Febrile seizures treatment and outcome

Brain and Development

Volumn 18, Issue 6, 1996, Pages 438-449

  Knudsen, Finn Ursin ^a  

^a GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Diazepam; Epilepsy; Febrile seizure; Outcome; Prophylaxis; Treatment

Indexed keywords

ANTICONVULSIVE AGENT; BENZODIAZEPINE DERIVATIVE; CARBAMAZEPINE; CHLORAL HYDRATE; CLONAZEPAM; DIAZEPAM; LIDOCAINE; LORAZEPAM; NITRAZEPAM; OXCARBAZEPINE; PARACETAMOL; PHENOBARBITAL; PHENYTOIN; THIOPENTAL; VALPROIC ACID; VIGABATRIN;

ATAXIA; BEHAVIOR DISORDER; CHILD; CLINICAL TRIAL; COGNITIVE DEFECT; DEPRESSION; DROWSINESS; DRUG EFFICACY; DRUG FATALITY; EPILEPSY; FEBRILE CONVULSION; HEALTH CARE COST; HEALTH CARE POLICY; HOME CARE; HUMAN; HYPERACTIVITY; HYPERKINESIA; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; META ANALYSIS; ORAL DRUG ADMINISTRATION; PATIENT COMPLIANCE; RECTAL DRUG ADMINISTRATION; RECURRENCE RISK; RESPIRATORY ARREST; REVIEW; RISK FACTOR; SEIZURE; SIDE EFFECT; TREATMENT OUTCOME; TREATMENT PLANNING;

EID: 0030292925     PISSN: 03877604     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0387-7604(96)00059-9     Document Type: Article

References (86)

