Toxins affecting K+ channels

Brazilian Journal of Medical and Biological Research

Volumn 29, Issue 12, 1996, Pages 1765-1780

  Rowan, E G ^a   Harvey, A L ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

Calcium dependent potassium channels; Molecular pharmacology; Neuropharmacology; Potassium channel toxins; Voltage dependent potassium channels

Indexed keywords

CALCIUM CHANNEL; POTASSIUM CHANNEL; TOXIN;

CELL MEMBRANE POTENTIAL; DRUG EFFECT; PHYSIOLOGY; REVIEW;

CALCIUM CHANNELS; MEMBRANE POTENTIALS; POTASSIUM CHANNELS; TOXINS, BIOLOGICAL;

EID: 0030321135     PISSN: 0100879X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (186)

1. Harvey AL, Anderson AJ & Rowan EG (1993). Toxins affecting ion channels. In: Harvey AL (Editor), Natural and Synthetic Neurotoxins. Academic Press Harcourt Brace Jovanovich, London, 129-185.
2. + channels in the central nervous system. In: Cook NS (Editor), Potassium Channels. Structure, Classification, Function and Therapeutic Potential. Horwood, Chichester, 348-381.
3. Rudy B (1988). Diversity and ubiquity of K channels. Neuroscience, 25: 729-749.
4. Adams DJ & Nonner W (1990). Voltage-dependent potassium channels: gating, ion permeation and block. In: Cook NS (Editor), Potassium Channels: Structure, Classification, Function and Therapeutic Potential. Horwood, Chichester, 40-69.
5. Pongs O (1992). Molecular biology of voltage-dependent potassium channels. Physiological Reviews, 72: S69-S88.
6. Aldrich R (1993). Advent of a new family. Nature, 362: 107-108.
7. Chiu SY, Ritchie JM, Rogart RB & Stagg D (1979). A quantitative description of the membrane currents in rabbit myelinated nerve. Journal of Physiology, 292: 149-166.
8. Brismar T (1980). Potential clamp analysis of membrane currents in rat myelinated nerve fibres. Journal of Physiology, 298: 171-184.
9. Dodge FA & Frankenhaeuser B (1958). Sodium currents in the myelinated nerve fibres of Xenopus laevis investigated with the voltage clamp technique. Journal of Physiology, 143: 76-90.
10. Dubois J-M (1983). Potassium currents in the frog node of Ranvier. Progress in Biophysical and Molecular Biology, 42: 1 -20.
11. Chiu SY & Ritchie JM (1980). Potassium channels in nodal and internodal axonal membrane of mammalian myelinated fibres. Nature, 284: 170-171.
12. Wilson GF & Chiu SY (1990). Ion channels in axon and Schwann cell membranes at paranodes of mammalian myelinated fibers studied with patch clamp. Journal of Neuroscience, 10: 3263-3274.
13. Hagiwara S, Kusano K & Saito N (1961). Membrane changes of Onchidium nerve cell in potassium-rich media. Journal of Physiology, 155: 470-489.
14. Rogawski MA (1985). The A-current: how ubiquitous a feature of excitable cells is it? Trends in Neurosciences, 8: 214-219.
15. + current in hippocampal neurons. Nature, 336: 379-381.
16. Vandenberg CA (1987). Inward rectification of a potassium channel in cardiac ventricular cells depends on internal magnesium ions. Proceedings of the National Academy of Sciences, USA, 84: 2560-2564.
17. Katz B (1949). Les constantes électriques de la membrane du muscle. Archives de Science Physiologique, 3: 285-299.
18. Marty A (1989). The physiological role of calcium-dependent channels. Trends in Neurosciences, 12: 420-424.
19. Marty A (1981). Ca-dependent K channels with large unitary conductance in chromaffin cell membranes. Nature, 291: 497-500.
20. Barren JN, Magleby KL & Pallotta BS (1982). Properties of single calcium-activated potassium channels in cultured-rat muscle. Journal of Physiology, 331: 211-230.
21. Haylett DG & Jenkinson DH (1990). Calcium-activated potassium channels. In: Cook NS (Editor), Potassium Channels, Structure, Classification, Function and Therapeutic Potential. Horwood, Chichester, 70-95.
