Immunization with dissociated neuraminidase, matrix, and nucleoproteins from influenza A virus eliminates cognate help and antigenic competition

Virology

Volumn 225, Issue 1, 1996, Pages 136-144

  Johansson, Bert E ^a   Kilbourne, Edwin D ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MATRIX PROTEIN; NUCLEOPROTEIN; SIALIDASE; VIRUS VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGENICITY; ARTICLE; CONTROLLED STUDY; HUMORAL IMMUNITY; IMMUNIZATION; INFLUENZA VIRUS A; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALIA; INFLUENZA A VIRUS; INFLUENZA VIRUS; INFLUENZAVIRUS A;

EID: 0030296823     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.1996.0581     Document Type: Article

References (45)

1. Andrew, M. E., Coupar, B. E., Ada, G. L., and Boyle, D. B. (1986). Cell-mediated immune responses to influenza virus antigens expressed by vaccinia virus recombinants. Microb. Pathol. 1, 443-451.
2. Andrew, M. E., Coupar, B. E., Boyle, D. B., and Ada, G. L. (1987). The roles of influenza virus hemagglutinin and nucleoprotein in protection: Analysis using vaccinia virus recombinants. Scan. J. Immunol. 25, 21-35.
3. Archetti, J., and Horsfall, F. (1950). Persistent antigenic variation of influenza A virus after incomplete neutralization in ovo with heterologous immune serum. J. Exp. Med. 92, 1521-1529.
4. Barr, M., and Llewellyn-Jones, M. (1953a). Some factors influencing the response of animals to immunization with combined prophylactics. Br. J. Exp. Pathol. 34, 12-22.
5. Barr, M., and Llewellyn-Jones, M. (1953b). Interferences with antitoxic responses in immunization with combined prophylactics. Br. J. Exp. Pathol. 34, 233-240.
6. Barr, M., and Llewellyn-Jones, M. (1955). Some factors influencing the response to immunization with single 9′ combined prophylactics. Br. J. Exp. Pathol. 36, 147-154.
7. Beutner, K., Chow, T., Rubi, E., Strussenberg, J., Clement, J., and Ogra, P. (1979). Evaluation of a neuraminidase specific influenza A virus vaccine in children: Antibody responses and effects on two successive outbreaks of natural infection. J. Infect. Dis. 140, 844-856.
8. Braciale, T. J. (1977). Immunologic recognition of influenza virus infected cells. Cell Immunol. 33, 423-434.
9. Braciale, T. J., and Yap, K. L. (1978). Role of viral infectivity in the induction of influenza virus-specific cytotoxic T cells. J. Exp. Med. 147, 1236-1256.
10. Claas, E. C. J., Kawaoka, Y., De Jong, J. C., Masurel, N., and Webster, R. (1994). Infection of children with avian-human reassortant influenza virus from pigs in Europe. Virology 204, 453-457.
11. Couch, R., Kasel, J., Gerin, J., Schulman, J., and Kilbourne, E. (1974). Induction of partial immunity to influenza by neuraminidase specific vaccine. J. Infect. Dis. 1, 411-423.
12. Ennis, F. A., Rock, A. H., Qi, K-L., Schild, G. C., Riley, D., Pratt, R., and Potter, C. W. (1981). HLA-restricted virus-specific cytotoxic T-lymphocyte responses to live and inactivated influenza vaccines. Lancet 2, 887-891.
13. Fleischer, B., Becht, H., and Rott, R. (1985). Recognition of viral antigens by human influenza A virus-specific T lymphocyte clones. J. Immunol. 135, 2800-2804.
14. Hocart, M., Grajower, B., Donabedian, A., Pokorny, B. A., Whitaker, C., and Kilbourne, E. D. (1995). Preparation and characterization of a purified influenza virus neuraminidase vaccine. Vaccine 13, 1793-1798.
15. Huddelston, J., and Brownlee, G. (1982). The sequence of the nucleoprotein gene of human influenza A virus strain A/NT/60/68. Nucleic Acids Res. 10, 1029-1038.
16. Jalil, F., Zuman, S., Carlsson, B., Glass, R. I., Kapikian, A. Z., Mellander, L., and Hanson, L. A. (1991). Immunogenicity and reactogenicity of rhesus rotavirus vaccine given in combination with oral or inactivated poliovirus vaccines and diphtheria-tetanus-pertussis vaccine. Trans. R. Soc. Trop. Med. Hyg. 85, 292-296.
17. Johansson, B. E., Bucher, D. J., and Kilbourne, E. D. (1989). Purified influenza virus hemagglutinin and neuraminidase are equivalent immunogens. J. Virol. 63, 1239-1246.
18. Johansson, B. E., Gradjower, B., and Kilbourne, E. D. (1993). Infection permissive immunization with influenza virus neuraminidase prevents weight loss of infected mice. Vaccine 10, 1037-1039.
19. Johansson, B. E., and Kilbourne, E. D. (1991). Comparative long term effects in a mouse model system of influenza whole virus vaccine and purified neuraminidase vaccine followed by sequential infections. J. Infect. Dis. 162, 800-809.
20. Johansson, B. E., and Kilbourne, E. D. (1994). Immunization with purified N1 and N2 influenza virus neuraminidase demonstrates cross-reactivity without antigenic competition. Proc. Natl. Acad. Sci. USA 91, 2358-2361.
21. Johansson, B. E., Moran, T. M., Bona, C. A., Popple, S. W., and Kilbourne, E. D. (1987a). Immunologic response to influenza virus neuraminidase is influenced by prior experience with the associated viral hemagglutinin II: Sequential infection of mice simulates human experience. J. Immunol. 139, 2010-2014.
