not prevent functional, membrane biochemical or histological changes in the chronically bile duct ligated rat
    • Watson KJR, Roufail S, Sotirelis N, Breen KJ, Desmond PV, Sawer WH. Ursodeoxycholic acid does not prevent functional, membrane biochemical or histological changes in the chronically bile duct ligated rat (abstract). Gastroenterology 1991; 100:A810.
    • (1991) Gastroenterology , vol.100
    • Watson, K.J.R.1    Roufail, S.2    Sotirelis, N.3    Breen, K.J.4    Desmond, P.V.5    Sawer, W.H.6
  • 52
    • 0027264613 scopus 로고
    • Effect of ursodeoxycholic acid administration on bile duct proliferation and cholestasis in bile duct ligated rats
    • Frezza EE, Gerunda GE, Plebani M, Galligioni A, Giacomini A, Neri D, et al. Effect of ursodeoxycholic acid administration on bile duct proliferation and cholestasis in bile duct ligated rats. Dig Dis Sci 1993;38:1291-6.
    • (1993) Dig Dis Sci , vol.38 , pp. 1291-1296
    • Frezza, E.E.1    Gerunda, G.E.2    Plebani, M.3    Galligioni, A.4    Giacomini, A.5    Neri, D.6
  • 53
    • 0025202952 scopus 로고
    • Effect of chronic administration of ursodeoxycholic acid on the ileal absorption of endogenous bile acids in man
    • Marteau P, Chazouillères O, Myara A, Jian R, Rambaud JC, Poupon R. Effect of chronic administration of ursodeoxycholic acid on the ileal absorption of endogenous bile acids in man. Hepatology 1990;12:1206-8.
    • (1990) Hepatology , vol.12 , pp. 1206-1208
    • Marteau, P.1    Chazouillères, O.2    Myara, A.3    Jian, R.4    Rambaud, J.C.5    Poupon, R.6
  • 54
    • 8944239503 scopus 로고
    • Evidence that the ileal absorption of bile acids is not increased in patients with chronic cholestasis: HCAT test results and effect of ursodeoxycholic acid
    • Chazouillères O, Hanniche M, Marteau P, Jian R, Poupon R. Evidence that the ileal absorption of bile acids is not increased in patients with chronic cholestasis: HCAT test results and effect of ursodeoxycholic acid (abstract). Hepatology 1994;20:258A.
    • (1994) Hepatology , vol.20
    • Chazouillères, O.1    Hanniche, M.2    Marteau, P.3    Jian, R.4    Poupon, R.5
  • 55
    • 0025017364 scopus 로고
    • Acute effects of ursodeoxycholic and chenodeoxycholic acid on the small intestinal absorption of bile acids
    • Stiehl A, Raedsch R, Rudolph G. Acute effects of ursodeoxycholic and chenodeoxycholic acid on the small intestinal absorption of bile acids. Gastroenterology 1990;98:424-8.
    • (1990) Gastroenterology , vol.98 , pp. 424-428
    • Stiehl, A.1    Raedsch, R.2    Rudolph, G.3
  • 56
    • 0027977645 scopus 로고    scopus 로고
    • Down regulation of taurocholate transport by ileal BBM liver BLM in biliary-diverted rats
    • Higgins JV, Paul JM, Dumaswala R, Heubi JE. Down regulation of taurocholate transport by ileal BBM liver BLM in biliary-diverted rats. Am J Physiol 267;30:G501-7.
    • Am J Physiol , vol.267 , Issue.30
    • Higgins, J.V.1    Paul, J.M.2    Dumaswala, R.3    Heubi, J.E.4
  • 57
    • 8944256496 scopus 로고
    • Increased liver tissue ursodeoxycholic acid concentration and reduced lithocholate formation in rats orally administered the taurine conjugate of UDCA compared with unconjugated UDCA
    • Rodrigues CMP, Kren BT, Steer CJ, Setchell KDR. Increased liver tissue ursodeoxycholic acid concentration and reduced lithocholate formation in rats orally administered the taurine conjugate of UDCA compared with unconjugated UDCA (abstract). Gastroenterology 1995;108:A1156.
    • (1995) Gastroenterology , vol.108
    • Rodrigues, C.M.P.1    Kren, B.T.2    Steer, C.J.3    Setchell, K.D.R.4
  • 59
    • 0026050266 scopus 로고
    • Failure of ursodeoxycholic acid to prevent cholestatic episode in a patient with benign recurrent intrahepatic cholestasis: A study of bile acid metabolism
    • Crosignani A, Podda M, Bertolini E, Battezzati PM, Zuin M, Setchell K. Failure of ursodeoxycholic acid to prevent cholestatic episode in a patient with benign recurrent intrahepatic cholestasis: a study of bile acid metabolism. Hepatology 1991;13:1076-83.