22. Bülbring E & Tomita T (1987). Catecholamine action on smooth muscle. Pharmacological Reviews, 39: 49-96.
23. Kaplan WD & Trout III WE (1969). The behavior of four neurological mutants of Drosophila, Genetics, 61: 399-409.
24. Wu C-F & Haugland FN (1989). Voltage clamp analysis of membrane currents in larval muscle fibers of Drosophila: alterations of potassium currents in shaker mutants. Journal of Neuroscience, 5: 2626-2640.
25. Ganetsky B & Wu C-F (1986). Neurogenetics of membrane excitability in Drosophila. Annual Review of Genetics, 20: 13-44.
26. Jan LY & Jan YN (1990). How might the diversity of potassium channels be generated? Trends in Neurosciences, 13: 415-419.
27. Strong PN (1990). The molecular structure of potassium channels. In: Cook NS (Editor), Potassium Channels: Structure, Classification, Function and Therapeutic Potential. Horwood, Chichester, 23-34.
28. Miller C (1989). Genetic manipulation of ion channels: a new approach to structure and mechanism. Neuron, 2: 1195-1205.
29. Pongs O, Kecskemethy N, Müller R, Krah-Jentgens I, Baumann A, Kiltz HH, Canal I, Llamazares S & Ferrus A (1988). Shaker encodes a family of putative potassium channel proteins in the nervous system of Drosophila. EMBO Journal, 7: 1087-1096.
30. Ruppersberg JP, Schroter KH, Sakman B, Stocker M, Sewing S & Pongs O (1990). Heteromultimeric channels formed by rat brain potassium-channel protein. Nature, 345: 535-537.
31. + channels detected in vivo. Nature, 365: 72-75.
32. + channels in terminal and juxtaparanodal regions of neurons. Nature, 365: 75-79.
33. + channels. Proceedings of the National Academy of Sciences, USA, 88: 5092-5095.
34. Aldrich RW, Hoshi T & Zagotta WN (1990). Biophysical and molecular mechanisms of shaker potassium channel inactivation. Science, 250: 533-538.
35. + channels: effects of alterations in the carboxy-terminal regions. Neuron, 7: 547-556.
36. Zagotta WN, Hoshi T & Aldrich RW (1990). Restoration of inactivation in mutants of shaker potassium channels by a peptide derived from ShB. Science, 250: 568-571.
37. MacKinnon R & Miller C (1989). Mutant potassium channels with altered binding of charybdotoxin, a pore-blocking peptide inhibitor. Science, 245: 1382-1385.
38. MacKinnon R, Heginbotham L & Abramson T (1990). Mapping the receptor site for charybdotoxin, a pore-blocking potassium channel inhibitor. Neuron, 5: 767-771.
39. Hurst RS, Busch AE, Kavanaugh MP, Osborne PB, North RA & Adelman JP (1991). Identification of amino acid residues involved in dendrotoxin block of rat voltage-dependent potassium channels. Molecular Pharmacology, 40: 572-576.
40. Adelman JP, Shen KZ, Kavanaugh MP, Warren RA, Wu YN, Lagrutta A, Bond CT & North RA (1992). Calcium-activated potassium channels expressed from cloned complementary DNAs. Neuron, 9: 209-216.
41. + channel modulated by a functionally associated protein kinase. Nature, 369: 563-565.
42. Wei A, Solaro C, Lingle C & Salkoff L (1994). Calcium sensitivity of BK-type K(Ca) channels determined by a separable domain. Neuron, 13: 671-681.
43. Reinhart PH, Chung S & Levitan IB (1989). A family of calcium-dependent potassium channels from rat brain. Neuron, 2: 1031-1041.
44. Cook NS & Quast U (1990). Potassium channel pharmacology. In: Cook NS (Editor), Potassium Channels: Structure, Classification, Function and Therapeutic Potential. Horwood, Chichester, 181-255.
45. Moczydlowski E, Lucchesi K & Ravindran A (1988). An emerging pharmacology of peptide toxins targeted against potassium channels. Journal of Membrane Biology, 105: 95-111.
46. Dreyer F (1990). Peptide toxins and potassium channels. Reviews of Physiology, Biochemistry and Pharmacology, 115: 93-136.
47. Strong PN (1990). Potassium channel toxins. Pharmacology and Therapeutics, 46: 137-162.
48. + channel blocking peptide, purified from the venom of the scorpion Centruroides noxius Hoffmann. Carlsberg Research Communications, 47: 285-289.
