Receptors mediating tachykinin-evoked depolarisations of neurons in the neonatal rat spinal cord

Acta Biologica Hungarica

Volumn 47, Issue 1-4, 1996, Pages 129-144

  Fox, Alyson J ^b   Naeem, S ^a   Patel, I A ^a   Walpole, C ^a   Urban L ^a  

^a Sandoz Institute for Medical Research   (United Kingdom)

^b NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

Spinal cord; Tachykinin antagonists; Tachykinin receptors

Indexed keywords

2 [1 IMINO 2 (2 METHOXYPHENYL)ETHYL] 7,7 DIPHENYLPERHYDROISOINDOL 4 ONE; 2 BENZHYDRYL 3 (2 METHOXYBENZYLAMINO) 1 AZABICYCLO[2.2.2]OCTANE; BIPHENYL DERIVATIVE; DRUG DERIVATIVE; INDOLE DERIVATIVE; NEUROKININ 1 RECEPTOR; NEUROKININ 2 RECEPTOR; NEUROKININ 3 RECEPTOR; NEUROKININ A; NEUROKININ A (4 10), BETA ALA(8); NEUROKININ A (4-10), BETA-ALA(8)-; NEUROKININ A(4 10), TYR(5) TRP(6,8,9) LYS(10); NEUROKININ A(4-10), TYR(5)-TRP(6,8,9)-LYS(10)-; PEPTIDE FRAGMENT; PYROGLUTAMIC ACID; SENKTIDE; SEPTIDE; SUBSTANCE P; SUBSTANCE P, METHYL ESTER; SUBSTANCE P, METHYL ESTER-; SUBSTANCE P, SAR(9) MET(O2)(11); SUBSTANCE P, SAR(9)-MET(O2)(11)-; TACHYKININ; TACHYKININ RECEPTOR;

ANIMAL; ARTICLE; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; EVOKED RESPONSE; IN VITRO STUDY; NERVE CELL; NEWBORN; PHYSIOLOGY; RAT; SPINAL CORD; SPRAGUE DAWLEY RAT;

ANIMALS; ANIMALS, NEWBORN; BIPHENYL COMPOUNDS; EVOKED POTENTIALS; INDOLES; NEUROKININ A; NEURONS; PEPTIDE FRAGMENTS; PYRROLIDONECARBOXYLIC ACID; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NEUROKININ-1; RECEPTORS, NEUROKININ-2; RECEPTORS, NEUROKININ-3; RECEPTORS, TACHYKININ; SPINAL CORD; SUBSTANCE P; TACHYKININS;