    • (1991) Hepatology , vol.13 , pp. 1076-1083
    • Crosignani, A.1    Podda, M.2    Bertolini, E.3    Battezzati, P.M.4    Zuin, M.5    Setchell, K.6
  • 60
    • 0022586861 scopus 로고
    • The effect of diet on bile acids kinetics and biliary lipid secretion in gallstone patients treated with ursodeoxycholic acid
    • Frenkiel PG, Lee DW, Cohen H, Gilmore CJ, Resser K, Bonorris GG, et al. The effect of diet on bile acids kinetics and biliary lipid secretion in gallstone patients treated with ursodeoxycholic acid. Am J Clin Nutr 1986;43:239-50.
    • (1986) Am J Clin Nutr , vol.43 , pp. 239-250
    • Frenkiel, P.G.1    Lee, D.W.2    Cohen, H.3    Gilmore, C.J.4    Resser, K.5    Bonorris, G.G.6
  • 61
    • 0027280229 scopus 로고
    • Effects of ursodeoxycholic acid on the kinetics of cholic acid and chenodeoxycholic acid in patients with primary sclerosing cholangitis
    • Rudolph G, Endele R, Senn M, Stiehl A. Effects of ursodeoxycholic acid on the kinetics of cholic acid and chenodeoxycholic acid in patients with primary sclerosing cholangitis. Hepatology 1993;17:1028-32.
    • (1993) Hepatology , vol.17 , pp. 1028-1032
    • Rudolph, G.1    Endele, R.2    Senn, M.3    Stiehl, A.4
  • 62
    • 0027297995 scopus 로고
    • Ursodeoxycholic acid administration on bile acid metabolism in patients with early stages of primary biliary cirrhosis
    • Mazella G, Parini P, Bazzoli F, Villanova N, Festi D, Aldini R, et al. Ursodeoxycholic acid administration on bile acid metabolism in patients with early stages of primary biliary cirrhosis. Dig Dis Sci 1993;38:896-902.
    • (1993) Dig Dis Sci , vol.38 , pp. 896-902
    • Mazella, G.1    Parini, P.2    Bazzoli, F.3    Villanova, N.4    Festi, D.5    Aldini, R.6
  • 63
    • 0026352217 scopus 로고
    • Changes in bile acids composition in patients with primary biliary cirrhosis induced by ursodeoxycholic acid administration
    • Crosignani A, Podda M, Battezzati PM, Bertolini E, Zuin M, Watson D, et al. Changes in bile acids composition in patients with primary biliary cirrhosis induced by ursodeoxycholic acid administration. Hepatology 1991;14:1000-7.
    • (1991) Hepatology , vol.14 , pp. 1000-1007
    • Crosignani, A.1    Podda, M.2    Battezzati, P.M.3    Bertolini, E.4    Zuin, M.5    Watson, D.6
  • 65
    • 0025320765 scopus 로고
    • Tauroursodeoxycholate prevents taurolithocholate-induced cholestasis and toxicity in rat liver
    • Schölmerich J, Baumgartner U, Miyai K, Gerok W. Tauroursodeoxycholate prevents taurolithocholate-induced cholestasis and toxicity in rat liver. J Hepatol 1990;10:280-3.
    • (1990) J Hepatol , vol.10 , pp. 280-283
    • Schölmerich, J.1    Baumgartner, U.2    Miyai, K.3    Gerok, W.4
  • 66
    • 8944229285 scopus 로고
    • Evidence that ursodeoxycholic acid (UDCA) increases biliary excretion of cholic acid (CA) and chenodeoxycholic acid (CDCA) in man
    • Loria A, Myara A, Chazouillères O, Serfaty L, Masini JP, Poupon R. Evidence that ursodeoxycholic acid (UDCA) increases biliary excretion of cholic acid (CA) and chenodeoxycholic acid (CDCA) in man (abstract). Gastroenterology 1994;106:A935.
    • (1994) Gastroenterology , vol.106
    • Loria, A.1    Myara, A.2    Chazouillères, O.3    Serfaty, L.4    Masini, J.P.5    Poupon, R.6
  • 67
    • 0023860986 scopus 로고
    • Hepatic transport of bile acids in the isolated perfused rat liver: Structure-kinetics relationship
    • Poupon R, Chrétien Y, Parquet M, Rey C, Ballet F, Infante R. Hepatic transport of bile acids in the isolated perfused rat liver: structure-kinetics relationship. Biochem Pharmacol 1988;37:209-12.
