Chloroquine bioassay of plasma specimens obtained from soldiers on chloroquine plus doxycycline for malaria prophylaxis

International Journal for Parasitology

Volumn 26, Issue 11, 1996, Pages 1325-1329

  Kotecka, Barbara M ^a   Edstein, Michael D ^a   Rieckmann, Karl H ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

chloroquine; doxycycline; in vitro antimalarial activity; Plasmodium falciparum

Indexed keywords

CHLOROQUINE; DOXYCYCLINE;

ADULT; ARTICLE; BIOASSAY; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALARIA; MALE; PATIENT COMPLIANCE; PLASMODIUM FALCIPARUM; PROPHYLAXIS;

ANTIMALARIALS; AUSTRALIA; BIOLOGICAL ASSAY; CHLOROQUINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOXYCYCLINE; HUMANS; MALARIA; MILITARY PERSONNEL; RANDOM ALLOCATION; REGRESSION ANALYSIS;

PLASMODIUM FALCIPARUM;

EID: 0030295353     PISSN: 00207519     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0020-7519(96)00116-6     Document Type: Article

References (15)

1. Alvan G., Ekman L. & Lindstrom B. 1982. Determination of chloroquine and its desethyl metabolite in plasma, red blood cells and urine by liquid chromatography. Journal of Chromatography 229: 241-247.
2. Bergqvist Y. & Churchill F. C. 1988. Detection and determination of antimalarial drugs and their metabolites in body fluids. Journal of Chromatography 434: 1-20.
3. Brown N. D., Stermer-Cox M. G. & Poon B. T. 1984. Separation and identification of a plasma and urinary mono-acetylated conjugate of chloroquine in man by ion-pair high-performance liquid chromatography. Journal of Chromatography 309: 426-430.
4. Kotecka B. & Rieckmann K. H. 1993. Chloroquine bioassay using malaria microcultures. American Journal of Tropical Medicine and Hygiene 49: 460-464.
5. McChesney E. W., Banks W. F. & McAuliff J. P. 1962. Laboratory studies of the 4-aminoquinoline antimalarials. II. Plasma levels of chloroquine and hydroxychloroquine in man after various oral dosage regimens. Antibiotic and Chemotherapy 12: 583-594.
6. Nieder M. & Jaeger H. 1988. Selective quantification of doxycycline in human plasma and urine with optimised chromatography. Chromatographia 25: 526-530.
7. Peters W. 1985. The problem of drug resistance in malaria. Parasitology 90: 705-715.
8. Rieckmann K. H. 1984. Antibiotics. In: Handbook of Experimental Pharmacology: Antimalarial Drugs, Vol. 68/II, Chapter 14, pp. 443-470. Springer, Berlin.
9. Rieckmann K. H., Sax L. S., Campbell G. H. & Mrema J. E. 1978. Drug sensitivity of Plasmodium falciparum. An in vitro microtechnique. Lancet i: 22-23.
10. Rieckmann K. H., Yeo A. E. T., Davis D. R., Hutton D. C., Wheatley P. F. & Simpson R. 1993. Recent military experience with malaria chemoprophylaxis. Medical Jouurnal of Australia 158: 446-449.
11. Shmuklarsky M. J., Boudreau E. F., Pang L. W., Smith J. I., Schneider I., Fleckenstein L., Abdelrahim M. M., Canfield C. J. & Schuster B. 1994. Failure of doxycycline as a causal prophylactic agent against Plasmodium falciparum malaria in healthy non-immune volunteers. Annals of International Medicine 120: 294-299.
12. Wildfeuer A., Laufen H., Leitold M., Zimmermann T. 1993. Comparison of the pharmacokinetics of three-day and five-day regimens of azithromycin in plasma and urine. Journal of Antimicrobial Chemotherapy 31: 51-56.
13. WHO, 1990. In vitro micro-test (Mark II) for the assessment of the response of Plasmodium falciparum to chloroquine, mefloquine, quinine, sulfadoxine/pyrimethamine and amodiaquine. World Health Organization, Geneva. Mimeographed document WHO/MAP/87.2, revised June 1990.
14. Yeo A. E. T. & Rieckmann K. H. 1992. A bioassay for mefloquine. Journal of Parasitology 78: 1096-1097.
15. Yeo A. E. T. & Rieckmann K. H. 1995. Increased antimalarial activity of azithromycin during prolonged exposure of Plasmodium falciparum in vitro. International Journal for Parasitology 25: 531-532.