메뉴 건너뛰기




Volumn 70, Issue 2, 1996, Pages 199-206

Intracellular signaling of tumor necrosis factor-α in brain microvascular endothelial cells is mediated by a protein tyrosine kinase and protein kinase C-dependent pathway

Author keywords

Brain microvascular endothelial cells; Signal transduction; Tumor necrosis factor

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; 2',3' DIDEOXYADENOSINE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; FORSKOLIN; GENISTEIN; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PROTEIN KINASE C INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; STAUROSPORINE; TUMOR NECROSIS FACTOR ALPHA;

EID: 0030298031     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(96)00116-6     Document Type: Article
Times cited : (9)

References (38)
  • 1
    • 0026793292 scopus 로고
    • Development and characteration of a rat brain capillary endothelial culture: Towards an in vitro blood-brain barrier
    • Abbott, N.J., Hughes, C.C.W., Revest, P.A. and Greenwood, J. (1992) Development and characteration of a rat brain capillary endothelial culture: towards an in vitro blood-brain barrier. J. Cell Sci. 103, 23-37.
    • (1992) J. Cell Sci. , vol.103 , pp. 23-37
    • Abbott, N.J.1    Hughes, C.C.W.2    Revest, P.A.3    Greenwood, J.4
  • 2
    • 0028174061 scopus 로고
    • Function and activation of NF-κB in the immune system
    • Baeuerle, P.A. and Henkel, T. (1994) Function and activation of NF-κB in the immune system. Ann. Rev. Immunol. 12, 141-179.
    • (1994) Ann. Rev. Immunol. , vol.12 , pp. 141-179
    • Baeuerle, P.A.1    Henkel, T.2
  • 3
    • 0027529932 scopus 로고
    • Surface expression of α4 integrin by CD4 cells is required for their entry into brain parenchyma
    • Baron, J.L., Madri, J.A., Ruddle, N.H., Hashim, G. and Janeway, Jr., C.A. (1993) Surface expression of α4 integrin by CD4 cells is required for their entry into brain parenchyma. J. Exp. Med. 177, 57-68.
    • (1993) J. Exp. Med. , vol.177 , pp. 57-68
    • Baron, J.L.1    Madri, J.A.2    Ruddle, N.H.3    Hashim, G.4    Janeway C.A., Jr.5
  • 4
    • 0025221490 scopus 로고
    • Lymphocyte adhesion to cultured peyer's patch high endothelial venule cells is mediated by organ-specific homing receptors and can be regulated by cytokines
    • Chin, Y., Cai, J. and Johnson, K. (1990) Lymphocyte adhesion to cultured peyer's patch high endothelial venule cells is mediated by organ-specific homing receptors and can be regulated by cytokines. J. Immunol. 145, 3669-3677.
    • (1990) J. Immunol. , vol.145 , pp. 3669-3677
    • Chin, Y.1    Cai, J.2    Johnson, K.3
  • 5
    • 0028050590 scopus 로고
    • Differential role of protein kinase C in cytokine induced lymphocyte-endothelium interaction in vitro
    • Eissner, G., Kolch, W., Mischak, H., Bornkamm, G.W. and Holler, E. (1994) Differential role of protein kinase C in cytokine induced lymphocyte-endothelium interaction in vitro. Scand. J. Immunol. 40, 395-402.
    • (1994) Scand. J. Immunol. , vol.40 , pp. 395-402
    • Eissner, G.1    Kolch, W.2    Mischak, H.3    Bornkamm, G.W.4    Holler, E.5
  • 6
    • 0028217047 scopus 로고
    • Nervous tissue as an immune compartment: The dialect of the immune response in the CNS
    • Fabry, Z., Raine, C.S. and Hart, M.N. (1994) Nervous tissue as an immune compartment: the dialect of the immune response in the CNS. Immunol. Today 15, 218-224.
    • (1994) Immunol. Today , vol.15 , pp. 218-224
    • Fabry, Z.1    Raine, C.S.2    Hart, M.N.3
  • 7
    • 0027179034 scopus 로고
    • IL-4, but not tumor necrosis factor-α, increases endothelial cell adhesiveness for lymphocytes by activating a cAMP-dependent pathway
    • Galea, P., Thibault, G., Lacord, M., Bardos, P. and Lebranchu Y. (1993) IL-4, but not tumor necrosis factor-α, increases endothelial cell adhesiveness for lymphocytes by activating a cAMP-dependent pathway. J. Immunol. 151, 588-596.
