The role of dietary folatein modulation of folate receptor expression, folylpolyglutamate synthetase activity and the efficacy and toxicity of lometrexol

Advances in Enzyme Regulation

Volumn 36, Issue , 1996, Pages 365-381

  Mendelsohn, Laurane G ^a   Gates, Susan B ^a   Habeck, Lillian L ^a   Shackelford, Katherine A ^a   Worzalla, John ^a   Shih, Chuan ^a   Grindey, Gerald B ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FOLIC ACID; FOLYLPOLYGLUTAMATE SYNTHASE; LOMETREXOL; 5 METHYLTETRAHYDROFOLIC ACID; 5-METHYLTETRAHYDROFOLATE; ACYLTRANSFERASE; CARRIER PROTEIN; CELL SURFACE RECEPTOR; ENZYME INHIBITOR; FOLATE BINDING PROTEIN; FOLATE-BINDING PROTEIN; PEPTIDE SYNTHASE; PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE; POLYGLUTAMIC ACID; TETRAHYDROFOLIC ACID DERIVATIVE; TRANSFERASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; CONFERENCE PAPER; CONTROLLED STUDY; DIET SUPPLEMENTATION; DISSOCIATION CONSTANT; DRUG EFFICACY; ENZYME ACTIVITY; ENZYME ASSAY; FOLIC ACID DEFICIENCY; GENE EXPRESSION REGULATION; MOUSE; NONHUMAN; RECEPTOR AFFINITY; RECEPTOR DENSITY; RECEPTOR UPREGULATION; ANIMAL; ARTICLE; CELL CULTURE; CHEMISTRY; DIET; DRUG EFFECT; ENZYMOLOGY; KIDNEY; LIVER; METABOLISM; NEOPLASM; PROTEIN BINDING;

ACYLTRANSFERASES; ANIMALS; CARRIER PROTEINS; DIET; ENZYME INHIBITORS; FOLIC ACID; HYDROXYMETHYL AND FORMYL TRANSFERASES; KIDNEY; LIVER; MICE; NEOPLASMS; PEPTIDE SYNTHASES; PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE; POLYGLUTAMIC ACID; PROTEIN BINDING; RECEPTORS, CELL SURFACE; TETRAHYDROFOLATES; TUMOR CELLS, CULTURED;

EID: 0030304135     PISSN: 00652571     EISSN: None     Source Type: Book Series    
DOI: 10.1016/0065-2571(96)00001-5     Document Type: Conference Paper

References (42)

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