Enhanced HIV-1 Activity in Bone Marrow Can Lead to Myelopoietic Suppression Partially Contributed by gag p24

Journal of Immunology

Volumn 157, Issue 9, 1996, Pages 4244-4250

  Rameshwar, Pranela ^a   Denny, Thomas N ^b   Gascón, Pedro ^a,b  

^a Division of Hematology   (United States)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; GAG PROTEIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN G; INTERLEUKIN 3; RECOMBINANT PROTEIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADIPOSE TISSUE; ARTICLE; BLOOD; BONE MARROW; BONE MARROW DISEASE; CELL CULTURE; CLONOGENIC ASSAY; CONNECTIVE TISSUE; DRUG EFFECT; HEMATOPOIESIS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; PATHOPHYSIOLOGY; PHYSIOLOGY; VIROLOGY;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ADIPOSE TISSUE; BONE MARROW; BONE MARROW DISEASES; CELLS, CULTURED; COLONY-FORMING UNITS ASSAY; CONNECTIVE TISSUE; ERYTHROPOIETIN; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HEMATOPOIESIS; HIV CORE PROTEIN P24; HIV-1; HUMANS; IMMUNOGLOBULIN G; INTERLEUKIN-3; RECOMBINANT PROTEINS;

EID: 0030292705     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. Rosenberg, Z. F., and A. S. Fauci. 1991. Immunopathogenesis of HIV infection. FASEB J. 5:2382.
2. Levy, J. A. 1993. Pathogenesis of human immunodeficiency virus infection. Microbiol. Rev. 57:183.
3. Brinchmann, J. E. 1993. Pathogenic aspects of HIV infection. Immunologist 1:167.
4. + lymphocytes. J. Immunol. 142:773.
5. Zack, J. A., S. J. Arrigo, S. R. Weitsman, A. S. Go, A. Haislip, and I. S. Chen. 1990. HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure. Cell 61:213.
6. Bukrinsky, M. I., S. Haggerty, M. P. Dempsey, N. Sharova, A. Adzhubel, L. Spitz, P. Lewis, D. Goldfarb, M. Emerman, and M. Stevenson. 1993. A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells. Nature 365:666.
7. Wineman, J. P., G. L. Gilmore, C. Gritzmacher, B. E. Torbett, and C. E. Müller-Sieburg. 1992. CD4 is expressed on murine pluripotent hematopoietic stem cells. Blood 80:1717.
8. Frederickson, G. G., and R. S. Basch. 1989. L3T4 antigen expression by hemopoietic precursor cells. J. Exp. Med. 169:1473.
9. Basch, R. S., Y. H. Kouri, and S. Karpatkin. 1990. Expression of CD4 by human megakaryocytes. Proc. Natl. Acad. Sci. USA 87:8085.
10. Chelucci, C., H. J. Hassan, C. Locardi, D. Bulgarini, E. Pelosi, G. Mariani, U. Testa, M. Federico, M. Valtieri, and C. Peshle. 1995. In vitro human immunodeficiency virus-1 infection of purified hematopoietic progenitors in single-cell culture. Blood 85:1181.
11. + bone marrow cells are infected with HIV in a subset of seropositive individuals. J. Immunol. 149:689.
12. Stutte, H. J., H. Müller, S. Falk, and H. L. Schmidts. 1990. Pathophysiological mechanisms of HIV-induced defects in haematopoiesis: pathology of the bone marrow. Res. Virol. 141:195.
13. Kojouharoff, G., O. G. Ottmann, H. von Briesen, G. Geissler, H. Rübsamen-Waigmann, D. Hoelzer, and A. Ganser. 1991. Infection of granulocyte/monocyte progenitor cells with HIV1. Res. Virol. 142:151.
14. Sakaguchi, M., T. Sato, and J. E. Groopman. 1991. Human immunodeficiency virus infection of megakaryocytic cells. Blood 77:481.
15. +) cells in AIDS patients. J. Infect. Dis. 166:710.
16. Louache, F., A. Henri, A. Bettaieb, E. Oksenhendler, G. Raguin, M. Tulliez, and W. Vainchenker. 1992. Role of human immunodeficiency virus replication in defective in vitro growth of hematopoietic progenitors. Blood 80:2991.
17. Folks, T. M., S. W. Kessler, J. M. Orenstein, J. S. Justement, E. S. Jaffe, and A. S. Fauci. 1988. Infection and replication of HIV-1 in purified progenitor cells of normal human bone marrow. Science 242:919.
