Nonshivering thermogenesis in adult and aged C57BL/6J mice housed at 22°C and at 29°C

Experimental Gerontology

Volumn 31, Issue 6, 1996, Pages 687-698

  Talan, Mark I ^a,d   Kirov, Sergey A ^a,b   Kosheleva, Nadejda A ^a,c  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c INSTITUTE OF EXPERIMENTAL CARDIOLOGY   (Russian Federation)

^d NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

body temperature; brown adipose tissue; cold tolerance; heat production; rodents; sympathetic nervous activity; thermogenin; thermoregulation; uncoupling protein

Indexed keywords

UNCOUPLING PROTEIN;

ADRENERGIC SYSTEM; ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL VENTILATION; BODY MASS; BODY TEMPERATURE; BROWN ADIPOSE TISSUE; COLD ACCLIMATIZATION; COLD STRESS; COLD TOLERANCE; CONTROLLED STUDY; MOUSE; MUSCLE RELAXATION; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; SHIVERING; SYMPATHETIC NERVE; SYMPATHETIC TONE; THERMOGENESIS; THERMOREGULATION;

ADIPOSE TISSUE, BROWN; AGING; ANIMALS; BODY TEMPERATURE REGULATION; BODY WEIGHT; COLD; MALE; MICE; MICE, INBRED C57BL; SHIVERING; SYMPATHETIC NERVOUS SYSTEM;

ANIMALIA; RODENTIA;

EID: 0030296499     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(96)00095-2     Document Type: Article

References (36)

