Telomerase as a therapeutic target

Acta Biochimica Polonica

Volumn 43, Issue 3, 1996, Pages 531-538

  Huminiecki, Łukasz ^a  

^a POLISH ACADEMY OF SCIENCES   (Poland)

Author keywords

Antisense; Cancer; Gene therapy; Telomerase

Indexed keywords

TELOMERASE;

ANIMAL; BIOLOGICAL MODEL; CELL AGING; CELL CULTURE; DRUG ANTAGONISM; ENZYME ACTIVATION; HUMAN; METABOLISM; REVIEW; RODENT;

ANIMALS; CELL AGING; CELLS, CULTURED; ENZYME ACTIVATION; HUMANS; MODELS, BIOLOGICAL; RODENTIA; TELOMERASE;

EID: 0030338557     PISSN: 0001527X     EISSN: None     Source Type: Journal    
DOI: 10.18388/abp.1996_4488     Document Type: Review

References (34)

1. Blackburn, E.H. (1991) Structure and function of telomeres. Nature (London) 350, 569-573.
2. Blackburn, E.H. (1992) Telomerases. Annu. Rev. Biochem. 61, 113-129.
3. Harley, C.B., Vaziri, H., Counter, C.M. & Allsopp, R.C. (1992) The telomere hypothesis of cellular ageing. Exp. Gerontol. 27, 375-382.
4. Allsopp, R.C., Vaziri, H., Patterson, C., Goldstein, S., Younglai, E.V., Futher, A.B., Greide, C.W. & Harley, C.B. (1992) Telomere lenghtening predicts replicative capacity of human fibroblasts. Proc. Natl. Acad. Sci. U.S.A. 89, 10114-10118.
5. Kim, N.W., Piatyszek, M.A., Prowse, K.R., Harley, C.B., West, M.D., Ho, P.L., Coviello, G.M., Wright, W.E., Weinrich, S.L. & Shay, J.W. (1994) Specific associations of human telomerase activity with immortal cells and cancer. Science 266, 2011-2015.
6. Giraroli, A.J., Jensen, F.C. & Koprowski, H. (1969) SV40-induced transformation of human diploid cells: Crisis and recovery. Int. J. Natl. Cancer Inst. 42, 867-870.
7. Counter, C.M., Botelho, F., Harley, C.B. & Bacchetti, S. (1994) Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus transformed human B lymphocytes. J. Virol. 68, 3410-3414.
8. Steel, M. (1995) Telomerase that shapes our ends. Lancet 345, 935-936.
9. Counter, M.C., Gupta, J., Harley, C.B., Leber, B. & Bacchetti, S. (1995) Telomerase activity in normal leukocytes and in hematologic malignancies. Blood 85, 2315-2320.
10. Schwartz, H.S., Juliao, S.F. & Sciadini, M.F. (1995) Telomerase activity and oncogenesis in giant cell tumor of bone. Cancer 75, 1094-1098.
11. Blasco, M.A., Funk, W., Villeponteau, B. & Greider, C.W. (1995) Functional characterization and developmental regulation of mouse telomerase RNA. Science 268, 1267-1270.
12. Huminiecki, Ł. (1995) Gene therapy - vectors and strategies. Adv. Biochem. 4, 220-230.
13. Fujiwara, T., Grim, H.A., Mukhopadhyay, T., Cai, D.W., Owen-Schaub, L.B. & Roth, J.A. (1993) A retroviral wild-type p53 expression vector penetrates human lung cancer spheroids and inhibits growth by inducing apoptosis. Cancer Res. 53, 4129-4133.
14. Zhang, Y., Mukhopartyay, T., Donehower, L.A., Georges, R.N. & Roth, J.A. (1993) Retroviral vector-mediated transduction of K-ras anti-sense RNA into human lung cancer cells inhibits expression of the malignant phenotype. Hum. Gene. Ther. 4, 451-460.
15. Ratajczak, M.Z., Kant, J.A. & Luger, S.M., Hijiya, N., Zhang, J., Zon, G. & Gewirtz, M. (1992) In vivo treatment of human leukaemia in a scid mouse model with c-myb antisense oligodeoxynucleotides. Proc. Natl. Acad. Sci. U.S.A. 89, 11823-11827.
16. Skorski, T., Nieborowska-Skorska, M. & Nicolaides, N.C. (1994) Suppression of Philadelphia 1 leukaemia cell growth in mice by BCR-ABL antisense oligonucletide. Proc. Natl. Acad. Sci. U.S.A. 91, 4504-4508.
17. Lange, W., Cantin, E.M., Finke, J. & Dolken, G. (1993) In vitro and in vivo effects of synthetic ribozymes targeted against BCR/ABL mRNA. Leukemia 11, 1786-1794.
18. Counter, C.M. (1992) Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J. 11, 1921-1929.
19. Shay, J.W., Wright, W.E. & Brasiskite, D. (1993) E6 of human papillomavirus type 16 can overcome the M1 stage of immortalization in human mammary epithelial cells but not in human fibroblasts. Oncogene 8, 1407-1413.
20. Vaziri, H., Dragowska, W. & Allsopp, R.C. (1994) Evidence for a mitotic clock in human hematopoietic stem cells, loss of telomeric DNA with age. Proc. Natl. Acad. Sci. U.S.A. 91, 9857-9860.
21. Feng, J., Funk, W.D., Wang, S.S., Weinrich, S.L., Avilion, A.A., Chiv, C.P., Adams, R.R., Chang, E., Allsopp, R.C. & Yu, J. (1995) The RNA component of human telomerase. Science 269, 1236-1240.
22. Allen, T.M. (1994) Long-circulating (sterically stabilized) liposomes for targeted drug delivery. Trends Pharmacol. Sci. 15, 215-220.
23. Kashani-Sabet, M. & Scanlon, J.K. (1995) Application of ribozymes to cancer therapy. Cancer Gene Ther. 2, 213-223.
24. Mercola, D. & Cohen, J.S. (1995) Antisense approaches to cancer therapy. Cancer Gene Ther. 2, 47-59.
25. Cotten, M., Schaffner, G. & Birnstiel, M.L. (1989) Ribozyme, antisense RNA, antisense DNA inhibition of U7 small nuclear ribonucleoprotein-mediated histone pre-mRNA processing in vitro. Mol. Cell. Biol. 9, 4479-4487.
26. Bridges, S.H. & Sarver, N. (1995) Gene therapy and immune restoration for HIV disease. Lancet 345, 427-432.
27. Lever, A.M.L. (1995) Gene therapy for HIV infection. Brit. Med. Bull. 51, 149-166.
28. Kipling, D. (1995) Telomerase: Immortalising enzyme or oncogene. Nature Genetics 9, 104-106.
29. Prowse, K.R. & Greider, C.W. (1995) Developmental and tissue-specific regulation of mouse telomerase and telomere length. Proc. Natl. Acad. Sci. U.S.A. 92, 4818-4822.
30. Morin, G.B. (1995) Is telomerase a universal cancer target? J. Natl. Canc. Inst. 87, 859-862.
31. Bednarek, A., Budunova, I., Slaga, T.J. & Aldaz, C.M. (1995) Increased telomerase activity in mouse skin premalignant progression. Cancer Res. 55, 4566-4569.
32. Bhattacharya, A. & Blackburn, E.H. (1995) Architecture of telomerase RNA. EMBO J. 13, 5721-5731.
33. McCormick-Graham, M. & Romero, D.P. (1995) Ciliate telomerase RNA structural features. Nucleic Acids Res. 23, 1091-1097.
34. Greider, C.W. (1990) Telomeres, telomerase and senescence. Bio-Essays 12, 363-369.