Triacylglycerol lowering properties of the adenosine analog GR 79236 during 5 days of dosing large, old rats: A pilot study

Nutrition Research

Volumn 16, Issue 11-12, 1996, Pages 1925-1932

  Thompson, Cecil S ^a   Strong, Peter ^b   Mikhailidis, Dimitri P ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Antilipolytic; Large Old Rats; Non Esterified Fatty Acids; Triacylglycerol

Indexed keywords

6 N (2 HYDROXYCYCLOPENTYL)ADENOSINE; ADENOSINE DERIVATIVE; ANTILIPEMIC AGENT; FATTY ACID; GLUCOSE; INSULIN; TRIACYLGLYCEROL; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; INSULIN RESISTANCE; LIPOLYSIS; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SYNDROME X;

EID: 0030297494     PISSN: 02715317     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0271-5317(96)00215-1     Document Type: Article

References (19)

1. 1. Hubert HB, Feinleib M, McNamara PM, Castelli WP. Obesity as independent risk factor for cardiovascular disease: A 26-year follow-up of participants in the Framingham Heart Study.. Circulation 1983; 67: 968-977.
2. 2. Larsson B, Svardsudd K, Welin L, Wilhelmsen L, Bjorntorp P, Tibblin G. Abdominal adipose tissue distribution, obesity and risk of cardiovascular disease and death: A 13-year follow-up of participants in the study of men born in 1913. Br Med J 1984; 288: 1401-1404.
3. 3. Hauner H, Stangl K, Schmatz C, Burger K, Blomer H, Pfeiffer EF. Body fat distribution in men with angiographically confirmed coronary artery disease. Atherosclerosis 1990;85: 203-210
4. 4. Avellone G, Di Garbo V, Cordova R, et al. Evaluation of cardiovascular risk factors in overweight and obese subjects. Int Angiol 1993; 13: 25-29.
5. 5. Bjorntorp P. "Portal" adipose tissue as a generator of risk factor for cardiovascular disease and diabetes. Arteriosclerosis 1990; 10: 493-496.
6. 6. Albrink MJ, Meigs JW, Granoff MA. Weight gain and serum triglycerides in normal men. N Eng J Med 1962; 266: 484-489.
7. 7. DeFronzo RA. Glucose intolerance and ageing. Diabetes 1979; 28: 1095-1101.
8. 8. Kotlterman OG, Insel J, Saekow M, Olefsky JM. Mechanisms of insulin resistance in human obesity. J Clin Invest. 1980; 65: 1272-1284.
9. 9. Narimimiya M, Azhar S, Dolkas CB, et al. Insulin resistance in older rats. Am J Physiol 1984; 246: E397-E404.
10. 10. Fujita T, Sugiyama Y, Taketomis S, et al. Reduction of insulin resistance in obese and/or diabetic animals by 5-[4-(1-Methylcyclohexyl (methoxy) benzyl]-thiazolidine-2, 4-dione (ADD-3878, U-63,287, Ciglitazone), a new antidiabetic agent. Diabetes. 1983; 32: 804-810.
11. 11. Thompson CS, Strong P, Mikhailidis DP. Improvement of ketoacidosis in the diabetic rat after the administration of the oral antilipolytic agent GR 79236. Clin Sci 1994; 86: 593-598.
12. 12. Thompson CS, Strong P, Mikhailidis DP. Interactions between insulin and the antilipolytic agent GR 79236 in ketoacidotic diabetic rats. J Drug Develop. 1994; 6: 183-186.
13. 13. Strong P, Anderson R, Coates J, et al. Suppresion of non-esterified fatty acids and triglycerides in experimental animals by the adenosine analogue GR 79236. Clin. Sci. 1993; 84: 663-669.
14. 14. Myles DD, Stratton GD, Strong P, Skidmore IF. The development of tolerance to antilipolytic agents in rats. Biochem Pharmacol 1985; 34: 269-272.
15. 15. Thompson GS, Mikhailidis DP, Gill DS, Jeremy JY, Bell JL, Dandona P. Effect of starvation and sampling time on plasma alkaline phosphatase activity and calcium homestasis in the rat. Lab Animals 1989; 23: 53-58.
16. 16. DeFronzo RA, Cooke CR, Andres R, Faloona G, Davis PJ. The effect of insulin on renal handling of sodium, potassium, calcium and phosphate in man. J Clin Invest 1975; 55: 845-855.
17. 17. Thompson CS, Mikhailidis DP. Streptozotocin-induced ketoacidosis and non ketonuric diabetes in the rat: useful models for drug action. J Pharm Med 1996 (in press).
18. 18. Thompson CS, Mikhailidis DP. Insulin resistance and mechanical dysfunction in hearts of Wistar rats with streptozotocin-induced non-insulin-dependent diabetes mellitus. Diabetologia 1993; 36: 880.
19. 19. Thompson CS, Mikhailidis DP. Partial correction of impaired creatine kinase activity in diabetic rat heart by physical training. Metab Clin Exp 1993; 42: 532-533.