The Effect of Low Brain Serotonin on Mood and Aggression in Humans: Influence of Baseline Mood and Genetic Factors

Advances in Experimental Medicine and Biology

Volumn 398, Issue , 1996, Pages 45-50

  Young, S N ^a   Pihl, R O ^a   Benkelfat, C ^a   Palmour, R ^a   Ellenbogen, M ^a   Lemarquand, D ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

SEROTONIN; TRYPTOPHAN;

AFFECT; AGGRESSION; BIOETHICS; BRAIN; GENETICS; HUMAN; PHYSIOLOGY; REVIEW;

AFFECT; AGGRESSION; BIOETHICS; BRAIN; HUMANS; SEROTONIN; TRYPTOPHAN;

EID: 0030333540     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4613-0381-7_5     Document Type: Article

References (24)

1. Abbott, F.V., Etienne, P., Franklin, K.B.J., Morgan, M.J., Sewitch, M.J. and Young, S.N., 1992, Acute tryptophan depletion blocks morphine analgesia in the cold-pressor test in humans, Psychopharmacology. 108:60.
2. Benkelfat, C., Ellenbogen, M.A., Dean, P., Palmour, R.M. and Young, S.N., 1994, Mood-lowering effect of tryptophan depletion: Enhanced susceptibility in young men at genetic risk for major affective disorders, Arch Gen Psychiatry. 51:687.
3. Blier, P. and de Montigny, C., 1994, Current advances and trends in the treatment of depression, Trends Pharmacol Sci. 15:220.
4. Chamberlain, B., Ervin, F.R., Pihl, R.O. and Young, S.N., 1987, The effect of raising or lowering tryptophan levels on aggression in vervet monkeys, Pharmacol Biochem Behav. 28:503.
5. Cleare, A.J. and Bond, A.J., 1995, The effect of tryptophan depletion and enhancement on subjective and behavioural aggression in normal male subjects, Psychopharmacology. 118:72.
6. Craig, A., 1986, Acute effects of meals on perceptual and cognitive efficiency, Nutr Rev. 44 (supplement):163.
7. Delgado, P.L., Charney, D.S., Price, L.H., Aghajanian, G.K., Landis, H. and Heninger, G.R., 1990, Serotonin function and the mechanism of antidepressant action: reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan, Arch Gen Psychiatry, 47:411.
8. Delgado, P.L., Miller, H.L., Salomon, R.M., Licinio, J., Heninger, G.R., Gelenberg, A.J. and Charney, D.S., 1993. Monoamines and the mechanism of antidepressant action: effects of catecholamine depletion on mood of patients treated with antidepressants, Psychopharmacol Bull. 29:389.
9. Delgado, P.L., Price, L.H., Miller, H.L., Salomon, R.M., Aghajanian, G.K., Heninger, G.R. and Charney, D.S., 1994. Serotonin and the neurobiology of depression: Effects of tryptophan depletion in drug-free depressed patients, Arch Gen Psychiatry. 51:865.
10. Eichelman, B., 1993, Bridges from the animal laboratory to the study of violent or criminal individuals, in: "Mental Disorders and Crime," S. Hodgins, ed., Sage, New York.pp. 194.
11. Finn, P.R., Young, S.N., Pihl, R.O. and Ervin, F.R., 1995, The influence of antisocial and low-anxious traits on altered mood, anxiety and hostility induced by acute tryptophan depletion, Psychopharmacology. in press:
12. Matos, F.F., Rollema, H., Brown, J.L. and Basbaum, A.I., 1992, Do opioids evoke the release of serotonin in the spinal cord? An in vivo microdialysis study of the regulation of extracellular serotonin in the rat, Pain. 48:439.
13. Moja, E.A., Restani, P., Corsini, E., Stacchezzini, M.C., Assereto, R. and Galli, C.L., 1991, Cycloheximide blocks the fall of plasma and tissue tryptophan levels after tryptophan-free amino acid mixtures, Life Sci. 49:1121.
14. Morand, C., Young, S.N. and Ervin, F.R., 1983, Clinical response of aggressive schizophrenics to oral tryptophan, Biol Psychiatry. 18:575.
15. Pihl, R.O., Young, S.N., Harden, P., Plotnick, S., Chamberlain, B. and Ervin, F.R., 1995, Acute effect of altered tryptophan levels and alcohol on aggression in normal human males, Psychopharmacology. in press:
16. Salomon, R.M., Mazure, C.M., Delgado, P.L., Mendia, P. and Charney, D.S., 1994, Serotonin function in aggression: the effect of acute plasma tryptophan depletion in aggressive patients, Biol Psychiatry. 35:570.
17. Smith, S.E., Pihl, R.O., Young, S.N. and Ervin, F.R., 1986, Elevation and reduction of plasma tryptophan and their effects on aggression and perceptual sensitivity in normal males, Aggress Behav. 12:393.
18. Trulson, M.E. and Jacobs, B.L., 1979, Raphe unit activity in freely moving cats: correlation with level of behavioral arousal, Brain Res. 163:135.
19. van Praag, H.M., 1994, Anxiety and aggression as pacemakers of depression: A dimensional variation of the serotonin hypothesis of depression, in: "Current Therapeutic Approaches to Panic and Other Anxiety Disorders," J. Mendlewicz, G. Racagni and N. Brunello, eds., Karger, Basel.pp. 144.
20. Volavka, J., Crowner, M., Brizer, D., Convit, A., van Praag, H.M. and Suckow, R.F., 1990, Tryptophan treatment of aggressive psychiatric inpatients, Biol Psychiatry. 28:728.
21. Wilkins, K., 1990, Eosinophilia-myalgia syndrome, Can Med Assoc J. 142:1265.
22. Wurtman, R.J., Hefti, F. and Melamed, E., 1981, Precursor control of neurotransmitter synthesis, Pharmacol Rev. 32:315.
23. Young, S.N., Smith, S.E., Pihl, R.O. and Ervin, F.R., 1985, Tryptophan depletion causes a rapid lowering of mood in normal males, Psychopharmacology. 87:173.
24. Young, S.N., Ervin, F.R., Pihl, R.O. and Finn, P., 1989, Biochemical aspects of tryptophan depletion in primates, Psychopharmacology. 98:508.