Functional activity of staphylococcal enterotoxin A requires interactions with both the alpha and beta chains of HLA-DR

Molecular Immunology

Volumn 33, Issue 16, 1996, Pages 1267-1274

  Dowd, James E ^a   Karr, Robert W ^b   Karp, David R ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b PFIZER INC   (United States)

Author keywords

HLA DR; staphylococcal enterotoxin; superantigen

Indexed keywords

HLA DR ANTIGEN; STAPHYLOCOCCUS ENTEROTOXIN A; SUPERANTIGEN;

AMINO ACID SEQUENCE; ARTICLE; CELL LINE; HUMAN; HUMAN CELL; HYBRIDOMA; LYMPHOCYTE ACTIVATION; POINT MUTATION; PRIORITY JOURNAL; T LYMPHOCYTE;

AMINO ACID SEQUENCE; ANIMALS; CONSERVED SEQUENCE; ENTEROTOXINS; HLA-DR ANTIGENS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; STAPHYLOCOCCUS AUREUS; SUPERANTIGENS;

EID: 0030292139     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-5890(96)00085-5     Document Type: Article

References (39)

1. Abrahmsén L., Dohlsten M., Segrén S., Bjørk P., Jonsson E. and Kalland T. ( 1995) Characterization of two distinct MHC class II binding sites in the superantigen staphylococcal enterotoxin A. EMBO J. 14, 2978-2986.
2. Acha O. H. and MacDonald H. R. (1995) Superantigens of mouse mammary tumor virus. Ann. Rev. Immun. 13, 459-486.
3. Acha-Orbea H., Shakhov A. N., Scarpellino L., Kolb E., Muller V., Vessaz-Shaw A., Fuchs R., Blochlinger K., Rollini P., Billote L., Sarafidou M., MacDonald H. R. and Diggelmann H. (1991) Clonal deletion of V β14-bearing T cells in mice transgenic for mammary tumor virus. Nature 350, 207-211.
4. Brown J. H., Jardetzky T. S., Gorga J. C., Stern L. J., Urban R. G., Strominger J. L. and Wiley D. C. (1993) Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature 364, 33-39.
5. Chintagumpala M. M., Mollick J. A. and Rich R. R. (1991) Staphylococcal toxins bind to different sites on HLA-DR. J. Immun. 147, 3876-3881.
6. Choi Y., Kotzin B., Herron J., Callahan J., Marrak P. and Kappler J. (1989) Interaction of Staphylococcus aureus toxin 'superantigens' with human T cells. Proc. natn. Acad. Sci. U.S.A. 86, 8941-8945.
7. Dellabona P., Peccoud J., Kappler J., Marrack P., Benoist C. and Mathis D. (1990) Superantigens interact with MHC class II molecules outside of the antigen groove. Cell 62, 1115-1121.
8. Fischer H., Dohlsten M., Lindvall M., Sjøgren H. O. and Carlsson R. (1989) Binding of staphylococcal enterotoxin A to HLA-DR on B cell lines. J. Immun. 142, 3151-3157.
9. Fraser J. D. (1989) High-affinity binding of staphylococcal enterotoxins A and B to HLA-DR. Nature 339, 221-223.
10. Fraser J. D., Urban R. G., Strominger J. L. and Robinson H. (1992) Zinc regulates the function of two superantigens. Proc. natn. Acad. Sci. U.S.A. 89, 5507-5511.
11. Fu X.-T. and Karr R. W. (1994) HLA-DRα chain residues located on the outer loops are involved in nonpolymorphic and polymorphic antibody-binding epitopes. Hum. Immun. 39, 253-260.
12. Hargreaves R. E. G., Brehm R. D., Tranter H., Warrens A. N., Lombardi G. and Lechler R. I. (1995) Definition of sites on HLA-DR1 involved in the T cell response to staphylococcal enterotoxins E and C2. Eur. J. Immun. 25, 3437-3444.
13. Held W., Shakhov A. N., Waanders G., Scarpellino L., Luethy R., Kraehenbuhl J. P., MacDonald H. R. and Acha O. H. (1992) An exogenous mouse mammary tumor virus with properties of Mis-1a (Mtv-7). J. Exp. Med. 175, 1623-1633.
14. Herman A., Kappler J. W., Marrack P. and Pullen A. M. (1991) Superantigens: Mechanism of T-cell stimulation and role in Immune responses. Ann. Rev. Immun. 9, 745-772.
15. Herman A., Labreque N., Thibodeau J., Marrack P., Kappler J. W. and Sekaly R. P. (1991) Identification of the staphylococcal enterotoxin A superantigen binding site in the β1 domain of the human histocompatibility antigen HLA-DR. Proc. natn. Acad. Sci. U.S.A. 88, 9954-9958.
16. Hudson K. R., Robinson H. and Fraser J. D. (1993) Two adjacent residues in staphylococcal enterotoxins A and E determine T cell receptor V beta specificity. J. Exp. Med. 177, 175-184.
17. Hudson K. R., Tiedemann R. E., Urban R. G., Lowe S. C., Strominger J. L. and Fraser J. D. (1995) Staphylococcal enterotoxin A has two cooperative binding sites on major histocompatibility complex class II. J. Exp. Med. 182, 711-720.
