Time course of methotrexate polyglutamate formation and degradation in the pre-B-leukaemia cell line Nalm6 and in lymphoblasts from children with leukaemia

European Journal of Cancer Part A

Volumn 32, Issue 12, 1996, Pages 2101-2107

  Buchholz, B ^a   Frei, E ^b   Eisenbarth, J ^b   Weigand, M ^b   Ludwig, R ^c  

^a Children's Hospital   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c NONE

Author keywords

leukaemia cell line; lymphoblasts; methotrexate metabolism; polyglutamates; resistance

Indexed keywords

DRUG METABOLITE; METHOTREXATE; METHOTREXATE POLYGLUTAMATE;

ARTICLE; CASE REPORT; CHILD; CHILDHOOD LEUKEMIA; CONTROLLED STUDY; DRUG METABOLISM; DRUG RESISTANCE; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LYMPHOBLAST; MALE; PRIORITY JOURNAL;

ANTIMETABOLITES, ANTINEOPLASTIC; CHILD; CHILD, PRESCHOOL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG RESISTANCE, NEOPLASM; HUMANS; KINETICS; LEUKEMIA, LYMPHOCYTIC, ACUTE; LEUKEMIA, PRE-B-CELL; LYMPHOCYTES; MALE; METHOTREXATE; POLYGLUTAMIC ACID; TUMOR CELLS, CULTURED;

EID: 0030297951     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-8049(96)00230-4     Document Type: Article

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