49. Harvey AL, Marshall DL & Possani LD (1990). Noxiustoxin blocks neuronal potassium channels and facilitates the evoked release of acetylcholine. Toxicon, 28: 152A.
50. + channel blocker is located on its amino-terminal portion. Journal of Neural Transmission, 77: 11-20.
51. + channels by a novel scorpion toxin. Nature, 296: 90-91.
52. + channel by noxiustoxin: a toxin from the venom of the scorpion Centruroides noxius. Pflügers Archives, 408: 423-431.
53. 2+) channel. FEBS Letters, 226: 280-284.
54. + permeability. Journal of Neuroscience, 6: 1570-1574.
55. + channels. British Journal of Pharmacology, 114: 1502-1506.
56. Prestipino G, Valdivia HH, Lievano A, Darszon A, Ramirez AN & Possani LD (1989). Purification and reconstitution of potassium channel proteins from squid axon membranes. FEBS Letters, 250: 570-574.
57. Swanson R, Marshall J, Smith JS, Williams JB, Boyle MB, Folander K, Luneau CJ, Antanavage J, Oliva C, Buhrow SA, Bennett C, Stein RB & Kaczmarek LK (1990). Cloning and expression of cDNA and genomic clones encoding three delayed rectifier potassium channels in rat brain. Neuron, 4: 929-939.
58. + channels. FEBS Letters, 278: 55-60.
59. + channels, types Kv1.1, 1.2, 1.3, 1.5 and 3.1, stably expressed in mammalian cell lines. Molecular Pharmacology, 45: 1227-1234.
60. Harvey AL & Karlsson E (1980). Dendrotoxin from the venom of the green mamba, Dendroaspis angusticeps. A neurotoxin that enhances acetylcholine release at neuromuscular junctions. Naunyn-Schmiedeberg's Archives of Pharmacology, 312: 1-6.
61. Harvey AL & Karlsson E (1982). Protease inhibitor homologues from mamba venoms: facilitation of acetylcholine release and interactions with prejunctional blocking toxins. British Journal of Pharmacology, 77: 153-161.
62. Strydom DJ (1976). Snake venom toxins: purification and properties of low-molecular-weight polypeptides from Dendroaspis polylepis polylepis (black mamba) venom. European Journal of Biochemistry, 69: 169-176.
63. Benishin CG, Sorensen RG, Brown WE, Krueger BK & Blaustein MP (1988). Four polypeptide components of green mamba venom selectively block certain potassium channels in rat brain synaptosomes. Molecular Pharmacology, 34: 152-159.
64. Marshall DL & Harvey AL (1990). Re-examination of the protease inhibitor activities of the dendrotoxins from mamba venoms. Toxicon, 28: 157-158.
65. +-channel probe alpha-dendrotoxin. Journal of Neurochemistry, 54: 343-346.
66. + channel sub-types in rat brain: characteristic locations revealed using beta-bungarotoxin, alpha- and beta-dendrotoxins. Neuroscience, 40: 29-39.
67. Harvey AL & Andersen AJ (1991). Dendrotoxins: snake toxins that block potassium channels and facilitate neurotransmitter release. In: Harvey AL (Editor), Snake Toxins. Pergamon Press, New York, 131-164.
68. Harvey AL & Anderson AJ (1985). Dendrotoxins: snake toxins that block potassium channels and facilitate neurotransmitter release. Pharmacology and Therapeutics, 31: 33-55.
69. Anderson AJ (1985). The effects of protease inhibitor homologues from mamba snake venoms on autonomic neurotransmission. Toxicon, 23: 947-954.
70. Anderson AJ & Harvey AL (1988). Effects of the potassium channel blocking dendrotoxins on acetylcholine release and motor nerve terminal activity. British Journal of Pharmacology, 93: 215-221.
71. Barrett JC & Harvey AL (1979). Effects of the venom of the green mamba Dendroaspis angusticeps on skeletal neuromuscular transmission. British Journal of Pharmacology, 67: 199-205.
72. Dolly JO, Halliwell JV, Black JD, Williams RS, Pelchen-Matthews A, Breeze AL, Mehraban F, Othman IB & Black AR (1984). Botulinum neurotoxin and dendrotoxin as probes for studies on transmitter release. Journal de Physiologie, 79: 280-303.
