Disfunción sexual secundaria a ISRS. Análisis comparativo en 308 pacientes

Actas Espanolas de Psiquiatria

Volumn 24, Issue 6, 1996, Pages 311-321

  Montejo, A L ^a,b   Llorca, G ^a   Izquierdo, J A ^a   Ledesma, A ^a   Bousono M ^a   Calcedo, A ^a   Carrasco, J L ^a   Daniel, E ^a   De Dios, A ^a   De La Gandara, J ^a   Derecho, J ^a   Franco, M ^a   Gomez, M J ^a   Macias, J A ^a   Martin, T ^a   Perez, V ^a   Sanchez, J M ^a   Sanchez, S ^a   Vicens, E ^a  

^a Grupo Espanol Trabajo Estud D

^b NONE   (Spain)

Author keywords

Amineptine; Fluoxetine; Fluvoxamine; Moclobemide; Paroxetine; Sertraline; Sexual dysfunction; SSRI

Indexed keywords

1 NAPHTHYLAMINE; AMINEPTINE; ANTIDEPRESSANT AGENT; BENZAMIDE DERIVATIVE; DIBENZO[A,D]CYCLOHEPTENE DERIVATIVE; DRUG DERIVATIVE; FLUOXETINE; FLUVOXAMINE; MOCLOBEMIDE; PAROXETINE; SEROTONIN UPTAKE INHIBITOR; SERTRALINE;

ADULT; ARTICLE; CHEMICALLY INDUCED DISORDER; CLINICAL TRIAL; DEPRESSION; DOSE RESPONSE; DRUG EFFECT; EJACULATION; FEMALE; HUMAN; MALE; MULTICENTER STUDY; ORGASM; PSYCHOSEXUAL DISORDER;

1-NAPHTHYLAMINE; ADULT; ANTIDEPRESSIVE AGENTS; BENZAMIDES; DEPRESSIVE DISORDER; DIBENZOCYCLOHEPTENES; DOSE-RESPONSE RELATIONSHIP, DRUG; EJACULATION; FEMALE; FLUOXETINE; FLUVOXAMINE; HUMANS; MALE; MOCLOBEMIDE; ORGASM; PAROXETINE; SEROTONIN UPTAKE INHIBITORS; SERTRALINE; SEXUAL DYSFUNCTIONS, PSYCHOLOGICAL;

EID: 0030281186     PISSN: 11399287     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (130)