    • (1993) J. Immunol. , vol.151 , pp. 588-596
    • Galea, P.1    Thibault, G.2    Lacord, M.3    Bardos, P.4    Lebranchu, Y.5
  • 8
    • 0025915049 scopus 로고
    • A comparison of primary cultures of rat cerebral microvascular endothelial cells to rat aortic endothelial cells
    • Gordon, E.L., Danielsson, P.E., Nguyen, T. and Winn, H.R. (1991) A comparison of primary cultures of rat cerebral microvascular endothelial cells to rat aortic endothelial cells. In Vitro Cell. Dev. Biol. A 27, 312-326.
    • (1991) In Vitro Cell. Dev. Biol. A , vol.27 , pp. 312-326
    • Gordon, E.L.1    Danielsson, P.E.2    Nguyen, T.3    Winn, H.R.4
  • 10
    • 0025924381 scopus 로고
    • Maintenance of NF-kappa B activity is dependent on protein synthesis and the continuous presence of external stimuli
    • Hohmann, H.-P., Remy, R., Scheidereit, C. and van Loon, A.P.G.M. (1991) Maintenance of NF-kappa B activity is dependent on protein synthesis and the continuous presence of external stimuli. Mol. Cell. Biol. 11, 259-266.
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 259-266
    • Hohmann, H.-P.1    Remy, R.2    Scheidereit, C.3    Van Loon, A.P.G.M.4
  • 11
    • 0025942325 scopus 로고
    • Effect of a new monoclonal antibody, TA-2, that inhibits lymphocyte adherence to cytokine stimulated endothelium in the rat
    • Issekutz, T. and Wykretowicz, A. (1991) Effect of a new monoclonal antibody, TA-2, that inhibits lymphocyte adherence to cytokine stimulated endothelium in the rat. J. Immunol. 147, 109-116.
    • (1991) J. Immunol. , vol.147 , pp. 109-116
    • Issekutz, T.1    Wykretowicz, A.2
  • 12
    • 0025336496 scopus 로고
    • Binding of human endothelium to ulex europaeus I-coated Dynabeads: Application to the isolation of microvascular endothelium
    • Jackson, C.J., Garbett, P.K., Nissen, B. and Schreiber, L. (1990) Binding of human endothelium to ulex europaeus I-coated Dynabeads: application to the isolation of microvascular endothelium. J. Cell Sci. 96, 257-262.
    • (1990) J. Cell Sci. , vol.96 , pp. 257-262
    • Jackson, C.J.1    Garbett, P.K.2    Nissen, B.3    Schreiber, L.4
  • 13
    • 0026672245 scopus 로고
    • Characterization of the promoter for vascular cell adhesion molecule-1 (VCAM-1)
    • Lademarco, M.F., McQuillan, J.J., Rosen, G.D. and Dean, D.C. (1992) Characterization of the promoter for vascular cell adhesion molecule-1 (VCAM-1). J. Biol. Chem. 267, 16323-16329.
    • (1992) J. Biol. Chem. , vol.267 , pp. 16323-16329
    • Lademarco, M.F.1    McQuillan, J.J.2    Rosen, G.D.3    Dean, D.C.4
  • 14
    • 0011950532 scopus 로고
    • Human cutanous microvascular endothelial cells
    • U. Tyan (Ed.) . CRC Press, New York
    • Lawley, T.J. and Kubota, Y. (1988) Human cutanous microvascular endothelial cells. In: U. Tyan (Ed.), Endothelial Cells. CRC Press, New York, pp. 229-234.
    • (1988) Endothelial Cells , pp. 229-234
    • Lawley, T.J.1    Kubota, Y.2
  • 15
    • 0027512562 scopus 로고
    • Tumor necrosis factor-α (TNF-α)-induced cell adhesion to human endothelial cells is under dominant control of one TNF receptor type, TNF-R55
    • Mackay, F., Loetscher, H., Stuber, D., Gehr, G. and Lesslauer, W. (1993) Tumor necrosis factor-α (TNF-α)-induced cell adhesion to human endothelial cells is under dominant control of one TNF receptor type, TNF-R55. J. Exp. Med. 177, 1277-1286.
    • (1993) J. Exp. Med. , vol.177 , pp. 1277-1286
    • Mackay, F.1    Loetscher, H.2    Stuber, D.3    Gehr, G.4    Lesslauer, W.5
  • 16
    • 0026066932 scopus 로고
    • Cytokine levels in the cerebrospinal fluid and serum of patients with multiple sclerosis
    • Maimone, D., Gregory, S., Arnason, B.G. and Reder, A.T. (1991) Cytokine levels in the cerebrospinal fluid and serum of patients with multiple sclerosis. J. Neuroimmunol. 32, 67-74.