73. Halliwell JV, Othman IB, Pelchen-Matthews A & Dolly JO (1986). Central action of dendrotoxin: selective reduction of transient K conductance in hippocampus and binding to localized acceptors. Proceedings of the National Academy of Sciences, USA, 83: 493-497.
74. McGivern J & Scolfield CN (1991). Dendrotoxin partially blocks potassium 'A' currents of nerve terminals in slices of rat brain. Journal of Physiology, 432: 20A.
75. Weller U, Bernhardt U, Siemen D, Dreyer F, Vogel W & Habermann E (1985). Electrophysiological and neurobiochemical evidence for the blockade of a potassium channel by dendrotoxin. Naunyn-Schmiedeberg's Archives of Pharmacology, 330: 77-83.
76. Benoit E & Dubois J-M (1986). Toxin I from the snake Dendroaspis polylepis polylepis: a high specific blocker of one type of potassium channel in myelinated nerve fibre. Brain Research, 377: 373-377.
77. + current in Xenopus nerve fibres selectively blocked by bee and snake toxins: binding and voltage-clamp experiments. Journal of Physiology, 420: 365-385.
78. Jonas P, Brau ME, Hermsteiner M & Vogel W (1989). Single-channel recording in myelinated nerve fibres reveals one type of Na channel but different K channels. Proceedings of the National Academy of Sciences, USA, 86: 7238-7242.
79. + channels in rat myelinated nerve fibres and their sensitivity to dendrotoxin. Pflügers Archives, 418: 408-416.
80. Penner R, Petersen M, Pierau F-K & Dreyer F (1986). Dendrotoxin: selective blocker of a non-inactivating potassium current in guinea-pig dorsal root ganglion neurones. Pflügers Archives, 407: 365-369.
81. Stansfeld CE, Marsh SJ, Halliwell JV & Brown DA (1986). 4-Aminopyridine and dendrotoxin induce repetitive firing in rat visceral sensory neurones by blocking a slowly inactivating outward current. Neuroscience Letters, 64: 299-304.
82. Stansfeld CE, Marsh SJ, Parcel DN, Dolly JO & Brown DA (1987). Mast cell degranulating peptide and dendrotoxin selectively inhibit a fast-activating potassium current and bind to common neuronal proteins. Neuroscience, 23: 893-902.
83. Stansfeld CE, Fagnit L, Marsh SJ, Brown DA & Feltz A (1991). Kinetics of the dendrotoxin-sensitive K-current in dissociated dorsal root ganglion (DRG) neurons of the rat. Journal of Physiology, 434: 91A.
84. + channels in dorsal root ganglion cells. Neuroscience Letters, 93: 49-55.
85. + currents in cultured sensory neurones from neonatal rats. British Journal of Pharmacology, 113: 959-967.
86. Harvey AL & Anderson AJ (1987). Pharmacological actions of facilitatory neurotoxins on peripheral synapses. In: Jenner PG (Editor), Neurotoxins and Their Pharmacological Implications. Raven Press, New York, 97-114.
87. Dreyer F & Penner R (1987). The actions of presynaptic snake toxins on membrane currents of mouse motor nerve terminals. Journal of Physiology, 386: 455-463.
88. Velluti JC, Caputi A & Macadar O (1987). Limbic epilepsy induced in the rat by dendrotoxin, a polypeptide isolated from the green mamba (Dendroaspis angusticeps) venom. Toxicon, 25: 649-657.
89. Silveira R, Siciliano J, Abo V, Viera L & Dajas F (1988). Intrastriatal dendrotoxin injection: behavioral and neurochemical effects. Toxicon, 26: 1009-1015.
90. Silveira R, Barbeito L & Dajas F (1988). Behavioural and neurochemical effects of intraperitoneally injected dendrotoxin. Toxicon, 26: 287-292.
91. + channel toxins, MCD peptide and dendrotoxin I. Brain Research, 495: 45-57.
92. + channel probe. Neuroscience, 29: 347-361.
93. + channel opener lemakalim. Brain Research, 554: 22-29.
94. Stutzmann J-M, Bohme GA, Gandolfo G, Gottesmann C, Lafforgue J, Blanchard J-C, Laduron PM & Lazdunski M (1991). Riluzole prevents hyperexcitability produced by the mast cell degranulating peptide and dendrotoxin I in the rat. European Journal of Pharmacology, 193: 223-229.