1. BALMAGIYA, T. and ROZOVSKI, S.J. Age-related changes in thermoregulation in male albino rats. Exp. Gerontol. 18, 199-210, 1983.
2. CANNON, B., BENGTSSON, T., DICKER, A., JACOBSSON, A., KUUSELA, P., THONBERG, H., TVTDIK, P., ZHAO, J., and NEDERGAARD, J. The role of adrenergic stimulation in regulation of heat production and recruitment of brown adipose tissue. In: Thermal Balance in Health and Disease: Advances in Pharmacological Sciences, Zeisberer, E., Schönbaum, E., Lomax, P (Editors), pp. 87-102, Birkhauser Verlag, Berlin, 1994.
3. COLLINS, K.J., DORE, C., EXTON-SMITH, A.N., FOX, R.H., MCDONALD, I.C., and WOODWARD, P.M. Accidental hypothermia and impired temperature homeostasis in the elderly. Br. Med. J. 1, 355-356, 1977.
4. COX, B., LEE, T.F., and PARKES, J. Decreased ability to cope with heat and cold linked to a dysfunction in central dopaminergic pathway in elderly rats. Life Sci. 28, 2039-2044, 1981.
5. DERRY, D.M., SCHÖNBAUM, E., and STEINER, G. Two sympathetic nerve supplies to brown adipose tissue of the rat. Can. J. Physiol. Pharmacol. 47, 57-63, 1969.
6. ENGEL, B.T., SATO, A., and SATO, Y. Responses of sympathetic nerves innervating blood vessels in interscapular brown adipose tissue and skin during cold stimulation in anesthetized C57BL/6J mice. Jpn. J. Physiol. 42, 549-559, 1992.
7. FLAIM, K.E., HOROWITZ, J.M., and HOROWITZ, B.A. Functional and anatomical characteristics of the nerve-brown adipose tissue interaction in the rats. Pflugers Arch. 365, 9-14, 1976.
8. FOSTER, D.O. Quantitative contribution of brown adipose tissue to overall metabolism. Can. J. Biochem. Cell Biol. 62, 618-622, 1984.
9. FOSTER, D.O. and FRYDMAN, M.L. Tissue distribution of cold-induced thermogenesis in conscious warm-or cold-acclimated rats reevaluated from changes in tissue blood flow: The dominant role of brown adipose tissue in the replacement of shivering by nonshivering thermogenesis. Can. J. Physiol. Pharmacol. 57, 267-270, 1979.
10. GORDON, C.J. Temperature Regulation in Laboratory Rodents. Cambridge UP, New York, 1993.
11. GRAD, B. and KRAL, V.A. The effect of senescence on resistance to stress. 1. Response of young and old mice to cold. J. Gerontol. 12, 172-181, 1957.
12. HIMMS-HAGEN, J. Brown adipose tissue and cold-acclimation. In: Brown Adipose Tissue, Trayhurn, P. and Nicholls, D.G. (Editors), pp. 214-286, Edward Arnold, London, 1986.
13. HIMMS-HAGEN, J. Brown adipose tissue thermogenesis: Role in thermoregulation, energy regulation and obesity. In: Thermoregulation Physiology and Biochemistry, Schönbaum, E. and Lomax, P. (Editors), pp. 327-414, Pergamon Press, New York, 1990.
14. ITO, K., SATO, A., SATO, Y., and SUZUKI, H. Increases in adrenal catecholamime secretion and adrenal sympathetic nerve unitary activities with aging in rats. Neurosci. Lett. 69, 263-268, 1986.
15. KAWATE, R., TALAN, M.I., and ENGEL, B.T. Aged C57BL/6J mice respond to cold with increased sympathetic nervous activity to interscapular brown adipose tissue. J. Gerontol. 48, B180-B183, 1993.
16. KAWATE, R., TALAN, M.I., and ENGEL, B.T. Sympathetic nervous activity to brown adipose tissue increases in cold-tolerant mice. Physiol. Behav. 55, 921-925, 1994.
17. KIANG-ULRICH, M. and HORVATH, S.M. Age related differences in food intake, body weight, and survival of male F344 rats in 5°C cold. Exp. Gerontol. 20, 107-117, 1985.
18. KIROV, S.A., TALAN, M.I., and ENGEL, B.T. Sympathetic outflow to interscapular brown adipose tissue in cold acclimated mice. Physiol. Behav. 59, 231-235, 1996.
19. KIROV, S.A., TALAN, M.I., KOSHELEVA, N.A., and ENGEL, B.T. Nonshivering thermogenesis during acute cold exposure in adult and aged C75BL/6J mice. Exp. Gerontol. 31, 409-419, 1996.
20. LEE, T.F. and WANG, L.C. Improving cold tolerance in elderly rats by aminophylline. Life Sci. 36(21), 2052-2053, 1985.
21. MABRY, T.R., GOLD, P.E., and MCCARTY, R. Age-related changes in plasma catecholamines to chronic intermittent stress. Physiol. Behav. 58, 49-56, 1995.
22. MCDONALD, R.B., STERN, J.S., and HORWITZ, B. Cold-induced metabolism and brown fat GDP binding in young and old rats. Exp. Gerontol. 22, 409-420, 1987.
23. MCLEAN, J.A. and TOBIN, T. Animal and Human Calorimetry. New York: Cambridge University Press, 1987.
24. 3H] SB 206606. Mol. Pharmacol. 46, 357-363, 1994.
25. NECHAD, M. Structure and development of brown adipose tissue. In: Brown Adipose Tissue, Trayhurn, P. and Nicholls, D.G. (Editors), pp. 1-30, Edward Arnold, London, 1986.
26. 3H] GDP binding and thermogenin amount in brown adipose tissue mitochondria from cold-exposed rats. Am. J. Physiol. 248, C365-C371, 1985.
27. SCARPACE, P.J., MATHENY, M., and BORST, S.E. Thermogenesis and mitochondrial GDP binding with age in response to the novel agonist CGO-12177A. Am. J. Physiol. 262, E185-E190, 1992.
28. SCARPACE, P.J., MATHENY, M., BORST, S.E., and TUMER, N. Thermoregulation with age: Role of thermogenesis and uncoupling protein expression in brown adipose tissue. Proc. Soc. Exp. Biol. Med. 205, 154-161, 1994.
29. SCARPACE, P.J., MOORADIAN, A.D., and MORLEY, J.E. Age-associated decrease in beta-adrenergic receptors and adenylate cyclase activity in rat brown adipose tissue. J. Gerontol. 43, B65-B70, 1988.
30. TALAN, M.I. and ENGEL, B.T. An improved cold stress test for aging mice. Exp. Gerontol. 19, 76-86, 1984.
31. TALAN, M.I., ENGEL, B.T., and WHITAKER, J.R. A longitudinal study of tolerance to cold stress among C57BL/6J mice. J. Gerontol. 40, 8-14, 1985.
32. TALAN, M.I. and KIROV, S.A. Sympathetic outflow to brown adipose tissue and metabolic heat production in adult, aged, and cold-acclimated adult mice. In: Thermal Balance in Health and Disease: Advances in Pharmacological Sciences, Zeisberer, E., Schönbaum, E., and Lomax, P. (Editors), pp. 109-114, Birkhauser Verlag, Berlin, 1994.
33. TATELMAN, H.M. and TALAN, M.I. Metabolic heat production during repeated cold stress in adult and aged male C57BL/6J mice. J. Gerontol. 45, B215-B219, 1990.
34. TAYLOR, P. Neuromuscular blocking agents. In: Goodman's and Gilman's The Pharmacological Basis of Therapeutics, Goodman, L.S. and Gilman, A. (Editors), pp. 222-235, Macmillan Publishing Co., New York, 1985.
35. YAMASHITA, H., YAMAMOTO, M., OOKAWARA, T., SATO, Y., UENO, N., and OHNO, H. Discordance between thermogenic activity and expression of uncoupling protein in brown adipose tissue of old rats. J. Gerontol. 49, B54-B59, 1994.
36. ZHAO, J., UNELIUS, L., BENGTSSON, T., CANNON, B., and NEDERGAARD, J. Coexisting β-adrenoreceptor subtypes: Significance for thermogenic process in brown fat cells. Am. J. Physiol. 267, C969-C979, 1994.