    • (1988) Biochem Pharmacol , vol.37 , pp. 209-212
    • Poupon, R.1    Chrétien, Y.2    Parquet, M.3    Rey, C.4    Ballet, F.5    Infante, R.6
  • 68
    • 0025332193 scopus 로고
    • Effects of ursodeoxycholate on maximal biliary secretion of bilirubin in the rat
    • Galan AI, Jimenez R, Munoz ME, Gonzalez J. Effects of ursodeoxycholate on maximal biliary secretion of bilirubin in the rat. Biochem Pharmacol 1990;39:1175-80.
    • (1990) Biochem Pharmacol , vol.39 , pp. 1175-1180
    • Galan, A.I.1    Jimenez, R.2    Munoz, M.E.3    Gonzalez, J.4
  • 69
    • 0026740735 scopus 로고
    • Effects of ursodeoxycholic acid in patients with intrahepatic cholestasis of pregnancy
    • Palma J, Reyes H, Ribalta J, Iglesias J, Gonsalez MC, Hernandez I, et al. Effects of ursodeoxycholic acid in patients with intrahepatic cholestasis of pregnancy. Hepatology 1992; 15:1043-7.
    • (1992) Hepatology , vol.15 , pp. 1043-1047
    • Palma, J.1    Reyes, H.2    Ribalta, J.3    Iglesias, J.4    Gonsalez, M.C.5    Hernandez, I.6
  • 70
    • 0019294767 scopus 로고
    • Hypercholeresis induced by ursodeoxycholic acid and 7-ketolithocholic acid in the rat: Possible role of bicarbonate transport
    • Dumont M, Uchman S, Erlinger S. Hypercholeresis induced by ursodeoxycholic acid and 7-ketolithocholic acid in the rat: possible role of bicarbonate transport. Gastroenterology 1980;79:82-9.
    • (1980) Gastroenterology , vol.79 , pp. 82-89
    • Dumont, M.1    Uchman, S.2    Erlinger, S.3
  • 71
    • 0025352101 scopus 로고
    • Hypercholeretic bile acids: A clue to the mechanism?
    • Erlinger S. Hypercholeretic bile acids: a clue to the mechanism? Hepatology 1990;11:888-90.
    • (1990) Hepatology , vol.11 , pp. 888-890
    • Erlinger, S.1
  • 73
    • 0022650127 scopus 로고
    • Effect of side-chain shortening on the physiologic properties of bile acids: Hepatic transport and effect on biliary secretion of 23-nor-ursodeoxycholate in rodents
    • Yoon YB, Hagey LR, Hofmann AF, Gurantz D, Michelotti EL, Steinbach JH. Effect of side-chain shortening on the physiologic properties of bile acids: hepatic transport and effect on biliary secretion of 23-nor-ursodeoxycholate in rodents. Gastroenterology 1986:90:837-52.
    • (1986) Gastroenterology , vol.90 , pp. 837-852
    • Yoon, Y.B.1    Hagey, L.R.2    Hofmann, A.F.3    Gurantz, D.4    Michelotti, E.L.5    Steinbach, J.H.6
  • 74
    • 84989565539 scopus 로고
    • Effect of ursodeoxycholic acid on intracellular pH in a bile duct epithelium-like cell line
    • Strazzabosco M, Poci C, Spirli C, Sartori L, Knuth A, Crepaldi G. Effect of ursodeoxycholic acid on intracellular pH in a bile duct epithelium-like cell line. Hepatology 1994;19: 145-54.
    • (1994) Hepatology , vol.19 , pp. 145-154
    • Strazzabosco, M.1    Poci, C.2    Spirli, C.3    Sartori, L.4    Knuth, A.5    Crepaldi, G.6
  • 75
    • 0026463241 scopus 로고
    • Immunoperoxidase localisation of ursodeoxycholic acid in rat biliary epithelial cell. Evidence for a cholehepatic circulation
    • Lamri Y, Erlinger S, Dumont M, Roda A, Feldman G. Immunoperoxidase localisation of ursodeoxycholic acid in rat biliary epithelial cell. Evidence for a cholehepatic circulation. Liver 1992;12:351-4.
    • (1992) Liver , vol.12 , pp. 351-354
    • Lamri, Y.1    Erlinger, S.2    Dumont, M.3    Roda, A.4    Feldman, G.5
  • 76
    • 0024309202 scopus 로고
    • The effects of intraduodenal bile acid administration on biliary secretion of ionised calcium and carbonate in man
    • Knyrim K, Vakil M, Pfab R, Classen M. The effects of intraduodenal bile acid administration on biliary secretion of ionised calcium and carbonate in man. Hepatology 1989; 10:134-42.