1. Barnes T, Bamber RWK, Watson JP. Psychotropic drugs and sexual behaviour. Br J Med, 1979; 6: 596-601.
2. Couper-Smartt JD, Rodham R. A technique for surveying side effects of tryciclic drugs with reference to reported sexual effects. J Int Med Res, 1973; 1: 473-6.
3. Beaumont, G. Sexual side-effects of clomipramine (Anafranil). J of International Medical Research, 1973; 1: 469-72.
4. Nininger J. Inhibition of ejaculation by amitriptyline. Am J Psychiatry, 1978; 135: 750-1.
5. Mitchel JE, Popkin MK. Antidepressant drug therapy and sexual dysfunction in men. a review. J Clin Psychopharmacol, 1983; 3: 76-80.
6. Merino MJ, García M. Antidepresivos y disfunciones sexuales: biología, clasificación y tratamiento. Rev Asoc Esp Neuropsiq, 1995, XV, 54: 431-42.
7. Settle ECJ r. Antidepressant side effects: Issues and options. J Clin Psychiatry Monograph, 1992; 10 (1): 48-61.
8. Pollack MH, Reiter S, Hammerness P. Genitourinary and Sexual Adverse effects of psychotropic medication. Int J Psychiatry in Medicine, 1992; 22: 305-327.
9. Baldwin DS. Psychotropic drugs and sexual dysfunction International Review of Psychiatry, 1995; 7: 261-73.
10. Buffom J. Pharmacology: the effects of drugs on sexual dysfunction, a review. J Psychoactive Drugs, 1982; 14 (1-2): 4-45.
11. Davidson JR. Sexual dysfunction and antidepressants. Depression, 1994/1995; 2: 233-40.
12. Harrison WM, Rabkin JG, Ehrhardt AA, et al. Effects of antidepressant medication on sexual function. A controlled study. J Clin Psychopharmacol, 1986; 6: 144-49.
13. Segraves RT. Effects of psychotropic drugs on human erection and ejaculation. Arch Gen Psychiatry, 1989; 46: 275-84.
14. Nofzinger EA, Thase ME, Reynolds CF, et al. antidepressants and sexual function in depressed men. In: New Research Program and Abstracts of the 146th Annual Meeting of the American Psychiatric Association, May 26, 1993; S. Francisco, California, Abstract NR 7456: 174.
15. Lesko LM, Stotland, Segraves T. Three cases of anorgasmia associated with MAOI. Am J Psychiatry, 1982; 139: 1383-4.
16. Quirk KC, Einarson TR. Sexual dysfunction and Clomipramine. Canadian Journal of Psychiatry, 1983; 27: 228-31.
17. Schubert DSP. Reversal of Doxepine-induced Hypoactive sexual desire by substitution of Nortriptyline. Journal of Sex Education and Therapy, 1992; 18: 42-44.
18. Cohn CK, Shrivastava R, Mendels J. Doubled blind multicenter comparison of Sertraline and amytriptiline in elderly depressed patients. J Clin Psychiatry, 1990; 51 (12 suppl B): 18-27.
19. Patterson WM. Fluoxetine induced sexual dysfunction (letter). J Clin Psychiatry, 1993; 54: 71.
20. Monteiro WO, Noshirvani HF, Marks IM, et al. Anorgasmia from clomipramine in obsessive-compulsive disorder. A controlled trial. British J Psychiatry, 1987; 151: 107-112.
21. Flores MP, Montes MJ, Cambronero V, et al. Inhibición por paroxetina de la eyaculación (a propósito de 2 casos). Anales de Psiquiatría, 1994; 10 (supl 1): 58-59.
22. Aizenberg D, Zemishlany Z, Hermesh H, et al. Painful ejaculation associated with antidepressants in four patients. J Clin Psychiatry, 1991; 52: 461-463.
23. Modell JG. Repeated observations of yawning, clitoral engorgement and orgasm associated with fluoxetine administration (letter). J Clin Psychopharmacol, 1989; 9: 63-65.
24. Cohen AJ. Fluoxetine-induced yawning and anorgasmia reversed by ciproheptadine treatment. J Clin Psychiatry, 1992; 53: 174.
25. McLean JD, Forsythe RG, Kapkin IA. Unusual side effects of clomipramine associated with yawning. Can J Psychiatry, 1983; 28: 569-70.
26. King VL, Horowitz IR. Vaginal anesthesia associated with Fluoxetine use (letter). Am J Psychiatry, 1993; 150: 984-985.
27. Neill JR. Penile anesthesia associated with fluoxetine use (letter). Am J Psychiatry, 1991; 148: 1603.