EID: 0030330014     PISSN: 02365383     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. 1 receptors. Br. J. Pharmacol. 108, 223-227.
2. 1 receptors by use of the non-peptide antagonist (±)-CP-96,345. Br. J. Pharmacol. 104, 292-293.
3. 125I/Bolton Hunter-eledoisin binding sites in rat spinal cord by quantitative autoradiography. Neuroscience 46, 225-232.
4. DeKoninck, Y., Henry, J. L. (1991) Substance P mediated slow excitatory potential elicited in dorsal horn neurons in vivo by noxious stimulation. Proc. Natl. Acad. Sci. USA 88, 11344-11348.
5. Duggan, A. W., Hendry, A. I., Morton, C. R., Hutchinson, W. D., Zhao, Z. Q. (1988) Cutaneous stimuli releasing immunoreactive substance P in the dorsal horn of the cat. Brain Res. 451, 262-273.
6. Duggan, A. W., Hope, P. J., Jarrott, B., Schaible, H.-G., Fleetwood-Walker, S. M. (1990) Release, spread and persistence of immunoreactive neurokinin A in the dorsal horn of the cat following noxious cutaneous stimulation. Neuroscience 35, 195-202.
7. 2) receptor. Life Sci. 50, 101-106.
8. Fleetwood-Walker, S. M., Mitchell, R., Hope, P. J., El-Yassir, N., Molony, V., Bladon, C. M. (1990) The involvement of neurokinin receptor subtypes in somatosensory processing in the superficial dorsal horn of the cat. Brain Res. 519, 169-182.
9. 2 receptors mediating brief nociceptive inputs to rat dorsal horn (laminae III-V) neurons. Eur. J. Pharmacol. 242, 173-181.
10. Garret, C., Carruette, A., Fardin, V., Moussaoui, S., Peyronel, J.-F., Blanchard, J.-C., Laduron, M. (1991) Pharmacological properties of a potent and selective nonpeptide substance P antagonist. Proc. Natl. Acad. Sci. USA 88, 10208-10212.
11. Guo, J.-Z., Yoshioka, K., Yanagisawa, M., Hosoki, R., Hagan, R. M., Otsuka, M. (1993) Depression of primary afferent-evoked responses by GR71252 in the isolated spinal cord of the neonatal rat. Br. J. Pharmacol. 110, 1142-1148.
12. 2 receptor antagonists. Reg. Peptides 46, 9-19.
13. Henry, J. L. (1976) Effects of substance P on functionally identified units in cat spinal cord. Brain Res. 114, 439-451.
14. 1 receptor antagonist, on a primary afferent-evoked response of ventral roots in the neonatal rat spinal cord. Br. J. Pharmacol. 113, 1141-1146.
15. Ireland, S. J., Wright, I. K., Jordan, C. C. (1992) Characterisation of tachykinin-induced ventral root depolarisation in the neonatal rat isolated spinal cord. Neuroscience 46, 217-223.
16. 1 receptor antagonist, on facilitation of a nociceptive spinal flexion reflex in the rat. Br. J. Pharmacol. 109, 713-718.
17. Lepre, M., Evans, R., Olpe, H.-R., Brugger, F. (1993) The modulation of the monosynaptic reflex by substance P in the hemisected spinal cord preparation of the rat and gerbil. Neuroscience 55, 727-735.
18. 2 receptor. Eur. J. Pharmacol. 258, 23-31.
19. 2 receptor selective antagonist, MEN 10,376. J. Pharmacol. Exp. Ther. 257, 1172-1178.
20. Maggi, C. A., Patacchini, R., Rovero, P., Giachetti, A. (1993) Tachykinin receptors and tachykinin receptor antagonists. J. Autonom. Pharmacol. 13, 23-93.
21. 2 receptors in the circular muscle of the guinea-pig ileum and proximal colon. Br. J. Pharmacol. 112, 150-160.
22. 3 type tachykinin receptor mRNA expression in the rat spinal cord dorsal horn is increased during adjuvant or formalin-induced nociception. J. Neurosci. 14, 712-720.
23. 3 receptors obtained by rational design. Br. J. Pharmacol. 113, 2P.
24. 1 receptor subtypes in the rat urinary bladder. Br. J. Pharmacol. 111, 739.
25. Nagy, I., Maggi, C. A., Dray, A., Woolf, C. J., Urbán, L. (1993) The role of neurokinin and NMDA receptors in capsaicin-sensitive synaptic transmission in the dorsal horn of the rat spinal cord. Neuroscience 52, 1029-1037.
26. Ogawa, T., Kanazawa, I., Kimura, S. (1985) Regional distribution of substance P, neurokinin A and neurokinin B in rat spinal cord, nerve roots and dorsal root ganglia and the effects of dorsal root section or spinal transection. Brain Res. 359, 151-157.
27. Petitet, F., Saffroy, M., Torrens, Y., Lavielle, S., Chassaing, G., Loeuillet, D., Glowinski, J., Beaujouan, J.-C. (1992) Possible existence of a new tachykinin receptor subtype in the guinea-pig ileum. Peptides 13, 383.
28. Randic, M., Miletic, V. (1977) Effect of substance P in cat dorsal horn neurons activated by noxious stimuli. Brain Res. 128, 161.
29. Salter, M. W., Henry, J. L. (1991) Responses of functionally identified neurones in the dorsal horn of the cat spinal cord to substance P, neurokinin A and physalaemin. Neuroscience 43, 601.
30. 1) receptor. Science 251, 435.
31. Sundler, F., Brodin, E., Elkbald, E., Hakanson, R., Uddman, R. (1985) Sensory nerve fibres: distribution of substance P, neurokinin A and calcitonin gene-related peptide. In: Hakanson, R., Sundle, R., Sundle F. (eds) Tachykinin Antagonists. Elsevier, Amsterdam, p. 3.
32. Suzuki, H., Yoshioka, K., Maehara, T., Hagan, R. M., Nakanishi, S., Otsuka, M. (1993) Pharmacological characteristics of tachykinin receptors mediating acetylcholine release from neonatal spinal cord. Eur. J. Pharmacol. 241, 105.
33. Thompson, S. W. N., Urban, L., Dray, A. (1993) Contribution of NK1 and NK2 receptor activation to high threshold afferent fibre evoked ventral root responses in the rat spinal cord in vitro. Brain Res. 625, 100.
34. Thompson, S. W. N., Dray, A., Urban, L. (1994) Injury-induced plasticity of spinal reflex activity: NK1 neurokinin receptor activation and enhanced A- and C-fiber mediated responses in the rat spinal cord in vitro. J. Neurosci. 14, 3672.
35. Urban, L., Naeem, S., Patel, I. A., Dray, A. (1994) Tachykinin induced regulation of excitatory amino acid responses in the rat spinal cord in vitro, Neurosci. Lett. 168, 185.
36. Wang, Z.-Y., Tung, S. R., Strichartz, G. R., Håckanson, R. (1994) Non-specific actions of the non-peptide tachykinin receptor antagonists CP-96,345, RP 67580 and SR 48968, on neurotransmission. Br. O. Pharmacol. 111, 179-184.
37. Woolf, C. J., Wiesanfeld-ttellin, Z. (1986) Substance P and calcitonin gene-related peptide synergistically modulate the gain of the nociceptor flexor withdrawal reflex in the rat, Neurosci. Lett, 66, 319-323.
38. 2 tachykinin receptors in the mediation of spinal reflex excitability in the rat. Neuroscience 44, 483-490.
39. Xu, X.-Y., Dalsgaard, C. J., Wiesenfeld-Hallin, Z. (1992) Intrathecal CP-96,345 blocks reflex facilitation induced in rats by substance P and C-fiber conditioning stimulation, Eur. J. Pharmacol. 216, 337-344.
40. Yaksh, T. L., Jessel, T. M., Gamse, R., Mudge, A. W., Leeman, S. E. (1980) Intrathecal morphine inhibits substance P release from mammalian spinal cord in vivo. Nature 286, 155-157.
41. Yanagisawa, M., Otsuka, M. (1990) Pharmacological profile of a tachykinin antagonist, spantide, as examined on rat spinal motorneurones. Br. J. Pharmacol. 100, 711-716.
42. Yasphal, K., Dam, T.-V., Quirion, R. (1990) Quantitative autoradiographic distribution of multiple neurokinin binding sites in rat spinal cord. Brain Res. 506, 259-266.