    • (1989) Hepatology , vol.10 , pp. 134-142
    • Knyrim, K.1    Vakil, M.2    Pfab, R.3    Classen, M.4
  • 77
    • 0026584970 scopus 로고
    • Scintigraphic documentation of an improvement in hepatobiliary excretory function after treatment with ursodeoxycholic acid in patients with cystic fibrosis and associated liver disease
    • Colombo C, Castellani MR, Balistreri WF, Seregni E, Assaisso ML, Giunta A. Scintigraphic documentation of an improvement in hepatobiliary excretory function after treatment with ursodeoxycholic acid in patients with cystic fibrosis and associated liver disease. Hepatology 1992;15:677-84.
    • (1992) Hepatology , vol.15 , pp. 677-684
    • Colombo, C.1    Castellani, M.R.2    Balistreri, W.F.3    Seregni, E.4    Assaisso, M.L.5    Giunta, A.6
  • 78
    • 0025180712 scopus 로고
    • Effects of ursodeoxycholic acid treatment on nutrition and liver function in patients with cystic fibrosis and longstanding cholestasis
    • Cotting J, Lentze MJ, Reichen J. Effects of ursodeoxycholic acid treatment on nutrition and liver function in patients with cystic fibrosis and longstanding cholestasis. Gut 1990;31: 918-21.
    • (1990) Gut , vol.31 , pp. 918-921
    • Cotting, J.1    Lentze, M.J.2    Reichen, J.3
  • 79
    • 4243629862 scopus 로고
    • Markedly decreased biliary ursodeoxycholic acid (UDCA) enrichment with high dose UDCA in cystic fibrosis associated liver disease. Optimization of therapeutic dose
    • Setchell KDR, O'Connell NC, Bern E, Rodrigues C, Fitz Simmons S, Terrin M, et al. Markedly decreased biliary ursodeoxycholic acid (UDCA) enrichment with high dose UDCA in cystic fibrosis associated liver disease. Optimization of therapeutic dose (abstract). Hepatology 1994;20:262A.
    • (1994) Hepatology , vol.20
    • Setchell, K.D.R.1    O'Connell, N.C.2    Bern, E.3    Rodrigues, C.4    Fitz Simmons, S.5    Terrin, M.6
  • 80
    • 0025790578 scopus 로고
    • Conjugates of ursodeoxycholate protect against cytotoxicity of more hydrophobic bile salts: In vitro studies in rat hepatocytes and human erythrocytes
    • Heuman D, Pandak W, Hylemon P, Vlahcevic Z. Conjugates of ursodeoxycholate protect against cytotoxicity of more hydrophobic bile salts: in vitro studies in rat hepatocytes and human erythrocytes. Hepatology 1991;14:920-6.
    • (1991) Hepatology , vol.14 , pp. 920-926
    • Heuman, D.1    Pandak, W.2    Hylemon, P.3    Vlahcevic, Z.4
  • 81
    • 8944229284 scopus 로고
    • Glycoursodeoxycholate is as effective as tauroursodeoxycholate in preventing the taurocholate-induced cholestasis in the rat
    • Kanai S, Kitani K. Glycoursodeoxycholate is as effective as tauroursodeoxycholate in preventing the taurocholate-induced cholestasis in the rat (abstract). Hepatology 1983;3:811.
    • (1983) Hepatology , vol.3 , pp. 811
    • Kanai, S.1    Kitani, K.2
  • 82
    • 8944224128 scopus 로고
    • Effects of bile acids on the cultured hepatocytes and Kupffer cells
    • Tanikawa K, Kawahara T, Kumashiro R, Yoshitake M. Effects of bile acids on the cultured hepatocytes and Kupffer cells (abstract). Hepatology 1986;6:779.
    • (1986) Hepatology , vol.6 , pp. 779
    • Tanikawa, K.1    Kawahara, T.2    Kumashiro, R.3    Yoshitake, M.4
  • 83
    • 0027435678 scopus 로고
    • Diminution of an acute cyclosporine A-induced cholestasis by tauroursodeoxycholate in the rat
    • Queneau PE, Bertault-Pérès P, Mesdjian E, Durand A, Montet JC. Diminution of an acute cyclosporine A-induced cholestasis by tauroursodeoxycholate in the rat. Transplantation 1993;56:530-4.
    • (1993) Transplantation , vol.56 , pp. 530-534
    • Queneau, P.E.1    Bertault-Pérès, P.2    Mesdjian, E.3    Durand, A.4    Montet, J.C.5
  • 84
    • 4243683013 scopus 로고
    • Ursodeoxycholic acid prevents chronically cyclosporin A-induced cholestasis without altering the drug concentration in blood. A study in the rat
    • Queneau PE, Montet AM, Guitaoui M, Bertault-Peres P, Montet JC. Ursodeoxycholic acid prevents chronically cyclosporin A-induced cholestasis without altering the drug concentration in blood. A study in the rat (abstract). Gastroenterology 1993;104:A976.