28. Gartrell N. Increased libido in women receiving trazodone. Am J Psychiatry, 1986; 143: 781-782.
29. Chiang PH, Tsai EM, Chiang CP. The role of Trazodone in the treatment of erectil dysfunction. Kao-Hsiung I Hsueh Ko Hsueh Tsa Chih (Kaohsiung Journal of Medical Sciences, 1994; 10 (6): 287-94.
30. Ahmad S. Paroxetine induced priapism (letter). Arch Intern Med, 1995; 155: 645.
31. Monteiro WO, Noshirvani HF, Marks IM, et al. Anorgasmia from clomipramine in obsessive-compulsive disorder. A controlled trial. British J Psychiatry, 1987, 151: 107-12.
32. Shen WW; Sata LS. Inhibited Female orgasm resulting from psychotropic drugs: A clinical review. Journal of Reproductive Medicine, 1983; 28: 497-9.
33. Leo D, Magni G. Sexual side effects of antidepressant drugs. Psychosomatics, 1983; 24 (12): 1076-1082.
34. Segraves RT. Psychiatric drugs and orgasm in the human female. Journal of Psychosomatic Obstetrics and Gynecology, 1985; 4: 125-128.
35. Segraves RT. Sexual side-effects of Psychiatric drugs. Int J Psychiatry Med, 1988; 18 (3): 243-52.
36. Kline MD. Fluoxetine and anorgasmia. Am J Psychiatry, 1989; 146: 804-5.
37. Herman JB, Brotman AW, Pollack, MH, et al. Fluoxetine-induced sexual dysfunction. J Clin Psychiatry, 1990; 51: 25-27.
38. Musher JS. Anorgasmia with the use of fluoxetine (letter). Am J Psychiatry, 1990; 147: 948.
39. Drucker F, Hollander JB. Fluoxetine and sexual dysfunction. Journal of the American Medical Association, 1994; 272 (3): 242.
40. Dorevitch A, Davis H. Fluvoxamine-associated sexual dysfunction. Annals of Pharmacotherapy, 1994; 28 (7-8): 872-4.
41. Segraves RT. Antidepressant-induced sexual disorder. Journal of Sex and Marital Therapy, 1995; 21, 3: 192-201.
42. Hsu JH, Shen WW. Male sexual side effects associated with antidepressants: a descriptive clinical study of 32 patients. Int J Psychiatry in Medicine, 1995; 25 (2): 191-201.
43. Shen W, Hsu JH. Female sexual side effects associated with selective serotonin reuptake inhibitors: a descriptive clinical study of 33 patients. Int J Psych Med, 1995; 25 (3): 239-248.
44. Montejo AL, Llorca G, Izquierdo JA, et al. Sexual Dysfunction with SSRIs. a comparative analysis. American Psychiatric Association. Abstracts of 149th Annual Meeting. New York, 1996; May-4-9: 266-267.
45. McGilp R. Case Report (2): Paroxetine and delayed ejaculation. a treatable side effect. J Drug Dev, 1993; 5 (4): 265-266.
46. Kowalsky A, Stanley RO, Dennerstein G, et al. The sexual side effects of antidepressant medication: a double blind comparison of a two antidepressants in a non psychiatric population. British J Psychiatry, 1985; 147: 413-418.
47. Fuell D. Ejaculatory disturbances in volunteer and depressed patient studies with paroxetine. Smith Kline Beecham. Internal position paper, 1992; 21 pages.
48. Remy L. The effect of selective 5HT re-uptake inhibitors on 5-methoxy-N, N, dimethyltriptamine induced ejaculation in the rat. Br J Pharmacol, 1986; 87: 639-48.
49. Baldesarani RJ, Mars E. Fluoxetine and side effects (letter). Arch Gen Psychiatry, 1990; 47: 191-2.
50. Zemishlany Z. The effects of Methylenedioxy-methanphetamine («Ecstasy») on Human sexual function. American Psychiatric Association. Abstracts of 149th Annual Meeting. New York. New York, 1996; May-4-9: 265.
51. Sorscher SM, Dilsaver SC. Antidepressant-induced sexual dysfunction in men: due to cholinergic blockade? J Clin Psychopharmacol, 1986; 6: 53-5.
52. Zajecka J, Fawcet J, et al. The role of serotonin in sexual disfunction: Fluoxetine associated orgasm dysfunction. J Clin Psychiatry, 1991; 52 (2): 66-7.
53. Kurt U, Ozkardes H, Altug U, et al. The efficacy of antiserotoninergic agents in the treatment of erectil dysfunction. Journal of Urology, 1994 (august), 152 (2): 407-9.
