Dissolution enhancement of an insoluble drug by physical mixture with a superdisintegrant: Optimization with a simplex lattice design

Pharmaceutical Development and Technology

Volumn 1, Issue 2, 1996, Pages 159-164

  Ferrari, Franca ^a   Bertoni, Moreno ^a   Bonferoni, Cristina M ^a   Rossi, Silvia ^a   Caramella, Carla ^a   Bolhuis, Gerard K ^b  

^a UNIVERSITY OF PAVIA   (Italy)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Dissolution; Physical mixtures; Simplex lattice design; Superdisintegrants

Indexed keywords

CALCIUM PHOSPHATE DIBASIC; CROSCARMELLOSE SODIUM; DISINTEGRATING AGENT; LACTOSE; PREDNISONE;

ARTICLE; CONTROLLED STUDY; DRUG SOLUBILITY; PRIORITY JOURNAL; REGRESSION ANALYSIS; TABLET COMPRESSION; TABLET DISINTEGRATION TIME; TABLET FORMULATION;

EID: 0030317743     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.3109/10837459609029890     Document Type: Article

References (14)

1. C. Nystrom and M. Westerberg, The use of ordered mixtures for improving the dissolution rate of low solubility compounds, J. Pharm. Pharmacol., 38, 161-165 (1986).
2. M. Westerberg, B. Jonsson, and C. Nystrom, Physicochemical aspects of drug release. IV. The effect of carrier particle properties on the dissolution rate from ordered mixtures, Int. J. Pharm., 28, 23-31 (1986).
3. P. Nilsson, M. Westerberg, and C. Nystrom, Physicochemical aspects of drug release. V. The importance of surface coverage and compaction on drug dissolution from ordered mixtures, Int. J. Pharm., 45, 111-121 (1988).
4. G. H. P. Te Wierik, G. K. Bolhuis, K. Zuurman, and C. F. Lerk, Improvement of dissolution of poorly soluble drugs by solid deposition on a superdisintegrant. I. Physical mixtures, Acta Pharm. Nord., 4, 239-244 (1992).
5. P. L. Gould, Optimization methods for the development of dosage forms, Int. J. Pharm. Tech. Prod. Mfr., 5(1), 19-24 (1984).
6. J. B. Schwarts, Optimization techniques in pharmaceutical formulation and processing, in Modern Pharmaceutics (G. S. Banker and C. T. Rhodes, eds.), Marcel Dekker, New York, 1990, pp. 803-828.
7. S. Bolton, Pharmaceutical Statistics, Marcel Dekker, New York, 1990, Chap. 16, pp. 532-570.
8. M. Bertoni, F. Ferrari, M.C. Bonferoni, S. Rossi, and C. Caramella, Functionality tests for tablet disintegrants: the case of sodium carboxymethylcelluloses, Pharm. Tech. Eur., 7(10), 17-22 (1995).
9. R. Huisman, H. V. van Kamp, J. E. Weyland, D. A. Doombos, G. K. Bolhuis, and C. F. Lerk, Development and optimization of pharmaceutical formulations using a simplex lattice design, Pharm. Weekbl. Sci. Ed., 6, 185-194 (1984).
10. H. V. van Kamp, G. K. Bolhuis, and C. F. Lerk, Optimization of a formulation for direct compression using a simplex lattice design, Pharm. Weekbl. Sci. Ed., 9, 265-273 (1987).
11. G. K. Bolhuis, C. A. A. Duineveld, J. H. De Boer and P. M. J. Coenegracht, Simultaneous optimization of multiple criteria in tablet formulation: Part I, Pharm. Tech. Eur., 7(6), 42-50 (1995).
12. N. R. Draper and H. Smith, Applied Regression Analysis, Wiley & Sons, New York, 1981, pp. 412-419.
13. C. Caramella, F. Ferrari, M. Ronchi, and A. K. Smilde, An integrated computer-aided approach for modeling disintegration related phenomena, Acta Pharm. Technol., 36, 249-253 (1990).
14. H. V van Kamp, G. K. Bolhuis, K. D. Kussendrager and C. F. Lerk, Studies on tabletting properties of lactose. IV. Dissolution and disintegration properties of different types of crystalline lactose, Int. J. Pharm., 28, 229-238 (1986).