18. Ho, D. D., T. R. Rota, and M. S. Hirsch. 1986. Infection of monocytes macrophage by human T-lymphotropic virus type III. J. Clin. Invest. 77:1712.
19. Gartner, S., P. Markovits, D. M. Markovitz, M. H. Kaplan, R. C. Gallo, and M. Popovic. 1986. The role of mononuclear phagocytes in HTLV-III/LAV infection. Science 233:215.
20. Kouri, Y. H., W. Borkowsky, M. Nardi, S. Karpatkin, and R. S. Basch. 1993. Human megakaryocytes have a CD4 molecule capable of binding human immunodeficiency virus-1. Blood 81:2664.
21. Weiss, R. A. 1993. How does HIV cause AIDS? Science 260:1273.
22. Scadden, D. T., L. I. Zon, and J. E. Groopman. 1989. Pathophysiology and management of HIV-associated hematologic disorders. Blood 74:1455.
23. McKeating, J. A., P. D. Griffiths, and R. A. Weiss. 1990. HIV susceptibility conferred to human fibroblasts by cytomegaloviras-induced Fc receptor. Nature 343:659.
24. Weissman, I. L. 1993. The whole body view: new insights into HIV pathogenesis are coming from studies of how the virus spreads within lymphoid organs in vivo and damages them. Curr. Biol. 3:766.
25. Spivak, J. L., B. S. Bender, and T. C. Quinn. 1984. Hematologic abnormalities in the acquired immunodeficiency syndrome. Am. J. Med. 77:224.
26. Castella, A., T. S. Croxson, D. Mildvan, C. H. Witt, and R. Zalusky. 1985. The bone marrow in AIDS: a histologic, hematologic and microbiologic study. Am. J. Clin. Pathol. 84:425.
27. Mehta, K., P. Gascón, and S. Robboy. 1992. The gelatinous bone marrow (serous atrophy) in patients with acquired immunodeficiency syndrome: evidence of excess sulfated glycosaminoglycans. Arch. Pathol. Lab. Med. 116:504.
28. Holland, H. K., and J. L. Spivak. 1990. The haematological manifestations of acquired immune deficiency syndrome. Baillieres Clin. Haematol. 3:103.
29. Sathe, S. S., P. Gascón, W. Lo, R. Pinto, and L B. Reichman. 1990. Severe anemia is an important negative predictor for survival with disseminated Mycobacterium avium-intracellulare in acquired immunodeficiency syndrome. Am. Rev. Respir. Dis. 142:1306.
30. Stella, C. C., A. Ganser, and D. Hoelzer. 1987. Defective in vitro growth of the hemopoietic progenitor cells in the acquired immunodeficiency syndrome. J. Clin. Invest. 80:286.
31. Bagnara, G. P., G. Zauli, M. Giovannini, M. C. Re, G. Furlini, and M. La Placa. 1990. Early loss of circulating hemopoietic progenitors in HIV-1-infected subjects. Exp. Hematol. 18:426.
32. Ganser, A., O. G. Ottmann, H. von Briesen, B. Völkers, H. Rübsamen-Waigmann, and D. Hoelzer. 1990. Changes in the haematopoietic progenitor cell compartment in the acquired immunodeficiency syndrome. Res. Virol. 141:185.
33. Gascón, P., S. S. Sathe, and P. Rameshwar. 1993. Impaired erythropoiesis in the acquired immunodeficiency syndrome with disseminated Mycobacterium avium complex. Am. J. Med. 94:41.
34. Donahue, R. E., M. M. Johnson, L. I. Zon, S. C. Clark, and J. E. Groopman. 1987. Suppression of in vitro haematopoiesis following human immunodeficiency virus infection. Nature 326:200.
35. Molina, J. M., D. T. Scadden, M. Sakaguchi, B. Fuller, A. Woon, and J. E. Groopman. 1990. Lack of evidence for infection of or effect on growth of hematopoietic progenitor cells after in vivo or in vitro exposure to human immunodeficiency virus. Blood 76:2476.
36. Steinberg, H. N., C. S. Crumpacker, and P. A. Chatis. 1991. In vitro suppression of normal human bone marrow progenitor cells by human immunodeficiency virus. J. Virol. 65:1765.
37. +) hematopoietic progenitors. J. Acquired Immune Defic. Syndr. 4:1251.
