Endogenous and synthetic glucocorticoids in the racing horse: A literature review;Natürliche und synthetische glukokortikoide beim sportpferd: Eine literaturübersicht

Deutsche Tierarztliche Wochenschrift

Volumn 103, Issue 12, 1996, Pages 494-500

  Klaus, Ana Maria ^a   Hapke, H J ^a  

^a UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETAMETHASONE; DEXAMETHASONE; GLUCOCORTICOID; HYDROCORTISONE; METHYLPREDNISOLONE; PREDNISOLONE; PREDNISONE; TRIAMCINOLONE;

ANIMAL; BLOOD; HORSE; HORSE DISEASE; REVIEW; SPECIES DIFFERENCE;

ANIMALS; BETAMETHASONE; DEXAMETHASONE; GLUCOCORTICOIDS; HORSE DISEASES; HORSES; HYDROCORTISONE; METHYLPREDNISOLONE; PREDNISOLONE; PREDNISONE; SPECIES SPECIFICITY; TRIAMCINOLONE;

EID: 0030332283     PISSN: 03416593     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (81)

1. ALEXANDER, S. L., C. H. G. IRVINE, M. J. ELLIS, R. A. DONALD (1991): The effect of acute exercise on the secretion of corticotropin-releasing factor, arginine vasopressin, and adrenocorticotropin as measured in pituitary venous blood from the horse. Endocrinology, 128, 65-72.
2. AUTEFAGE, A., M. ALVINERIE and P. L. TOUTAIN (1986): Synovial fluid and plasma kinetics of methylprednisolone and methylprednisolone acetate in horses following intraarticular administration of methylprednisolone acetate. Equine Vet. J., 18, 193-198.
3. BAKER, H. W. G., I. D. C. BAKER and V. M. EPSTEIN (1982): Effect of stress on steroid hormone levels in racehorses. Aust. Vet. J. 58, 70-71.
4. BONNAIRE, Y., M. A. POPOT, P. PLOU, D. ALJABI and J. GUERIS (1992): GC/MS/NICI method for natural and synthetic corticosteroid detection in equine urine. Administration of dexamethasone and synacthen. Proceedings of the 9th International Conference of Racing Analysts and Veterinarians, New Orleans, Vol. I, 93-102.
5. BOTTOMS, G. D., O. F. ROESEL, F. D. RAUSCH and A. L. AKINS (1972): Circadian variation in plasma cortisol and corticosterone in pigs and mares. Am. J. Vet. Res. 33, 785-790.
6. BURNS, S. J. (1973): Clinical safety of dexamethasone in mares during pregnancy. Equine Vet. J. 5, 91-93.
7. CARAKOSTAS, M. C., W. E. MOORE, J. E. SMITH and D. JOHNSON (1981): Effects of etiocholanolone and prednisolone on intravascular granulocyte kinetics in horses. Am. J. Vet. Res. 42, 626-628.
8. CHAPMAN, D. I., M. S. MOSS and J. WHITESIDE (1977): The urinary excretion of synthetic corticosteroids by the horse. Vet. Rec. 100, 447-450.
9. CHAPMAN, D. I. (1979): The detection of anabolic steroids and corticosteroids by radio-immunoassay. Ir. Vet. J. 33, 37-44.
10. CHEN, C. L., J. A. SAILOR, J. COLLIER and J. WIEGAND (1992): Synovial and serum levels of triamcinolone following intra-articular administration of triamcinolon acetonide in the horse. J. Vet. Pharmacol. Therap. 15, 240-246.
11. CHUI, Y. C., B. ESAW and V. ROBILLO (1992): Detection and confirmation of flumethasone in equine urine. Proceedings of the 9th International Conference of Racing Analysts and Veterinarians, New Orleans, Vol. I, 121-131.
12. CHURCH, D. B., D. L. EVANS, D. R. LEWIS and R. J. ROSE (1987): The effect of exercise on plasma adrenocorticotropin, cortisol and insulin in the horse and adaptations with training. Equine exercise physiology, 2, 506-515.
13. COLBORN, D. R., D. L. THOMPSON jr., T. L. ROTH, J. S. CAPEHART and K. L. WHITE (1991): Responses of cortisol and prolactin to sexual excitement and stress in stallions and geldings. J. Animal Sci. 69, 2556-2562.
