Effects of IL-12 and antibodies to IL-12 on established granulomatous colitis in mice

Annals of the New York Academy of Sciences

Volumn 795, Issue , 1996, Pages 368-370

  Neurath, Markus F ^a   Fuss, Ivan ^a   Kelsall, Brian ^a   Zum Büschenfelde, K H Meyer ^a   Strober, Warren ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CD4 ANTIGEN; CD45 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4; MESSENGER RNA; TRINITROBENZENESULFONIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; CELL TRANSFER; COLITIS; CONFERENCE PAPER; CONTROLLED STUDY; CROHN DISEASE; ELECTROPHORETIC MOBILITY; GRANULOMATOSIS; HISTOPATHOLOGY; LAMINA PROPRIA; LYMPHOCYTIC INFILTRATION; MONONUCLEAR CELL; MOUSE; NONHUMAN; PATHOGENESIS; POLYMERASE CHAIN REACTION; T LYMPHOCYTE; ANIMAL; ARTICLE; BAGG ALBINO MOUSE; DRUG ANTAGONISM; GRANULOMA; IMMUNOLOGICAL PROCEDURES; IMMUNOLOGY; PATHOLOGY;

ANIMALS; COLITIS; GRANULOMA; IMMUNOLOGIC TECHNIQUES; INTERLEUKIN-12; MICE; MICE, INBRED BALB C; TRINITROBENZENESULFONIC ACID;

EID: 0030299841     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1996.tb52695.x     Document Type: Conference Paper

References (9)

1. PODOLSKY, D. K. 1991. Inflammatory bowel disease. N. Engl. J. Med. 325: 928-936.
2. STROBER, W. & M. F. NEURATH. 1995. Immunological diseases of the gastrointestinal tract. In R. R. Rich, Ed. Clinical Immunology. Chapter 94. Mosby. St. Louis.
3. HAMMER, R. E., S. D. MAIKA, J. A. RICHARDSON, Y. P. TANG & J. D. TAUROG. 1990. Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human β2m: An animal model of HLAB-27-associated human disorders. Cell 63: 1099-1109.
4. SADLACK, B., H. MERZ, H. SCHORLE, A. SCHIMPL, A. C. FELLER & I. HORVAK. 1993. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75: 253-262.
5. KÜHN, R., J. LÖHLER, D. RENNICK, K. RAJEWSKY & W. MÜLLER. 1993. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75: 263-277.
6. i2-deficient mice. Nature Gen. 10: 143-149.
7. MOMBAERTS, P., E. MIZOGUCHI, M. J. GRUSBY, L. H. GLIMCHER, A. K. BAHN & S. TONEGAWA. 1993. Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice. Cell 75: 275-288.
8. + T cells. Immunity 1: 553-565.
9. NEURATH, M. F., I. FUSS, B. L. KELSALL, E. STÜBER & W. STROBER. 1995. Antibodies to IL-12 abrogate established experimental colitis in mice. J. Exp. Med. 182: 1281-1290.