The serum neutralizing antibody response in cattle to Fusobacterium Necrophorum leukotoxoid and possible protection against experimentally induced hepatic abscesses

Veterinary Research Communications

Volumn 20, Issue 6, 1996, Pages 493-504

  Saginala, S ^a   Nagaraja, T G ^a   Tan, Z L ^a   Lechtenberg, K F ^b   Chengappa, M M ^a   Hine, P M ^c  

^a KANSAS STATE UNIVERSITY   (United States)

^b Midwest Veterinary Sciences   (United States)

^c MALLINCKRODT PHARMACEUTICALS   (United States)

Author keywords

Abscesses; Adjuvant; Antibody; Antileukotoxin; Cattle; Fusobacterium necrophorum; Immunity; Leukotoxoid; Liver; Protection

Indexed keywords

BACTERIAL VACCINE; BACTERIUM ANTIBODY; CELL WALL SKELETON; CORD FACTOR; DRUG DERIVATIVE; EXOTOXIN; IMMUNOLOGICAL ADJUVANT; LEUKOTOXIN; LIPID A; RIBI ADJUVANT; TOXOID; VIRUS PROTEIN;

ANIMAL; ANIMAL DISEASE; ARTICLE; BACTERIAL INFECTION; BIOSYNTHESIS; BLOOD; CATTLE; CATTLE DISEASE; DOSE RESPONSE; FUSOBACTERIUM NECROPHORUM; IMMUNOLOGY; LIVER ABSCESS; MALE; RANDOMIZATION; VACCINATION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODIES, BACTERIAL; BACTERIAL VACCINES; CATTLE; CATTLE DISEASES; CELL WALL SKELETON; CORD FACTORS; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; EXOTOXINS; FUSOBACTERIUM INFECTIONS; FUSOBACTERIUM NECROPHORUM; LIPID A; LIVER ABSCESS; MALE; RANDOM ALLOCATION; TOXOIDS; VACCINATION; VIRAL PROTEINS;

EID: 0030333710     PISSN: 01657380     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00396292     Document Type: Article

References (31)

