Modulation of GABA(A) receptor function by G protein-coupled 5-HT(2C) receptors

Neuropharmacology

Volumn 35, Issue 9-10, 1996, Pages 1355-1363

  Huidobro Toro, J P ^a,b   Valenzuela, C F ^a   Harris, R A ^a,c  

^a UNIVERSITY OF COLORADO   (United States)

^b PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

5 HT(2C) receptors; 5 Hydroxytryptamine; G protein; GABA(A) receptors; Phosphorylation; Xenopus oocytes

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; CALCIUM; CALYCULIN A; COMPLEMENTARY DNA; COMPLEMENTARY RNA; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; GUANINE NUCLEOTIDE BINDING PROTEIN; INOSITOL 1,4,5 TRISPHOSPHATE; NEUROTRANSMITTER; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; RECEPTOR SUBUNIT; SEROTONIN; SEROTONIN 1C RECEPTOR; STAUROSPORINE; 1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N',N'-TETRAACETIC ACID; CHELATING AGENT; CHLORIDE CHANNEL; DRUG DERIVATIVE; EGTAZIC ACID; ENZYME INHIBITOR; MESSENGER RNA; OXAZOLE DERIVATIVE; SEROTONIN RECEPTOR;

ANIMAL CELL; ARTICLE; CHLORIDE CURRENT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; FEMALE; GENE EXPRESSION; HUMAN; MICROINJECTION; NONHUMAN; OOCYTE; PHOSPHORYLATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; XENOPUS LAEVIS; ANIMAL; BIOSYNTHESIS; DRUG ANTAGONISM; DRUG EFFECT; GENETIC TRANSCRIPTION; METABOLISM;

ANIMALS; CHELATING AGENTS; CHLORIDE CHANNELS; EGTAZIC ACID; ENZYME INHIBITORS; GTP-BINDING PROTEINS; HUMANS; OOCYTES; OXAZOLES; PHOSPHOPROTEIN PHOSPHATASE; RECEPTORS, GABA-A; RECEPTORS, SEROTONIN; RNA, MESSENGER; STAUROSPORINE; TRANSCRIPTION, GENETIC; XENOPUS LAEVIS;

EID: 0030299872     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(96)00084-6     Document Type: Article

References (62)