95. Stühmer W, Ruppersberg JP, Schroter LH, Sakmann B, Stocker M, Giese CP, Perschke A, Baumann A & Pongs O (1989). Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain. EMBO Journal, 8: 3235-3244.
96. + channel-specific drugs and mutations. Journal of Experimental Biology, 147: 21-41.
97. +-channel. Neuroscience, 50: 935-946.
98. Black AR, Donegan CM, Denny BJ & Dolly JO (1988). Solubilization and physical characterization of acceptors for dendrotoxin and beta-bungarotoxin from synaptic membranes of rat brain. Biochemistry, 27: 6814-6820.
99. +-channel protein identified by its binding properties for dendrotoxin. Proceedings of the National Academy of Sciences, USA, 85: 4919-4923.
100. Parcej DM & Dolly JO (1989). Dendrotoxin acceptor from bovine synaptic plasma membranes. Biochemical Journal, 257: 899-903.
101. Sorensen RG & Blaustein MP (1989). Rat brain dendrotoxin receptors associated with voltage-gated potassium channels: dendrotoxin binding and receptor solubilization. Molecular Pharmacology, 36: 689-698.
102. + channel protein. Journal of Biological Chemistry, 265: 20094-20097.
103. + channels. Biochemistry, 27: 1827-1832.
104. + channel. FEBS Letters, 249: 224-228.
105. Busch A, Hurst R, Kavanaugh MP, Christie MJ, Osborne PB, Adelman JP & North RA (1991). The site of binding of alpha-dendrotoxin to voltage-dependent oocytes. Journal of Physiology, 434: 32A.
106. Breithaupt H & Habermann E (1968). Mastzelldegranulierendes Peptid (MCD-peptid). Naunyn-Schmiedeberg's Archiv für Pharmakologie und Experimentelle Pathologie, 261: 252-270.
107. Hanson JM, Morley J & Soria-Herrera O (1974). Anti-inflammatory property of 401 (MCD-peptide). a peptide from the venom of the bee Apis mellifera (L). British Journal of Pharmacology, 50: 383-392.
108. Dotimas EM, Hamid KR, Hider RC & Ragnarsson U (1987). Isolation and structure analysis of the bee venom mast cell degranulating peptide. Biochimica et Biophysica Acta, 911: 285-293.
109. Kumar NV, Wemmer DE & Kallenbach NR (1988). Structure of p401 (mast cell degranulating peptide) in solution. Biophysical Chemistry, 31: 113-119.
110. Kobayashi Y, Sato A, Takashima H, Tamaoki H, Nishimura S, Kyogoku Y, Ikenaka K, Kondo T, Mikoshiba K, Hojo H, Aimoto S & Moroder L (1991). A new alpha-helical motif in membrane active peptides. Neurochemistry International, 18: 525-534.
111. Fujimoto I, Ikenaka K, Kondo T, Aimoto S, Kuno M & Mikoshiba K (1991). Mast cell degranulating (MCD) peptide and its optical isomer activate GTP binding protein in rat mast cells. FEBS Letters, 287: 15-18.
112. Taylor JW, Bidard J-N & Lazdunski M (1984). The characterization of high-affinity binding sites in rat brain for the mast cell-degranulating peptide from bee venom using the purified monoiodinated peptide. Journal of Biological Chemistry, 259: 13957-13967.
113. + channel ligands co-fractionate upon partial purification. FEBS Letters, 240: 65-70.
114. Tomita U, Takahashi K, Ikenaka K, Kondo T, Fujimoto I, Aimoto S, Mikoshiba K, Ui M & Katada T (1991). Direct activation of GTP-binding proteins by venom peptides that contain cationic clusters within their alpha-helical structures. Biochemical and Biophysical Research Communications, 178: 400-406.
115. Habermann E (1977). Neurotoxicity of apamine and MCD peptide upon central application. Naunyn-Schmiedeberg's Archives of Pharmacology, 300: 189-191.
116. + channels, have interacting receptor sites. Biochemical and Biophysical Research Communications, 143: 383-389.
117. Neuman R, Ben Ari Y & Cherubini E (1991). Mast cell degranulating peptide increases the frequency of spontaneous miniature postsynaptic currents in CA3 rat hippocampal neurons. European Journal of Neuroscience, 3: 523-530.
118. Cherubini E, Ben Ari Y, Gho M, Bidard JN & Lazdunski M (1987). Long-term potentiation of synaptic transmission in the hippocampus induced by bee venom peptide. Nature, 328: 70-73.
