Cross-sensitivity of X-ray-hypersensitive cells derived from LEC strain rats to DNA-damaging agents

Journal of Veterinary Medical Science

Volumn 58, Issue 11, 1996, Pages 1067-1071

  Okui, Toyo ^d   Endoh, Daiji ^a   Arai, Soichiro ^b   Isogai, Emiko ^c   Hayashi, Masanobu ^b  

^a HOKKAIDO UNIVERSITY   (Japan)

^b RAKUNO GAKUEN UNIVERSITY   (Japan)

^c HEALTH SCIENCES UNIVERSITY OF HOKKAIDO   (Japan)

^d HOKKAIDO INSTITUTE OF PUBLIC HEALTH   (Japan)

Author keywords

Alkylating agent; Bieomycin; Cross sensitivity; LEC rat cell; Mitomycin C

Indexed keywords

ALKYLATING AGENT; ANTINEOPLASTIC ANTIBIOTIC; BLEOMYCIN; DNA; ETHYLNITROSOUREA; METHYLNITRONITROSOGUANIDINE; MITOMYCIN;

ANIMAL; ANIMAL DISEASE; ARTICLE; CELL CULTURE; CELL SURVIVAL; CHEMISTRY; COMPARATIVE STUDY; CROSS REACTION; CYTOLOGY; DNA DAMAGE; DRUG EFFECT; FIBROBLAST; GENETICS; HYPERSENSITIVITY; LUNG; RADIATION EXPOSURE; RAT; RAT STRAIN; ULTRAVIOLET RADIATION; X RAY;

ALKYLATING AGENTS; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BLEOMYCIN; CELL SURVIVAL; CELLS, CULTURED; CROSS REACTIONS; DNA; DNA DAMAGE; ETHYLNITROSOUREA; FIBROBLASTS; HYPERSENSITIVITY; LUNG; METHYLNITRONITROSOGUANIDINE; MITOMYCIN; RATS; RATS, INBRED STRAINS; ULTRAVIOLET RAYS; X-RAYS;

EID: 0030281292     PISSN: 09167250     EISSN: None     Source Type: Journal    
DOI: 10.1292/jvms.58.11_1067     Document Type: Article

References (33)