    • (1993) Gastroenterology , vol.104
    • Queneau, P.E.1    Montet, A.M.2    Guitaoui, M.3    Bertault-Peres, P.4    Montet, J.C.5
  • 85
    • 0027165658 scopus 로고
    • Influence of oral treatment with ursodeoxycholic and tauroursodeoxycholic acids on estrogen-induced cholestasis in rats: Effects on bile formation and liver plasma membranes
    • Bouchard G, Youssef IM, Tuchweber B. Influence of oral treatment with ursodeoxycholic and tauroursodeoxycholic acids on estrogen-induced cholestasis in rats: effects on bile formation and liver plasma membranes. Liver 1993;13:193-202.
    • (1993) Liver , vol.13 , pp. 193-202
    • Bouchard, G.1    Youssef, I.M.2    Tuchweber, B.3
  • 86
    • 0025335902 scopus 로고
    • Estradiol-17b-D-glucuronide (E-17-G) cholestasis in perfused rat liver: Fate of E-17-G and choleretic response to bile salts
    • Utili R, Tripodi MF, Adinolfi LE, Gaeta GB, Abernathy CO, Zimmerman HJ, et al. Estradiol-17b-D-glucuronide (E-17-G) cholestasis in perfused rat liver: fate of E-17-G and choleretic response to bile salts. Hepatology 1990;11:735-42.
    • (1990) Hepatology , vol.11 , pp. 735-742
    • Utili, R.1    Tripodi, M.F.2    Adinolfi, L.E.3    Gaeta, G.B.4    Abernathy, C.O.5    Zimmerman, H.J.6
  • 87
    • 0027209627 scopus 로고
    • Hepatoprotective properties of ursodeoxycholic acid
    • Heuman D. Hepatoprotective properties of ursodeoxycholic acid. Gastroenterology 1993;104:1865-70.
    • (1993) Gastroenterology , vol.104 , pp. 1865-1870
    • Heuman, D.1
  • 88
    • 0028351832 scopus 로고
    • Ursodeoxycholate conjugates protect against disruption of cholesterol rich membranes by bile salts
    • Heuman D, Bajaj R. Ursodeoxycholate conjugates protect against disruption of cholesterol rich membranes by bile salts. Gastroenterology 1994;106:1333-41.
    • (1994) Gastroenterology , vol.106 , pp. 1333-1341
    • Heuman, D.1    Bajaj, R.2
  • 89
    • 8944245937 scopus 로고
    • Ursodeoxycholate cytoprotection against hepatocyte killing by hydrophobic bile salts cannot be explained solely by changes in the hydrophobicity index
    • Vadakekalam J, Gores GJ. Ursodeoxycholate cytoprotection against hepatocyte killing by hydrophobic bile salts cannot be explained solely by changes in the hydrophobicity index (abstract). Hepatology 1992;16:134A.
    • (1992) Hepatology , vol.16
    • Vadakekalam, J.1    Gores, G.J.2
  • 90
    • 0027467410 scopus 로고
    • Tauroursodeoxycholate and tauro-b-muricholate exert cytoprotection by reducing intrahepatic taurochenodeoxycholate content
    • Ohiwa T, Katagiri K, Hishino M, Hayakawa T, Nakai T. Tauroursodeoxycholate and tauro-b-muricholate exert cytoprotection by reducing intrahepatic taurochenodeoxycholate content. Hepatology 1993;17:470-6.
    • (1993) Hepatology , vol.17 , pp. 470-476
    • Ohiwa, T.1    Katagiri, K.2    Hishino, M.3    Hayakawa, T.4    Nakai, T.5
  • 91
    • 0028816461 scopus 로고
    • Ursodeoxycholate inhibits the mitochondrial membrane permeability transition induced by glycochenodeoxycholate: A mechanism of UDCA cytoprotection
    • Botla R, Spivey JR, Aguilar H, Bronk SF, Gores GJ. Ursodeoxycholate inhibits the mitochondrial membrane permeability transition induced by glycochenodeoxycholate: a mechanism of UDCA cytoprotection. J Pharmacol Exp Ther 1995;272:930-8.
    • (1995) J Pharmacol Exp Ther , vol.272 , pp. 930-938
    • Botla, R.1    Spivey, J.R.2    Aguilar, H.3    Bronk, S.F.4    Gores, G.J.5
  • 92
    • 0028151424 scopus 로고
    • Ursodeoxycholate protects oxidative mitochondrial metabolism from bile acid toxicity: Dose-response study in isolated rat liver mitochondria
    • Krähenbuhl S, Fischer S, Talos C, Reichen J. Ursodeoxycholate protects oxidative mitochondrial metabolism from bile acid toxicity: dose-response study in isolated rat liver mitochondria. Hepatology 1994;20:1595-601.
