Increased sensitivity of the inositol-phospholipid system in neutrophils from patients with acute major depressive episodes

Psychiatry Research

Volumn 65, Issue 1, 1996, Pages 45-51

  Bohus, Martin ^a   Förstner, Ulrich ^a   Kiefer, Christian ^a   Gebicke Härter, Peter ^a   Timmer, Jens ^a   Spraul, Gebhard ^a   Wark, Hans Jörg ^a   Hecht, Heidemarie ^a   Berger, Mathias ^a   Van Calker, Dietrich ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

affective disorder; calcium; formylmethionylleucylphenylalanine

Indexed keywords

CALCIUM; FORMYLMETHIONYLLEUCYLPHENYLALANINE; INOSITOL; PHOSPHOLIPID;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DEPRESSION; FEMALE; HUMAN; HYPERSENSITIVITY; MALE; NEUTROPHIL; PRIORITY JOURNAL;

EID: 0030298471     PISSN: 01651781     EISSN: None     Source Type: Journal    
DOI: 10.1016/0165-1781(96)02913-7     Document Type: Article

References (30)

1. American Psychiatric Association. (1987) DSM-III-R: Diagnostic and Statistical Manual of Mental Disorders. 3rd rev. edn. American Psychiatric Press, Washington, DC.
2. Ashley, C.C., Castell, L.M., Ledingham, J.G.G., Osborn, C., Pritchard, K., Raine, A.E.G. and Somers, V.K. (1986) Relationships between lymphocyte and platelet intracellular free calcium concentrations, plasma-ionized calcium, and blood pressure in essential hypertension in humans. (Abstract) J Physiol 372, 81P.
3. + in the treatment of bipolar disorder. Trends Neurosci 18, 343-349.
4. Berridge, M.J., Downes, C.P. and Hanley, M.R. (1990) Neural and developmental actions of lithium: A unifying hypothesis. Cell 59, 411-419.
5. Berridge, M.J. and Irvine, R.F. (1989) Inositol phosphates and cell signalling. Nature 341, 197-205.
6. Bothwell, R.A., Eccleston, D. and Marshall, E. (1994) Platelet intracellular calcium in patients with recurrent affective disorders. Psychopharmacology 114, 375-381.
7. Brown, G.W. (1989) A psychosocial view of depression. In: Bennett, D.H. and Freeman, H. (Eds.), Community Psychiatry. Churchill-Livingstone, London, pp. 71-114.
8. De Lean, A., Munson, P.J. and Rodbard, B. (1978) Simultaneous analysis of families of sigmoidal curves: Application to bioassay, radioligand assay, and physiological dose-response-curves. Am J Physiol 235/E, 97-102.
9. Dubovsky, S.L., Christiano, J., Daniell, L.C., Franks, R.D., Murphy, J., Adler, L., Baker, N. and Harris, A. (1989) Increased platelet intracellular calcium concentration in patients with bipolar affective disorders. Arch Gen Psychiatry 46, 632-638.
10. Dubovsky, S.L., Lee, C., Christiano, J. and Murphy, J. (1991) Elevated platelet intracellular calcium concentration in bipolar depression. Biol Psychiatry 29, 441-450.
11. 2 receptor stimulation in platelets of depressed patients. Biol Psychiatry 34, 565-568.
12. Förstner, U., Bohus, M., Gebicke-Härter, P.J., Berger, M. and van Calker, D. (1994) Chronic lithium treatment decreases the agonist-stimulated accumulation of cytosolic free calcium in neutrophils from manic depressive patients. Eur Arch Psychiatry Clin Neurosci 243, 240-243.
13. Goodwin, F.K. and Jamison, K.R. (1990) Manic-Depressive Illness. Oxford University Press, New York.
14. Greil, W., Steber, R. and van Calker, D. (1991) The agonist-stimulated accumulation of inositol phosphates is attenuated in neutrophils from male patients under chronic lithium therapy. Biol Psychiatry 30, 443-451.
15. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 260, 3440-3450.
16. Hamilton, M. (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23, 56-62.
17. Henn, F.A. (1989) Animal models. In: Mann, J.J. (Ed.), Models of Depressive Disorders. Plenum Press, New York, pp. 93-107.
18. +- response is increased in the blood platelets of depressed patients. Biol Psychiatry 30, 310-312.
19. Kusumi, I., Koyama, T. and Yamashita, I. (1992) Thrombin-induced platelet calcium mobilization is enhanced in bipolar disorders. Biol Psychiatry 32, 731-734.
20. Lindner, A., Kenny, M. and Meacham, A.J. (1987) Effects of a circulating factor in patients with essential hypertension on intracellular free calcium in normal platelets. N Engl J Med 316, 509-513.
21. Mikuni, M., Kagaya, A., Takahashi, K. and Meltzer, H.Y. (1992) Serotonin but not norepinephine-induced calcium mobilization of platelets is enhanced in affective disorders. Psychopharmacology 106, 311-314.
22. Mikuni, M., Kusumi, I., Kagaya, A., Kuroda, Y., Mori, H. and Takahashi, K. (1991) Increased 5-HT-2 receptor function as measured by serotonin-stimulated phosphoinositide hydrolysis in platelets of depressed patients. Prog Neuropsychopharmacol Biol Psychiatry 15, 49-61.
23. Nahorski, S.R., Ragan, C.I. and Challiss, R.A.J. (1991) Lithium and the phosphoinositide cycle: An example of uncompetitive inhibition and its pharmacological consequences. Trends Pharmacol Sci 12, 297-303.
24. Okamoto, Y., Kagaya, A., Shinno, H., Motohashi, N. and Yamawaki, S. (1995) Serotonin-induced platelet calcium mobilization is enhanced in mania. Life Sci 56, 327-332.
25. Omann, G.M., Allen, R.A., Bokoch, G.M., Painter, R.G., Traynor, E.E. and Sklar, L.A. (1987) Signal transduction and cytoskeletal activation in the neutrophil. Physiol Rev 67, 285-340.
26. Souza, F.G.M. and Goodwin, G.M. (1991) Lithium treatment and prophylaxis in unipolar depression: A meta-analysis. Br J Psychiatry 1558, 666-675.
27. Spitzer, R.L., Williams, J.B., Gibbon, M. and First, M.B. (1990) Structured Clinical Interview for DSM-III-R. American Psychiatric Press, Washington, DC.
28. 2+ response in neutrophils of manic-depressive patients: Effect of lithium therapy. Neuropsychobiology 27, 180-183.
29. Veith, R.C., Lewis, N., Linares, O.A., Barnes, R.F., Raskind, M.A., Villacres, E.C., Murburg, M.M., Ashleigh, E.A., Castillo, S., Peskind, E.P., Pascualy, M. and Halter, J.B. (1994) Sympathetic nervous system activity in major depression. Arch Gen Psychiatry 51, 411-422.
30. Willner, P. (1991) Animal models as simulations of depression. Trends Pharmacol Sci 12, 131-136.