Novel technology for the preparation of sterile alginate-poly-l-lysine microcapsules in a bioreactor

Pharmaceutical Development and Technology

Volumn 1, Issue 1, 1996, Pages 63-68

  Abraham, Sanjay M ^a   Vieth, Robert F ^a   Burgess, Diane J ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

Alginate polylysine; Atomization; Bioreactor; Microencapsulation; Microorganisms; Sterile manufacture

Indexed keywords

ALGINIC ACID; CALCIUM CHLORIDE; POLYLYSINE;

ARTICLE; ASEPSIS; BIOREACTOR; DEVICE; DRUG DOSAGE FORM; GAS FLOW; MICROCAPSULE; PRIORITY JOURNAL; STATISTICAL ANALYSIS;

EID: 0030317451     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.3109/10837459609031419     Document Type: Article

References (7)

1. K. K. Kwok, M. J. Groves, and D. J. Burgess, Production of 5-15 μm alginate-polylysine microcapsules by an air-atomizing technique, Pharm. Res., 8(3), 341-344 (1991).
2. K. K. Kwok, M. J. Groves, and D. J. Burgess, A novel method for the determination of sterility of microcapsules and measurement of viability of encapsulated organisms, Pharm. Res., 9, 410-413 (1992).
3. F. Lim and A. M. Sun, Microencapsulated islets as bioartificial endocrine pancrease, Science, 210, 908-910 (1980).
4. L. Oner and M. J. Groves, Preparation of small gelatin and albumin microparticles by a carbon dioxide atomization process, Pharm. Res., 10 (9), 1385-1388 (1993).
5. T. L. Bowersock, H. HogenEsch, H. Park, and K. Park, Uptake of alginate microspheres by Peyer's patches, in Proceedings of the 21st International Symposium on Controlled Release of Bioactive Materials, 1994, pp. 839-840.
6. S. M. Abraham, R. F. Vieth, and D. J. Burgess, Axenic-polylysine microcapsules prepared in a bioreactor using an atomizing device, Pharm.Res., 11(10), S-135 (1994)
7. T. J. Smith, Calcium alginate hydrogel as a matrix for enteric delivery of nucleic acids, Pharm. Tech., April 1994, pp. 26-30.