1. 1. Saper CB, Breder CD. The neurologie basis of fever. N Engl J Med 1994; 330: 1880-6.
2. 2. Cassano PA, Koepsell TD, Farwell JR. Risk of febrile seizures in childhood in relation to prenatal maternal cigarette smoking and alcohol intake. Am J Epidemiol 1990; 132: 462-73.
3. 3. Knudsen FU. Frequent febrile episodes and recurrent febrile convulsions. Acta Neurol Scand 1988; 78: 414-7.
4. 4. Rantala H, Uhari M. Risk factors for recurrences of febrile convulsions. Acta Neurol Scand 1994; 90: 207-10.
5. 5. Uhari M, Rantala H, Vainionpää L, Kurttila R. Effect of acetaminophen and of low intermittent doses of diazepam on prevention of recurrences of febrile seizures. J Pediatr 1995; 126: 991-5.
6. 6. Consensus statement of febrile seizures. In: Nelson KB, Ellenberg JH, eds. Febrile seizures. New York; Raven Press, 1981: 301-6.
7. 7. Research Unit of Royal College of Physicians and British Paediatric Association, London. Guidelines for the management of convulsions with fever. BMJ 1991; 303: 634-6.
8. 8. Stephenson JBS. Two types of febrile seizure: anoxic (syncopal) and epileptic mechanisms differentiated by oculocardiac reflex. BMJ 1978; 2: 726-8.
9. 9. Wallace SJ. The child with febrile seizures. London: Butterworth & Company. 1988: 1-182.
10. 10. Knudsen FU. Recurrence risk after first febrile seizure and effect of short term diazepam prophylaxis. Arch Dis Child 1985; 60: 1045-9.
11. 11. Knudsen FU. Intermittent diazepam prophylaxis in febrile convulsions. Acta Neurol Scand 1991; 83 (suppl.): 1-24.
12. 12. Verity CM, Butler NR, Golding J. Febrile convulsions in a national cohort followed up from birth. I. Prevalence and recurrence in the first five years of life. BMJ 1985; 290: 1307-10.
13. 13. Shirts SB, Hauser WA, Annegers JF, Kurland LT. Risk of recurrence of febrile seizures in a population-based cohort of children, Rochester, Minnesota. Neurology 1987; 37 (suppl. 1): 149.
14. 14. Offringa M, Bossuyt PMM, Lubsen J et al. Risk factors for seizure recurrence in children with febrile seizures: a pooled analysis of individual patient data from five studies. J Pediatr 1994; 124: 574-84.
15. 15. Knudsen FU. Effective short-term diazepam prophylaxis in febrile convulsions. J Pediatr 1985; 106: 487-90.
16. 16. Greenblatt DJ, Shader RI. Clinical pharmacokinetics of the benzodiazepines. In: Smith DE, Wesson DR, eds. The benzodiazepines. Lancaster: MTP Press, 1985: 43-58.
17. 17. Rylance GW, Poulton J, Cherry RC, Cullen RE. Plasma concentrations of clonazepam after single rectal administration. Arch Dis Child 1986; 61: 186-8.
18. 18. Dooley JM, Tibbies JAR, Rumney PG, Dooley KC. Rectal lorazepam in the treatment of acute seizures in childhood. Ann Neurol 1985; 18: 412-3.
19. 19. Lacey DJ, Singer WD, Horwitz SJ, Gilmore H. Lorazepam therapy of status epilepticus in children and adolescents. J Pediatr 1986; 108: 771-4.
20. 20. Bleck TP. Review: therapy for status epilepticus. Clin Neuropharmacol 1983; 6: 255-65.
21. 21. Giang DW, McBride MC. Lorazepam versus diazepam for the treatment of status epilepticus. Pediatr Neurol 1988; 4: 358-61.
22. 22. Knudsen FU. Optimum management of febrile seizures in childhood. Drugs 1988; 36: 111-20.
23. 23. Agurell S, Berlin A, Ferngren H, Hellström B. Plasma levels of diazepam after parenteral and rectal administration in children. Epilepsia 1975; 16: 277-83.
24. 24. Knudsen FU. Plasma-diazepam in infants after rectal administration in solution and by suppository. Acta Paediatr Scand 1977; 66: 563-7.
25. 25. Dulac O, Aicardi J, Rey E, Olive G. Blood levels of diazepam after single rectal administration in infants and children. J Pediatr 1978; 93: 1039-41.
26. 26. Meberg A, Langslet A, Bredesen JE, Lunde PKM. Plasma concentration of diazepam and Af-desmethyldiazepam in children after a single rectal or intramuscular dose of diazepam. Eur J Clin Pharmacol 1978; 14: 273-6.
27. 27. Dhillon S, Ngwane E, Richens A. Rectal absorption of diazepam in epileptic children. Arch Dis Child 1982; 57: 264-7.
28. 28. Minagawa K, Miura H, Kaneko T, Sudo Y. Plasma concentrations of diazepam and Af-desmethyldiazepam in infants with febrile convulsions after single rectal administrations of diazepam suppositories or solutions. Brain Dev (Tokyo) 1982; 14: 11-9.
29. 29. Moolenaar F, Bakker S, Visser J, Huizinga T. Biopharmaceutics of rectal administration of drugs in man. IX. Comparative biopharmaceutics of diazepam after single rectal, oral, intramuscular and intravenous administration in man. Int J Pharmacol 1980; 5: 127-37.
30. 30. Minagawa K, Mizuno S, Shirai H, Miura H. A pharmacokinetic study on the effectiveness of intermittent oral diazepam in the prevention of recurrent febrile convulsions (in Japanese). No To Hattatsu (Tokyo) 1985; 17: 162-7.