1. Berg, J.N. and Scanlan, C.M., 1962. Studies of Fusobacterium necrophorum from bovine hepatic abscesses: biotypes, quantitation, virulence, and antibiotic susceptibility. American Journal of Veterinary Research, 43, 1580-1586
2. Brink, D.R., Lowry, S.R., Stock, R.A. and Parrott, J.C., 1990. Severity of liver abscesses and efficiency of feed utilization of feedlot cattle. Journal of Animal Science, 68, 1201-1207
3. Brown, H., Bing, R.F., Grueter, H.P., McAskill, J.W., Cooley, CO. and Rathmacher, R.P., 1975. Tylosin and chlortetracycline for the prevention of liver abscesses, improved weight gains and feed efficiency in feedlot cattle. Journal of Animal Science, 40, 207-213
4. Clark, B.L., Emery, D.L., Stewart, D.J., Dufty, J.H. and Anderson, D.A., 1986. Studies into immunization of cattle against interdigital necrobacillosis. Australian Veterinary Journal, 63, 107-110.
5. Coyle-Dennis, J.E. and Lauerman, L.H., 1979. Correlations between leukocidin production and virulence of two isolates of Fusobacterium necrophorum. American Journal of Veterinary Research, 40, 274-276
6. Emery, D.L. and Vaughan, J.A., 1986. Generation of immunity against Fusobacterium necrophorum or mice inoculated with extracts containing leukotoxin. Veterinary Microbiology, 12, 255-268
7. Emery, D.L., Duffy, J.H. and Clark, B.L., 1984. Biochemical and functional properties of a leukocidin produced by several strains of Fusobacterium necrophorum. Australian Veterinary Journal, 61, 382-386
8. Emery, D.L., Vaughan, J.A., Clark, B.L., Duffy, J.H. and Stewart, D.J., 1985. Cultural characteristics and virulence of strains of Fusobacterium necrophorum isolated from the feet of cattle and sheep. Australian Veterinary Journal, 62, 43-46
9. Garcia, M.M., Dorward, W.J., Alexander, D.C., Magwood, S.E. and McKay, K.A., 1974. Results of a preliminary trial with Sphaerophorus necrophorus toxoids to control liver abscesses in feedlot cattle. Canadian Journal of Comparative Medicine, 38, 222-226
10. Jensen, R., Deane, H.M., Cooper, L.J., Miller, V.A. and Graham, W.R., 1954a. The rumenitis-liver abscess complex in beef cattle. American Journal of Veterinary Research, 15, 202-216
11. Jensen, R., Flint, J.C. and Griner, L.A., 1954b. Experimental hepatic necrobacillosis in beef cattle. American Journal of Veterinary Research, 15, 5-14
12. Kanoe, M., Ishii, T. and Kai, K., 1987. Effects of Fusobacterium necrophorum leukocidin on bovine ruminai cells in vitro. FEMS Microbiology Letters, 35, 119-123
13. Langworth, B.F., 1977. Fusobacterium necrophorum: its characteristics and role as an animal pathogen. Bacteriological Reviews, 41, 373-390
14. Lechtenberg, K.F. and Nagaraja, T.G., 1991. Hepatic ultrasonography and blood changes in steers with experimentally induced liver abscesses. American Journal of Veterinary Research, 52, 803-809
15. Lechtenberg, K.F., Nagaraja, T.G., Leipold, H.W. and Chengappa, M.M., 1988. Bacteriologic and histologic studies of hepatic abscesses in cattle. American Journal of Veterinary Research, 49, 58-62
16. Potter, E.L.,Wray, M.I., Muller, R.D., Grueter, H.P., McAskill, J. and Young, C., 1985. Effect of monensin on average daily gain, feed efficiency and liver abscess incidence in feedlot cattle. Journal of Animal Science, 61, 1058-1065
17. Roberts, D.S., 1967. The pathogenic synergy of Fusiformis necrophorus and Corynbacterium pyogenes. I. Influence of the leukocidal exotoxin of F. necrophorus. British Journal of Experimental Pathology, 48, 665-673
18. Roberts, D.S., 1970. Toxic, allergenic and immunogenic factors of Fusiformis necrophorus. Journal of Comparative Pathology, 80, 247-257
19. SAS. 1987. SAS/STAT Guide for personal computers. (SAS Institute Inc, Cary, NQ
20. Scanlan, C.M. and Hathcock, T.L., 1983. Bovine rumenitis-liver abscess complex: a bacteriological review. Cornell Veterinarian, 73, 288-297
21. Smith, H.A., 1944. Ulcerative lesions of the bovine rumen and their possible relation to hepatic abscesses. American Journal of Veterinary Research, 5, 234-242
22. Smith, G.R. and Wallace, L.M., 1992. Further observations on the weak immunogenicity of Fusobacterium necrophorum. Research in Veterinary Science, 52, 262-263
23. Smith, G.R., Turner, A., Murray, L.G. and Oliphant, J.C., 1985. The weak immunogenicity of Fusobacterium necrophorum. Journal of Hygiene, Cambridge, 95, 59-68
24. Smith GR, Wallace LM and Till, D., 1989. Necrobacillosis and immunity in mice. Epidemiology and Infection, 103, 211-215
25. Takeuchi, S., Nakajima, Y., Ueda, J., Motoi, Y., Kobayashi, Y. and Morozumi, T., 1984. Hepatic abscess formation in cattle inoculated with Fusobacterium necrophorum. Japanese Journal of Veterinary Science, 46, 339-344
26. Tan, Z.L., Nagaraja, T.G. and Chengappa, M.M., 1992. Factors affecting the leukotoxin activity of Fusobacterium necrophorum. Veterinary Microbiology, 32, 15-28
27. Tan, Z.L., Lechtenberg, K.F., Nagaraja, T.G., Chengappa, M.M. and Brandt, R.T., 1994a. Serum neutralizing antibodies against Fusobacterium necrophorum leukotoxin in cattle with experimentally induced or naturally developed hepatic abscesses. Journal of Animal Sciences, 72, 502-508
28. Tan, Z.L., Nagaraja, T.G. and Chengappa, M.M., 1994b. Biochemical and biological characterization of ruminal Fusobacterium necrophorum. FEMS Microbiology Letters, 120, 81-86
29. Tan, Z.L., Nagaraja, T.G., Chengappa, M.M. and Smith, J.S., 1994c. Biochemical and biological characterization of Fusobacterium necrophorum leukotoxin. American Journal of Veterinary Research, 55, 515-521
30. Tan, Z.L., Nagaraja, T.G., Chengappa, M.M. and Staats, J.J., 1994d. Purification and quantitation of Fusobacterium necrophorum leukotoxin by using monoclonal antibodies. Veterinary Microbiology, 42, 121-133
31. Vega, M.V., Maheswaran, S.K., Leininger, J.R. and Ames, T.R., 1987. Adaptation of a colorimetric microtitration assay for quantifying Pasteurella haemolytica Al leukotoxin and antileukotoxin. American Journal of Veterinary Research, 48, 1559-1564