54. Rodríguez M, Castro R, Hernández G, et al. Different roles of catecholaminergic and serotonergic neurons in the medial forebrain bundle on male rat sexual behavior. Physiol Behav, 1984; 33: 5-11.
55. Mas M, et al. Stimulation of spinal serotonergic receptor facilitates seminal emission and suppresses penile erectil reflexes. Brain Research, 1985; 342: 639-48.
56. Dunbar GC, Cohn JB, Fabre LF, et al. A comparison of Paroxetine, Imipramine and placebo in depressed out-patients. British J Psychiatry, 1991; 159: 394-8.
57. Pollack MH, Rosenbaum JF. Management of antidepressant-induced side-effects: a practical guide for the clinician. J Clin Psychiatry, 1987; 48: 3-8.
58. Segraves RT. Treatment of drug-induced anorgasmia. British J Psychiatry, 1994; (oct), 165: 554.
59. Jacobsen FM. Managing sexual Dysfunction and SSRIs. Psychiatric Times, 1995; (February), 12: 38-9.
60. Nurnberg HG, Levine PE. Spontaneous remission of MAO-I induced anorgasmia. Am J Psychiatry, 1987; 144: 805-7.
61. Sovner R. Treatment of tricyclic antidepressant-induced orgasmic inhibition with cyproheptadine (letter) J Clin Psychopharmacol, 1984; 4: 169.
62. Castro RM de. Reversal of MAOI-induced anorgasmia with cyproheptadine (letter). Am J Psychiatry, 1985; 142: 783.
63. Steele TE, Howell EF. Cyproheptadine for imipramine-induced anorgasmia (letter). J Clin Psychopharmacol, 1986; 6: 326-7.
64. Arnott S, Nutt D. Successful treatment of fluvoxamine-induced anorgasmia by cyproheptadine. British J Psychiatry, 1994; 164: 838-9.
65. McCormick S, Olin J, Wrotman AW. Reversal of Fluoxetine induced anorgasmia by Cyproheptadine in two patients. J Clin Psychiatry, 51 1990; 51: 383-4.
66. Cohen AJ. Fluoxetine -induced yawning and anorgasmia reversed by ciproheptadine treatment. J Clin Psychiatry, 1992; 53: 174.
67. Riley AJ, Riley EJ. Cyproheptadine and antidepressant-induced anorgasmia (letter). Br J Psychiatry, 1986; 148: 217-8.
68. Price J, Grunhaus LJ. Treatment of clomipramine-induced anorgasmia with yohimbine: a case report. J Clin Psychiatry, 1990; 51: 32-3.
69. Hollander E, McCarley A. Yohimbine treatment of sexual side effects induced by serotonin reuptake blockers. J Clin Psychiatry, 1992; 53: 207-9.
70. Jacobsen FM. Fluoxetine -induced sexual dysfunction and an open trial of yohimbine. J Clin Psychiatry, 1992; 53: 119-22.
71. Balon R. Fluoxetine-induced sexual dysfunction and yohimbine. J Clin Psychiatry, 1993; 54 (4): 161.
72. Singh A, Scurlock H, Catalan J. Paroxetine induced erectile dysfunction successfully treated with yohimbine in patients suffering from HIV infection. Journal of Serotonin Research, 1995; 4: 283-5.
73. Jacobsen FM. A double-blind placebo-controlled trial of yohimbine for treatment of SRI-induced sexual dysfunction. American Psychiatric Association. Abstracts of 149th Annual Meeting. New York, New York. 1996; May-4-9: 266.
74. Nessel MA. Yohimbine and pentoxifiline in the treatment of erectil dysfunction (letter). Am J Psychiatry, 1994; 151, 3: 453.
75. Balogh S, Hendricks SE, Kang J. Treatment of fluoxetine-induced anorgasmia with amantadine (letter). J Clin Psychiatry, 1992; 53: 212-3.
76. Shrivastava RK, Shrivastava S, Overweg N. Amantadine in the treatment of sexual dysfunction associated with selective serotonin reuptake inhibitors (letter). J Clin Psychopharmacol, 1995; 15 (1): 83-4.
77. Gitlin MJ. Treatment of sexual side effects with dopaminergic agents (letter). J Clin Psychiatry, 1995; (March), 56, 3: 124.
78. Norden MJ. Buspirone treatment of sexual dysfunction associated with selective serotonin re-uptake inhibitors. Depression, 1994; 2: 109-12.
79. Gross MD. Reversal by bethanechol of sexual dysfunction caused by anticholinergic antidepressants. Am J Psychiatry, 1982; 139: 1193-4.
80. Yager J. Bethanechol chloride can reverse erectile and ejaculatory dysfunction by tricyclic antidepressants and mazindol: case report. J Clin Psychiatry, 1986; 47: 210-1.