119. Cherubini E, Neuman R, Rovira C & Ben Ari Y (1988). Epileptogenic properties of the mast cell degranulating peptide in CA3 hippocampal neurones. Brain Research, 445: 91-100.
120. Kondo T, Ikenaka K, Kato H, Ito K, Aimoto S, Hojo H & Mikoshiba K (1990). Long-term enhancement of synaptic transmission by synthetic mast cell degranulating peptide and its localization of binding sites of hippocampus. Neuroscience Research, 8: 147-157.
121. Sequier J-M & Lazdunski M (1990). Mast cell degranulating peptide induces the expression of the c-fos proto-oncogene in hippocampus. European Journal of Pharmacology, 180: 179-181.
122. + channel openers prevent epilepsy induced by the bee venom peptide MCDP. European Journal of Pharmacology, 159: 329-330.
123. Bidard J-N, Gandolfo G, Mourre C, Gottesmann C & Lazdunski M (1987). The brain response to the bee venom peptide MCD. Activation and desensitization of a hippocampal target. Brain Research, 418: 235-244.
124. +-channel ligands β-bungarotoxin, dendro toxin and mast cell-degranulating peptide. European Journal of Biochemistry, 178: 771-778.
125. Sequier J-M, Brennand J, Barhanin J & Lazdunski M (1990). Regional expression of a MCD-peptide and dendrotoxin 1-sensitive voltage-dependent potassium channel in rat brain. FEBS Letters, 263: 163-165.
126. 2 activity in snake venoms. Proceedings of the National Science Council Republic of China. Part B, 9: 126-142.
127. Harris JB (1991). Phospholipases in snake venoms and their effects on nerve and muscle. In: Harvey AL (Editor), Snake Toxins. Pergamon Press, New York, 91-129.
128. Petersen M, Penner R, Pierau F-K & Dreyer F (1986). Beta-bungarotoxin inhibits a non-inactivating potassium current in guinea-pig dorsal root ganglion neurones. Neuroscience Letters, 68: 141-145.
129. Andersen AJ, Harvey AL & Rowan EG (1987). Facilitation of neurotransmitter release by snake toxins. In: Tucek S (Editor), Synaptic Transmitters and Receptors. Academia, Prague, 392-398.
130. Rowan EG & Harvey AL (1988). Potassium channel blocking actions of beta-bungarotoxin and related toxins on mouse and frog motor nerve terminals. British Journal of Pharmacology, 94: 839-847.
131. Rowan EG, Pemberton KE & Harvey AL (1990). On the blockade of acetylcholine release at mouse motor nerve terminals by beta-bungarotoxin and crotoxin. British Journal of Pharmacology, 100: 301-304.
132. 3H-beta-bungarotoxin: demonstration of saturable binding to brain synapses and its inhibition by toxin I. European Journal of Biochemistry, 128: 267-276.
133. 2 activity to synaptosomal membrane preparations from the guinea pig brain. Journal of Protein Chemistry, 5: 221-228.
134. Degn LL, Seebart CS & Kaiser H (1991). Specific binding of crotoxin to brain synaptosomes and synaptosomal membranes. Toxicon, 29: 973-988.
135. + channel synaptosomes. Proceedings of the National Academy of Sciences, USA, 91: 1475-1479.
136. Eccles CU, Rogowski RS, Gu X, Alger BE & Blaustein MP (1994). Tityustoxin-K alpha, from scorpion venom, blocks voltage-gated, non-inactivating potassium current in cultured central neurons. Neuropharmacology, 33: 1523-1528.
137. Garcia-Calvo M, Leonard RJ, Novick J, Stevens SP, Schmalhofer W, Kaczorowski GJ & Garcia ML (1993). Purification, characterization, and biosynthesis of margatoxin, a component of Centruroides margaritatus venom that selectively inhibits voltage-dependent potassium channels. Journal of Biological Chemistry, 268: 18866-18874.
138. Karlsson E, Adem A, Aneiros A, Castaneda O, Harvey A, Jolkkonen M & Sotolongo V (1991). New toxins from marine organisms. Toxicon, 29: 1168.
139. Harvey AL, Anderson AJ, Rowan EG, Marshall DL, Castaneda O & Karlsson E (1991). Dendrotoxin-like activity isolated from sea-anemones. British Journal of Pharmacology, 104: 34A.
