Inhibition of GABA(A) receptor chloride channel by quinolones and norfloxacin-biphenylacetic acid hybrid compounds

Neuropharmacology

Volumn 35, Issue 9-10, 1996, Pages 1263-1269

  Ito, Y ^a   Miyasaka, T ^a   Fukuda, H ^a   Akahane, K ^b   Kimura, Y ^b  

^a NIHON UNIVERSITY   (Japan)

^b DAIICHI SANKYO CO   (Japan)

Author keywords

36Cl uptake; Anti inflammatory agent; Antibacterial agents; Drug interaction; Synaptoneurosomes

Indexed keywords

3 AMINO 2 (3 CARBOXYPROPYL) 6 (4 METHOXYPHENYL)PYRIDAZINIUM BROMIDE; 4 AMINOBUTYRIC ACID A RECEPTOR; ANTIINFLAMMATORY AGENT; BICUCULLINE; CHLORIDE CHANNEL; CHLORINE 36; CIPROFLOXACIN; DRUG METABOLITE; ENOXACIN; FELBINAC; FENBUFEN; LEVOFLOXACIN; LOMEFLOXACIN; MUSCIMOL; NORFLOXACIN; NORFLOXACIN BIPHENYLACETIC ACID DERIVATIVE; OFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; ANTIINFECTIVE AGENT; CHLORINE; PHENYLACETIC ACID DERIVATIVE; PYRIDAZINE DERIVATIVE; QUINOLONE DERIVATIVE;

ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN SYNAPTOSOME; CHLORIDE TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENTIATION; DRUG SYNTHESIS; HYBRID; MALE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; RAT; SYNAPTOSOME; WISTAR RAT;

ANIMALS; ANTI-INFECTIVE AGENTS; CHLORIDE CHANNELS; CHLORINE; ENOXACIN; GABA AGONISTS; GABA ANTAGONISTS; MALE; MUSCIMOL; NORFLOXACIN; PHENYLACETATES; PYRIDAZINES; QUINOLONES; RATS; RATS, WISTAR; RECEPTORS, GABA-A; SYNAPTOSOMES;

EID: 0030299871     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(96)00057-3     Document Type: Article

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