A hypothesis to explain the substrate reactivity of ribosomal and stem-loop RNA with ricin A-chain

Toxicon

Volumn 34, Issue 11-12, 1996, Pages 1317-1324

  Link, Todd ^a   Chen, Xiang Yang ^a   Niu, Lin Hao ^a   Schramm, Vern L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RIBOSOME RNA; RICIN A; RNA;

BINDING SITE; CATALYSIS; CONFERENCE PAPER; ENZYME SPECIFICITY; HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; RNA STRUCTURE;

HUMANS; KINETICS; NUCLEIC ACID CONFORMATION; RICIN; RNA, RIBOSOMAL; RNA-BINDING PROTEINS; SUBSTRATE SPECIFICITY;

EID: 0030293025     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(96)00102-X     Document Type: Conference Paper

References (12)

1. DeWolf, W. E., Fullin, F. A. and Schramm, V. L. (1979) The catalytic site of AMP nucleosidase. J. biol. Chem. 254, 10868-10875.
2. Endo, Y. and Tsurugi, K. (1988) The RNA N-glycosidase activity of ricin A-chain. J. biol. Chem. 263, 8735-8739.
3. Endo, Y., Gluck, A. and Wool, I. G. (1991) Ribosomal RNA identity elements for ricin A-chain recognition and catalysis. J. molec. Biol. 221, 193-207.
4. Garrett, E. R. and Mehta, P. J. (1972) Solvolysis of adenine nucleosides. I. Effects of sugars and adenine substituents on acid solvolyses. J. Am. chem. Soc. 94, 8532-8541.
5. Gluck, A., Endo, Y. and Wool, I. G. (1992) Ribosomal RNA identity elements for ricin A-chain recognition and catalysis - Analysis with tetraloop mutants. J. molec. Biol. 226, 411-424.
6. Milligan, J. F., Groebe, D. R., Witherell, G. W. and Uhlenbeck, O. C. (1987) Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates. Nucl. Acids Res. 15, 8783-8798.
7. Monzingo, A. F. and Robertus, J. D. (1992) X-ray analysis of substrate anologs in the ricin A-chain active site. J. molec. Biol. 227, 1136-1145.
8. Orita, M., Nishikawa, F., Shimayama, T., Taira, K., Endo, Y. and Nishikawa, S. (1993) High-resolution NMR study of a synthetic oligoribonucleotide with the tetranucleotide GAGA loop that is a substrate for the cytotoxic protein. Nucl. Acids Res. 21, 5670-5678.
9. SantaLucia, J. Jr, Kierzek, R. and Turner, D. H. (1992) Context dependence of hydrogen bond free energy revealed by substitutions in the RNA hairpin. Science 256, 217-219.
10. Szewczak, A. A., Moore, P. B., Chan, Y.-L. and Wool, I. G. (1993) The conformation of the sarcin/ricin loop from 28S ribosomal RNA. Proc. natn. Acad. Sci. U.S.A. 90, 9581-9585.
11. Turner, D. H., Sugimoto, N. and Freier, S. M. (1988) RNA structure prediction. A. Rev. biophys. Chem. 17, 167-192.
12. Wolfenden, R. (1972) Analog approaches to the structure of the transition state in enzyme reactions. Accts Chem. Res. 5, 10-18.