1. 3H-muscimol binding sites within the rat choroid plexus: pharmacological characterization and autoradiographic localization. Pharmacological Res. 21:1989;369-373.
2. Andreasen M., Lambert J.D.C. Noradrenaline receptors participate in the regulation of GABAergic inhibition in area CA1 of the rat hippocampus. J. Physiol. 439:1991;649-669.
3. Badwey J.A., Erickson R.W., Curnutte J.T. Staurosporine inhibits the soluble and membrane-bound protein tyrosine kinases of human neutrophils. Biochem. Biophys. Res. Comm. 178:1991;423-429.
4. Barrett J.E., Vanover K.E. 5-HT receptors as targets for the development of novel anxiolytic drugs: models, mechanism and future directions. Psychopharmacology. 112:1993;1-12.
5. 2+-mediated suppression of the GABA-response through modulation of chloride channel gating in frog sensory neurons. Neurosci. Lett. 86:1988;311-316.
6. 2 receptors in nucleus prepositus hypoglossi. J. Neurosci. 14:1994;2428-2434.
7. Bobker D.H., Williams J.T. Serotonin-mediated inhibitory postsynaptic potential in guinea-pig prepositus hypoglossi and feedback inhibition by serotonin. J. Physiol. 422:1990;447-462.
8. A receptor function is regulated by phosphorylation in acutely dissociated guinea-pig hippocampal neurones. J. Physiol. 420:1990;207-221.
9. Colman A. (1984) Expression of exogenous DNA in Xenopus oocytes. In: Transcription and Translation: A Practical Approach (Hames B.D. and Higgins S.J., Eds), pp 49-59. Oxford Press, Washington, DC. U.S.A.
10. 2C receptors in the regulation of sleep and wakefulness in the rat. Psychopharmacology. 97:1989;436-442.
11. Fallon R.J. Staurosporine inhibits a tyrosine protein kinase in human hepatoma cell membranes. Biochem. Biophys. Res. Comm. 170:1990;1191-1196.
12. Feigenspan A., Bormann J. Facilitation of GABAergic signaling in the retina by receptors stimulating adenylate cyclase. Proc. Natl. Acad. Sci. U.S.A. 91:1994;10893-10897.
13. A-receptor subtypes: differential association of the α1- and α3-subunits with serotoninergic and gabaergic neurons. Neuroscience. 54:1993;881-892.
14. Glaum S.R., Miller R.J. Activation of metabotropic glutamate receptors produces reciprocal regulation of ionotropic glutamate and GABA responses in the nucleus of the tractus solitarius of the rat. J. Neurosci. 13:1993;1636-1641.
15. A receptors. Mol. Pharmacol. 43:1993;970-975.
16. A receptors. Mol. Pharmacol. 44:1993;1211-1218.
17. A receptors. FASEB J. 5:1991;2466-2472.
18. Hartig P.R., Hoffman B.J., Kaufman M.J., Hirata F. The 5-HT1C receptor. Ann. N.Y. Acad. Sci. U.S.A. 600:1990;149-166.
19. 3H]-staurosporine on various protein kinases. Biochem. Biophys. Res. Comm. 171:1990;189-195.
20. Hille B. G protein-coupled mechanisms and nervous signaling. Neuron. 9:1992;187-195.
21. Hoyer D., Clarke D.E., Fozard J.R., Hartig P.R., Martin G.R., Mylecharane E.W., Saxena P.R., Humphrey P.P.A. International union of pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol. Rev. 46:1994;157-203.
22. A receptor-activated chloride exchange. Multiple mechanisms of the chloride channel inactivation. Biochem. Pharmacol. 38:1989;2587-2591.
23. Kim H.G., Wang T., Olafsson P., Lu B. Neurotrophin 3 potentiates neuronal activity and inhibits γ-aminobutyratergic acid synaptic transmission in cortical neurons. Proc. Natl. Acad. Sci. U.S.A. 91:1994;12341-12345.
24. A receptor function by protein kinase C phosphorylation. Neuron. 12:1994;1081-1095.
25. - uptake by brain microsacs. J. Neurochem. 57:1991;722-725.
26. A receptor: role of desensitization. Mol. Pharmacol. 41:1992;1116-1123.
27. A receptors expressed by Xenopus oocytes: lack of involvement of intracellular calcium. J. Pharmacol. Exp. Ther. 263:1992;569-578.
28. Liu Y.B., Disterhoft J.F., Slater T. Activation of metabotropic glutamate receptors induces long-term depression of GABAergic inhibition in hippocampus. J. Neurophysiol. 69:1993;1000-1004.
29. A receptor whole-cell currents expressed in L929 fibroblasts. Neuron. 13:1994;1421-1431.
30. Lo D.C. Neurotrophic factors and synaptic plasticity. Neuron. 15:1995;978-981.
31. Matsumoto H., Sasaki Y. Staurosporine, a protein kinase C inhibitor interferes with proliferation of arterial smooth muscle cells. Biochem. Biophys. Res. Comm. 158:1989;105-109.
32. McDonald B.J., Moss S.J. Differential phosphorylation intracellular domains of the γ-aminobutyric acid type A receptor subunits by calcium/calmodulin type 2-dependent protein kinase and cGMP-dependent protein kinase. J. Biol. Chem. 269:1994;18111-18117.
33. Millhorn D.E., Hokfelt T., Seroogy K., Oertel W., Verhofstad A.A.J., Wu J.-Y. Immunohistochemical evidence for colocalization of γ-aminobutyric acid and serotonin in neurons of the ventral medulla oblongata projecting to the spinal cord. Brain Res. 410:1987;179-185.