14. COPPOC, G. L. (1984): Relationship of a dosage form of a corticosteroid to its therapeutic efficacy. J. A. V. M. A. 185, 1098-1101.
15. COVALESKY, M. E., C. R. RUSSONIELLO and K. MALINOWSKI (1992): Effects of show-jumping performance stress on plasma cortisol and lactate concentrations and heart rate and behaviour in horses. J. Eq. Vet. Sci. 12, 244-251.
16. DUMASIA, M. C., E. HOUGHTON, M. S. MOSS and J. CHAKRABORTY (1979): Metabolism of dexamethasone in the horse. Proceedings of the 3rd International Symposium on Equine Medication Control, Lexington, Kentucky, June 12-14, 1979, 247-252.
17. DYKE, T. M. (1989): Pharmacokinetics of therapeutic substances in racehorses. Australian Equine Veterinarian 7, Suppl. 1, 1-54.
18. EILER, H., J. OLIVER and D. GOBLE (1979): Adrenal gland function in the horse: effect of dexamethasone on hydrocortisone secretion and blood cellularity and plasma electrolyte concentrations. Am. J. Vet. Res. 40, 727-729.
19. EILER, H., J. OLIVER and D. GOBLE (1980): Combined dexamethasone-suppression cosyntropin (synthetic ACTH) stimulation test in the horse: a new approach to testing of adrenal gland function. Am. J. Vet. Res. 41, 430-434.
20. FLISINSKA-BOJANOWSKA, A., K. SKWARLO and J. LUKASZEWSKA et al. (1974): Diurnal variation of serum cortisol and PBI in the thorough-bred horse and effect of physical effort on plasma cortisol concentration. Bull. Acad. Pol. Sci. (biol.). 22, 719-724, zit. nach TOUTAIN und BRANDON 1982.
21. POLAND, J. W., C. W. MCILWRAITH, G. W. TROTTER, B. E. POWERS and R. H. WRIGLEY (1991): Effect of corticosteroids on articular cartilage in equine joints with an osteochondral fragment with and without exercise. Vet. Surgery 20, 335-336.
22. FREESTONE, J. F., K. J. WOLFSHEIMER, R. B. FORD, G. CHURCH and R. BESSIN (1991): Triglyceride, insulin and cortisol responses of ponies, to fasting and dexamethasone administration. J. Vet. Int. Med. 5, 15-22.
23. FRIEDRICH, A., H.-W. HAGEDORN and R. SCHULZ (1990): Nachweis von Dexamethason im Pferd. Tierärztl. Praxis 18, 613-617.
24. FRIEDRICH, A., R. SCHULZ and H. H. D. MEYER (1992): Use of enzyme immunoassay and reversephase high-performance liquid chromatography to detect and confirm identity of dexamethasone in equine blood. Am. J. Vet. Res. 53, 2213-2220.
25. FUBINI, S. L, C. E. BOATWRIGHT, R. J. TODHUNTER and G. LUST (1993): Effect of intramusculary administered polysulfated glycosaminglycan on articular cartilage from equine joints injected with methylprednisolone acetate. Am. J. Vet. Res. 54, 1359-1365.
26. GABEL, A. A., D. W. MILNE, R. S. RAY, J. NOONAN, W. W. MUIR, R. T. SKARDA and M. F. WEINGOLD (1983): A study of the effects of methylprednisolone, promazine, amphetamine, and furosemide on physiological parameters in standardbred horses performing a submaximal exercise test. Equine Exercise Physiology, Proceedings of the first international conference, 531-537.
27. GYLSTORFF, B., und D. HEGNER (1982): Radioimmunologische Bestimmung der Triamcinolonacetonid-Konzentration im Pferdeplasma. Berl. Münchn. Tierärztl. Wschr. 95, 325-330.
28. GYLSTORFF, B., und D. HEGNER (1983): Die Beeinflussung der endogenen Cortisolkonzentration im Pferdeplasma durch eine einmalige i. m. Applikation von Triamcinolonacetonid (Volon A®) beim Pferd - Möglichkeit einer Wirkungskontrolle. Prakt. Tierarzt 64, 206-210.
29. HIGGINS, A. J., P. LEES and A. D. SEDGWICK (1987): Development of equine models of inflammation. Vet. Rec. 120, 517-522.