140. Harvey AL, Anderson AJ, Marshall DL, Rowan EG, Vatanpour H, Castaneda O & Karlsson E (1992). Neurotoxins acting on ion channels and modulating transmitter release. In: Kawai N (Editor), Neuroreceptors, Ion Channels and Brain, Elsevier, Amsterdam, 35-41.
141. Aneiros A, Garcia I, Martinez JR, Harvey AL, Anderson AJ, Marshall DL, Engstrom A, Hellman U & Karlsson E (1993). A potassium channel toxin from the secretion of the sea anemone activity. Biochimica et Biophysica Acta, 1157: 86-92.
142. + channels. Journal of Biological Chemistry, 270: 25121-25126.
143. Pappone PA & Cahalan MD (1988). Pandinus imperator scorpion venom blocks voltage-gated potassium channels in GH3 cells. Journal of General Physiology, 91: 817-833.
144. Pappone PA & Cahalan MD (1987). Pandinus imperator scorpion venom blocks voltage-gated potassium channels in nerve fibers. Journal of Neuroscience, 7: 3300-3305.
145. Marshall DL & Harvey AL (1989). Block of potassium channels and facilitation of acetylcholine release at the neuromuscular junction by the venom of the scorpion, Pandinus imperator. Toxicon, 27: 493-498.
146. Koppenhoper E & Schmidt H (1968). Die Wirkung von Skorpiongift auf die lonenströme des Ranvierschen Schnurrings. Pflügers Archives, 303: 133-149.
147. + channels from Leiurus quinquestriatus var hebraeus venom. Biochemistry, 33: 6834-6839.
148. Habermann E (1984). Apamin. Pharmacology and Therapeutics, 25: 255-270.
149. + channels. Brain Research, 451: 274-284.
150. + channels, on learning and memory processes. Brain Research, 551: 322-326.
151. Hugues M, Duval D, Kitabgi P, Lazdunski M & Vincent J-P (1982). Preparation of a pure monoiodo derivative of the bee venom neurotoxin apamin and its binding properties to rat brain synaptosomes. Journal of Biological Chemistry, 257: 2762-2769.
152. Pennefather P, Lancaster B, Adams PR & Nicoll RA (1985). Two distinct Ca-dependent K currents in bullfrog sympathetic ganglion cells. Proceedings of the National Academy of Sciences, USA, 82: 3040-3044.
153. Lancaster B & Nicoll RA (1987). Properties of two calcium-activated hyperpolarizations in rat hippocampal neurones. Journal of Physiology, 389: 187-203.
154. Zhang L & Krnjevic K (1987). Apamin depresses selectively the after-hyperpolarisation of cat spinal cord motoneurons. Neuroscience Letters, 74: 58-62.
155. + channels, on motor nerve terminals. British Journal of Pharmacology, 95: 1329-1335.
156. Labbe-Jullie C, Granier C, Albericio F, Defendini M-L, Ceard B, Rochat H & Van Rietschoten J (1991). Binding and toxicity of apamin. Characterization of the active site. European Journal of Biochemistry, 196: 639-645.
157. Hugues M, Romey G, Duval D, Vincent JP & Lazdunski M (1982). Apamin as a selective blocker of the calcium-dependent potassium channel in neuroblastoma cells: voltage-clamp and biochemical characterization of the toxin receptor. Proceedings of the National Academy of Sciences, USA, 79: 1308-1312.
158. + channels. In: Jenner PG (Editor), Neurotoxins and Their Pharmacological Significance. Raven Press, New York, 65-80.
159. Chicchi GC, Gimenez-Gallego G, Ber E, Garcia ML, Winquist R & Cascieri MA (1988). Purification and characterization of a unique, potent inhibitor of apamin binding from Leiurus quinquestriatus hebraeus. Journal of Biological Chemistry, 263: 10192-10197.
160. Levleque C, Marqueze B, Couraud F & Seagar M (1990). Polypeptide components of the apamin receptor associated with a calcium activated potassium channel. FEBS Letters, 275: 185-189.
161. + channels from mammalian skeletal muscle. Nature, 313: 316-318.
162. Gimenez-Gallego G, Navia MA, Reuben JP, Katz GM, Kaczorowski GJ & Garcia ML (1988). Purification, sequence, and model structure of charybdotoxin, a potent selective inhibitor of calcium-activated potassium channels. Proceedings of the National Academy of Sciences, USA, 85: 3329-3333.