34. Millhorn D.E., Hokfelt T., Seroogy K., Oertel W., Verhofstad A.A.J. Extent of colocalization of serotonin and GABA in neurons of the ventral medulla oblongata in rat. Brain Res. 461:1988;169-174.
35. Moss S.J., Doherty C.A., Huganir R.L. Identification of the cAMP-dependent protein kinase and protein kinase C phosphorylation sites within the major intracellular domains of the β1, γ2S, and γ2L subunits of the γ-aminobutytic acid type A receptor. J. Biol. Chem. 267:1992;14470-14476.
36. A receptors by cAMP-dependent protein phosphorylation. Science. 257:1992;661-665.
37. A receptors by tyrosine phosphorylation. Nature. 377:1995;344-348.
38. Mulle C., Choquet D., Korn H., Changeux J.-P. Calcium influx through nicotinic receptor in rat central neurons: its relevance to cellular regulation. Neuron. 8:1992;135-143.
39. Pan Z.Z., Colmers W.F., Williams J.T. 5-HT-mediated synaptic potentials in the dorsal raphe nucleus: interactions with excitatory amino acid and GABA neurotransmission. J. Neurophysiol. 62:1989;481-486.
40. Parfitt K.D., Hoffer B.J., Bickford-Wimer P.C. Potentiation of gamma-aminobutyric acid-mediated inhibition by isoproterenol in the cerebellar cortex: receptor specificity. Neuropharmacology. 29:1990;909-916.
41. 2+ in Xenopus oocytes and facilitates responses to inositol trisphosphate. J. Physiol. 433:1991;207-227.
42. Pessia M., Jiang Z.-G., North R.A., Johnson S.W. Actions of 5-hydroxytryptamine on ventral tegmental area neurons of the rat in vitro. Brain Res. 654:1994;324-330.
43. A receptor current in mouse spinal neurons. Neuron. 5:1990;789-796.
44. Ragozzino D., Eusebi F. Inhibition of GABA and Glycine responses by glutamate in rat hippocampal neurons. Brain Res. 628:1993;115-120.
45. Sanna E., Dildy-Mayfield J.E., Harris R.A. Ethanol inhibits the function of 5-hydroxytryptamine type 1c and muscarinic M1 G protein-linked receptors in Xenopus oocytes expressing brain mRNA: role of protein kinase C. Mol. Pharmacol. 45:1994;1004-1012.
46. Saxena P.R. Serotonin receptors: subtypes, functional responses and therapeutic relevance. Pharmacol. Ther. 66:1995;339-368.
47. Sessler F.M., Mouradian R.D., Cheng J.T., Yeh H.H., Liu W., Waterhouse B.D. Noradrenergic potentiation of cerebellar purkinje cell responses to GABA: evidence for mediation through the β-adrenoreceptor-coupled cyclic AMP system. Brain Res. 499:1989;27-38.
48. 2+, and γ-amino-butyric acid type A channels. Proc. Natl. Acad. Sci. U.S.A. 85:1988;6192-6196.
49. A receptor by intracellular ATP in dissociated nucleus tractus solitarii neurones of rat. J. Physiol. 449:1992;551-572.
50. Stamp J.A., Semba K. Extent of colocalization of serotonin and GABA in the neurons of the rat raphe nuclei. Brain Res. 677:1995;39-49.
51. Strahlendorf J.C., Lee M., Strahlendorf H. Serotonin modulates muscimol- and baclofen-elicited inhibition of cerebellar Purkinje cells. Eur. J. Pharmacol. 201:1991;239-242.
52. Takahashi T., Neher E., Sakmann B. Rat brain serotonin receptors in Xenopus oocytes are coupled by intracellular calcium to endogenous channels. Proc. Natl. Acad. Sci. U.S.A. 84:1987;5063-5067.
53. 2+-dependent protein kinase. Biochem. Biophys. Res. Comm. 135:1986;397-402.
54. A receptors. Mol. Brain Res. 31:1995;165-172.
55. Valenzuela C.F., Kazlauskas A., Brozowski S.J., Weiner J.L., DeMali K.A., McDonald B.J., Moss S.J., Dunwiddie T.V., Harris R.A. Platelet-derived growth factor receptor is a novel modulator of type A γ-aminobutyric acid-gated ion channels. Mol. Pharmacol. 48:1995;1099-1107.
56. Valenzuela C.F., Xiong Z., MacDonald J.F., Weiner J.L., Frazier C.J., Dunwiddie T.V., Kazlauskas A., Whiting P.J., Harris R.A. Platelet-derived growth factor (PDGF) induces a long-term inhibition of NMDA receptor function. J. Biol. Chem. 271:1996;16151-16159.
57. A/benzodiazepine receptors. Mol. Pharmacol. 44:1993;437-442.
58. Wang R.A., Cheng G., Kolaj M., Randic M. α-subunit of calcium/calmodulin-dependent protein kinase II enhances γ-aminobutyric acid and inhibitory synaptic responses of rat neurons in vitro. J. Neurophysiol. 73:1995;2099-2106.
59. Waterhouse B.D., Moises H.C., Yeh H.H., Woodward D.J. Norepinephrine enhancement of inhibitory synaptic mechanisms in cerebellum and cerebral cortex: mediation by beta adrenergic receptors. J. Pharmacol. Exp. Ther. 221:1982;495-506.
60. Whiting P., McKernan R.M., Iversen L.L. Another mechanism for creating diversity in γ-aminobutyrate type A receptors: RNA splicing directs expression of two forms of γ2 subunit, one of which contains a protein kinase C phosphorylation site. Proc. Natl. Acad. Sci. U.S.A. 87:1990;9966-9970.
61. A receptor subunit mRNA in the rat brain: I. Telencephalon, diencephalon and mesencephalon. J. Neurosci. 12:1992;1040-1062.
62. 2+/calmodulin-dependent protein kinase II. J. Neurochem. 56:1991;294-298.