31. 31. Hillestad L, Hansen T, Melsom H, Drivenes A. Diazepam metabolism in normal man. I. Serum concentrations and clinical effects after intravenous, intramuscular and oral administration. Clin Pharmacol Ther 1974; 16: 479-84.
32. 32. Mizuno S, Miura H, Minagawa K, Shirai H. A pharmacokinetic study on the effectiveness of rectal administration of diazepam in solutions: a comparison with intravenous administration (in Japanese). No To Hattatsu (Tokyo) 1987; 19: 1182-94.
33. 33. Knudsen FU. Rectal administration of diazepam in solution in the acute treatment of convulsions in infants and children. Arch Dis Child 1979; 54: 855-7.
34. 34. Hoppu K, Santavuori P. Diazepam rectal solution for home treatment of acute seizures in children. Acta Paediatr Scand 1981; 70: 369-72.
35. 35. Ventura A, Basso T, Bortolan G. et al. Home treatment of seizures as a strategy for the long term management of febrile convulsions in children. Helv Paediatr Acta 1982; 37: 581-7.
36. 36. Sykes RM, Okonofua JA. Rectal diazepam solution in the treatment of convulsions in the children's emergency room. Ann Trop Pediatr 1988; 8: 259-61.
37. 37. Camfield CS, Camfield PR, Smith E, Dooley JM. Home use of rectal diazepam to prevent status epilepticus in children with convulsive disorders. J Child Neurol 1989; 4: 125-6.
38. 38. Newton RW. Randomised controlled trials of phenobarbitone and valproate in febrile convulsions. Arch Dis Child 1988; 63: 1189-91.
39. 39. Newton RW, McKinlay I. Subsequent management of children with febrile convulsions. Dev Med Child Neurol 1988; 30: 402-6.
40. 40. Camfield PR, Camfield CS, Gordon K, Dooley JM. Prevention of recurrent febrile seizures. J Pediatr 1995; 126, 929-30.
41. 41. Knudsen FU, Vestermark S. Prophylactic diazepam or phenobarbitone in febrile convulsions: a prospective controlled study. Arch Dis Child 1978; S3: 660-3.
42. 42. Camfield CS, Chaplin S, Doyle AB, Shapiro SH, Cunnings C, Camfield PR. Side effects of phenobarbital in toddlers: behavioral and cognitive aspects. J Pediatr 1979; 95: 361-5.
43. 43. Vining EPG, Mellits ED, Dorsen MM et al. Psychologic and behavioral effects of antiepileptic drugs in children: a double-blind comparison between phenobarbital and valproic acid. Pediatrics 1987; 80: 165-74.
44. 44. Farwell JR, Lee YJ, Hirtz DG, Sulzbacher SI, Ellenberg JH, Nelson KB. Phenobarbital for febrile seizures - effects on intelligence and on seizure recurrence. N Engl J Med 1990; 322: 364-9.
45. 45. Byrne JM, Camfield PR, Clark-Touesnard M, Hondas BJ. Effects of phenobarbital on early intellectual and behavioral development: a concordant twin case study. J Clin Exp Neuropsychol 1987; 9: 393-8.
46. 46. Brent DA, Crumrine PK, Varma RR, Allan M, Allman C. Phenobarbital treatment and major depressive disorder in children with epilepsy. Pediatrics 1987; 80: 909-17.
47. 47. Minagawa K, Miura H. Phenobarbital, primidone and sodium valproate in the prophylaxis of febrile convulsions. Brain Dev (Tokyo) 1981; 3: 385-93.
48. 48. Dreifuss FE, Santilli N, Langer DH, Sweeney KP, Moline KA, Menander KB. Valproic acid hepatic fatalities: a retrospective review. Neurology 1987; 37: 379-85.
49. 49. Scheffner D, König S, Rauterberg-Ruland I, Kochen W, Hofmann WJ, Unkelbach S. Fatal liver failure in 16 children with valproate therapy. Epilepsia 1988; 29: 530-42.
50. 50. Daugbjerg P, Brems M, Mai J, Ankerhus J, Knudsen FU. Intermittent prophylaxis in febrile convulsions: diazepam or valproic acid? Acta Neurol Scand 1990; 82: 17-20.
51. 51. Dianese G. Prophylactic diazepam in febrile convulsions. Arch Dis Child 1979; 54: 244-5.
52. 52. Ramakrishnan K, Thomas K. Long term prophylaxis of febrile seizures. Indian J Pediatr 1986; 53: 397-400.
53. 53. Thorn I. Prevention of recurrent febrile seizures: intermittent prophylaxis with diazepam compared with continuous treatment with phenobarbital. In: Nelson KB, Ellenberg JH, eds. Febrile seizures. New York: Raven Press, 1981: 119-26.
54. 54. Lee K, Taudorf K, Hvorslev V. Prophylactic treatment with valproic acid or diazepam in children with febrile convulsions. Acta Paediatr Scand 1986; 75: 593-7.
55. 55. Shirai H, Miura H, Sunaoshi W. A clinical study on the effectiveness of intermittent therapy with rectal diazepam suppositories for the prevention of recurrent febrile convulsions: a further study (in Japanese). Tenkan Kenkyu (Tokyo) 1988; 6: 1-10.
56. 56. Minagawa K, Miura H, Mizuno S, Shirai H. Pharmacokinetics of rectal diazepam in the prevention of recurrent febrile convulsions. Brain Dev (Tokyo) 1986; 8: 53-9.