22. Johansson, B. E., Moran, T. M., Bona, C. A., and Kilbourne, E. D. (1987b). Immunologic response to influenza virus neuraminidase is influenced by prior experience with the associated viral hemagglutinin III: Reduced generation of neuraminidase specific helper T cells in hemagglutinin primed mice. J. Immunol. 139, 2015-2019.
23. Johansson, B. E., Moran, T. M., and Kilbourne, E. D. (1987c). Antigen-presenting B cells cooperatively mediate intravirionic antigenic competition between influenza A virus surface glycoproteins. Proc. Natl. Acad. Sci. USA 84, 6869-6873.
24. Johansson, B. E., Price, P. M., and Kilbourne, E. D. (1995). Immunogenicity of influenza A virus N2 neuraminidase produced in insects larvae by baculovirus recombinants. Vaccine 13, 841-845.
25. Kida, H., Ito, T., Yasuda, J., Shimizu, Y., Itakura, C., Shortridge, K., Kawaoka, Y., and Webster, R. (1994). Potential for transmission of avian viruses to pigs. J. Gen. Virol. 75, 2183-2188.
26. Kilbourne, E. D. (1976). Comparative efficacy of neuraminidase-specific and conventional influenza virus vaccines in induction of antibody to neuraminidase in humans. J. Infect. Dis. 134, 384-389.
27. Kilbourne, E. D., Cerini, C. P., Khan, M. W., Mitchell, J. W., Jr., and Ogra, P. O. (1987). Immunologic response to the influenza virus neuraminidase is influenced by prior experience with the associated viral hemagglutinin. I. Studies in human vaccinees. J. Immunol. 138, 3010-3013.
28. Kilbourne, E. D., Couch, R. B., Kasel, J. A., Keitel, W. A., Cate, T. R., Quarles, J. H., Grajower, B., Pokorny, B. A., and Johansson, B. E. (1995). Purified influenza A virus N2 neuraminidase vaccine is immunogenic and non-toxic in humans. Vaccine 13, 1799-1803.
29. Lawson, C., Bennink, J. R., Restifo, N., Yewdell, J., and Murphy, B. R. (1994). Primary pulmonary cytotoxic T lymphocytes induced by immunization with a vaccinia virus recombinant expressing influenza A virus nucleoprotein peptide do not protect mice against challenge. J. Virol. 68, 3505-3511.
30. Mandler, J., and Scholtissek, C. (1989). Localization of the temperature-sensitive defect in the nucleoprotein of an influenza A/FPV/Rostock/34. Virus Res. 12(2), 113-121.
31. McMichael, A., Gotch, F., Cullen, P., Askonas, B., and Webster, R. (1981). The human cytotoxic T cell response to influenza vaccination. Clin. Exp. Immunol. 43, 276-284.
32. McMichael, A., Gotch, F., Noble, G., and Beare, P. (1983). Cytotoxic T-cell immunity to influenza. N. Engl. J. Med. 309, 13-17.
33. McMichael, A., Michie, C., Gotch, F., Smith, G., and Moss, B. (1986). Recognition of influenza A virus nucleoprotein by human cytotoxic T lymphocytes. J. Gen. Virol. 164, 1397-1406.
34. Reiss, C., and Schulman, J. (1980). Influenza type A virus M protein expression on infected cells is responsible for cross-reactive recognition by cytotoxic thymus-derived lymphocytes. Infect. Immun. 29, 719-723.
35. Russell, S., and Liew, F. (1979). T cells primed by influenza virion internal components can cooperate in the antibody response to hemagglutinin. Nature 280, 147-151.
36. Russell, S., and Liew, F. (1980). Cell cooperation in antibody responses to influenza virus. I. Priming of helper T cells by internal components of the virion. Eur. J. Immunol. 10, 791-796.
37. Scherle, P. A., and Gerhard, W. A. (1986). Functional analysis of influenza-specific helper T cell clones in vivo. J. Exp. Med. 164, 1114-1128.
38. Schulman, J. L., and Kilbourne, E. D. (1963). Experimental transmission of influenza virus infection in mice. I. Period of transmissibility. J. Exp. Med. 118, 257-261.
39. Taussig, M. (1977). Antigenic competition. In "The Antigens" (M. Sela, Ed.), Vol. IV, pp. 333-368. Academic Press, New York.
40. Townsend, A. R. M., McMichael, A. J., Carter, N. P., Huddleston, J. A., and Brownlee G. G. (1984). Cytotoxic T Cell recognition of the influenza nucleoprotein and hemagglutinin expressed in transfected mouse L cells. Cell 39, 13-25.
41. Ulmer, J. B., Donnelly, J. J., Parker, S. E., et al. (1993). Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 259, 1745-1748.
42. Webster, R. G., and Askonas, B. A. (1980). Cross-protection and cross-reactive cytotoxic T cells induced by influenza virus vaccines in mice. Eur. J. Immunol. 10, 396-401.
43. Wraith, D. C. (1986). Induction of influenza A virus cross reactive cytotoxic T lymphocytes by purified viral proteins. In "Options for the Control of Influenza" (A. P. Kendal and P. A. Patriarca, Eds.), pp. 461-469. A. R. Liss, New York.
44. Yap, K. L., and Ada, G. L. (1977). Cytotoxic T cells specific for influenza virus-infected target cells. Immunology 32, 151-159.
45. Yewdell, J. W., Bennink, J. R., Smith, G. L., and Moss, B. (1985). Influenza A virus nucleoprotein is a major target antigen for cross reactive anti-influenza A virus cytotoxic T lymphocytes. Proc. Natl. Acad. Sci. USA 83, 1785-1789.