Overexpression of tissue inhibitors of metalloproteinase-1 and -2 in the stroma of gastric cancer

Journal of Korean Medical Science

Volumn 11, Issue 6, 1996, Pages 474-479

  Hong, Seok Il ^a   Park, In Chul ^a,d   Hong, Weon Seon ^b   Son, Young Sook ^a   Lee, Seung Hoon ^a   Lee, Jong Inn ^a   Choi, Dong Wook ^a   Moon, Nan Mo ^a   Choe, Tae Boo ^d   Jang, Ja Jun ^c  

^a Korea Cancer Center Hospital   (South Korea)

^b University of Ulsan College of Medicine   (South Korea)

^c Seoul National University   (South Korea)

^d Konkuk University   (South Korea)

Author keywords

Gastric cancer; Immunohistochemistry; Metastasis; Northern blot analysis; TIMP 1; TIMP 2

Indexed keywords

GLYCOPROTEIN; MESSENGER RNA; PROTEIN; TISSUE INHIBITOR OF METALLOPROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 2;

ADENOCARCINOMA; ARTICLE; BIOSYNTHESIS; ENZYMOLOGY; GENETICS; HUMAN; NORTHERN BLOTTING; PROTEIN SYNTHESIS; STOMACH TUMOR;

ADENOCARCINOMA; BLOTTING, NORTHERN; GLYCOPROTEINS; HUMANS; PROTEIN BIOSYNTHESIS; PROTEINS; RNA, MESSENGER; STOMACH NEOPLASMS; TISSUE INHIBITOR OF METALLOPROTEINASE-2; TISSUE INHIBITOR OF METALLOPROTEINASES;

EID: 0030333008     PISSN: 10118934     EISSN: None     Source Type: Journal    
DOI: 10.3346/jkms.1996.11.6.474     Document Type: Article

References (22)

1. Buck MR, Karustis DG, Day NA, Honn KV, Sloane BF. Degradation of extracellular-matrix proteins by human cathepsin B from normal and tumor tissues. Biochem J 1992 ; 282 : 272-8.
2. Carmichael DF, Sommer A, Thompson RC, Anderson DC, Smith CG, Welgus HG, Stricklin GP. Primary structure and cDNA cloning of human fibroblast collagenase inhibitor. Proc Natl Acad Sci USA 1986 ; 83 : 2407-11.
3. DeClerck YA, Perez N, Shimada H, Boone TC, Langley KE, Taylor SM. Inhibition of invasion and metastasis in cells transfected with an inhibitor of metalloproteinses. Cancer Res 1992 ; 52 : 701-8.
4. Fidler IJ. Critical factors in the biology of human cancer metastasis: twenty-eight G.H.A. Clowes Memorial Award Lecture. Cancer Res 1990 ; 50 : 6130-38.
5. Goldberg GI, Marmer BL, Grant GA, Eisen AZ, Wilhelm A, He C. Human 72-kilodalton type N collagenase forms a complex with a tissue inhibitor of metalloproteinses designated TIMP-2. Proc Natl Acad Sci 1989 ; 86 : 8207-11.
6. Hart IR, Goode NT, Wilson RE. Molecular aspects of the metastatic cascade. Biochem Biophys Acta 1989 ; 989 : 65-84.
7. Herron GS, Banda MJ, Clark EJ, Gavrilovic J, Werb Z. Secretion of metalloproteinase and stromelysin activities is regulated by endogenous inhibitors. J Biol Chem 1986 ; 261 : 2814-8.
8. Hoyhtya M, Fridman R, Komarek D, Porter-Jordan K, Stetler-Stevenson WG, Liotta LA, Liang C-M. Immunohistochemical localization of matrix, metalloproteinase 2 and its specific inhibitor TIMP-2 in neoplastic tissues with monoclonal antibodies. Int J Cancer 1994 ; 56 : 500-5.
9. Kubota S, Fridman R, Yamada Y. Transforming growth factor-suppresses the invasiveness of human fibrosarcoma cells in vitro by increasing expression of tissue inhibitor of metalloproteinase. BBRC 1991 ; 176 : 129-36.
10. Liotta LA. Tumor invasion and metastases-role of the extracellular matrix: Rhoads Memorial Award Lecture. Cancer Res 1986 ; 46 : 1-7.
11. Mullins DE, Rohrlich ST. The role of proteinases in cellular invasiveness. Biochem Biophys Acta 1983 ; 695 : 177-214.
12. Sato H, Kida Y, Endo M, Sasaki T, Tanaka J, Seiki M. Expression of genes encoding type IV collagen-degrading metalloproteinases and tissue inhibitors of metalloproteinases in various human tumor cells. Oncogene 1992 ; 7: 77-83.
13. Stetler-Stevenson WG, Aznavoorian S, Liotta LA. Tumor cell interactions with the extracellular matrix during invasion and metastasis. Annu Rev Cell Biol 1993 ; 9 : 541-73.
14. Stetler-Stevenson WG, Brown PD, Onisto M, Levy AT, Liotta LA. Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor Tissues. J Biolog Chem 1990 ; 265 : 13933-8.
15. Stetler-Stevenson WG, Krutzsch HC, Liotta LA. Tissue inhibitor of metalloproteinase (TIMP-2). J Biol Chem 1989 ; 264 : 17374-8.
16. Testa J. Loss of the metastatic phenotype by a human epidermoid carcinoma cell line HEp-3, is accompanied by increased expression of tissue inhibitor of metalloproteinse-2. Cancer Res 1992 ; 52 : 5597-603.
17. Ward RV, Atkinson SJ, Slocombe PM, Docherty AJP, Reynolds JJ, Murphy G. Tissue inhibitor of metalloproteinase-2 inhibits the activation of 72 kDa progelatinase by fibroblast membranes. Biochim Biophys Acta 1991 ; 1079 : 242-6.
18. Welgus HG, Campell EJ, Bar-Shavit Z, Senior RM, Teitelbaum SL. Human alveolar macrophage produce a fibroblast-like collagenase and collagenase inhibitor. J Clin Invet 1985a ; 76 : 219-24.
19. Welgus HG, Jeffery JJ, Eisen AZ, Roswit WT, Stricklin GP. Human skin fibroblast collagenase : interaction with substrate and inhibitor. Collagen Relat Res 1985b ; 5 : 167-79.
20. Welgus HG, Stricklin GP. Human skin fibroblast collagenase inhibitor. comparative studies in human connective tissues, serum, and amniotic fluid. J Biol Chem 1983 ; 258 : 12259-64.
21. Wilhelm SM, Collier IE, Marmer BL, Eisen AZ, Grant GA, Goldberg GI. SV40-transformed human lung fibroblasts secrete a 92-kDa type N collagenase which is identical to that secreted by normal human macrophages. J Biol Chem 1989 ; 264 : 17213-21.
22. Woessner JF Jr. Matrix metalloproteinses and their inhibitors in connective tissue remodeling. FASEB 1991 ; 5 : 2145-54.