57. 57. Echenne B, Cheminal R, Martin P et al. Utilisation du diazépam dans le traitement préventif à domicile des récidives de convulsions fébriles. Arch Fr Pédiatr 1983; 40: 499-501.
58. 58. Garcia FO, Campos-Castello J, Maldonado JC. Fenobarbital oral continuado o diazepam rectal intermitente para la prevención de la crisis febriles. An Esp Pediatr 1984; 20: 763-9.
59. 59. Mosquera C, Rodrigues J, Cabrero A, Fidalgo I, Fernández RM. Prevención de la recurrencia de crisis febriles: profilaxis intermitente con diacepam rectal comparada in tratamiento continue con valproato sódica. An Esp Pediatr 1987; 27: 379-81.
60. 60. Vanasse M, Masson P, Geoffroy G, Larbrisseau A, David PC. Intermittent treatment of febrile convulsions with nitrazepam. Can J Neurot Sci 1984; 11: 377-9.
61. 61. McKinley I, Newton RW. Intention to treat febrile convulsions with rectal diazepam, valproate or phenobarbitone. Dev Med Child Neurol 1989; 31: 617-25.
62. 62. Eysenck HJ. Meta-analysis and its problems. BMJ 1994; 309: 789-92.
63. 63. Rosman NP, Colton T, Labazzo J et al. A controlled trial of diazepam administered during febrile illnesses to prevent recurrence of febrile seizures. N Engl J Med 1993; 329: 79-84.
64. 64. Autret E, Billard C, Bertrand P, Motte J, Pouplard F, Jonville AP. Double-blind, randomized trial of diazepam versus placebo for prevention of recurrence of febrile seizures. J Pediatr 1990; 117: 490-4.
65. 65. Herlitz G. Studien über die Sog. Initialen Fieberkrämpfe bei Kindern. Acta Pediatr Scand 1941; 29: 9-142.
66. 66. Taylor DC, Ounsted C. Biological mechanisms influencing the outcome of febrile seizures in response to fever. Epilepsy 1971; 12: 33-45.
67. 67. Falconer MA. Mesial temporal sclerosis as a common cause of epilepsy: aetiology, treatment and prevention. Lancet 1974; ii: 767-70.
68. 68. Nelson KB, Ellenberg JH. Prognosis in children with febrile seizures. Pediatrics 1978; 61: 720-7.
69. 69. Nelson KB, Ellenberg JH. Predictors of epilepsy in children who have experienced febrile seizures. N Engl J Med 1976; 295: 1029-33.
70. 70. Verity CM, Butler NR, Golding J. Febrile convulsions in a national cohort followed up from birth. II. Medical history and intellectual ability at 5 years of age. BMJ 1985; 290: 1311-5.
71. 71. Verity CM, Golding J. Risk of epilepsy after febrile convulsions: a national cohort study. BMJ 1991; 303: 1373-6.
72. 72. Annegers JF, Hauser WA, Shirts SB, Kurland LT. Factors prognostic of unprovoked seizures after febrile convulsions. N Engl J Med 1987; 316: 493-8.
73. 73. Roos EM, Peckham CS, West PB, Butler NR. Epilepsy in childhood: findings from the national child development study. BMJ 1980; 280: 207-10.
74. 74. Knudsen FU, Paerregaard A, Andersen R, Andresen J. Long term outcome of prophylaxis for febrile convulsions. Arch Dis Child 1996; 74: 13-8.
75. 75. Schiøttz-Christensen E. Feberkramper. Studier af œtiologi og følgetilstande med udgangspunkt i tvillingeundersøgelser. Copenhagen: FADLs Forlag, 1976.
76. 76. Heijbel J, Blom S, Bergfors PG. Simple febrile convulsions. A prospective incidence study and an evaluation of investigations initially needed. Neuropediatrics 1980; 11: 45-56.
77. 77. Berkovic SF, Howell RA, Hay DA, Hopper JL. Epilepsies in twins. In: Wolf P, ed, Epileptic seizures and syndromes. London: John Libbey, 1994: 157-64.
78. 78. Kajitani T, Kimura T, Sumita M, Kaneko M. Relationship between benign epilepsy of children with centrotemporal EEG foci and febrile convulsions. Brain Dev (Tokyo) 1992; 14: 230-4.
79. 79. Verity CM, Ross EM, Golding J. Outcome of childhood status epilepticus and lengthy febrile convulsions: findings of national cohort study. BMJ 1993; 307: 225-8.
80. 80. Gross-Tsur V, Shinnar S. Convulsive status epilepticus in children. Epilepsia 1993; 34 (suppl.): 12-20.
81. 81. Maytal J, Shinnar S, Moshé SL, Alvarez LA. Low morbidity and mortality of status epilepticus in children. Pediatrics 1989; 83: 323-31.
82. 82. Holthausen H. Febrile convulsions, mesial temporal sclerosis and temporal lobe epilepsy. In: Wolf P, ed. Epileptic seizures and syndromes. London: John Libbey, 1994: 449-67.
83. 83. Lee K, Diaz M, Melchior JC. Temporal lobe epilepsy - not a consequence of childhood febrile convulsions in Denmark. Acta Neurol Scand 1981; 63: 231-6.
84. 84. Camfield P, Camfield C, Gordon K, Dooley J. What types of epilepsy are preceded by febrile seizures? A population based study of children. Dev Med Child Neurol 1994; 36: 887-92.
85. 85. Tsuboi T. Prevalence and incidence of epilepsy in Tokyo. Epilepsia 1988; 29; 103-10.
86. 86. Finkle BS. Benzodiazepine overdosage. In: Usdin E, Skolnick P, Tallman JF, Greenblatt D, Paul SM, eds. Pharmacology of benzodiazepines. London: MacMillan Press, 1982: 619-28.