163. Massefski Jr W, Redfield AG, Hare DR & Miller C (1990). Molecular structure of charybdotoxin, a pore-directed inhibitor of potassium ion channels. Science, 249: 521-524.
164. 1H-NMR. Charybdotoxin possesses a structural motif found in other scorpion toxins. European Journal of Biochemistry, 196: 19-28.
165. + channel blocker. Biochemical and Biophysical Research Communications, 170: 684-690.
166. + channel. Journal of Biological Chemistry, 265: 18745-18748.
167. Robitaille R & Charlton MP (1992). Presynaptic calcium signals and transmitter release are modulated by calcium-activated potassium channels. Journal of Neuroscience, 12: 297-305.
168. Sivarsamakrishnan S, Bittner GD & Brodwick MS (1988). A charybdotoxin-sensitive calcium-activated potassium conductance at the crayfish neuromuscular junction: implications for transmitter release and facilitation. Neuroscience Abstracts, 13: 69.
169. Alger BE & Williamson A (1983). A transient calcium-dependent potassium component of the epileptiform burst after-hyperpolarisation in rat hippocampus. Journal of Physiology, 399: 191-205.
170. + channels. FEBS Letters, 250: 519-522.
171. Harvey AL, Marshall DL, De-Allie FA & Strong PN (1989). Interactions between dendrotoxin, a blocker of calcium-activated potassium channels, at binding sites on neuronal membranes. Biochemical and Biophysical Research Communications, 163: 394-397.
172. Vasquez J, Feigenbaum P, King VF, Kaczorowski GJ & Garcia ML (1990). Characterization of high affinity binding sites for charybdotoxin in synaptic plasma membranes from rat brain. Journal of Biological Chemistry, 265: 15564-15571.
173. Schneider MJ, Rogowski RS, Krueger BK & Blaustein MP (1989). Charybdotoxin blocks both Ca-activated channels and Ca-independent voltage-gated K channels in rat brain synaptosomes. FEBS Letters, 250: 433-436.
174. 2+ in cerebrocortical synaptosomes: an effect not shared by apamin. FEBS Letters, 255: 159-162.
175. + channel-blocking peptides. Neuron, 15: 5-10.
176. Chesnut TJ, Carpenter DO & Strichartz GR (1987). Effects of venom from Conns striatus on the delayed rectifier potassium current of molluscan neurons. Toxicon, 25: 267-278.
177. Gossen D, Gesquiere JC, Tastenoy M, De Neef P, Waelbroeck M & Christophe J (1991). Characterisation and regulation of the expression of scyllatoxin (leiurotoxin I) receptors in the human neuroblastoma cell line NB-OK. FEBS Letters, 285: 271-274.
178. Galvez A, Gimenez-Gallego G, Reuben JP, Roy-Contancin L, Feigenbaum P, Kaczorowski GJ & Garcia ML (1990). Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus. Journal of Biological Chemistry, 265: 11083-11090.
179. + channels characterized from Androctomus mauretanicus mauretanicus venom. Journal of Biological Chemistry, 267: 1640-1647.
180. Robitaille R, Garcia ML, Kaczorowski GJ & Charlton MP (1993). Functional colocalization of calcium and calcium-gated potassium channels in control of transmitter release. Neuron, 11: 645-655.
181. + channels. Proceedings of the National Academy of Sciences, USA, 87: 8903-8907.
182. Stühmer W, Stocker M, Sakmann B, Seeburg P, Baumann A, Grupe A & Pongs A (1988). Potassium channels expressed from rat brain. cDNA have delayed rectifier properties. FEBS Letters, 242: 199-206.
183. Christie MJ, Adelman JP, Douglass J & North RA(1989). Expression of a cloned rat brain potassium channel in Xenopus oocytes. Science, 244: 221-224.
184. Grupe A, Schröter KH, Ruppersberg JP, Stocker M, Drewes T, Beckh S & Pongs O (1990), Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family. EMBO Journal, 9: 1749-1756.
185. + currents. Journal of Neuroscience, 11: 918-927.
186. Schröter K-H, Ruppersberg JP, Wunder F, Rettig J, Stocker M & Pongs O (1991). Cloning and functional expression of a TEA-sensitive A-type potassium channel from rat brain. FEBS Letters, 278: 211-216.