Molecular Characterisation of Kynurenine Pathway Enzymes: 3-Hydroxyanthranilic-Acid Dioxygenase and Kynurenine Aminotransferase

Advances in Experimental Medicine and Biology

Volumn 398, Issue , 1996, Pages 477-483

  Cesura, A M ^a   Alberati Giani, D ^a   Buchli, R ^a   Broger, C ^b   Kohler C ^a   Vilbois, F ^b   Lahm, H W ^b   Heitz, M P ^a   Malherbe, P ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYANTHRANILATE 3,4 DIOXYGENASE; AMINOTRANSFERASE; DIOXYGENASE; GLUTAMINE - PHENYLPYRUVATE TRANSAMINASE; GLUTAMINE PHENYLPYRUVATE AMINOTRANSFERASE; KYNURENINE; KYNURENINE OXOGLUTARATE TRANSAMINASE; KYNURENINE-OXOGLUTARATE TRANSAMINASE; LYASE; OXYGENASE; RECOMBINANT PROTEIN;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BIOSYNTHESIS; BRAIN; CHEMISTRY; COMPARATIVE STUDY; ENZYMOLOGY; HUMAN; KIDNEY; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; RAT; SEQUENCE HOMOLOGY;

3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BRAIN; CLONING, MOLECULAR; CONSERVED SEQUENCE; DIOXYGENASES; HUMANS; KIDNEY; KYNURENINE; LYASES; MOLECULAR SEQUENCE DATA; OXYGENASES; POLYMERASE CHAIN REACTION; RATS; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TRANSAMINASES;

EID: 0030332645     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4613-0381-7_74     Document Type: Article

References (20)

1. Alberati-Giani, D., Malherbe, P., Köhler, C., Lang, G., Kiefer, V., and Cesura, A. M., 1995, Cloning and characterisation of a soluble kynurenine aminotransferase from rat brain: identity with kidney cysteine conjugate β-lyase, J. Neurochem. 64:1448
2. Cooper A.J., Abraham D.G., Gelbard A.S., Lai J.C.K., and Petito C.K., 1993, High activities of glutamine transaminase K (dichlorovinylcysteine β-lyase) and ω-amidase in the choroid plexus of rat brain, J. Neurochem. 61:1731.
3. Cooper A.J.L., 1994, Enzymology of cysteine S-conjugate β-lyases, Adv. Pharmacol. 27:71.
4. Heyes, M.P., 1993, Metabolism and neuropathologic significance of quinolinic acid and kynurenic acid, Biochem. Soc. Transac. 21:83.
5. Jaeger, J., Moser, M., sauder, U., and Jansonius, J.N., 1994, Crystal structure of Escherichia coli aspartate aminotransferase in two conformations. Comparison of an unliganded and two liganded closed forms. J. Mol. Biol. 239:285.
6. Köhler, C., Eriksson, L.G., Okuno, E., and Schwarcz, R., 1988, Localisation of quinolinic acid metabolising enzymes in the rat brain. Immunohistochemical studies using antibodies to 3-hydroxyanthranilic acid oxygenase and quinolinic acid phosphoribosyltransferase, Neuroscience 27:49.
7. Lüthy, R., Bowie, J.U. and Eisenberg, D., 1992, Assessment of protein models with three-dimensional profiles, Nature 356:83.
8. Malherbe P., Köhler C., Da Prada M., Lang, G., Kiefer V., Schwarcz R., Lahm H.-W and Cesura A.M., 1994, Molecular cloning and functional expression of human 3-hydroxyanthranilic-acid dioxygenase, J. Biol. Chem. 269:13792.
9. Malherbe, P., Alberati-Giani, D., Köhler, C, and Cesura A.M., 1995, Identification of a mitochondrial form of kynurenine aminotransferase/glutamine transaminase K from rat brain. FEBS Lett., in press.
10. Mosca, M., Cozzi, L., Breton, J., Speciale, C., Okuno, E., Schwarcz, R., and Benatti, L., 1994, Molecular cloning of rat kynurenine aminotransferase: identity with glutamine transaminase K. FEBS Letters 353:21.
11. Okuno E., Du F., Ishikawa T., Tsujimoto M., Nakamura M., Schwarcz R., and Kydo R., 1990, Purification and characterization of kynurenine-pyruvate aminotransferase from rat kidney and brain. Brain Res. 534:37.
12. Okuno E., Schmidt W., Parks D.A., Nakamura M., and Schwarcz R., 1991, Measurement of rat brain kynurenine aminotransferase at physiological kynurenine concentrations, J. Neurochem. 57:533.
13. Pellicciari R., Natalini B., Costantino G., Mahmoud M.R., Mattoli L., Sadeghpour B.M., Moroni F., Chiarugi A., and Carpenedo R., 1994, Modulation of the kynurenine pathway in search for new neuroprotective agents. Synthesis and preliminary evaluation of (m-Nitrobenzoyl)alanine, a potent inhibitor of kynurenine-3-hydroxylase, J. Med. Chem. 37:647.
14. Perry S.J., Schofield M.A., MacFarlane M., Lock E.A., King L.J., Gibson G., and Goldfarb P.S., 1993, Isolation and expression of a cDNA coding for rat kidney cytosolic cysteine conjugate β-lyase, Mol. Pharmacol. 43:660.
15. Perry, S., Harries, H., Scholfield, C., Lock, T., Ling, L., Gibson, G., and Goldfarb, P., 1995, Molecular cloning and expression of a cDNA for human kidney cysteine conjugate β-lyase. FEBS Lett. 360:277.
16. 3H]kynurenine as substrate, Neuroscience 55,: 177.
17. Stevens J.L., Ayoubi N., and Robbins J.D., 1988, The role of mitochondrial matrix enzymes in the metabolism and toxicity of cysteine conjugates, J Biol. Chem. 263:3395.
18. Stone T.W., 1993, Neuropharmacology of quinolinic and kynurenic acids, Pharmacol.Rev. 45:309.
19. von Heijne, G., 1989, Domain structure of mitochondrial and chloroplast targeting peptide, Eur. J. Biochem. 180:535.
20. Walsh, J.L., Todd, W.P., Carpenter, B.K., and Schwarcz, R., 1991, 4-Halo-3-hydroxyanthranilic acids: potent competitive inhibitors of 3-hydroxyanthralic acid oxygenase in vitro, Biochem. Pharmacol. 42:985.