1. Arlett, C. F. 1977. Lethal response to DNA damaging agents in a variety of human fibroblast cell strains. Mutat. Res. 46: 106.
2. Barfknecht, T. B. and Little, J. B. 1982. Hypersensitivity of ataxia telangiectasia skin fibroblasts to DNA alkylating agents. Mutat. Res. 94: 369-380.
3. Biederman, K. A., Sun, J., Giaccia, A. J., Tosto, L. M., and Brown, J. M. 1991. Scid mutation in mice confers hypersensitivity to ionizing radiation and deficiency in DNA double-strand break repair. Proc. Natl. Acad. Sci. U.S.A. 88: 1394-1397.
4. Collins, A. R. 1993. Mutant rodent cell lines sensitive to ultraviolet, ionizing radiation and cross-linking agents: a comprehensive survey of genetic and biochemical characteristics. Mutat. Res. 293: 99-118.
5. German, J. 1969. Chromosomal breakage syndromes. Birth Defects 5: 117-130.
6. Hayashi, M., Endoh, D., Kon, Y., Yamashita, T., Hashimoto, N., Sato, F., Kasai, N., and Namioka, S. 1992. Higher sensitivity of LEC strain rats in radiation-induced acute intestinal death. J. Vet. Med. Sci. 54: 269-273.
7. Hayashi, M., Endoh, D., Kon, Y., Yamashita, T., Sato, F., Kasai, N., and Namioka, S. 1993. Hypersensitivity of LEC strain rats in radiation-induced acute bone marrow death. J. Vet. Med. Sci. 55: 13-18.
8. Hayashi, M., Ishimori, K., Maeda, A., Watanabe, T., Arai, S., and Okui, T. 1996. Radioresistant DNA synthesis in fibroblast cell lines derived from LEC strain rats. Mutat. Res. 352: 117-121.
9. Hayashi, M., Okui, T., Endoh, D., Sato, F., Kasai, N., and Namioka, S. 1994. Radiation-hypersensitivity of LEC strain rats controlled by a single autosomal recessive gene. Mutat. Res. 314: 135-142.
10. Hecht, F., Koeler, R. D., Rigas, D. A., Dahnke, G. S., Case, M. P., Eisdale, V., and Miller, R. W. 1966. Leukemia and lymphocytes in ataxia telangiectasia. Lancet 2: 1193.
11. Jaspers, N. G. J., de Wit, J., Regulski, M. R., and Bootsma, D. 1982. Abnormal regulation of DNA replication and increased lethality in ataxia telangiectasia cells exposed to carcinogenic reagents. Cancer Res. 42: 335-341.
12. Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., and Fornace, J. Jr. 1992. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 71: 587-597.
13. Lehman, A. R., Kirk-Bell, S., Arlett, C. F., Harcourt, S. A., de Weerd-Kastelein, E. A., Keijzer, W., and Hall-Smith, P. 1977. Repair of ultraviolet light damage in a variety of human fibroblast cell strains. Cancer Res. 37: 904-910.
14. Mckay, M. J., Mann, G. M., McDonald, D. A., Jones, S., and Kefford, R. F. 1994. Isolation and preliminary characterization of an X-ray-sensitive mammalian mutant cell line (WMXRS-1). Mutat. Res. 314: 261-271.
15. Okui, T., Hayashi, M., Endoh, D., Sato, F., Kasai, N., Watanabe, T., and Namioka, S. 1994. A high frequency of induction of chromosome aberrations in the bone marrow cells of LEC strain rats by X-irradiation. Mutat. Res. Lett. 324: 165-169.
16. Painter, R. B. and Young, B. R. 1980. Radiosensitivity in ataxia-telangiectasia: a new explanation. Proc. Natl. Acad. Sci. U.S.A. 77: 7315-7317.
17. Paterson, M. C. and Smith, P. J. 1979. Ataxia-telangiectasia: an inherited human disorder involving hypersensitivity to ionizing radiation and related DNA-damaging chemicals. Annu. Rev. Genet. 13: 291-318.
18. Paterson, M. C., Smith, P. J., Middlestadt, M. V., Smith, B. P., and Bech-Hansen, N. T. 1979. Hvpersensitivity to ethyl nitrosourea in cultured fibroblast strains from patients with ataxia telangiectasia. Annu. Meet. Environ. Mutagen Soc. 10th, 76.
19. Radford, I. R. 1986. Evidence for a general relationship between the induced level of DNA double-strand breakage and cell-killing after X-irradiation of mammalian cells. Int. J. Radiol. Biol. 49: 611-620.
20. Reed, E. B., Epstein, W. L., Border, W., and Sedgwick. R. 1966. Cutaneous manifestions of ataxia-telangiectasia. J. A. M. A. 195: 746-753.
21. Rudolph, N. S. and Lau, S. A. 1989. Flow cytometric analysis of X-ray sensitivity in ataxia telangiectasia. Mutat. Res. 211: 31-41.
22. Sasaki, M., Yoshida, M. C., Kagamori, K., Takeichi, N., Kobayashi, H., Dempo, K., and Mori, M. 1985. Spontaneous hepatitis in an inbred strain of Long-Evans rats. Rat News Lett. 14: 4-6.
23. Savitsky, K., Bar-Shira, A., Gilad, S., Rotman, G., Ziv, Y., Vanagaite, L., Tagle, D. A., Smith, S., Uziel, T., Sfez, S., Ashkenazi, M., Pecker, I., Frydman, M., Harnik, R., Patanjali, S. R., Simmons, A., Clines, G. A., Satiel, A., Gatti, R. A., Cheesa, L., Sanal, O., Lavin, M. F., Jaspers, N. G. J., Malcolm, A., Taylor, R., Ariett, C. F., Miki, T., Weissman, S. M., Lovett, M., Collins, F. S., and Shiloh, Y. 1995. A single ataxia telangieclasia gene with a product similar to PI-3 kinase. Science 278: 1749-1753.
24. Schans, G. P., van der Centen, H. B., and Loman, P. H. M. 1982. DNA lesions induced by ionizing radiation. Progress in Mutation Res. 4: 285-299.
25. Scudiero, D. A. 1980. Decreased DNA repair synthesis and defective colony-forming ability of ataxia telangiectasia fibroblast cell strains treated with N-methyl-N′-nitro-N-nitrosoguanidine. Cancer Res. 40: 984-990.
26. Siloh, Y., Tabor, E., and Becker, Y. 1983. Abnormal response of ataxia telangiectasia cells to agents that the deoxyribose moiety of DNA via a targeted free radical mechanism. Carcinogenesis 4: 1317-1322.
27. Swift, M. R., Reitnauer, P. J., Morrell, D., and Chase, C. L. 1987. Breast and other cancers in families with ataxia-telangiectasia. New. Engl. J. Med. 316: 1289-1294.
28. Taylor, A. R. M., Harnden, D. G., Arlett, C. F., Harcourt, S. A., Lehman, A. R., Stevens, S., and Bridges, B. A. 1979. Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity. Nature (Lond.) 258: 427-429.
29. Taylor, A. R. M., Rosney, C. M., and Campbell, J. B. 1979. Unusual sensitivity of ataxia telangiectasia to bleomycin. Cancer Res. 39: 1046-1050.
30. Verhaegh, G. W. C. T., Jongmans, W., Morolli, B., Jaspers, N. G. J., van der Schans, G. P., Loman, P. H. M., and Zdzienicka, M. Z. 1995. A novel type of X-ray-sensitive Chinese hamster cell mutant with radioresistant DNA synthesis and hampered DNA double-strand break repair. Mutat. Res. 337: 119-129.
31. Waters, R. L. and Lyons, B. W. 1990. Detection of ionizing radiation-induced DNA double-strand breaks by filter elution is affected by nuclear chromatin structure. Radiat. Res. 124: 309-316.
32. Yoshida, M. C., Masuda, R., Sasaki, M., Takeichi, N., Kobayashi, H., Dempo, K., and Mori, M. 1987. New mutation causing hereditary hepatitis in the laboratory rat. J. Hered. 78: 361-365.
33. Zszienicka, M. Z., Tran, Q., van der Schans, G. P., and Simons. J. W. I. M. 1988. Characterization of an X-ray-hypersensitive mutant of V79 Chinese hamster cells. Mutat. Res. 194: 239-249.