    • (1994) Hepatology , vol.20 , pp. 1595-1601
    • Krähenbuhl, S.1    Fischer, S.2    Talos, C.3    Reichen, J.4
  • 93
    • 0025890136 scopus 로고
    • Effective treatment of cyclosporine-induced cholestasis in heart transplanted patients treated with ursodeoxycholic acid
    • Kallinowski B, Theilmann L, Zimmerman R, Gams E, Kommerell B, Steihl A. Effective treatment of cyclosporine-induced cholestasis in heart transplanted patients treated with ursodeoxycholic acid. Transplantation 1991;51:1128-9.
    • (1991) Transplantation , vol.51 , pp. 1128-1129
    • Kallinowski, B.1    Theilmann, L.2    Zimmerman, R.3    Gams, E.4    Kommerell, B.5    Steihl, A.6
  • 94
    • 0028217182 scopus 로고
    • Does ursodeoxycholic acid have a place in the treatment of amiodarone-induced cholestasis?
    • Reshef R, Cohen I, Shiller M, Szvalb S, Loberant N. Does ursodeoxycholic acid have a place in the treatment of amiodarone-induced cholestasis? J Clin Gastroenterol 1994;18:177-8.
    • (1994) J Clin Gastroenterol , vol.18 , pp. 177-178
    • Reshef, R.1    Cohen, I.2    Shiller, M.3    Szvalb, S.4    Loberant, N.5
  • 97
  • 98
    • 0023866562 scopus 로고
    • Release of calcium from the endoplasmic reticulum by bile acids in rat liver cells
    • Combettes L, Dumont M, Berthon B, Erlinger S, Claret M. Release of calcium from the endoplasmic reticulum by bile acids in rat liver cells. J Biol Chem 1988;263:2299-303.
    • (1988) J Biol Chem , vol.263 , pp. 2299-2303
    • Combettes, L.1    Dumont, M.2    Berthon, B.3    Erlinger, S.4    Claret, M.5
  • 103
    • 0025804361 scopus 로고
    • Expression hépatique des molécules du complexe majeur d'histocompatibilité
    • Calmus Y, Weill B, Poupon R. Expression hépatique des molécules du complexe majeur d'histocompatibilité. Gastroenterol Clin Biol 1991;15:110-9.
    • (1991) Gastroenterol Clin Biol , vol.15 , pp. 110-119
    • Calmus, Y.1    Weill, B.2    Poupon, R.3
  • 104
    • 0027932658 scopus 로고
    • Effects of bile acids and cholestasis on major histocompatibility complex class I in human and rat hepatocytes
    • Hillaire S, Boucher E, Calmus Y, Gane P, Ballet F, Franco D, et al. Effects of bile acids and cholestasis on major histocompatibility complex class I in human and rat hepatocytes. Gastroenterology 1994;107:781-8.
    • (1994) Gastroenterology , vol.107 , pp. 781-788
    • Hillaire, S.1    Boucher, E.2    Calmus, Y.3    Gane, P.4    Ballet, F.5    Franco, D.6
  • 105
    • 0022658483 scopus 로고
    • 2-microglobulin distribution in primary biliary cirrhosis
    • 2-microglobulin distribution in primary biliary cirrhosis. J Hepatol 1986;2:73-80.
    • (1986) J Hepatol , vol.2 , pp. 73-80
    • Nagafuchi, Y.1    Scheuer, P.J.2
  • 106
    • 0026730984 scopus 로고
    • Ursodeoxycholic acid for treatment of primary sclerosing cholangitis: A placebo-controlled trial
    • Beuers U, Spenger U, Kruis W, Aydemir U, Wiebecke B, Heldwein W, et al. Ursodeoxycholic acid for treatment of primary sclerosing cholangitis: a placebo-controlled trial. Hepatology 1992;16:707-14.
    • (1992) Hepatology , vol.16 , pp. 707-714
    • Beuers, U.1    Spenger, U.2    Kruis, W.3    Aydemir, U.4    Wiebecke, B.5    Heldwein, W.6
  • 107
    • 0025098908 scopus 로고
    • Hepatic expression of class I and class II major histocompatibility complex molecules in primary biliary cirrhosis: Effect of ursodeoxycholic acid
    • Calmus Y, Gane P, Rouger P, Poupon R. Hepatic expression of class I and class II major histocompatibility complex molecules in primary biliary cirrhosis: effect of ursodeoxycholic acid. Hepatology 1990;11:12-5.
    • (1990) Hepatology , vol.11 , pp. 12-15
    • Calmus, Y.1    Gane, P.2    Rouger, P.3    Poupon, R.4
  • 108
    • 0026505862 scopus 로고
    • Cholestasis induces major histocompatibility complex class I expression in hepatocytes
    • Calmus Y, Arvieux C, Gane P, Boucher E, Nordlinger B, Rouger P, et al. Cholestasis induces major histocompatibility complex class I expression in hepatocytes. Gastroenterology 1992;102:1371-7.