    • (1991) J. Neuroimmunol. , vol.32 , pp. 67-74
    • Maimone, D.1    Gregory, S.2    Arnason, B.G.3    Reder, A.T.4
  • 17
    • 0028070678 scopus 로고
    • Lymphocyte migration into the CNS modelled in vitro: Role of LFA-1, ICAM-1, and VLA-4
    • Male, D., Rahman, G., Price, G., Tamatani, T. and Miyasaka, M. (1994) Lymphocyte migration into the CNS modelled in vitro: role of LFA-1, ICAM-1, and VLA-4. Immunology 81, 366-372.
    • (1994) Immunology , vol.81 , pp. 366-372
    • Male, D.1    Rahman, G.2    Price, G.3    Tamatani, T.4    Miyasaka, M.5
  • 18
    • 0025343188 scopus 로고
    • Lymphocyte migration into the brain modeled in vitro: Control by lymphocyte activation, cytokines and antigen
    • Male, D.K., Pryce, G., Hughes, C.C.W. and Lantos, P. (1990) Lymphocyte migration into the brain modeled in vitro: control by lymphocyte activation, cytokines and antigen. Cell. Immunol. 127, 1-11.
    • (1990) Cell. Immunol. , vol.127 , pp. 1-11
    • Male, D.K.1    Pryce, G.2    Hughes, C.C.W.3    Lantos, P.4
  • 19
    • 0026729650 scopus 로고
    • TNF alpha-induced expression of endothelial adhesion molecules, ICAM-1 and VCAM-1, is linked to protein kinase C activation
    • Mattila, P., Majuri, M.-L., Mattila, P.S. and Renkonen, R. (1992) TNF alpha-induced expression of endothelial adhesion molecules, ICAM-1 and VCAM-1, is linked to protein kinase C activation. Scand. J. Immunol. 36, 159-162.
    • (1992) Scand. J. Immunol. , vol.36 , pp. 159-162
    • Mattila, P.1    Majuri, M.-L.2    Mattila, P.S.3    Renkonen, R.4
  • 20
    • 0027407956 scopus 로고
    • Cytokine-regulated adhesion between encephalitogenic T lymphocytes and cerebrovascular endothelial cells
    • McCarron, R.M., Wang, L., Racke, M.K., McFarlin, D.E. and Spatz, M. (1993) Cytokine-regulated adhesion between encephalitogenic T lymphocytes and cerebrovascular endothelial cells. J. Neuroimmunol. 43, 23-30.
    • (1993) J. Neuroimmunol. , vol.43 , pp. 23-30
    • McCarron, R.M.1    Wang, L.2    Racke, M.K.3    McFarlin, D.E.4    Spatz, M.5
  • 21
    • 0342742310 scopus 로고
    • Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B
    • Osborn, L., Kunkel, S. and Nabel, G.J. (1989) Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B. Proc. Natl. Acad. Sci. USA 86, 2336-2340.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 2336-2340
    • Osborn, L.1    Kunkel, S.2    Nabel, G.J.3
  • 22
    • 0027246226 scopus 로고
    • Elevated cyclic AMP inhibits endothelial cell synthesis and expression of TNF-induced endothelial leukocyte adhesion molecule-1, and vascular cell adhesion molecule-1, but not intercellular adhesion molecule-1
    • Pober, J.S., Slowik, M.R., De Luca, L.G. and Ritchie, A.J. (1993) Elevated cyclic AMP inhibits endothelial cell synthesis and expression of TNF-induced endothelial leukocyte adhesion molecule-1, and vascular cell adhesion molecule-1, but not intercellular adhesion molecule-1. J. Immunol. 150, 5114-5123.
    • (1993) J. Immunol. , vol.150 , pp. 5114-5123
    • Pober, J.S.1    Slowik, M.R.2    De Luca, L.G.3    Ritchie, A.J.4
  • 23
    • 0025313253 scopus 로고
    • Lymphotoxin and tumor necrosis factor-α production by myelin basic protein-specific T cell clones correlates with encephalitogenicity
    • Powell, M.B., Mitchell, D., Lederman, J., Buckmeier, J., Zamvil, S.S., Graham, M., Ruddle, N.H. and Steinman, L. (1990) Lymphotoxin and tumor necrosis factor-α production by myelin basic protein-specific T cell clones correlates with encephalitogenicity. Int. Immunol. 2, 539-544.
