Effect of benzodiazepines on plasma levels of homovanillic acid in anxious patients and control subjects

Psychiatry Research

Volumn 65, Issue 1, 1996, Pages 53-59

  Wingerson, Dane K ^a   Cowley, Deborah S ^a   Kramer, Gerald L ^b   Petty, Frederick ^b   Roy Byrne, Peter P ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

diazepam; dopamine; generalized anxiety disorder; panic disorder

Indexed keywords

BENZODIAZEPINE; DIAZEPAM; DOPAMINE; HOMOVANILLIC ACID; PLACEBO;

ADULT; ANXIETY; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; PANIC; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

EID: 0030297975     PISSN: 01651781     EISSN: None     Source Type: Journal    
DOI: 10.1016/0165-1781(96)02886-7     Document Type: Article

References (40)

1. Amin, F., Davidson, M. and Davis, K.L. (1992) Homovanillic acid measurement in clinical research: a review of methodology. Schizophr Bull 18, 123-148.
2. Bacopoulos, N.G., Hattox, S.E. and Roth, R.H. (1979) 3,4-Dihydroxyphenylacetic acid and homovanillic acid in rat plasma: possible indicators of central dopaminergic activity. Eur J Pharmacol 56, 225-236.
3. Beck, A.T., Ward, C.H., Mendelson, M., Mock, J. and Erbaugh, J. (1961) An inventory for measuring depression. Arch Gen Psychiatry 4, 561-571.
4. Biggio, G., Concas, A., Corda, M.G., Giorgi, O., Sanna, E. and Serra, M. (1990) Gabaergic and dopaminergic transmission in the rat cerebral cortex: effect of stress, anxiolytic and anxiogenic drugs. Pharmacol Ther 48, 121-142.
5. Chang, W.-H., Scheinin, M., Burns, R.S. and Linnoila, M. (1983) Rapid and simple determination of homovanillic acid in plasma using high performance liquid chromatography with electrochemical detection. J Pharmacol Toxicol 53, 275-279.
6. Coco, M.L., Kuhn, C.M., Ely, T.D. and Kilts, C.D. (1992) Selective activation of mesoamygdaloid dopamine neurons by conditioned stress: attenuation by diazepam. Brain Res 590, 39-47.
7. Davidson, M., Giordani, A.B., Mohs, R.C., Mykytyn, V.V., Platt, S., Aryan, Z.S. and Davis, K.L. (1987) Control of exogenous factors affecting plasma homovanillic acid concentration. Psychiatry Res 20, 307-312.
8. Davidson, M. and Davis, K.L. (1988) A comparison of plasma homovanilllic acid concentrations in schizophrenic patients and normal controls. Arch Gen Psychiatry 45, 561-563.
9. Deutch, A.Y. and Roth, R.H. (1990) The determinants of stress-induced activation of the prefrontal cortical dopamine system. Prog Brain Res 85, 367-403.
10. Doran, A.R., Pickar, D., Labarca, R., Douillet, P., Wolkowitz, O.M., Thomas, J.W., Roy, A. and Paul, S.M. (1985) Evidence for a daily rhythm of plasma HVA in normal controls but not in schizophrenia patients. Psychopharmacol Bull 21, 694-697.
11. Eriksson, E., Carlsson, M., Nilsson, C. and Soderpalm, B. (1986) Does alprazolam, in contrast to diazepam, activate alpha 2-adrenoceptors involved in the regulation of rat growth hormone secretion? Life Sci 38, 1491-1498.
12. Eriksson, E., Westberg, P., Ailing, C., Thuresson, K. and Modigh, K. (1991) Cerebrospinal fluid levels of monoamine metabolites in panic disorder. Psychiatry Res 36, 243-251.
13. Feenstra, M.G.P., Botterblom, M.H.A. and Vanuum, J.F.M. (1995) Novelty-induced increase in dopamine release in the rat prefrontal cortex in vivo: inhibition by diazepam. Neurosci Lett 189, 81-84.
14. Finlay, J.M., Zigmond, M.J. and Abercrombie, E.D. (1995) Increased dopamine and norepinephrine release in medial prefrontal cortex induced by acute and chronic stress: Effects of diazepam. Neuroscience 64, 619-628.
15. Gardner, D.L., Lucas, P.B. and Cowdry, R.W. (1990) CSF metabolites in borderline personality disorder compared with normal controls. Biol Psychiatry 28, 247-254.
16. Gurguis, G.N.M., Mefford, I.N. and Uhde, T.W. (1991) Hypothalamic-pituitary-adrenocortical activity in panic disorder: relationship to plasma catecholamine metabolites. Biol Psychiatry 30, 502-506.
17. Hamilton, M. (1959) The assessment of anxiety states by rating. Br J Med Psychol 32, 50-55.
18. Johnson, M.R., Lydiard, R.B., Zealberg, J.J., Fossey, M.D. and Ballenger, J.C. (1994) Plasma and CSF HVA levels in panic patients with comorbid social phobia. Biol Psychiatry 36, 426-427.