30. HOEIJMAKERS, M., A. COERT and D. HAACK (1994): Comparative pharmacokinetics of dexamethasone in dogs, horses and cows after intravenous administration, in: Proceedings 6th Internat Congress EAVPT, Edinburgh, 52.
31. HOFFSIS, G. F., P. W. MURDICK, V. L. THARP and K. AULT (1970): Plasma concentrations of cortisol and corticosterone in the normal horse. Am. J. Vet. Res. 31, 1379-1387.
32. HOUGHTON, E., and A. GINN (1992): Studies related to hydrocortisone. Proceedings of the 9th International Conference of Racing Analysts and Veterinarians, New Orleans, Vol. II, 209-222.
33. IRVINE, C. H. G., R. J. HUUN, S. L. ALEXANDER (1988): The cortisol concentration in post-race urine of racehorses, and factors affecting it. Proceedings of the 7th International Conference of Racing Analysts and Veterinarians, Lexington, 101-105.
34. IRVINE, C. H. G. (1989): Corticosteroids and ACTH. In: Proceedings of a course in Drug Usage in Horses. Publication No. 122, Veterinary Continuing Education, Massey University, 25-32.
35. JAMES, V. H. T., M. W. HORNER and M. S. MOSS et al. (1970): Adrenocortical function in the horse. J. Endocrinol. 48, 319-335.
36. JOHNSON, A. L., and K. MALINOWSKI (1986): Daily rhythm of cortisol and evidence for a photo-inducible phase for prolactin secretion in nonpregnant mares housed under non-interrupted and skeleton photoperiods. J. Anim. Sci. 63, 169-175.
37. JOUANY, J. M., Y. BONNAIRE, J. BELLGAUD and C. BOUDENE (1981): High performance liquid chromatography and routine screening for steroids. In: Proceedings of the 4th International Conference on the Control of the Use of Drugs in Racehorses, Melbourne, 135-142.
38. KAMERLING, S., M. KEOWEN, C. BAGWELL and J. OWENS (1992): Dexamethasone effects on equine behavior. Proceedings of the 9th International Conference of Racing Analysts and Veterinarians, New Orleans, Vol. II, 309-312.
39. KIETZMANN, M., D. ARENS, W. LÖSCHER and D. LUBACH (1991): Studies on the percutaneous absorption of dexamethasone using a new in vitro model, the isolated perfused bovine udder. In: R. C. SCOTT, R. H. GUY, J. HADGRAFT und H. E. BODDÉ: Prediction of percutaneous penetration. Vol. 2, S. 519-526.
40. KOLK van-der-, J. H., H. C. KALSBEEK, T. WENSING, H. J. BREUKINK and J. H. Van-der KOLK (1994): Urinary concentration of corticoid in normal horses and horses with hyperadrenocorticism. Res. Vet. Sci., 56, 126-129.
41. KUMAR, M. S. A., T. F. LIAO and C. L. CHEN (1976): Diurnal variation in serum cortisol in ponies. J. Anim. Sci. 42, 1360.
42. LANE, P. (1986): Untersuchungen über die Wirkung von Dexamethason-21-isonicotinat bei Pferden. Inaug.-Diss., Tierärztliche Hochschule Hannover.
43. LAPOINTE, J. M., J. P. LAVOIE and A. A. VRINS (1993): Effects of triamcinolone acetonide on pulmonary function and bronchoalveolar lavage cytologic features in horses with chronic obstructive pulmonary disease. Am J. Vet. Res. 54, 1310-1316.
44. LARSSON, M., L. E. EDQVIST, L. EKMAN and S. PERSSON (1979): Plasma cortisol in the horse, diurnal rhythm and effects of exogenous ACTH. Acta Vet. Scand. 20, 16-24.
45. LEES, P., A. J. HIGGINS, A. D. SEDGWICK and M. J. DANIEL (1987): Actions of betamethasone in models of acute non-immune inflammation. Brit. Vet. J. 143, 143-158.
46. LENTJES, E. G., F. ROMIJN, R. J. MAASSEN, L. de GRAF, P. GAUTIER and A. J. MOOLENAAR (1993): Free cortisol in serum assayed by temperature-controlled ultrafiltration before fluorescence polarization immunoassay. Clin. Chim. 39, 2518-2521.
47. LEPAGE, O. M., S. LAVERTY, M. MARCOUX and G. DUMAS (1993): Serum osteocalcin concentration in horses treated with triamcinolone acetonide. Am. J. Vet. Res. 54, 1209-1212.