    • (1990) Int. Immunol. , vol.2 , pp. 539-544
    • Powell, M.B.1    Mitchell, D.2    Lederman, J.3    Buckmeier, J.4    Zamvil, S.S.5    Graham, M.6    Ruddle, N.H.7    Steinman, L.8
  • 24
    • 0025004166 scopus 로고
    • Activation of protein kinase C is crucial in the regulation of ICAM-1 expression on endothelial cells by interferon-γ
    • Renkonen, R., Mennander, A., Ustinov, J. and Mattila, P. (1990) Activation of protein kinase C is crucial in the regulation of ICAM-1 expression on endothelial cells by interferon-γ. Int. Immunol. 2, 719-724.
    • (1990) Int. Immunol. , vol.2 , pp. 719-724
    • Renkonen, R.1    Mennander, A.2    Ustinov, J.3    Mattila, P.4
  • 25
    • 0025761919 scopus 로고
    • Tumor necrosis factor induction of endothelial cell surface antigens is independent of protein kinase C activation or inactivation: Studies with phorbol myristate acetate and staurosporine
    • Ritchie, A.R., Johnson, D.R., Ewenstein, B.M. and Pober, J.S. (1991) Tumor necrosis factor induction of endothelial cell surface antigens is independent of protein kinase C activation or inactivation: studies with phorbol myristate acetate and staurosporine. J. Immunol. 146, 3056-3062.
    • (1991) J. Immunol. , vol.146 , pp. 3056-3062
    • Ritchie, A.R.1    Johnson, D.R.2    Ewenstein, B.M.3    Pober, J.S.4
  • 26
    • 0025000863 scopus 로고
    • An antibody to lymphotoxin and tumor necrosis factor-α prevents transfer of experimental allergic encephalomyelitis
    • Ruddle, N.H., Bergman, C.M., McGrath, K.M., Lingenheld, E.G., Grunnet, M.L., Padula, S.J. and Clark, R.B. (1990) An antibody to lymphotoxin and tumor necrosis factor-α prevents transfer of experimental allergic encephalomyelitis. J. Exp. Med. 172, 1193-1200.
    • (1990) J. Exp. Med. , vol.172 , pp. 1193-1200
    • Ruddle, N.H.1    Bergman, C.M.2    McGrath, K.M.3    Lingenheld, E.G.4    Grunnet, M.L.5    Padula, S.J.6    Clark, R.B.7
  • 27
    • 0026458406 scopus 로고
    • TNF activates NF-kappa B by phosphatidyl-choline-specific phospholipase C-induced 'acidic' sphingomyelin breakdown
    • Schutze, S., Pothoff, K., Machleidt, T., Bercovic, D., Wiegmann, K. and Kronke, M. (1992) TNF activates NF-kappa B by phosphatidyl-choline-specific phospholipase C-induced 'acidic' sphingomyelin breakdown. Cell. 71, 765-776.
    • (1992) Cell , vol.71 , pp. 765-776
    • Schutze, S.1    Pothoff, K.2    Machleidt, T.3    Bercovic, D.4    Wiegmann, K.5    Kronke, M.6
  • 28
    • 0025852567 scopus 로고
    • Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions
    • Selmaj, K., Raine, C.S., Cannella, B. and Brosnan, C.F. (1991) Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions. J. Clin. Invest. 87, 949-954.
    • (1991) J. Clin. Invest. , vol.87 , pp. 949-954
    • Selmaj, K.1    Raine, C.S.2    Cannella, B.3    Brosnan, C.F.4
  • 29
    • 0027982876 scopus 로고
    • Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
    • Springer, T.A. (1994) Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell. 76, 301-314.
    • (1994) Cell , vol.76 , pp. 301-314
    • Springer, T.A.1
  • 30
    • 0017088029 scopus 로고
    • Lymphocyte homing into lymph nodes: In vitro demonstration of the selective affinity of recirculating lymphocytes for high endothelial venules
    • Stamper, H.B. and Woodruff, J.J. (1976) Lymphocyte homing into lymph nodes: in vitro demonstration of the selective affinity of recirculating lymphocytes for high endothelial venules. J. Exp. Med. 144, 828-833.
    • (1976) J. Exp. Med. , vol.144 , pp. 828-833
    • Stamper, H.B.1    Woodruff, J.J.2
  • 31
    • 0028283232 scopus 로고
    • Evidence for involvement of ICAM-1 and VCAM-1 in lymphocyte interaction with endothelium in experimental autoimmune encephalomyelitis in the central nervous system in the SJL/J mouse
    • Steffen, B.J., Butcher, E.C. and Engelhardt, B. (1994) Evidence for involvement of ICAM-1 and VCAM-1 in lymphocyte interaction with endothelium in experimental autoimmune encephalomyelitis in the central nervous system in the SJL/J mouse. Am. J. Path. 145, 189-201.