81. Segraves RT. Reversal by Bethanechol of imipramine-induced ejaculatory dysfunction. Am J Psychiatry, 1987; 144: 1243-4.
82. Cohen AJ. Treatment of antidepressant-induced sexual dysfunction with Ginkgo Biloba Extract. American Psychiatric Association. Abstracts of 149th Annual Meeting. New York, New York. 1996; May-4-9: 266.
83. Walker PW, Cole JO, Gardner EA, et al. Improvement in Fluoxetine-associated sexual dysfunction in patients switched to bupropion. J Clin Psychiatry, 1993; 54: 459-65.
84. Labbate LA, Pollack MH. Treatment of fluoxetine-induced sexual dysfunction with bupropion: A case report. Ann Clin Psychiatry, 1994; 6 (1): 13-5.
85. Gardner EA, Johnston JA. Bupropion: an antidepressant without sexual pathophysiological action. J Clin Psychopharm, 1985; 5: 24-9.
86. Sovner R. Anorgasmia associated with imipramine but not desipramine: case report. J Clin Psychiatry, 1983; 44: 345-6.
87. Philipp M, Kohnen R, Benkert O. A comparison study of Moclobemide and Doxepine in major depression with special reference to effects of sexual dysfunction. Int Clin Psychopharmachol, 1993; 7: 123-32.
88. Ferguson JM, Shrivastava RK, Stahl S, et al. Effects of double-blind treatment with Nefazodone or Sertraline on re-emergence of sexual dysfunction in depressed patients. American Psychiatric Association. Abstracts of 149th Annual Meeting. New York, New York. 1996; May-4-9: NR 358.
89. Rothschild AJ. Selective serotonin reuptake inhibitors-induced sexual dysfunction: efficacy of a drug (and sex) Holiday. American Psychiatric Association. Abstracts of 148th Annual Meeting. Miami, Florida. 1995; May-20-25: NR 454.
90. Feder R. Reversal of antidepressant activity of fluoxetine in three patients. J Clin Psychiatry, 1991; 52: 163-4.
91. Goldbloom DS, Kennedy SH. Adverse interaction of fluoxetine and cyproheptadine in two patients with bulimia Nervosa. J Clin Psychiatry, 1991; 52: 261-2.
92. Baier D, Philipp M. Effects of antidepressants on sexual function. Fortschr. Neurol. Psychiatry, 1994; 62: 14-21.
93. Segraves RT. Overview of Sexual dysfunction complicating the treatment of depression. J Clin Psychiatry Monograph, 1992; 10, 2: 4-8.
94. Balon R, Yeragany VK, Pohl R, Ramesh C. Sexual dysfunction during antidepressant treatment. J Clin Psychiatry, 1993; 54 (6): 209-12.
95. Cohn CK, Shrivastava R, Mendels J. Doubled blind multicenter comparison of Sertraline and Amytriptiline in elderly depressed patients. J Clin Psychiatry, 1990; 51 (12 suppl B): 18-27.
96. Stratta P, Mancini F, Cupillary M, et al. Fluoxetine in premature ejaculation. Human Psychopharmacology, 1993; 8: 61-4.
97. Power-Smith, P. Beneficial sexual side -effects from Fluoxetine, British J Psychiatry, 1994; 164: 249-50.
98. MacHale S, Phanjoo AL. SSRIs to treat sexual dysfunction (letter). Br J Psychiatry, 1994; 164: 854.
99. Forster P, King J. Fluoxetine for premature ejaculation (letter). Am J Psychiatry, 1994; (oct), 151 (10): 1523.
100. Wise TN. Sertraline as a treatment for premature ejaculation. J Clin Psychiatry, 1994; 55 (9): 417.
101. Assalian, P. Clomipramine in the treatment of premature ejaculation. Journal of Sexual Research, 1988; 24: 213-5.
102. Waldinger MD, Hengeveld MW, Zwinderman AH. Paroxetine treatment of premature ejaculation: A double blind, randomized, placebo-controlled study. Am J Psychiatry, 1994; 151: 1377-9.
103. Zohar J, Kaplan J, Benjamin J. Compulsive exhibitionism successfully treated with Fluvoxamine. A controled case study. J Clinical Psychiatry, 1994; 55 (3): 86-8.
104. Hyttel J. Pharmacological profile of Selective Serotonin Reuptake inhibitors (SSRI). Int Clin Psychopharmacology, 1994; 9 (supl 1): 19-26.
