Application of immobilized lipase in production of camptosar (CPT-11)

JAOCS, Journal of the American Oil Chemists' Society

Volumn 73, Issue 11, 1996, Pages 1377-1378

  Sih, John C ^a  

^a PFIZER INC   (United States)

Author keywords

Anticancer drug; Camptosar; Immobilized PS 30 lipase; Selective acylation

Indexed keywords

ACYLATION; CATALYST ACTIVITY; ENZYME IMMOBILIZATION; ONCOLOGY; ORGANIC SOLVENTS; SYNTHESIS (CHEMICAL);

ANTICANCER DRUG; CAMPTOSAR; IMMOBILIZED PS30 LIPASE;

DRUG PRODUCTS;

EID: 0030288608     PISSN: 0003021X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02523499     Document Type: Article

References (4)

1. Shen, W., C.A. Colburn, W.G. Bormann, and S.J. Danishefsky, Concise Total Syntheses of dl-Camptothecin and Related Anticancer Drugs, J. Org. Chem. 53:611-617 (1993).
2. Henegar, K.E., and J.C. Sih, Novel Intermediates and Process for the Manufacture of Camptothecin Derivatives (CPT-11) and Related Compounds, U.S. Patent application filed April 2, 1996.
3. Kabushiki, Kaisha Yacult Honsha, Camptothecin Derivatives, U.S. Patent 5,061,800 (1991).
4. Chen, C.-S., Y. Fujimoto, G. Gidrankas, and C.J. Sih, Quantitative Analyses of Biochemical Kinetic Resolutions of Enantiomers, J. Am. Chem. Soc. 104:7294-7299 (1982).