    • (1994) Am. J. Path. , vol.145 , pp. 189-201
    • Steffen, B.J.1    Butcher, E.C.2    Engelhardt, B.3
  • 32
    • 0026567377 scopus 로고
    • Human dermal microvascular endothelial but not human umbilical vein endothelial cells express CD36 in vivo and in vitro
    • Swerlick, R.A., Lee, K.H., Wick, T.M. and Lawley, T.J. (1992) Human dermal microvascular endothelial but not human umbilical vein endothelial cells express CD36 in vivo and in vitro. J. Immunol. 148, 78-83.
    • (1992) J. Immunol. , vol.148 , pp. 78-83
    • Swerlick, R.A.1    Lee, K.H.2    Wick, T.M.3    Lawley, T.J.4
  • 33
    • 0025021730 scopus 로고
    • Identification of monoclonal antibodies reactive with the rat homolog of ICAM-1, and evidence for a differential involvement of ICAM-1 in the adherence of resting versus activated lymphocytes to high endothelial cells
    • Tamatani, T. and Miyasaka, M. (1990) Identification of monoclonal antibodies reactive with the rat homolog of ICAM-1, and evidence for a differential involvement of ICAM-1 in the adherence of resting versus activated lymphocytes to high endothelial cells. Int. Immunol. 2, 165-171.
    • (1990) Int. Immunol. , vol.2 , pp. 165-171
    • Tamatani, T.1    Miyasaka, M.2
  • 34
    • 0025981454 scopus 로고
    • Molecular mechanisms underlying lymphocyte recirculation II. Differential regulation of LFA-1 in the interaction between lymphocytes and high endothelial cells
    • Tamatani, T., Tanaka, T. and Miyasaka, M. (1991) Molecular mechanisms underlying lymphocyte recirculation II. Differential regulation of LFA-1 in the interaction between lymphocytes and high endothelial cells. Eur. J. Immunol. 21, 855-858.
    • (1991) Eur. J. Immunol. , vol.21 , pp. 855-858
    • Tamatani, T.1    Tanaka, T.2    Miyasaka, M.3
  • 35
    • 0019847284 scopus 로고
    • Autoimmune encephalomyelitis: Simultaneous identification of T and B cells in the target organ
    • Traugott, U., Shevach, E., Chiba, J., Stone, H.J. and Raine, C.S. (1981) Autoimmune encephalomyelitis: Simultaneous identification of T and B cells in the target organ. Science 214, 1251-1253.
    • (1981) Science , vol.214 , pp. 1251-1253
    • Traugott, U.1    Shevach, E.2    Chiba, J.3    Stone, H.J.4    Raine, C.S.5
  • 36
    • 0020676803 scopus 로고
    • Multiple sclerosis distribution of T cells within active chronic lesions
    • Traugott, U., Reinherz, E.L. and Raine, C.S. (1983) Multiple sclerosis Distribution of T cells within active chronic lesions. Science 219, 308-310.
    • (1983) Science , vol.219 , pp. 308-310
    • Traugott, U.1    Reinherz, E.L.2    Raine, C.S.3
  • 37
    • 0027474924 scopus 로고
    • Adhesion molecules involved in protein kinase A-and C-dependent lymphocyte adherence to microvascular endothelial cells
    • Turunen, J.P., Ustinov, J. and Renkonen, R. (1993) Adhesion molecules involved in protein kinase A-and C-dependent lymphocyte adherence to microvascular endothelial cells. Scand. J. Immunol. 37, 282-288.
    • (1993) Scand. J. Immunol. , vol.37 , pp. 282-288
    • Turunen, J.P.1    Ustinov, J.2    Renkonen, R.3
  • 38
    • 0026506799 scopus 로고
    • Prevention of experimental autoimmune encephalomyelitis by antibodies against α4β1 integrin
    • Yednock, T.A., Cannon, C., Fritz, L.C., Sanchez-Madrid, F., Steinman, L. and Karin, N. (1992) Prevention of experimental autoimmune encephalomyelitis by antibodies against α4β1 integrin. Nature 356, 63-66.
    • (1992) Nature , vol.356 , pp. 63-66
    • Yednock, T.A.1    Cannon, C.2    Fritz, L.C.3    Sanchez-Madrid, F.4    Steinman, L.5    Karin, N.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.