38. Zauli, G., B. R. Davis, M. C. Re, G. Visani, G. Furlini, and M. La Placa. 1992. tat protein stimulates production of transforming growth factor-β1 by marrow macrophages: a potential mechanism for human immunodeficiency virus-1-induced hematopoietic suppression. Blood 80:3036.
39. Zauli, G., M. Vitale, M. C. Re, G. Furlini, L. Zamai, E. Falcieri, D. Gibellini, G. Visani, B. R. Davis, S. Capitani, and M. La Placa. 1994. In vitro exposure to human immunodeficiency virus type 1 induces apoptotic cell death of the factor-dependent TF-1 hematopoietic cell line. Blood 83:167.
40. Calenda, V., P. Graber, J. F. Delamarter, and J. C. Chermann. 1994. Involvement of HIV nef protein in abnormal hematopoiesis in AIDS: in vitro study on bone marrow progenitor cells. Eur. J. Haematol. 52:103.
41. Mosmann, T. R. 1994. Cytokine patterns during the progression to AIDS. Science 265:193.
42. Centers for Disease Control. 1987. Revision of the CDC surveillance case definition for acquired immunodeficiency syndrome. Morb. Mortal. Wkly. Rep. 36: 1S.
43. Gascón, P., N. C. Zoumbos, G. Scala, J. Y. Djeu, G. J. Moore, and N. S. Young. 1985. Lymphokine abnormalities in aplastic anemia: implications for the mechanism of action of ATG. Blood 65:407.
44. Rameshwar, P., and P. Gascón. 1996. Induction of negative hematopoietic regulators by neurokinin-A in bone marrow stroma. Blood 88:98.
45. Marcus, S. L., M. J. Modak, and L. F. Cavalieri. 1974. Purification of avian Myeloblastosis virus DNA polymerase by affinity chromatography on polycytidylate-agarose. J. Virol. 14:853.
46. Tanese, N., J. Sodroski, W. A. Haseltine, and S. P. Goff. 1986. Expression of reverse transcriptase activity of human T-lymphotropic virus type III (HTLV-III/ LAV) in Escherichia coli. J. Virol. 59:743.
47. Renko, M., N. Quarto, T. Morimoto, and D. B. Rifkin. 1990. Nuclear and cytoplasmic localization of different basic fibroblast growth factor species. J. Cell Physiol. 144:108.
48. Lamballe, F., R. Klein, and M. Barbacid. 1991. trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3. Cell 66:967.
49. Rameshwar, P., and P. Gascón. 1992. Release of interleukin-1 and interleukin-6 from human monocytes by antithymocyte globulin: requirement for de novo synthesis. Blood 80:2531.
50. Schneider, D. R., and L. J. Picker. 1985. Myelodysplasia in the acquired immunodeficiency syndrome. Am. J. Clin. Pathol. 84:144.
51. Maciejewski, J. P., F. F. Weichold, and N. S. Young. 1994. HIV-1 suppression of hematopoiesis in vitro mediated by envelope glycoprotein and TNF-α. J. Immunol. 153:4303.
52. Geissler, R. G., O. G. Ottmann, K. Kleiner, U. Mentzel, A. Bickelhaupt, D. Hoelzer, and A. Ganser. 1993. Decreased haematopoietic colony growth in long-term bone marrow cultures of HIV-positive patients. Res. Virol. 144:69.
53. Dexter, T. M., T. D. Allen, and L. G. Lajtha. 1977. Conditions controlling the proliferation of haematopoietic stem cells in vitro. J. Cell Physiol. 91:335.
54. Lichtman, M. A. 1984. The relationship of stromal cells to hematopoietic cells in marrow. In Long-Term Bone Marrow Culture. D. G. Wright and J. S. Greenberger, eds. Alan R. Liss Inc, New York, p. 3.
55. Scadden, D. T., M. Zeira, A. Woon, Z. Wang, L. Schieve, K. Ikeuchi, B. Lim, and J. E. Groopman. 1990. Human immunodeficiency virus infection of human bone marrow stromal fibroblasts. Blood 76:317.
56. Cen, D., G. Zauli, R. Szarnicki, and B. R. Davis. 1993. Effect of different human immunodeficiency virus type-1 (HIV-1) isolates on long-term bone marrow haemapoiesis. Br. J. Haematol. 85:596.
57. Scadden, D. T. 1992. The clinical applications of colony-stimulating factors in acquired immunodeficiency syndrome. Semin. Hematol. 29:33.