48. LILLICH, J. D., A. L. BERTONE, L. M. SCHMALL, A. J. RUGGLES, R. A. SAMS (1994): Detection and absorption of methylprednisolone acetate and isoflupredone acetate after intra-articular administration. Vet. Surgery 23, 407.
49. LINDEN, A., T. ART, H. AMORY, D. DESMECHT and P. LEKEUX (1990): Comparison of the adrenocortical response to both pharmacological and physiological stresses in sport horses. J. Vet. Med. Series A 37, 601-604.
50. LOTH, J., R. L. MASON, J. C. NG, A. A. SEAWRIGHT and D. P. STEELE (1981): Radioimmunoassay for dexamethasone and cortisol in the blood and urine of racing thoroughbred. In: Proceedings of the 4th International Conference on the Control of the Use of Drugs in Racehorses, Melbourne, 74-81.
51. MACHARG, M. A., G. D. BOTTOMS, G. K. CARTER and M. A. JOHNSON (1985): Effects of multiple intramuscular injections and doses of dexamethasone on plasma cortisol concentrations and adrenal responses to ACTH in horses. Am. J. Vet. Res. 46, 2285-2287.
52. MCCARTHY, R., L. JEFFCOTT, I. CLARKE, J. FUNDER, I. SMITH and C. A. WALLACE (1991): Evaluation of stress in horses. Austral. Equine Vet. 9, 34.
53. MOSS, M. S. und E. G. C. CLARKE (1977): A review of drug "clearance times" in racehorses. Equine Vet. J. 9, 53-56.
54. 2-adrenoceptor stimulation in horses. In: Proc. 6th Internat. Congress EAVPT, Edinburgh, 283.
55. RALSTON, J. M., A. M. STENHOUSE, N. S. STENHOUSE, G. J. BUCK, S. F. LUCK, J. A. REYNOLDSEN, J. R. BOLTON (1988): Cortisol concentrations in blood and urine of horses. Australian Vet. J. 65, 1-5.
56. RALSTON, J. M., and A.M. STENHOUSE (1990): Urinary excretion of methylprednisolone. Proceedings of the 8th International Conference of Racing Analysts and Veterinarians, Harare, 95-105.
57. RALSTON, J. M., A. M. STENHOUSE and C. I. RUSSO (1990): Cortisol levels in blood and urine of horses. Proceedings of the 8th International Conference of Racing Analysts and Veterinarians, Harare, 181-186.
58. REIMERS, T. J., R. G. COWAN, H. P. DAVIDSON and E. D. COLBY (1931): Validation of radioimmunoassay for triiodothyronine, thyroxine and hydrocortisone (cortisol) in canine, feline, and equine sera. Am. J. Vet. Res. 42, 2016-2021.
59. RIVET. J.-M., L. STINUS, M. LEMOAL and P. MORMEDE (1989): Behavioral sensitization to amphetamine is dependent on corticosteroid receptor activation. Brain Res. 498, 149-153.
60. SCHIERZ, H. G. (1988): Zur Bestimmung von Triamcinolonacetonid und Kortisol beim Pferd und Hund, insbesondere bei der Ankaufsuntersuchung der Pferde. Inaug.-Diss., Justus-LJebig-Universität, Gießen.
61. SCHLINGLOFF, Y.: Inaug.-Diss. Tierärztliche Hochschule Hannover, in Vorbereitung.
62. SEAWRIGHT, A. A., J. C. NG, D. P. STEELE, R. MASON, J. J. LOTH (1979): The detection of dexamethasone administrations in thoroughbred horses, in: Proceedings of the 3rd International Symposium on Equine Medication Control, Lexington, 227-246.
63. SHOEMAKER, R. S., A. L. BERTONE, G. S. MARTIN, C. W. MCILWRAITH, E. D. ROBERTS, R. PECHMAN and M. T. KEARNEY (1992): Effects of intra-articular administration of methylprednisolone acetate on normal articular cartilage and on healing of experimentally induced osteochondral defects in horses. Am. J. Vet. Res. 53, 1446-1453.
64. SIMON, F., P. LACZAY, Z. MORA and J. LEHEL (1990): Target animal safety test of a dexamethasone-prednisolone combination in horses. Dtsch. tierärztl. Wschr. 97, 339-340.
