Gonadectomy modifies the gender specific pattern of desensitization of pituitary cells by gonadotropin-releasing hormone in the superfusion system

Acta Biologica Hungarica

Volumn 47, Issue 1-4, 1996, Pages 195-205

  Horváth, Judit E ^a,b   Helyes, Zsuzsa ^a   Flerko B ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

^b UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

Desensitization; GnRH; Gonadectomy; Pituitary cells; Rat

Indexed keywords

GONADORELIN; LUTEINIZING HORMONE;

ADENOHYPOPHYSIS; ANIMAL; ARTICLE; COMPARATIVE STUDY; DRUG EFFECT; DRUG RESISTANCE; FEMALE; IN VITRO STUDY; MALE; ORCHIECTOMY; OVARIECTOMY; OVARY; PHYSIOLOGY; RAT; SECRETION; SEXUAL DEVELOPMENT; TESTIS; WISTAR RAT;

ANIMALS; DRUG RESISTANCE; FEMALE; GONADOTROPIN-RELEASING HORMONE; LUTEINIZING HORMONE; MALE; ORCHIECTOMY; OVARIECTOMY; OVARY; PITUITARY GLAND, ANTERIOR; RATS; RATS, WISTAR; SEX CHARACTERISTICS; TESTIS;

EID: 0030330670     PISSN: 02365383     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Bauer-Dantoin, A. C., Hollenberg, A. N., Jameson, J. L. (1993) Dynamic regulations of gonadotropin-releasing hormone receptor mRNA levels in the anterior pituitary gland during the rat estrous cycle. Endrocrinology 133, 1911-1914.
2. Clayton, R. N. (1982) Gonadotropin-releasing hormone modulation of its own pituitary receptors: evidence for biphasic regulation. Endocrinology 111, 152-161.
3. Csernus, V., Schally, A. V. (1991) The dispersed cell superfusion system. In: Greenstein, B. (ed.) Neuroendocrine Research Methods. Harwood Academic Publishers, London, pp. 66-102.
4. Evans, W. S., Krieg, R. J., Limber, E. R., Kaiser, D. L., Thorner, M. O. (1985) Effects of in vivo gonadal hormone environment on in vitro hGRF-40-stimulated GH release. Am. J. Physiol. 249, E276-E280.
5. Gharib, S. D., Wierman, M. E., Badger, T. M., Chin, W. (1987) Sex steroid hormone regulation of follicle stimulating a hormone subunit messenger ribonucleic acid (mRNA) levels in the rat. J. Clin. Invest. 80, 294-299.
6. Horváth, J. E., Kéri, Gy., Seprodi, A., Teplán, I., Flerkó, B. (1992) Desensitization of pituitary cells by gonadotrophin-releasing hormone or its analogues in the superfusion system: different pattern for males and females. J. Neuroendocrinology 4, 565-573.
7. Horváth, J. E., Schally, A. V. (1994) Reciprocal changes in prolactin and growth hormone secretion in vitro after in vivo estrogen treatment. Acta Biol. Hung. 45, 249-262.
8. Huckle, W. R., Conn, M. (1988) Molecular mechanism of gonadotropin releasing hormone action. II. The effector system. Endocr. Rev. 9, 387-395.
9. Janovick, J. A., Conn, P. M. (1993) A cholera toxin-sensitive guanyl nucleotide binding protein mediates the movement of pituitary luteinizing hormone into a releasable pool: loss of this event is associated with the onset of homologous desensitization to gonadotropin-releasing hormone. Endocrinology 132, 2131-2135.
10. Lamberts, S. W. J., Macleod, R. M. (1990) Regulation of prolactin secretion at the level of the lactotroph. Physiol. Rev. 70, 279-318.
11. Loumaye, E., Catt, K. J. (1982) Homologous regulation of gonadotropin-releasing hormone receptors in cultured pituitary cells. Science 215, 983-985.
12. Mercer, J. E., Clemens, J. A., Funder, J. W., Clarke, I. J. (1989) Regulation of follicle stimulating hormone β and common α-subunit messenger ribonucleic acid by gonadotropin-releasing hormone and estrogen in the sheep pituitary. Neuroendocrinology 50, 321-326.
13. Meredith, J. M., Levine, J. E. (1992) Effects of castration on LH-RH patterns in intrahypophysial microdialysates. Brain Res. 571, 181-188.
14. Moenter, S. M., Brand, R. M., Midgley, A. R., Karsch, F. J. (1992) Dynamics of gonadotropin-releasing hormone release during a pulse. Endocrinology 130, 503-510.
15. Savoy-Moore, R. T., Schwartz, N. B., Duncan, J. A., Marshall, J. C. (1980) Pituitary gonadotropin releasing-hormone receptors during the rat estrous cycle. Science 209, 942-944.
16. Smith, M. A., Perrin, M. H., Vale, W. W. (1983) Desensitization of cultured pituitary cells to gonadotropin-releasing hormone: evidence for a postreceptor mechanism. Mol. Cell. Endocrinol. 30, 85-96.
17. Vigh, S., Schally, A. V. (1984) Interaction between hypothalamic peptides in a superfused pituitary cell system. Peptides 5 (Suppl. 1), 241-247.
18. Weiss, J., Cote, C. R., Jameson, J. L., Crowley, W. F. (1995) Homologous desensitization of gonadotropin-releasing hormone (GnRH)-stimulated luteinizing hormone secretion in vitro occurs within the duration of an endogenous GnRH pulse. Endocrinology 136, 138-143.