4(R)- And 4(S)-(5-phenylpentyl)-glutamic Acids Attenuate Excitatory Postsynaptic Potential on Hippocampus without Inhibiting Postsynaptic NMDA and AMPA Receptors

Chinese Journal of Physiology

Volumn 39, Issue 2, 1996, Pages 131-137

  Tyan, Sheue Houy ^a   Chang, Hsiuming ^a   Gean, Po Wu ^b   Hon, Yung Son ^c   Chang, Yen Chung ^a  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c NATIONAL CHUNG CHENG UNIVERSITY   (Taiwan)

Author keywords

Brain slice; EPSP; Glutamate receptor; Inhibition; Rat hippocampus; Synthetic L glutamate analogue; Whole cell patch clamp

Indexed keywords

5 PHENYLPENTYLGLUTAMIC ACID; 5-PHENYLPENTYLGLUTAMIC ACID; AMPA RECEPTOR; DRUG DERIVATIVE; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL; ARTICLE; CHEMICAL PHENOMENA; DRUG EFFECT; ELECTROPHYSIOLOGY; EVOKED RESPONSE; HIPPOCAMPUS; MALE; NERVE CELL; PATCH CLAMP; PHYSIOLOGY; RAT; SPRAGUE DAWLEY RAT; STEREOISOMERISM; SYNAPSE;

ANIMALS; DEPRESSION, CHEMICAL; ELECTROPHYSIOLOGY; EVOKED POTENTIALS; GLUTAMIC ACID; HIPPOCAMPUS; MALE; NEURONS; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, AMPA; RECEPTORS, N-METHYL-D-ASPARTATE; STEREOISOMERISM; SYNAPSES;

EID: 0030330017     PISSN: 03044920     EISSN: 26660059     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Bliss, T.V.P. and G.L. Collingridge A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361: 31-39, 1993.
2. Chang, Y.-C, Y.-S. Hon, W.-Y. Chow, T.-A. Lin, P.-Y. Cheng, and C.-M. Wang. Study of the stereoselectivity of L-glutamate receptors by synthetic 4(R)- and 4(S)- substituted L-glutamate analogues. Brain Res. 604: 86-89, 1993.
3. Chittajallu, R., M. Vignes, K.K. Dev, J.M.Barnes, G.L. Collingridge and J.M. Henley. Regulation of glutamate release by presynaptic kainate receptors in hippocampus. Nature 379: 78-81, 1996.
4. Choi, D.W. The role of glutamate neuotoxicity in hypoxic-ischemic neuronal death. Annu. Rev. Neurol. 13: 171-182, 1990.
5. 2+ accumulation in cortical cell culture correlates with subsequent neuronal degeneration. Neurosci. 13: 1993-2000, 1993.
6. Hollmann, M. and S. Heinemann. Cloned glutamate receptors. Annu. Rev. Neurosci. 17: 31-108, 1994.
7. Hon, Y.-S., Y.-C. Chang and M.-L. Gong. Syntheses of (2S,4S)-and (2S,4R)-4-substituted glutamic acid analogues for neuroexcitatory activity studies. Heterocycles 31: 191-195, 1990.
8. + ) of N-methyl-D-aspartate-activated currents in rat hippocampal neurons. Neurosci. Lett. 189: 17-20, 1995.
9. Monaghan, D.T., R.J. Bridge, and C.W. Cotman. The excitatory amino acid receptors. Annu. Rev. Pharmacol. Toxicol. 29:365-402, 1989.
10. Monyer, H., R. Sprengel, R. Schoepfer, A. Herb, M. Higuchi, H. Lomeli, N. Burnashev, B. Sakmann, and P.H. Seeburg. Heteromeric NMDA receptors-molecular and functional distinction of subtypes. Science 256: 1217-1221, 1992.
11. ++ -free solutions. Neuron 8: 181-187, 1992.
12. Pellegrini-Giampietro, D.E., R.S. Zukin, M.V.L. Bennett, S. Cho and W.A. Pulsinelli. Switch in glutamate receptor subunit gene expression in CA1 subfield of hippocampus following global ischemia in rats. Proc. Natl. Acad. Sci. USA 89: 10499-10503, 1993.
13. Pollard, H., C. Charriaut-Marlangue, S. Cantagrel, A. Represa, O. Robain, J. Moreau, Y. Ben-Ari. Kainate-induced apoptotic cell death in hippocampal neurons. Neuroscience 63: 7-18, 1994.
14. Sawada, S., Higashima, M and Yamamoto, C. Inhibition of high affinity uptake augment depolarization of hippocampal neurons induced by glutamate, kainate & related compounds. Exp. Brain Res. 60: 323-329, 1985.
15. Watkins, J.C, P. Krogsgaard-Larsen, and T. Honore. Structure-activity relationship in the development of excitatory amino acid receptor agonists and competitive antagonists, Trends Pharmacol. Sci. 11: 25-33, 1990.