    • (1992) Gastroenterology , vol.102 , pp. 1371-1377
    • Calmus, Y.1    Arvieux, C.2    Gane, P.3    Boucher, E.4    Nordlinger, B.5    Rouger, P.6
  • 109
    • 0026663426 scopus 로고
    • Immunosuppressive properties of chenodeoxycholic and ursodeoxycholic acids in the mouse
    • Calmus Y, Weill B, Ozier Y, Chéreau C, Houssin D, Poupon R. Immunosuppressive properties of chenodeoxycholic and ursodeoxycholic acids in the mouse. Gastroenterology 1992;103:617-21.
    • (1992) Gastroenterology , vol.103 , pp. 617-621
    • Calmus, Y.1    Weill, B.2    Ozier, Y.3    Chéreau, C.4    Houssin, D.5    Poupon, R.6
  • 110
    • 0028954737 scopus 로고
    • Ursodeoxycholic acid inhibits glucagon-induced cAMP formation in hamster hepatocytes: A role for PKC
    • Bouscarel B, Gettys TW, Fromm H, Dubner H. Ursodeoxycholic acid inhibits glucagon-induced cAMP formation in hamster hepatocytes: a role for PKC. Am J Physiol 1995; 268:G300-10.
    • (1995) Am J Physiol , vol.268
    • Bouscarel, B.1    Gettys, T.W.2    Fromm, H.3    Dubner, H.4
  • 111
    • 8944260489 scopus 로고
    • Differences in the effect of ursodeoxycholic acid and chenodeoxycholic acid on the expression of HLA-molecules on human primary hepatocytes
    • Töx U, Arnold JC, Otto G, Theilmann L, Kommerell B, Stiehl A. Differences in the effect of ursodeoxycholic acid and chenodeoxycholic acid on the expression of HLA-molecules on human primary hepatocytes (abstract). Hepatology 1993;18:176A.
    • (1993) Hepatology , vol.18
    • Töx, U.1    Arnold, J.C.2    Otto, G.3    Theilmann, L.4    Kommerell, B.5    Stiehl, A.6
  • 112
    • 4243444733 scopus 로고
    • Aberrant HLA-DR expression by bile duct epithelium in primary sclerosing cholangitis is down-regulated by ursodeoxycholic acid
    • Lo SK, Chapman RW, Dooley JS, Fleming KA. Aberrant HLA-DR expression by bile duct epithelium in primary sclerosing cholangitis is down-regulated by ursodeoxycholic acid (abstract). Gastroenterology 1993;104(suppl.):A111.
    • (1993) Gastroenterology , vol.104 , Issue.SUPPL.
    • Lo, S.K.1    Chapman, R.W.2    Dooley, J.S.3    Fleming, K.A.4
  • 113
    • 0023751460 scopus 로고
    • Antigen presentation and autoimmunity
    • Allen PM. Antigen presentation and autoimmunity. Hepatology 1988;8:677-9.
    • (1988) Hepatology , vol.8 , pp. 677-679
    • Allen, P.M.1
  • 115
    • 0028211919 scopus 로고
    • Differential effects of chenodeoxycholic and ursodeoxycholic acids on expression of procoagulant activity by human monocytes
    • Calmus Y, Podevin P, Robert A, Poupon R. Differential effects of chenodeoxycholic and ursodeoxycholic acids on expression of procoagulant activity by human monocytes. J Hepatology 1994;20:466-72 .
    • (1994) J Hepatology , vol.20 , pp. 466-472
    • Calmus, Y.1    Podevin, P.2    Robert, A.3    Poupon, R.4
  • 116
    • 0027221534 scopus 로고
    • The immunosuppressive effect of ursodeoxycholic acid: A comparative in vitro study on human peripheral blood mononuclear cells
    • Lacaille F, Paradis K. The immunosuppressive effect of ursodeoxycholic acid: a comparative in vitro study on human peripheral blood mononuclear cells. Hepatology 1993;18: 165-72.
    • (1993) Hepatology , vol.18 , pp. 165-172
    • Lacaille, F.1    Paradis, K.2
  • 118
    • 0025876404 scopus 로고
    • A multicenter, controlled trial of ursodiol for the treatment of primary biliary cirrhosis
    • Poupon RE, Balkau B, Eschwège E, Poupon R, UDCA-PBC Study Group. A multicenter, controlled trial of ursodiol for the treatment of primary biliary cirrhosis. N Engl J Med 1991;324:1548-54.