18. Jardetzky T. S., Brown J. H., Gorga J. C., Stern L. J., Urban R. G., Chi Y., Stauffacher C., Strominger J. L. and Wiley D. C. (1994) Three-dimensional structure of a human class II histocompatibilty molecule complexed with superantigen. Nature 368, 711-718.
19. Kappler J., Kotzin B., Herron L., Gelfand E. W., Bigler R. D., Boylston A., Carrel S., Posnett D. N., Choi Y. and Marrack P. (1989) V beta-specific stimulation of human T cells by staphylococcal toxins. Science 244, 811-813.
20. Karp D. R. and Long E. O. (1992) Identification of HLA-DR1 β chain residues critical for binding staphylococcal enterotoxins A and E. J. Exp. Med. 175, 415-424.
21. Karp D. R., Teletski C. L., Jaraquemada D., Maloy W. L., Coligan J. E. and Long E. O. (1990) Structural requirements for pairing of α and β chains in HLA-DR and HLA-DP molecules. J. Exp. Med. 171, 615-628.
22. Karp D. R., Teletski C. L., Scholl P., Geha R. and Long E. O. (1990) The alpha 1 domain of the HLA-DR molecule is essential for high-affinity binding of the toxic shock syndrome toxin-1. Nature 346, 474-476.
23. Kim J., Urban R. G., Strominger J. L. and Wiley D. C. (1994) Toxic shock syndrome toxin-1 complexed with a class II major histocompatibility molecule HLA-DR1. Science 266, 1870-1874.
24. Kozono H., Parker D., White J., Marrack P. and Kappler J. (1995) Multiple binding sites for bacterial superantigens on soluble class II MHC molecules. Immunity 3, 187-196.
25. Lafon M., Lafage L., Martinez-Arends A., Ramirez R., Vuillier F., Charron D., Lotteau V. and Scott-Algara D. (1992) Evidence for a viral superantigen in humans. Nature 358, 507-510.
26. Long E. O., Rosen-Bronsen S., Karp D. R., Malnati M., Sekaly R.-P. and Jaraquemada D. (1991) Efficient cDNA expression vectors for stable and transient expression of HLA-DR in transfected fibroblast and lymphoid cells. Hum. Immun. 31, 229-235.
27. Madrigal J. A., Ikeda H., Marsh S. G. E., Heyes J. M., Kennedy L. J., Trowsdale J. and Bodmer J. G. (1989) Epitope mapping of an HLA-DR-specific monoclonal antibody produced by using human-mouse transfectant cells. J. Immun. 143, 4084-4089.
28. Marrack P. and Kappler J. (1990) The staphylococcal enterotoxins, and their relatives. Science 248, 705-711.
29. Mollick J. A., McMasters R. L., Grossman D. and Rich R. R. (1993) Localization of a site on bacterial superantigens that determines T cell receptor beta chain specificity. J. Exp. Med. 177, 283-293.
30. Mollick J. A., Musser J. M., Miller G., Cook R. G. and Rich R. R. (1992) Production of a novel superantigen by streptococcal strains that cause toxic-shock-like-syndrome and recurrent pharyngitis. Clin. Res. 40, 199A.
31. Panina B. P., Fu X. T., Lanzavecchia A. and Karr R. W. (1992) Identification of HLA-DR alpha chain residues critical for binding of the toxic shock syndrome toxin superantigen. J. Exp. Med. 176, 1779-1784.
32. Pullen A. M., Wade T., Marrack P. and Kappler J. W. (1990) Identification of the region of T cell receptor beta chain that interacts with the self-superantigen MIs-1a. Cell 61, 1365-1374.
33. Russell J. K., Pontzer C. H. and Johnson H. M. (1990) The I-A beta region (65-85) is a binding site for the superantigen, staphylococcal enterotoxin A. Biochem. Biophys. Res. Comm. 168, 696-701.
34. Russell J. K., Pontzer C. H. and Johnson H. M. (1991) Both alpha-helices along the major histocompatibility complex binding cleft are required for staphylococcal enterotoxin A function. Proc. natn. Acad. Sci. U.S.A. 88, 7228-7232.
35. Schad E. M., Zaitseva I., Zaitsev V. N., Dohlsten M., Kalland T., Schlievert P. M., Ohlendorf D. H. and Svensson L. A. (1995) Crystal structure of the superantigen staphylococcal enterotoxin type A. EMBO. J. 14, 3292-3301.
36. Schlievert P. M. (1984) Biological properties of toxic shock syndrome exotoxin. Surv. Synth. Path. Res. 3, 54-62.
37. Scholl P., Diez A., Mourad W., Parsonnet J., Geha R. S. and Chatila T. (1989) Toxic shock syndrome toxin 1 binds to major histocompatibility complex class II molecules. Proc. natn. Acad. Sci. U.S.A. 86, 4210-4214.
38. Tiedemann R. E., Urban R. J., Strominger J. L. and Fraser J. D. (1995) Isolation of HLA-DR1. (staphylococcal enterotoxin A) 2 trimers in solution. Proc. natn. Acad. Sci. U.S.A. 92, 12156-12159.
39. White J., Herman A., Pullen A. M., Kubo R., Kappler J. W. and Marrack P. (1989) The V beta-specific superantigen staphylococcal enterotoxin B: stimulation of mature T cells and clonal deletion in neonatal mice. Cell 56, 27-35.