65. SLONE, D. E., R. C. PUROHIT, V. K. GANJAM and J. L. LOWE (1983): Sodium retention and cortisol (hydrocortisone) suppression caused by dexamethasone and triamcinolone in equids. Am. J. Vet. Res. 44, 359-372.
66. SOJKA, J. E., M. A. JOHNSON and G. D. BOTTOMS (1993): The effect of starting time on dexamethasone suppression test results in horses. Domestic Animal Endocrinology 10, 1-5.
67. TOBIN, T. (1978): Pharmacology review: testing for drugs in horses. J. Equine Med. Surg. 2, 518-524, zit. nach DYKE, 1989.
68. TOBIN, T., and W. E. WOODS (1989): Steroidal anti-inflammatory agents and adrenocorticotropic hormone. In: Proceedings of a course in drug usage in horses. Publication No. 122, Veterinary Continuing Education, Massey University, Palmerston North, 33-48.
69. TOUTAIN, P. L, and R. A. BRANDON (1982): Steroidal anti-inflammatory agents in the horse: pharmacokinetics and action on the adrenal gland. In: Proceedings from the 2nd European Association for Veterinary Pharmacology and Toxicology 353-366.
70. TOUTAIN, P. L., R. A. BRANDON, H. de POMYERS, M. ALVINERIE and J. D. BAGGOT (1984): Dexamethasone and prednisolone in the horse: pharmacokinetics and action on the adrenal gland. Am. J. Vet Res. 45, 1750-1756.
71. TROTTER, G. W., C. W. MCILLWRAITH, J. V. YOVICH, R. W. NORDIN, R. H. WRIGLEY and C. H. LAMAR (1991): Effects of intraarticular administration of methylprednisolone acetate on normal equine articular cartilage. Am. J. Vet. Res. 52, 83-87.
72. UNGEMACH, F. R. (1992): Beurteilung fixer Glukokortikoid-Antibiotika-Kombinationen. Dtsch. tierärztl. Wschr. 99, 249-254.
73. UNGEMACH, F. R. (1994): Pharmakologische Beeinflussung von Entzündungen. - Kortikosteroide. In: LÖSCHER, W., F. R. UNGEMACH und R. KROKER: Grundlagen der Pharmakotherapie bei Haus- und Nutztieren. 2. Auflage, Verlag Paul Parey, Berlin und Hamburg, 325-342.
74. VERNIMB, G. D., L. M. VAN HOOSE and P. W. HENNESSEY (1977): Onset and duration of corticosteroid effect after injection of Betasone® for treating equine arthropathies. Vet. Med. Small Animal Clinician 72, 241-244.
75. VERSCHOOTEN, F., P. DESMET, K. PEREMANS, T. PICAVET (1990): Navicular disease in the horse: the effect of controlled intrabursal corticoid injection. Equine Veterinary Science/Equine Sports Medicine, July/August, 316-320.
76. VINE, J. H., D. C. BATTY, K. E. MASON, A. M. STENHOUSE, J. M. RALSTON and C. I. RUSSO (1992): The detection of corticosteroids by GC/MS and GC/MS/MS. Proceedings of the 9th International Conference of Racing Analysts and Veterinarians, New Orleans, Vol. I, 103-110.
77. WATRIN, L. R. (1988): The influence of synthetic corticosteroids on racing performance. In: Proceedings of the 7th International Conference of Racing Analysts and Veterinarians, Louisville, 1988, 37-39.
78. WILCKENS, T. (1995): Glucocorticoids and immune function: physiological relevance and pathogenic potential of hormonal dysfunction. TiPS 16,193-197.
79. YOUNG, L., und T. YEOW (1983): A study on the determination of fluprednisolone in equine plasma and urine. Proceedings 5th International Conference on Control of the Use of Drugs in Racehorses, Toronto, 96-103.
80. ZHU, D., K. D. GILLIS and C.-L. CHEN (1992): Development of ELISA and RIA for detection of dexamethasone in horse serum, plasma, and urine. Proceedings of the 9th International Conference of Racing Analysts and Veterinarians, New Orleans, Vol. I, 393-394.
81. ZOLOVICK, A., D. W. UPSON and B. E. ELEFTHERIOUS (1966): Diurnal variation in plasma glucocorticosteroid levels in the horse. J. Endocrin. 35, 249-253.