    • (1991) N Engl J Med , vol.324 , pp. 1548-1554
    • Poupon, R.E.1    Balkau, B.2    Eschwège, E.3    Poupon, R.4
  • 119
    • 0026504193 scopus 로고
    • Adjuvant treatment with ursodeoxycholic acid reduces acute rejection after liver transplantation
    • Friman S, Persson H, Shersten T, Svanvik J, Karlberg I. Adjuvant treatment with ursodeoxycholic acid reduces acute rejection after liver transplantation. Transplant Proc 1992; 24:389-90 .
    • (1992) Transplant Proc , vol.24 , pp. 389-390
    • Friman, S.1    Persson, H.2    Shersten, T.3    Svanvik, J.4    Karlberg, I.5
  • 121
    • 0024693592 scopus 로고
    • Die Behandlung der primar sklerosierenden Cholangitis mit Ursodeoxycholsaur
    • Stiehl A, Raedsch R. Die Behandlung der primar sklerosierenden Cholangitis mit Ursodeoxycholsaur. Z Gastroenterologie 1989;24:136.
    • (1989) Z Gastroenterologie , vol.24 , pp. 136
    • Stiehl, A.1    Raedsch, R.2
  • 123
    • 0025790576 scopus 로고
    • Ursodeoxycholic acid for the treatment of primary sclerosing cholangitis: A 30-month pilot study
    • O'Brien CB, Senior JR, Arora-Mirchandani R, Batta AK, Salen G. Ursodeoxycholic acid for the treatment of primary sclerosing cholangitis: a 30-month pilot study. Hepatology 1991;14:838-47.
    • (1991) Hepatology , vol.14 , pp. 838-847
    • O'Brien, C.B.1    Senior, J.R.2    Arora-Mirchandani, R.3    Batta, A.K.4    Salen, G.5
  • 124
    • 0027954535 scopus 로고
    • Effect of ursodeoxycholic acid on liver and bile duct disease in primary sclerosing cholangitis. A 3-year pilot study with a placebo-controlled study period
    • Stiehl A, Walker S, Stiehl L, Rudolph G, Hofmann WJ, Theilmann L. Effect of ursodeoxycholic acid on liver and bile duct disease in primary sclerosing cholangitis. A 3-year pilot study with a placebo-controlled study period. J Hepatol 1994;20:57-64.
    • (1994) J Hepatol , vol.20 , pp. 57-64
    • Stiehl, A.1    Walker, S.2    Stiehl, L.3    Rudolph, G.4    Hofmann, W.J.5    Theilmann, L.6
  • 125
    • 0027453845 scopus 로고
    • Inhibitory effect of ursodeoxycholic acid on the progression of chronic hepatic disorders with special reference to increases in blood flow
    • Kurihara T, Akimoto M, Abe K, Hashimoto H, Ishiguro H, Niimi A, et al. Inhibitory effect of ursodeoxycholic acid on the progression of chronic hepatic disorders with special reference to increases in blood flow. Clin Ther 1993;15:866-74.
    • (1993) Clin Ther , vol.15 , pp. 866-874
    • Kurihara, T.1    Akimoto, M.2    Abe, K.3    Hashimoto, H.4    Ishiguro, H.5    Niimi, A.6
  • 126
    • 0028960364 scopus 로고
    • Interferon and ursodeoxycholic acid combined therapy in the treament of chronic viral C hepatitis: Results from a controlled randomized trial in 80 patients
    • Boucher E, Jouanolle H, André P, Ruffault A, Guyader D, Moirand R, et al. Interferon and ursodeoxycholic acid combined therapy in the treament of chronic viral C hepatitis: results from a controlled randomized trial in 80 patients. Hepatology 1995;21:322-7.
    • (1995) Hepatology , vol.21 , pp. 322-327
    • Boucher, E.1    Jouanolle, H.2    André, P.3    Ruffault, A.4    Guyader, D.5    Moirand, R.6
  • 127
    • 0027963209 scopus 로고
    • A multicenter randomized controlled study of ursodeoxycholic acid for chronic hepatitis C
    • Takano S, Ito Y, Yokosuka O, Uchiumi K, Hirota K, Omata M. A multicenter randomized controlled study of ursodeoxycholic acid for chronic hepatitis C. Hepatology 1994;20:558-64.
    • (1994) Hepatology , vol.20 , pp. 558-564
    • Takano, S.1    Ito, Y.2    Yokosuka, O.3    Uchiumi, K.4    Hirota, K.5    Omata, M.6
  • 130
    • 0027263534 scopus 로고
    • Beta-muricholic acid: A new hepato-protective agent
    • Zhao XM, Montet JC. Beta-muricholic acid: a new hepato-protective agent. J Nutr Biochem 1993;4:105-12.
    • (1993) J Nutr Biochem , vol.4 , pp. 105-112
    • Zhao, X.M.1    Montet, J.C.2


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