19. Kaneyuki, H., Yokoo, H., Tsuda, A., Yoshida, M., Mizuki, Y., Yamada, M. and Tanaka, M. (1991) Psychological stress increases dopamine turnover selectively in mesoprefrontal dopamine neurons of rats: reversal by diazepam. Brain Res 557, 154-161.
20. Kendler, K.S., Heninger, G.R. and Roth, R.H. (1981) Brain contribution to the haloperidol-induced increase in plasma homovanillic acid. Eur J Pharmacology 71, 321-326.
21. Kendler, K.S., Mohs, R.C. and Davis, K.L. (1983) The effects of diet and physical activity on plasma homovanillic acid in normal human subjects. Psychiatry Res 8, 215-223.
22. Kopin, I.J. (1978) Measuring turnover of neurotransmitters in human brain. In: Lipton, M.A., DiMascio, A. and Killam, K.F. (Eds.), Psychopharmacology: A Generation of Progress. Raven Press, New York, pp. 933-942.
23. Lepola, U., Jolkkonen, J., Rimon, R. and Riekkinen, P. (1989) Long-term effects of alprazolam and imipramine on cerebrospinal fluid monoamine metabolites and neuropeptides in panic disorder. Neuropsychobiology 21, 182-186.
24. Limson, R., Goldman, D., Roy, A., Lamparski, D., Ravitz, B., Adinoff, B. and Linnoila, M. (1991) Personality and cerebrospinal fluid monamine metabolites in alcoholics and controls. Arch Gen Psychiatry 48, 437-441.
25. Lydiard, R., Ballenger, J., Laraia, M. and Fossey, M. (1989) Noradrenergic dysregulation in panic disorder: New CSF findings. Presented at the Annual Meeting of the American College of Neuropsychopharmacology, San Juan, PR.
26. Maas, J.W., Hattox, S.E., Martin, D.M. and Landis, D.H. (1979) A direct method for determining dopamine synthesis and output of dopamine metabolites from brain in awake animals. J Neurochem 32, 839-843.
27. Pickar, D., Labarca, R., Linnoila, M., Roy, A., Hommer, D., Everett, D. and Paul, S.M. (1984) Neuroleptic-induced decrease in plasma homovanillic acid and antipsychotic activity in schizophrenic patients. Science 225, 954-957.
28. Ribeyre, J.M., Lesieur, P., Varoquaux, O., Dollfus, S., Pays, M. and Petit, M. (1994) A comparison of plasma homovanillic acid in the deficit and nondeficit subtypes of schizophrenia. Biol Psychiatry 36, 230-236.
29. Roy-Byrne, P.P., Uhde, T., Sack, D., Linnoila, M. and Post, R. (1986) Plasma HVA and anxiety in patients with panic disorder. Biol Psychiatry 21, 847-849.
30. Roy-Byrne, P.P., Cowley, D.S., Greenblatt, D., Shader, R.I. and Hommer, D. (1990) Reduced benzodiazepine sensitivity in panic disorder. Arch Gen Psychiatry 47, 534-538.
31. Roy-Byrne, P.P. and Wingerson, D. (1992) Pharmacotherapy of anxiety disorders. In: Tasman, A. and Riba, M. (Eds.), Review of Psychiatry, Vol. 11. American Psychiatric Press, Washington, DC, pp. 260-284.
32. Sano, H., Suzuki, Y., Ohara, K., Miyasato, K. and Yokoyama, T. (1994) Circadian variations in plasma monoamine metabolites level in alcoholic patients - a possible predictor of alcohol withdrawal delirium. Prog Neuropsychopharmacol Biol Psychiatry 18, 741-752.
33. Schneider, P., Evans, L., Ross, L.L., Wiltshire, B., Eadie, M., Kenardy, J. and Hoey, H. (1987) Plasma biogenic amine levels in agoraphobia with panic attacks. Pharmacopsychiatry 20, 102-104.
34. Sharma, R., Javaid, J.I., Janicak, P., Faull, K., Comaty, J. and Davis, J.M. (1989) Plasma and CSF HVA before and after pharmacological treatment. Psychiatry Res 28, 97-104.
35. Spielberger, C. (1983) Manual for the State-Trait Anxiety Inventory. Consulting Psychologists Press, Palo Alto, CA.
36. Spitzer, R.L., Williams, J.B., Gibbon, M. and First, M.B. (1990) Structured Clinical Interview for DSM-III-R - Patient Edition. American Psychiatric Press, Washington, DC.
37. Wolkowitz, O.M., Breier, A., Doran, A., Kelsoe, J., Lucas, P., Paul, S.M. and Pickar, D. (1988) Alprazolam augmentation of the antipsychotic effects of fluphenazine in schizophrenic patients. Arch Gen Psychiatry 45, 664-671.
38. Wolkowitz, O.M. and Pickar, D. (1991) Benzodiazepines in the treatment of schizophrenia: a review and reappraisal. Am J Psychiatry 148, 714-726.
39. Wolkowitz, O.M., Turetsky, N., Reus, V.I. and Hargreaves, W.A. (1992) Benzodiazepine augmentation of neuroleptics in treatment-resistant schizophrenia. Psychopharmacol Bull 28, 291-295.
40. Zemishlany, Z., Davidson, M., Jaff, S. and McQueeney, R. (1991) Acute administration of alprazolam has no effect on plasma homovanillic acid concentration in normal subjects. Schizophr Res 5, 81-83.