105. Aldrich A. Retrospective review of psychotropic-induced sexual dysfunction in women. American Psychiatric Association. Abstracts of 149th Annual Meeting. New York. New York, 1996; May-4-9: 266.
106. Segraves RT. Psychiatric drugs and orgasm in the human female. Journal of Psychosomatic Obstetrics and Gynecology, 1985; 4: 125-8.
107. Magnus RV, Dean BC. Clorazepate: doble-blind crossover comparison of a single nightly dose with diazepam twice daily in anxiety. Diseases of the Nervous System, 1977; 38: 317-21.
108. Hughes JM. Failure to ejaculate with Chlordiazepoxide. Am J Psychiatry, 1964; 121: 610-1.
109. Sangal R. Inhibited female orgasm as a side effect of Alprazolam. Am J Psychiatry, 1985; 142: 1223-4.
110. Lydiard RB, Howell EF, Laraia MT, et al. Sexual side effects of alprazolam (letter). Am J Psychiatry, 1987; 144: 254-5.
111. Munjack DJ, Crocker B. Alprazolam-induced ejaculatory inhibition. journal of Clinical Psychopharmacology, 1986; 6: 57-8.
112. Uhde TW, Tancer ME, Shea CA. Sexual dysfunction related to alprazolam treatment of social phobia. Am J Psychiatry, 1988; 145: 531-2.
113. Yeragani VK, Pohl R, Balon R. Sexual dysfunction related to alprazolam treatment of social phobia (letter). Am J Psychiatry, 1988; 145: 531-2.
114. Segraves RT. Treatment of premature ejaculation with Lorazepam. Am J Psychiatry, 1987; 144: 1240.
115. Benazzi F, Mazzoli M. Fluoxetine-induced sexual dysfunction: A dose-dependent effect? Pharmacopsychiatry, 1994; 27 (6): 246.
116. Beasley CM, Bosomworth JC, et al. Fluoxetine: relationships among dose response, adverse events and plasma concentrations in the treatment of depression. Psychopharmacol Bull, 1990; 26: 18-24.
117. Fahrer R, Nazar J, Suárez M, et al. efficacy and tolerance of Moclobemide in 120 patients with depressive syndrome, in Therapeutic Advantages of Moclobemide RIMA Reversible Inhibition of MAO-A. 6th European Congress Assoc Europ Psychiatry, Barcelona, 1992; Nov 4: 28.
118. Schweitzer I, Tiller J, Maguire K, Davies B. Treatment of atypical depression with Moclobemide. A sequential double controlled study. Int J Clin Pharm Res, 1989; IX (2): 111-7.
119. Rudorfer MV, Manji HK, Potter WZ. Comparative tolerability profiles of the newer versus older antidepressants. Drug Safety, 1994; 10 (1): 18-46.
120. Reynaert C, Parent M, Mirel J, et al. Moclobemide versus Fluoxetine for a major depressive episode. Psychopharmacology, 1995; 118: 183-7.
121. Baier D, Philipp M. Sexual Dysfunction in depression. Focus in depression and anxiety, 1996; 1-11.
122. Philipp M, Kohnen R, Benkert O. A comparison study of Moclobemide and Doxepine in major depression with special reference to effects on sexual dysfunction. Int. Clin. Psychopharmacol, 1993; 7: 149-53.
123. Davidson JR. Monoamine oxidase inhibitors. En: Paykel ES, editor. Handbook of Affective Disorders, 2nd edition. New York: Guilford Press,1992: 345-58.
124. Bressler R, Katz MD. Drug therapy for geriatric depression. Drugs & Aging, 1993; 3 (3): 195-219.
125. Harrison WM, Stewart J, Ehrhardt AA, et al. A controlled study of the effects of antidepressants on sexual function. Psychopharmacol Bulletin, 1985; 21 (1): 85-8.
126. Warneke L. Phenelzine and sexuality (letter). J of Clinical Psychiatry, 1994; 55 (5): 216-7.
127. Versiani M, Nardi AE, Mundim FD, et al. Pharmacotherapy of social phobia. A controlled study with Moclobemide and Phenelzine. British J Psychiatry, 1992; 161: 353-60.
128. Mann JJ, Aarons SF, Wilner PJ, et al. A controlled study of the antidepressant efficacy and side effects of Deprenyl. Arch Gen Psychiatry, 1989; 46: 45-50.
129. Schiavi RC. Interview, psychometric and psychophysiologic strategies to asses sexual disorder Etiology. J Clin Psychiatry Monograph, 1992; 10 (2): 19-26.
130. Wise TN. A model for the assessment of sexual dysfunction etiology. J Clin Psychiatry Monograph, 1992; 10 (2): 11-8.